The impact of opioid analgesics with concomitant antipsychotic use on pain modulation and management in internal medicine: a cross-sequential study protocol by Nicola Grignoli, Nicola Grignoli, Nicola Grignoli, Simone Livoti, Simone Livoti, Angela Greco, Angela Greco, Michela Pironi, Roberta Noseda, Alessandro Ceschi, Alessandro Ceschi, Alessandro Ceschi, Alessandro Ceschi, Maria Luisa Garo, Luca Gabutti, Luca Gabutti

“…All patients with documented pain intensity assessment through a Visual Analogue Scale (VAS ≥ 1) will be included. …”
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Rethinking timing residuals: advancing PET detectors with explicit TOF corrections by Stephan Naunheim, Stephan Naunheim, Luis Lopes de Paiva, Luis Lopes de Paiva, Vanessa Nadig, Yannick Kuhl, Yannick Kuhl, Stefan Gundacker, Stefan Gundacker, Florian Mueller, Volkmar Schulz, Volkmar Schulz, Volkmar Schulz, Volkmar Schulz

“…PET is a functional imaging method that can visualize metabolic processes and relies on the coincidence detection of emitted annihilation quanta. …”
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DINOV2-FCS: a model for fruit leaf disease classification and severity prediction by Chunhui Bai, Chunhui Bai, Chunhui Bai, Lilian Zhang, Lilian Zhang, Lilian Zhang, Lutao Gao, Lutao Gao, Lutao Gao, Lin Peng, Lin Peng, Lin Peng, Peishan Li, Peishan Li, Peishan Li, Linnan Yang, Linnan Yang, Linnan Yang

“…However, the current prediction of disease degree by machine learning methods still faces challenges, including suboptimal accuracy and limited generalizability.MethodsIn light of the growing application of large model technology across a range of fields, this study draws upon the DINOV2 visual large vision model backbone network to construct the DINOV2-Fruit Leaf Classification and Segmentation Model (DINOV2-FCS), a model designed for the classification and severity prediction of diverse fruit leaf diseases. …”
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Effectiveness and Safety of Pharmacopuncture Therapy Compared to Standard Physical Therapy in Patients with Chronic Knee Pain: A Pilot Study for a Pragmatic Randomized Controlled T... by Myung In Jeong, Jun Kyu Lim, Yong Jun Kim, Yu Sun Jeon, Suna Kim, Chang Youn Kim, Yeon-Cheol Park, Eun-Jung Kim, Yejin Hong, Dongwoo Nam, Yoon Jae Lee, Doori Kim, In-Hyuk Ha

“…The type of PT solution or PT method was not determined in advance, leaving it to the clinician’s judgment. …”
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Retained Intrauterine Device (IUD): Triple Case Report and Review of the Literature by Mon-Lai Cheung, Shadi Rezai, Janelle M. Jackman, Neil D. Patel, Basem Z. Bernaba, Omid Hakimian, Dilfuza Nuritdinova, Catherine L. Turley, Ray Mercado, Takeko Takeshige, Sudha M. Reddy, Paul N. Fuller, Cassandra E. Henderson

“…Throughout the world, intrauterine contraceptive devices (IUDs) are a frequently used, reversible, popular contraceptive method. They are usually placed without major complications. …”
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Machine learning for epithelial ovarian cancer platinum resistance recurrence identification using routine clinical data by Li-Rong Yang, Mei Yang, Liu-Lin Chen, Yong-Lin Shen, Yuan He, Zong-Ting Meng, Wan-Qi Wang, Feng Li, Zhi-Jin Liu, Lin-Hui Li, Yu-Feng Wang, Xin-Lei Luo

“…We used laboratory and clinical data to create models based on machine learning for EOC platinum resistance recurrence identification.MethodsThis study was designed as a retrospective cohort analysis. …”
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Construction and validation of a prediction model for developing type 2 diabetes mellitus in patients with chronic obstructive pulmonary disease by Xi Kang, Tianye Li, Qinyang Chen, Hao Xu, Yanqiu Jiang, Hongjun Zhao, Xuhong Chang

