Tranexamic acid and tourniquet versus tourniquet for controlling blood loss during open abdominal myomectomy: a double-blind placebo-controlled randomised trial by George U Eleje, Kingsley E Ekwuazi, Victor I Amulu, Joseph T Enebe, Cyril C Dim, David M Aqua, Chidinma C Okafor, Chigozie G Okafor

“…The participants were randomised equally (ratio of 1:1) to receive either 1 g of intravenous tranexamic acid plus tourniquet (study group) or tourniquet plus placebo (control group) during the procedure. …”
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LncRNA PVT1 Promotes the Progress of Hypertrophic Scar via Regulating the Proliferation and Migration of Myofibroblasts Through Targeting miR-29a-3p/STAT3 by Han P, Liu R, Guan X

“…This research was aimed at exploring the clinical value of lncRNA PVT1 in HS formation and its potential mechanisms in human hyperplastic scar myofibroblasts (HSFs).Patients and Methods: Fifty-seven HS patients were enrolled. RT-qPCR was conducted to examine the RNA levels of lncRNA PVT1, miR-29a-3p and STAT3. …”
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Vaccarin Ameliorates Renal Fibrosis by Inhibiting Ferroptosis via Nrf2/SLC7A11/GPX4 Signaling Pathway by Cui M, Xu Q, Duan L, Lu J, Hu J

“…This study aimed to investigate the effects of vaccarin on RF and its molecular mechanisms.Methods: Network pharmacology was used to analyze the effect of vaccarin on RF, and molecular docking and molecular dynamics simulations were performed to assess the binding of nuclear factor erythroid 2-related factor 2 (Nrf2) to vaccarin. …”
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Development of Hybrid District Heating Systems by A. V. Sednin, K. M. Dyussenov

“…The issue of using electricity in district heating systems as an excess resource of integrated energy systems within the framework of equalizing the daily and seasonal schedule of energy consumption is also considered. …”
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The significance of the expression of cell proliferation and inflammation markers in the development of acquired middle ear cholesteatoma by Erdoglija Milan, Grgurević Uglješa, Cerović Snežana, Jović Milena, Baletić Nenad, Sotirović Jelena

“…Expression of PCNA, Ki-67, COX-2 and CD 8 lymphocytes in more serious clinical picture of cholesteatoma was almost equal as in less serious clinical picture of cholesteatoma. …”
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Strategi komunikasi pembangunan Andromeda Learning Center dalam mengembangkan pariwisata berbasis masyarakat di Yogyakarta by Habib Diki Setiawan, Benni Setiawan

“…Informants were selected and determined using the purposive judgment method. Data collection used in-depth interview and non-participant observation methods. …”
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Effect of benign prostatic hyperplasia surgery on ejaculatory function by M. P. Dianov, P. S. Kyzlasov, A. G. Martov, P. N. Korolev, V. A. Perepechay, V. V. Khvorov

“…However, the choice of method rarely considers its effect on ejaculatory function.Objectives. …”
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Runoff Variations and Quantitative Analysis in the Qinghai Lake Basin Under Changing Environments by Li Mo, Xinxiao Yu, Yonghan Feng, Tao Jiang

“…Abrupt changes were detected using the Mann–Kendall and cumulative anomaly methods, while the Budyko framework attributed runoff variations to dominant factors. …”
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Effects of Different Blood Flow Restriction Training Modes on Body Composition and Maximal Strength of Untrained Individuals by Hualong Chang, Xudong Yang, Biao Chen, Jianli Zhang

“…Background: The objective of this study was to examine the impacts of absolute cuff pressure blood flow restriction (A-BFR) training and incremental cuff pressure blood flow restriction (I-BFR) training, under equal cuff pressures, on body composition and maximal strength among untrained adults. …”
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Effects of Aerobic Versus Resisted Intradialytic Exercises on Quality of Life, Pain, and Physiological Outcomes in Chronic Kidney Disease by Rania Nagy Karkousha, Amira Hussin Draz, Nesreen Gharib ElNahas, Efrem Kentiba, Mohamed Magdy ElMeligie

“…Patients were randomly assigned equally to either the resistance exercise group or the aerobic exercise group and underwent respective exercise interventions for 8 weeks. …”
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Succinate Facilitates CD4+ T Cell Infiltration and CCL1 Production to Promote Myofibroblast Activation and Renal Fibrosis in UUO Mice by Tao Y, Zhang W, Liu D, Cao H, Yi X, Deng X, Li P, Shen X, Zhou H

“…However, the precise pathogenic mechanisms of succinate in obstructive nephropathy remain to be elucidated.Methods: Succinate was supplemented in the drinking water to study its impact on the pathogenesis of obstructive nephropathy induced by unilateral ureteral obstruction (UUO) in mice. …”
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Effect of ARG1 Gene (rs2781666) Polymorphism on Plasma Arginase Activity and Bronchial Asthma Prevalence and Severity by Al-Ghunmieen EM, Shatanawi A, Al-Akhras FM, Al Oweidat K, Alzayadneh EM

