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20241
Magnitude and determinants of intimate partner violence against women in Somalia: evidence from the SDHS survey 2020 dataset
Published 2025-01-01“…Purpose This study aims to identify the prevalence and key determinants of IPV in Somalia, including age groups, administrative regions, place of residence, educational level, household size, husband/partner’s education and work, respondent’s work, and total children ever born. Methods Data from the Somali Demographic and Health Survey (SDHS) 2020 were analyzed. …”
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20242
Molecular Mechanisms in Idiopathic Mitral Valve Chordae Tendineae Rupture: Insights from Transcriptome Analysis and Inflammation Evaluation
Published 2025-04-01“…Qiuji Wang,1– 3,* Lishan Zhong,1,2,* Linbin Hua,1– 3 Shanwen Pang,1– 3 Yuxin Li,1,2 Zhaolong Zhang,1,2 Junfei Zhao,1,2 Huanlei Huang1– 3 1Department of Cardiac Surgery, Guangdong Provincial People’s Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou, 510080, People’s Republic of China; 2Guangdong Cardiovascular Institute, Guangzhou, 510030, People’s Republic of China; 3Guangdong Provincial Key Laboratory of South China Structural Heart Disease, Guangzhou, People’s Republic of China*These authors contributed equally to this workCorrespondence: Huanlei Huang, Department of Cardiac Surgery, Guangdong Provincial People’s Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, 106 Zhongshan Second Road, Yuexiu District, Guangzhou, Guangdong, People’s Republic of China, Email hhuanlei@hotmail.com Junfei Zhao, Department of Cardiac Surgery, Guangdong Provincial People’s Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, 106 Zhongshan Second Road, Yuexiu District, Guangzhou, Guangdong, People’s Republic of China, Email zhaojunfei@gdph.org.cnObjective: This study investigates the molecular mechanisms and hub genes in idiopathic rupture of mitral valve chordae tendineae (iRCT).Methods: Histological changes were assessed via pathological staining, and transcriptome sequencing was performed on samples from 8 iRCT patients and 6 controls. …”
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20243
Cubosomes as Delivery System to Repositioning Nitrofurantoin in Breast Cancer Management
Published 2024-12-01“…This activation mechanism has led to its exploration for repositioning applications in controlling and treating breast cancer, which express a Nitro reductase gene.Methods: NITRO Cubosomes were developed using hot homogenization according to 23-full factorial design. …”
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20244
Effect of transdermal immunomodulation on liver regeneration
Published 2022-04-01“…Assessment of the mitotic index (MI) of hepatocytes 48 hours after EHR revealed a significant increase in MI in both groups in comparison with the baseline (before liver resection) equal to 0.14 ± 0.07‰. The MI in group 1 and group 2 animals was 12.70 ± 4.9‰ and 17.43 ± 4.90‰, respectively (p ≤ 0.05).Conclusion. …”
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20245
Immune Dysregulation and Cellular Composition in Lichen Sclerosus Revealed by Integrative Epigenetic Analysis with Cell Type Deconvolution
Published 2025-01-01“…Its etiology is unknown, possibly involving immune dysregulation and inflammation.Methods: Study used DNA methylation (DNAme) and single-cell RNA sequencing (scRNA-seq) to compare LS with normal skin. …”
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20246
Research on the Developmental Trajectory of Movement-Evoked Pain and Its Potential Predictors in Patients After Knee Arthroplasty
Published 2025-04-01“…Shanshan Ai,1,* Sumin Zhao,1,* Lihui Yan,1 Hangying Hu,1 Pengli Niu,2 Yueli Zhu,1,* Meifang Zheng1,* 1Department of Nursing, Integrated Traditional Chinese and Western Medicine of Linping District Hospital, Hangzhou, Zhejiang, People’s Republic of China; 2Department of Nursing, The First Hospital of Dalian Medical University, Dalian, Liaoning, People’s Republic of China*These authors contributed equally to this workCorrespondence: Yueli Zhu, Department of Nursing, Integrated Traditional Chinese and Western Medicine of Linping District Hospital, No. 15, Baojian Road, Linping District, Hangzhou, Zhejiang, 311100, People’s Republic of China, Tel +86 189 0681 1351, Email 2582840555@qq.comPurpose: This study aimed to investigate the developmental trajectory of movement-evoked pain after knee arthroplasty and analyze the predictors of different developmental trajectory categories.Patients and Methods: In this study, a total of 178 patients undergoing knee arthroplasty were recruited from the Department of Joint Surgery at a tertiary care hospital in China. …”
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20247
Controlled Nitric Oxide-Releasing Nanovehicles for Enhanced Infected Wound Healing: A Study on PDA@BNN6 Encapsulated in GelMA Hydrogel
Published 2024-11-01“…This dual action promotes the healing of full-thickness skin wounds that are infected.Methods: Gel/PDA@BNN6 was developed, and both in vitro and in vivo experiments were carried out to evaluate its structure, physicochemical properties, antibacterial effects, effectiveness in promoting infected wound healing, and biocompatibility.Results: Gel/PDA@BNN6 was successfully synthesized, exhibiting a porous three-dimensional lattice structure and excellent mechanical properties. …”
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20248
Extraperitoneal Open Radical Cystectomy: A New Standard in Frail Patients with Muscle-Invasive Bladder Cancer?