“…Therefore, the purpose of this study was to identify the influencing factors of COPD complicated by T2DM and to construct a visualized disease prediction model.MethodWe included the medical records of 1,773 patients with COPD treated at Quzhou People’s Hospital from 2020 to 2023. …”
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KONSEP PERANCANGAN TAMAN RAMAH DIFABEL PADA TEPIAN SUNGAI MAHAKAM SAMARINDA KALIMANTAN TIMUR by Nur Husniah Thamrin, Hatta Musthafa AP

“…Edukasi akan disampaikan secara visual melalui bentukan-bentukan bangunan pada taman berupa bangunan dengan konsep Neo Vernakular khas Kalimantan Timur, ragam ornamen yang didesain pada pola lantai, ramp, dan bentuk taman labirin. …”
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Rationale and design of a comparison of angiography-derived fractional flow reserve-guided and intravascular ultrasound-guided intervention strategy for clinical outcomes in patien... by Qiang Liu, Shiqiang Li, Jinlong Zhang, Fan Jiang, Bin Yang, Jianan Wang, Jun Pu, Jun Jiang, Hao Zhou, Peng Chen, Liang Lu, Dongsheng Lu, Bon-Kwon Koo, Jinyu Huang, Lijun Guo, Xinyang Hu, Eun-Seok Shin, Shengxian Tu, Xiaoping Peng, Yibin Pan, Wenming He, Jilin Li, Zhenfeng Cheng, Jianliang Ma, Daqing Song, Yongzhen Fan, Zhaohui Meng, Lijiang Tang

“…However, whether this finding can be applied to angiography-derived FFR in significant coronary artery disease (CAD) remains unclear.Method and analysis The comparison of angiography-derived FFR-guided and IVUS-guided intervention strategies for clinical outcomes in patients with coronary artery disease (FLAVOUR II) trial is a multicentre, prospective, randomised controlled trial. …”
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Development and validation of a multimodal automatic interictal epileptiform discharge detection model: a prospective multi-center study by Nan Lin, Lian Li, Weifang Gao, Peng Hu, Gonglin Yuan, Heyang Sun, Fang Qi, Lin Wang, Shengsong Wang, Zi Liang, Haibo He, Yisu Dong, Zaifen Gao, Xiaoqiu Shao, Liying Cui, Qiang Lu

“…Abstract Background Visual identification of interictal epileptiform discharge (IED) is expert-biased and time-consuming. …”
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Children’s Headache Through Drawings: A Narrative Review and a Portrait Gallery by Floriana Ferro, Caterina Gaspari, Giulia Manfrè, Federica Cernigliaro, Daniela D’Agnano, Ruben Panzica, Edvige Correnti, Maria Rosita Ruta, Francesca Marchese, Renata Pitino, Mariarita Capizzi, Giuseppe Santangelo, Antonella Versace, Vittorio Sciruicchio, Vincenzo Raieli

“…Our goal is to create a visual reference that can aid clinicians in the accurate interpretation of children’s drawings. …”
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Assessing the psychometric properties of generic (EQ-5D-5L) and disease-specific (KCCQ) quality of life in patients with hypertrophic cardiomyopathy in the AFFECT-HCM study by Alexander Hirsch, Mickael Hiligsmann, Peter-paul Zwetsloot, Michelle Michels, Christian Knackstedt, Tjeerd Germans, Isabell Wiethoff, Stephan A.C. Schoonvelde, Rudolf A. de Boer, Silvia M.A.A. Evers, Wouter P. te Rijdt, Marjon A. van Slegtenhorst, Arend F.L. Schinkel

“…Background To assess the psychometric properties (content validity, reliability and construct validity) of generic and disease-specific health-related quality of life (HRQoL) instruments in patients with hypertrophic cardiomyopathy (HCM) and genotype-positive, phenotype-negative (G+/P−) individuals.Methods As part of the multicentre, observational AFFECT-HCM study, HRQoL was measured using the generic EuroQoL-5 Dimension-5 Level (EQ-5D-5L) questionnaire, the Visual Analogue Scale (EQ VAS) and the disease-specific Kansas City Cardiomyopathy Questionnaire (KCCQ). …”
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Acute Lateral Ankle Sprain Impairs Function and Strength Without Altering Muscle or Tendon Stiffness: A Controlled Observational Study by Pedro Bainy Franz, José Roberto deSouza Júnior, Hortência Cordeiro deLima, Estevão deSouza Diniz, Rogério deBrito Aguiar, Jeam Marcel Geremia, Henrique Mansur, Rita deCássia Marqueti, João Luiz Quagliotti Durigan