“…Furthermore, increased serum arginase activity has been reported in patients with asthma, suggesting an association with bronchial asthma phenotypes.Purpose: To determine the frequency of ARG1 rs2781666 polymorphism among Jordanians, we compared plasma arginase activity and ARG1 rs2781666 polymorphism in asthmatic patients and non-asthmatic volunteers, and analyzed the distribution of rs2781666 genotypes among asthma severity groups.Patients and Methods: Four hundred and twenty-four asthmatic and non-asthmatic Jordanian subjects visiting the Jordan University Hospital were genotyped for ARG1 rs2781666 polymorphism using the polymerase chain reaction-restriction fragment length polymorphism method and were examined for serum arginase activity using an arginase activity assay.Results and conclusions: There was a significant association between ARG1 rs2781666 G/T polymorphism and bronchial asthma frequency and severity. …”
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Predictors of Cervical Cancer Screening Uptake among Healthcare Providers in Siaya County, Kenya by Zilper Imbuye, Damaris Ochanda, John Arudo

“…Methods: The study was conducted in Siaya County hospitals and adopted analytical cross-sectional study design. …”
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General practitioners’ familiarity, attitudes and practices with regard to Attention Deficit Hyperactivity Disorder (ADHD) in children and adults by Charmaine Louw, Marietjie M. Oswald, Mariechen D. Perold

“…GPs should acknowledge the educational psychologist as an equal partner within a multidisciplinary team.…”
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Combining Dual Biologics Therapy for Severe Asthma: A Series of Ten Cases by Chen Y, Wang L, Xie J

“…Dual biologic therapy has emerged as a promising strategy, but its efficacy and safety are not yet fully understood.Objective: To describe the characteristics, endotyping features, decision-making process and therapeutic response of patients with severe asthma on dual biologic therapy in a real-world setting.Methods: We present ten patients on dual biologics for severe asthma. …”
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Causal Pathways Between Breast Cancer and Cardiovascular Disease Through Mediator Factors: A Two-Step Mendelian Randomization Analysis by Lu W, Li K, Wu H, Li J, Ding Y, Li X, Liu Z, Xu H, Zhu Y

“…Our study endeavors to investigate the causal association between BC and CVD, with a focus on identifying potential metabolic mediators and elucidating their mediation effects in this causality.Methods: In this study, we conducted two-sample Mendelian randomization (MR) to estimate the causal effect of BC (overall BC, ER+ BC, ER- BC) from the Breast Cancer Association Consortium (BCAC) on CVD including coronary heart disease (CHD), hypertensive heart disease (HHD), ischaemic heart disease (IHD), and heart failure (HF) from the FinnGen consortium. …”
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Clinical Characteristics and Prognostic Factors of Severe COVID-19 by Yang Y, Huang Z, Pei Y, Huang Y, Chen C, Zhou T

“…We aimed to identify the severe cases in early stages to improve the prognosis and mortality.Patients and Methods: We collected the clinical data of 98 patients with severe COVID-19, who were admitted to the Second Affiliated Hospital of Soochow University (Jiangsu, China) from December 2022 to November 2023. …”
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Aloe Vera Gel and Rind-Derived Nanoparticles Mitigate Skin Photoaging via Activation of Nrf2/ARE Pathway by Sun Z, Zheng Y, Wang T, Zhang J, Li J, Wu Z, Zhang F, Gao T, Yu L, Xu X, Qian H, Tan Y

“…Aloe vera, known for its natural active ingredients that benefit the skin, aloe-derived exosome-like nanoparticles (ADNPs) have not yet been studied for their potential in delaying skin aging.Methods: In this study, nanoparticles were isolated from two different sites, aloe vera gel and aloe vera rind (gADNPs and rADNPs), and characterized by TEM, SEM, AFM, NTA and BCA. …”
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The impact of different angiotensin II receptor blockers on the stiffness of the large arteries and effectiveness of therapy by O. L. Rekovets, Yu. M. Sirenko, O. O. Torbas

“…In recent years, the method of determining the Cardio-Ankle Vascular Index (CAVI) has been introduced into clinical practice, which can be used to determine changes in the stiffness of the large arteries regardless of changes in blood pressure (BP). …”
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Identification and Experimental Verification of Potential Immune Cell-Associated Gene Biomarkers in Human Intervertebral Disc Degeneration by Shi WH, Zou HS, Wang XY, Lu J, Yu HQ, Zhang PP, Huang LL, Chu PC, Liang DC, Zhang YN, Li B

“…This study aimed to conduct a bioinformatic analysis to identify biomarkers associated with IDD immune cells.Methods: We obtained the gene expression profiles of IDD by downloading the Gene Expression Omnibus Series (GSE)150408 and GSE124272 from the Gene Expression Omnibus (GEO) database. …”
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