Published 2024-11-01“…The purpose of this study was to evaluate the feasibility and the safety of extraperitoneal open RC in our experience; <b>Methods</b>: We retrospectively collected the data of 75 frail patients who underwent an extraperitoneal open RC, performed by a single experienced surgeon. …”
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20249
Association Between Systemic Immune-Inflammation Index and Stress Urinary Incontinence in Adult Women: A Population-Based Study
Published 2025-02-01“…This study aims to explore the association between SII and SUI in women.Methods: Adult participants from the 2007– 2018 NHANES were included. …”
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20250
Representation of women in scientific subjects: overview of systematic reviews investigating career progress in academic publishing with a focus on mental health
Published 2025-03-01“…The rate of change for psychology and psychiatry women authors was also higher every 10 years: 8.56% (95% CI 6.44–10.69%) for first and 6.86% (95% CI 4.57–9.15%) for last author, and rate was 2.35% higher for first author and 2.65% higher for last author than in medicine. Different methods of classifying gender and identification method did not affect our results. …”
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20251
Toxicity of treatment regimens for drugresistant tuberculosis.
Published 2022-03-01“…Combinations of fluoroquinolones, bedaquiline, and linezolid with traditional anti-tuberculosis drugs are used in new regimens for the treatment of patients with multidrug- and extensively drug-resistant tuberculosis, but the safety of new regimens has yet to be sufficiently studied.The aim was to study the features of toxic effect manifestations of the 5-component antimycobacterial drug complexes in an experiment on rats.Methods. The study was carried out on 64 non-pedigree rats, old females, divided equally into 3 experimental groups and 1 control. …”
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20252
Integrating Machine Learning Algorithms to Construct a Triaptosis-Related Prognostic Model in Melanoma
Published 2025-06-01“…However, its role in melanoma remains largely unexplored.Methods: We explored the role of triaptosis in melanoma by integrating single-cell and bulk RNA sequencing data. …”
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20253
Motor development in premature infants: Study protocol for an interdisciplinary hospital-home intervention
Published 2023-09-01“…This study aimed to determine the effect of an interdisciplinary hospital-home intervention addressing motor development adaptation in premature infants in Colombia in comparison with traditional interventions. Methods: This study was based on a parallel design, with two groups, namely, experimental and control. …”
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20254
Spot Urine PCR as an Independent Predictor of Renal Disease in Patients with Essential Hypertension
Published 2025-04-01“…Results: The majority of participants were aged 51–60 years (26.7%), with a near-equal gender distribution (50 males; 51 females). …”
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20255
Thyroid Stimulating Hormone May Facilitates Adipose Tissue Insulin Resistance by Inducing M1 Macrophage Polarization
Published 2025-06-01“…However, currently the regulatory mechanism of TSH on the adipose tissue is not fully investigated yet.Methods: We constructed a subclinical hypothyroidism (SCH) mouse model induced by methimazole with elevated TSH levels and then observed its metabolic profile, adipose tissue IR, and the adipose tissue macrophages (ATMs) phenotype. …”
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20256
Risk factors precipitating exacerbations in adult asthma patients presenting at Kalafong Hospital, Pretoria
Published 2008-08-01“…Asthma is reported as taking up 1 to 2% of the total health budget in direct costs, with equally large indirect costs being incurred for time lost from work and reduced productivity. …”
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20257
The impact of the training program and the irregular interruption in the performance of the skill and some physiological indicators of young football players
Published 2022-07-01“…The researchers used the experimental method with equal groups, because it is the most appropriate methods to suit the nature of the problem and reach the achievement of the research objectives. …”
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20258
Evaluation of Olaparib Tablet Safety and Pharmacokinetics in Healthy Chinese Male Subjects
Published 2024-12-01“…., Shijiazhuang, Hebei Province, People’s Republic of China*These authors contributed equally to this workCorrespondence: Xueyuan Zhang, Clinical Department, CSPC Zhongqi Pharmaceutical Technology (SJZ) Co., LTD., Shijiazhuang, Hebei Province, 050035, People’s Republic of China, Tel +86-311-69085585, Email xueyuanzhang1987@163.comPurpose: To evaluate the safety and pharmacokinetics of olaparib tablet test formulation (T) and reference formulation (R) in healthy Chinese male subjects.Subjects and Methods: This was a single-dose, randomized-sequence, two-way crossover study including three parts: part A: a safety exploration design in lower dose (n = 14, 100 mg), part B: a pivotal comparative pharmacokinetic (PK) trial under fast condition (n = 44, 150 mg) and part C: a pivotal comparative PK trial under food condition (n = 44, 150 mg). …”
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20259
Phthalate Metabolites Were Related to the Risk of High-Frequency Hearing Loss: A Cross-Sectional Study of National Health and Nutrition Examination Survey
Published 2024-11-01“…This study aimed to investigate the relationship between phthalate metabolites and hearing loss.Methods: We conducted a cross-sectional study with 1713 participants based on the National Health and Nutrition Examination Survey 2015– 2018. …”
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20260
Readiness for Discharge, Quality of Discharge Teaching, Anxiety and Depression in Surgical Patients With Cervical Cancer: A Cross-Sectional Survey
Published 2025-03-01“…Jing Yuan,1,* Jia Zhang,1,* XiuYun Cui,1 YuTing Zhang,1 Yaru Wu,1 ChunYan Xu2 1School of Nursing, Xinjiang Medical University, Urumqi, Xinjiang, People’s Republic of China; 2Department of Gynecological Surgery, Affiliated Tumor Hospital of Xinjiang Medical University, Urumqi, Xinjiang, People’s Republic of China*These authors contributed equally to this workCorrespondence: ChunYan Xu, Email xcy101413@163.comPurpose: This quantitative study aimed to determine whether the quality of discharge teaching, anxiety, depression, and various demographic and disease-related factors predict discharge readiness among cervical cancer surgical patients in Western Region of China.Methods: From November 2023 to May 2024, a convenience sampling method was employed to administer a questionnaire to cervical cancer surgery patients at a tertiary Grade A specialized hospital in Xinjiang. …”
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