“…Ankle function, pain, and edema were evaluated using the Foot and Ankle Outcome Score, Visual Analog Scale, and figure‐of‐eight method. Plantar flexion strength was measured via isometric dynamometry. …”
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Rapid and sensitive detection of Mycobacterium tuberculosis using the RPA/Cas12f1_ge4.1 system with fluorescence and lateral flow readouts by Zhongliang Deng, Xingyong Weng, Honghua Tang, Tintao Zou, Xuan Zhou, Hangxi Liu, Piaoting Wen, Gemiao Luo, Tian Gan, Jun He

“…ABSTRACT Tuberculosis remains a major global health threat, with existing detection methods often limited by efficiency and resource demands. …”
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Heel kicking exercise rapidly improves pain and function in patients with acute lateral ankle sprain: a randomized controlled trial by Qi-Ning Qin, Xin Zhang, Ying-Feng Cai, Tian-Zhao Tian, Jian-Peng Zhou, Lin Li, Min Shi, Peng Huang, Hao-dong Liang, Jia-Hui Li, Zhan-Liang Tan, Yi-Xuan Fang, Jia-Wen Wang, Fang Zheng, Bao-Xin Liu

“…In this study, we designed an exercise—heel kicking exercise (HKE) based on the principles and methods of BST. This study aims to observe its true efficacy and safety. …”
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Technology-Enhanced Differentiated Instruction: A Narrative Review by Ata Barzegari, Esmaeil Azimi Yancheshmeh, Javad Hatami

“…Inclusion criteria focused on research that addressed DI at various educational levels and in different contexts, particularly those that investigated the use of TEL.Thematic analysis was used as the primary method of data analysis to identify recurring challenges faced by educators when implementing DI in online learning environments. …”
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Comparative Assessment of Efficiency and Patient Tolerance of Hybrid Arch Bar, Erich’s Arch Bar and Maxillomandibular Fixation Screw Placement in Treatment of Jaw Fractures: A Pros... by Sherwin Samuel, Kalyani Bhate, Akash Muralidharan, Manoj Bafna, Rushab Chordia

“…The presence of these different methods warrants a study to evaluate the efficiency, advantages, and disadvantages of each method. …”
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Comparison of clinical efficacy and radiological findings of interspinous dynamic stabilization system versus unilateral biportal endoscopy for lumbar spinal stenosis: a retrospect... by Dongyue Li, Yunzhong Cheng, Xuanyu Chen, Peng Yin, Qingjun Su

“…However, there remains a paucity of comparative studies directly evaluating the therapeutic efficacy between these two distinct non-fusion approaches—IDSS as a motion-preserving stabilization method and UBE as a minimally invasive decompression technique‌. …”
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Synthesis, characterization, molecular docking and pharmacological evaluation of isoxazole derivatives as potent anti-inflammatory agents by Sonu, Kamal YT, Girendra Kumar Gautam, Arun Kumar Mishra, Baby Rabiya Parveen, Arvind Kumar, Mhaveer Singh, Harpreet Singh

“…Methods: Substituted chalcones (0.01 mol) (2a-2m), sodium ethoxide (0.01 mol), and hydroxylamine hydrochloride (0.01 mol) were dissolved in absolute ethanol (15 ml), and then the mixture was refluxed for 6 h in an oil bath and monitored by TLC (ethyl acetate:hexane 7:3 v/v as eluent; a UV lamp was used to visualize the plates). …”
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How to estimate the probability of a live birth after one or more complete IVF cycles? the development of a novel model in a single-center by Xiangyi Kong, Zhiqiang Liu, Chunyu Huang, Xiuyu Hu, Meilan Mo, Hongzhan Zhang, Yong Zeng

“…Abstract Objective To develop a predictive tool in the form of a Nomogram based on the Cox regression model, which incorporates the impact of the length of treatment cycles on the outcome of live birth, to evaluate the probability of infertile couples having a live birth after one or more complete cycles of In Vitro Fertilization (IVF), and to provide patients with a risk assessment that is easy to understand and visualize. Methods A retrospective study for establishing a prediction model was conducted in the reproductive center of Shenzhen Zhongshan Obstetrics & Gynecology Hospital (formerly Shenzhen Zhongshan Urology Hospital). …”
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