HUMANE: Harmonious Understanding of Machine Learning Analytics Network—global consensus for research on artificial intelligence in medicine by Neha Deo, Faisal A. Nawaz, Clea du Toit, Tran Tran, Chaitanya Mamillapalli, Piyush Mathur, Sandeep Reddy, Shyam Visweswaran, Thanga Prabhu, Khalid Moidu, Sandosh Padmanabhan, Rahul Kashyap

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A Predictive Model Using Six Genes DNA Methylation Markers to Identify Individuals With High Risks of High-Grade Squamous Intraepithelial Lesions and Cervical Cancer by Ding H, Ke Z, Xiao X, Xin B, Xiong H, Lu W

“…Therefore, new detection methods that can improve the accuracy of cervical cancer screening are needed.Methods: In the present study, cervical exfoliated cell samples were collected from 228 Chinese individuals, including 114 healthy control individuals, 46 patients with LSIL, 21 patients with HSIL and 47 patients with cervical cancer. …”
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Klasifikasi Kelas Kata (Part-Of-Speech Tagging) untuk Bahasa Madura Menggunakan Algoritme Viterbi by Ilham Firmansyah, Putra Pandu Adikara, Sigit Adinugroho

“…Part-Of-Speech Tagging is a method to assign a predefined set of tags (word classes) into a word or a phrase. …”
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Painting the Portrait of Fibro-osseous Lesions: An In-vitro Study on Staining Duel of Modified Gallego versus Hematoxylin and Eosin (H&E) Staining by Akash Shegaonkar, Shilpa Patel, Jigna Pathak, Niharika Swain, Rashmi Hosalkar, Rutuj Waghmare

“…Conclusion: The MGS is a better histochemical stain than the routine H&E stain, with increased differentiation and clarity in identifying bone and cemental tissues; hence, it can be considered a reliable method to differentiate pathological tissues.…”
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Comparing the impact of foot and hand reflexology on anxiety and physiological indices in colonoscopy candidates: A randomized clinical trial by Mohamad Golitaleb, Ali Safdari, Fatemeh Rafiei, Ameneh Yaghoobzadeh, Najmeh Mohamadi, Razieh Mokhtari

“…These results highlight the potential of reflexology as an effective complementary method for managing anxiety and enhancing patient comfort during medical procedures.…”
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Getting Up in the Morning and Chronotype in Relation to Polycystic Ovarian Syndrome: A Mendelian Randomization and Cross-Sectional Study by Dilimulati D, Lu J, Li J, Cai M, Zhang Y, Shao X, Chen H, Wan Q, He F, Yue C, Zhang M, Qu S

“…Diliqingna Dilimulati,1,* Jiayi Lu,2,* Jinghua Li,2,* Meili Cai,1 Yuqin Zhang,1 Xiaowen Shao,3 Haibing Chen,1 Qian Wan,4 Fang He,4 Chaoyan Yue,5 Manna Zhang,1,6 Shen Qu1 1Department of Endocrinology and Metabolism, Shanghai Tenth People’s Hospital, Tongji University School of Medicine, Shanghai, 200072, People’s Republic of China; 2Department of Clinical Laboratory, Shanghai Tenth People’s Hospital, Tongji University School of Medicine, Shanghai, 200072, People’s Republic of China; 3Department of Obstetrics and Gynecology, Shanghai Tenth People’s Hospital, Tongji University School of Medicine, Shanghai, 200072, People’s Republic of China; 4Department of Endocrinology and Metabolism, The First People’s Hospital of Chenzhou, Chenzhou, Hunan, 423000, People’s Republic of China; 5Department of Laboratory Medicine, Obstetrics and Gynecology Hospital of Fudan University, Shanghai, 200011, People’s Republic of China; 6Department of General Practice, Shanghai Tenth People’s Hospital, Tongji University School of Medicine, Shanghai, 200072, People’s Republic of China*These authors contributed equally to this workCorrespondence: Manna Zhang, Department of Endocrinology and Metabolism, Shanghai Tenth People’s Hospital, No. 301, Middle Yanchang Road, Jingan District, Shanghai, 200072, People’s Republic of China, Tel +86 13774448495, Email mannazhang@126.com Chaoyan Yue, Department of Laboratory Medicine, Obstetrics and Gynecology Hospital of Fudan University, No. 419, Fangxie Road, Huangpu District, Shanghai, 200011, People’s Republic of China, Tel +86 02133189900, Email 20111250007@fudan.edu.cnBackground: Although a connection between circadian rhythm and polycystic ovarian syndrome (PCOS) has been shown in previous studies, the exact cause of this association is not well understood.Purpose: This study aimed to use Mendelian randomization (MR) method to analyze the potential association between getting up in the morning and chronotype with PCOS, and a cross-sectional study was conducted to further validate these results.Methods: Using summary information from large-scale genome-wide association studies (GWASs) in people of European ancestry, we conducted univariable MR (UVMR) and multivariable MR (MVMR) analyses to examine the causal effect of genetically determined getting up in the morning and chronotype on PCOS. …”
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Evolución de la presencia de mujeres en los órganos de decisión del Sistema Nacional de Salud en España by Christian Gil-Borrelli, Blanca Obón Azuara, M. Ángeles Rodríguez-Arenas, Elisa Chilet Rosell, Pello Latasa Zamalloa

