Analysis and Validation of Autophagy-Related Gene Biomarkers and Immune Cell Infiltration Characteristic in Bronchopulmonary Dysplasia by Integrating Bioinformatics and Machine Lea... by Xiao S, Ding Y, Du C, Lv Y, Yang S, Zheng Q, Wang Z, Zheng Q, Huang M, Xiao Q, Ren Z, Bi G, Yang J

“…We aim to screen and validate the signature genes of BPD by bioinformatics and in vivo experiment.Methods: GSE8586 was obtained from the Gene Expression Omnibus (GEO) database. …”
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Causal Effect of Obstructive Sleep Apnea on Sick Sinus Syndrome: A Bidirectional Mendelian Randomization Study by Chen W, Pan W, Ling L, Jiang B, Zhang Y, Su X, Jiang T, Lin J

“…This study aims to investigate the potential causal relationship between OSA and the development of SSS.Methods: To evaluate the association between OSA and SSS, we utilized a bidirectional two-sample Mendelian randomization (MR) method. …”
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Comparison of Point-of-Care and Highly Sensitive Laboratory Troponin Testing in Patients Suspicious of Acute Myocardial Infarction and Its Efficacy in Clinical Outcome by Sahand Mohammadzadeh, Nasim Matani, Neda Soleimani, Hamed Bazrafshan drissi

“…In this small sample-size study, a new qualitative POC-cTnI assay was statistically equal to a hs-cTnI assay in terms of diagnostic accuracy for AMI or MACE in patients with suspected myocardial infarction. …”
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Rotavirus breakthrough infections responsible for gastroenteritis in vaccinated infants who presented with acute diarrhoea at University Teaching Hospitals, Children's Hospital in... by Julia Simwaka, Mapaseka Seheri, Gina Mulundu, Patrick Kaonga, Jason M Mwenda, Roma Chilengi, Evans Mpabalwani, Sody Munsaka

“…A 20-point Vesikari clinical score between 1-5 was considered as mild, 6-10 as moderate and greater or equal to 11 as severe.<h4>Results</h4>A total of 424 stool specimens were tested of which 153 (36%, 95% CI 31.5% to 40.9%) were positive for VP6 rotavirus antigen. …”
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Fibrinogen-to-Albumin Ratio as a Novel Predictor of Intracerebral Hemorrhage in Maintenance Hemodialysis Patients by He X, Wang Y, Wang Y, Li X

“…The fibrinogen-to-albumin ratio (FAR), a composite inflammatory and nutritional marker, may offer predictive value for ICH in this high-risk population.Methods: This retrospective study analyzed a total of 536 MHD patients (ICH group: n=207; non-ICH group: n=329) from June 2019 to June 2024. …”
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Boosting Hydroxyl Radical Generation with Nitrogen Vacancy&amp;ndash;Modified Carbon Nitride for Triggering Dual Damage of Cancer Nucleus DNA&amp;ndash;Mitochondria against Hypoxic... by Zhang Y, Liu M, Xue S, Li N, Hong J, Gu J, Ren X, Li H, Xu J, Zhang C, Liang T, Zhao B, Wang X

“…A hypoxic tumor microenvironment is the bottleneck of photodynamic therapy (PDT) and significantly weakens overall therapeutic efficacy.Methods: In this study, we introduce nitrogen vacancy–modified PCN (NV-PCN), a novel metal-free and O2-independent photosensitizer designed for PDT. …”
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Estimating the risk of zoonotic transmission of swine influenza A variant during agricultural fairs in the United States: a mathematical modeling by Dana C. Pittman Ratterree, Sapna Chitlapilly Dass, Martial L. Ndeffo-Mbah, Martial L. Ndeffo-Mbah

“…For attendees, we showed that the probability equals 0.0168 (95% CI: 0.0167–0.0169), when R0 = 2 with 1 initially infected pig, and 0.00371 (95% CI: 0.00368–0.00373), when R0 = 2 with 5 initially infected pigs. …”
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Kidney sparing surgery versus radical nephroureterectomy in upper tract urothelial carcinoma: a meta-analysis and systematic review by Leqing Zhou, Chuyang Huang, Sheng Sun, Keping Ning, Shan Tang