“…Concrete actions must be taken to continue advancing equality and improving health outcomes in society as a whole.…”
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Association of <i>SEPT9</i> Gene Methylation with the Clinicopathologic Features and <i>Fusobacterium nucleatum</i> Infection in Colorectal Cancer Patients by Siew-Wai Pang, Subasri Armon, Jack-Bee Chook, Kaik-Boo Peh, Suat-Cheng Peh, Sin-Yeang Teow

“…For FN detection, a TaqMan probe-based method targeting the 16S rRNA gene was used. The differences in <i>mSEPT9</i> levels and FN expression between cancer and non-cancer tissues were evaluated. …”
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Investigating Falls Risk Awareness in Hospitals Using the Self‐Awareness of Falls Risk Measure (SAFRM): Empirical Research Quantitative by Elissa Dabkowski, Simon J. Cooper, Jhodie Duncan, Karen Missen

“…Impact: Registered nurses, health professionals, inpatients. Reporting Method: STROBE checklist for cross‐sectional studies. …”
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p16 gene silencing along with p53 single-nucleotide polymorphism and risk of esophageal cancer in Northeast India by Mandakini Das, Santanu Kumar Sharma, Gaganpreet Singh Sekhon, Jagadish Mahanta, Rup Kumar Phukan, Bimal Kumar Jalan

“…A total of 100 newly diagnosed esophageal cancer cases along with equal number of age-, sex-, and ethnicity-matched controls were included in this study. …”
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Gold Nanoparticles Functionalized With 5-Amino-2-Mercaptobenzimidazole: A Promising Antimicrobial Strategy Against Carbapenem-Resistant Gram-Negative Bacteria by Zhang J, Zhang X, Yao Z, Pan J, Ye J, Xia P, Zhou T, Cao J

“…This study introduces 5-amino-2-mercaptobenzimidazole (5-A-2MBI) functionalized gold nanoparticles (5-A-2MBI_Au NPs) and evaluates their antibacterial activity against CR-GNB.Methods: The 5-A-2MBI_Au NPs was synthesized using a one-pot method. …”
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A Clinical Risk Score Based on Albumin and Electrolyte Levels for Predicting Death Risk in Hospitalized Elderly COVID-19 Patients by Wang C, Zheng X, Bi S, Shao M, Xie Z, Wei N, Zhou Q, Feng S

“…Patients were classified into low- and high-risk groups using optimal segmentation thresholds, with survival curves generated by the Kaplan–Meier method. An online risk calculator was developed to facilitate real-time risk assessment in clinical settings.Results: The cohort included 1413 hospitalized COVID-19 patients. …”
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Marker weighting improves single-step genomic prediction reliabilities of udder health traits in Nordic Red and Jersey dairy cattle populations by Arash Chegini, Ismo Strandén, Emre Karaman, Terhi Iso-Touru, Jukka Pösö, Gert P. Aamand, Martin H. Lidauer

“…ABSTRACT: The standard single-step genomic prediction model assumes that all SNP markers explain an equal amount of genetic variance, which, however, may not be true. …”
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Acute tonsillitis and pediatric functional gastrointestinal disorders: the first result of a possible association analysis by E. R. Meskina, L. A. Galkina, T. V. Stashko

“…The aim is to discover a possible relationship between acute exudative tonsillitis and FDDS in children in the context of clinical and medico-social assessment. Materials and Methods: An observational cross-sectional study was performed using the continuous sampling method. …”
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Current Strategies to Reducing Interval Breast Cancers: A Systematic Review by Goh RSJ, Chong B, Yeo S, Neo SY, Ng QX, Goh SSN