“…We aim to conduct a systematic review and meta-analysis comparing the long-term oncologic and renal function outcomes of KSS with those of radical nephroureterectomy (RNU) for UTUC.Materials and methodsA literature search was conducted on PubMed, Embase, and Web of Science in January 2024. …”
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Digital mapping of Ghana’s soil properties and nutrients: performance of spline and weighted average approaches by Kora B.D. Simperegui, Anselme K.K. Kouame, Benjamin Kwesie, Prem S. Bindraban, William Adzawla, Eric Asamoah, Mohamed El Gharous

“…This involved two profile data harmonization methods—equal-area spline and thickness-weighted average—with a quantile random forest model. …”
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Vincristine Regulates C/EBP-&beta;/TGF-&beta;1 to Promote A1 Astrocyte Polarization and Induce Neuropathic Pain by Chen Y, Tang G, Lu J, Tang S, Xiong X, Chen C, Pei L, Shi J

“…This study aims to clarify the mechanism of C/EBP-β regulating TGF-β 1 mediated spinal astrocyte A1/A2 polarization in the neuropathic pain caused by vincristine.Methods: Neuropathic pain model was established in rats by intraperitoneal injection of Vincristine (VCR). …”
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The interplay between home and job demands, resources, and the intention to stay in nursing: A cross-sectional study by Jasperina Brouwer, Stéfanie André, Nienke Renting

“…Background: Concerns about the global nursing shortage highlight that, while increasing graduates is considered as essential, addressing retention issues is equally critical to mitigate the shortage effectively. …”
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Knowledge, Attitude, and Belief of Healthcare Professionals Toward Obesity Stigmatization by Lang H, Zhang X, Yan N, Du J, Jiang X

“…This study aimed to investigate healthcare professionals’ knowledge about obesity-related health impacts, attitudes regarding weight bias (negative or discriminatory attitudes toward individuals with obesity), and beliefs about the causes and nature of obesity.Methods: This cross-sectional study was conducted among healthcare professionals between Jan, 2024 and Feb, 2024 in The Department of General Medicine, Chengdu Second People’s Hospital, using a self-designed questionnaire.Results: A total of 388 valid questionnaires [303 (78.09%) female and a mean age of 37.71 ± 8.46 years] were included. …”
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From Gene to Intervention: NLRC4 and WIPI1 Regulate Septic Acute Lung Injury Through Autophagy by Yang X, Sun Z, Liu Z, Chen H, Fang Y, Tao W, Zhao N, Ouyang X, Liu F, Qian K

“…Although autophagy is crucially involved in the inflammatory response, its precise molecular mechanisms in SALI remain unclear, forming the basis of this study.Methods: Herein, two microarray datasets (GSE33118 and GSE131761) and three single-cell sequencing datasets (SCP43, SCP548, and SCP2156) derived from human samples were used to ascertain the interrelationship between Differentially Expressed Autophagy-Related Genes (DEARGs) and SALI. …”
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The allocation and fairness of hospital pharmacist human resources in China: a time-series study by Hengfan Ni, Ma Yuan, Peng Wan, Qiu Xiang, Du Hongling, Tang Minghai, Li Jian

“…In addition, the contribution rates of the within-group Theil indexes of pharmacist human resources based on population and geographical area distributions to the total Theil index were all greater than or equal to 50%. Conclusions The allocation level of pharmacist human resources in China continues to improve, but there are differences in different economic development areas. …”
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Ultrasonic Parameters as Biomarkers for Tumor Staging and Aggressiveness in Breast Cancer: Correlation with GP73 and miR-27a by Tao ZY, Rong R, Zhou LP

“…Zi-Yu Tao,1,&amp;ast; Rong Rong,2,&amp;ast; Lei-Ping Zhou3 1Obstetrics and Gynecology Hospital Fudan University, Shanghai, 200233, People’s Republic of China; 2Department of Clinical Laboratory, The Second People’s Hospital of Hefei, Hefei Hospital Affiliated to Anhui Medical University, Hefei, 230000, People’s Republic of China; 3Department of Ultrasound, International Peace Maternity and Child Health Hospital, Shaghai, 200063, People’s Republic of China&amp;ast;These authors contributed equally to this workCorrespondence: Lei-Ping Zhou, Department of Ultrasound, International Peace Maternity and Child Health Hospital, Shaghai, 200063, People’s Republic of China, Tel +86-13761708810, Email Zhouleiping68@163.comObjective: To investigate correlations between CEUS parameters and serum GP73/miR-27a in breast cancer.Methods: In the study, 117 highly suspected breast cancer diagnosed and treated in our hospital during March 2022 to April 2024 were included. …”
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SEMAGLUTIDE: Weight loss, glycaemic control and safety profile in obese patients with and without type-II diabetes-An experience from Karachi, Pakistan by Muhammad Y. Memon, Tasnim Ahsan, Rukhshanda Jabeen, Saba Latif, Saeeda F. Qasim, Paras Imran

“…Objective To assess the efficacy and safety of Semaglutide (a GLP-1 receptor agonist) in obese patients with and without Type-II Diabetes Mellitus. Methods This observational analytic cohort study was conducted in a private medical institute in Karachi Pakistan; from August 2022 to January 2023. …”
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Comparing the Prognostic Value of Lactate to the Neutrophil to Lymphocyte Ratio Among Sepsis Patients: A Prospective Cohort Study by Bou Chebl R, Haidar S, Kattouf N, Assaf M, Alwan JS, Khamis MM, Abdeldaem K, Makki M, Tamim H, Abou Dagher G

“…This study compares the prognostic value of lactate and NLR in septic patients.Methods: This prospective cohort study included 874 adult septic or septic shock patients presenting to a tertiary care center’s Emergency Department between September 2018 and February 2021. …”
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Alkannin Induces G2/M-Phase Arrest, Apoptosis, and Inhibition of Invasion by Targeting GSK3&beta; in Esophageal Squamous Cell Carcinoma by Ma H, Xu P, Jia Y, Zhou Y, Li X, Wang Y, Ma K

“…This study aims to investigate the therapeutic effects of Alkannin on ESCC and elucidate its potential targets and molecular mechanisms.Methods: Cell Counting Kit-8 (CCK-8) assays, colony formation assays, Hoechst 33342 staining, wound healing assays, Transwell migration assays, flow cytometry, and Western blotting were used to investigate the therapeutic effects of Alkannin on ESCC in vitro. …”
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Analysis of Electroacupuncture Parameters for Irritable Bowel Syndrome: A Data Mining Approach by Tang Y, Tang X, Wen Q

“…This study endeavors to identify effective EA parameters for IBS through data mining methodologies.Methods: To retrieve randomized controlled trials (RCTs) on EA for IBS published between 2013 and 2024, a comprehensive search was conducted across nine databases. …”
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MDT Reduces Perioperative Thrombotic Events in Elderly Orthopedic Patients by Chen T, Lei X, Tian J, Mai H, Yu Y, Wu W, Wen L, Saw PE, Zhang M

“…Tonghua Chen,1,&amp;ast; Xiaojun Lei,1,&amp;ast; Jingwei Tian,1,&amp;ast; Haochen Mai,1 Yuanfang Yu,1 Wenxia Wu,1 Liqiang Wen,1 Phei Er Saw,1 Meng Zhang1,2 1Department of General Practice, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, Guangdong, People’s Republic of China; 2Department of General Practice, Shenshan Medical Center, Sun Yat-sen Memorial Hospital, Shanwei, Guangdong, People’s Republic of China&amp;ast;These authors contributed equally to this workCorrespondence: Phei Er Saw; Meng Zhang, Email caipeie@mail.sysu.edu.cn; zhangm7@mail.sysu.edu.cnPurpose: To minimize the occurrence of acute thromboembolic events in elderly patients during the perioperative period and prevent adverse clinical outcomes, this study explores an efficient, and precise approach to the formulation of antithrombotic regimens under a multidisciplinary team (MDT) consultation model.Patients and Methods: This single-center retrospective study included elderly patients on long-term antithrombotic therapy who underwent orthopedic surgery in our hospital between January 2019 and May 2023. …”
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