“…We found that using digital breast tomosynthesis (a 3D imaging method) generally reduced missed cancers compared to traditional mammograms, especially in women with dense breasts. …”
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Exploring the Incidence and Risk Factors of Diabetic Nephropathy in Type 1 Diabetes: Insights from a Retrospective Cohort Study in Northwest China by Du Z, Liu X, Zhang L, Zhao H, Tian L

“…Zouxi Du,1,2,&amp;ast; Xiaoning Liu,3,&amp;ast; Leyuan Zhang,4 Hui Zhao,5,6 Limin Tian1,7 1The First School of Clinical Medicine, Lanzhou University, Lanzhou, Gansu, People’s Republic of China; 2Department of Endocrinology, Gansu Provincial Hospital, Lanzhou, Gansu, People’s Republic of China; 3Department of Epidemiology and Health Statistics, School of Public Health, Lanzhou University, Lanzhou, Gansu, People’s Republic of China; 4The First Clinical College, Gansu University of Traditional Chinese Medicine, Lanzhou, Gansu, People’s Republic of China; 5College of Integrated Traditional Chinese and Western Medicine, Gansu University of Traditional Chinese Medicine, Lanzhou, Gansu, People’s Republic of China; 6Department of Nephrology, Gansu Provincial Hospital, Lanzhou, Gansu, People’s Republic of China; 7Department of Endocrinology, Sichuan Provincial People’s Hospital, University of Electronic Science and Technology of China, Chengdu, Sichuan, People’s Republic of China&amp;ast;These authors contributed equally to this workCorrespondence: Limin Tian, The First School of Clinical Medicine, Lanzhou University, Lanzhou, Gansu, 730000, People’s Republic of China, Email tlm7066@sina.comPurpose: The study aimed to investigate the incidence of diabetic nephropathy (DN) and their relationship with certain risk factors in patients with type 1 diabetes (T1D) across hospitals in Gansu Province, China.Methods: There were 434 T1D patients recruited from Gansu Province, China, in the present retrospective cohort study between January 2016 and December 2024. …”
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Nasal mRNA Nanovaccine with Key Activators of Dendritic and MAIT Cells for Effective Against Lung Tumor Metastasis in Mice Model by Li A, Cai X, Li D, Yu Y, Liu C, Shen J, You J, Qiao J, Wang F

“…Intranasal immunization has emerged as a more effective method of inducing local immune responses against cancer cells in the lungs.Methods: An innovative layered double hydroxide- and 5-OP-RU–based mRNA nanovaccine (Mg/Al LDH-5-OP-RU/mRNA) was synthesized via coprecipitation. …”
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Hypopharyngeal Squamous Cell Carcinoma in Elderly Patients Aged &amp;ge;70 Years: Surgery and Postoperative Radiotherapy Improves Outcomes in Selected Patients by Wang R, Hariri AA, Tao H, Wei Y, Lyu Z

“…Ru Wang,1,&amp;ast; Ahmad A Hariri,2,&amp;ast; Hengmin Tao,1 Yumei Wei,1 Zhenghua Lyu3 1Department of Head and Neck Radiotherapy, Shandong Provincial ENT Hospital, Shandong University, Jinan, Shandong, People’s Republic of China; 2Department of Otolaryngology-Head and Neck Surgery, London North West University Healthcare NHS Trust, London, England, UK; 3Department of Otolaryngology-Head and Neck Surgery, Shandong Provincial ENT Hospital, Shandong University, Jinan, Shandong, People’s Republic of China&amp;ast;These authors contributed equally to this workCorrespondence: Yumei Wei, Email 15553119268@163.com Zhenghua Lyu, Email entlvzhenghua@163.comObjective: To summarize the efficacy of surgery plus postoperative radiotherapy as initial treatment in elderly patients aged ≥ 70 years with advanced hypopharyngeal cancer and to analyze prognostic factors.Methods: Retrospective analysis of 77 elderly patients aged ≥ 70 years with stage III–IV hypopharyngeal squamous cell carcinoma who underwent surgery as initial treatment at Shandong Provincial ENT Hospital between 2006– 2020. …”
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Drought adaptation index (DAI) based on BLUP as a selection approach for drought-resilient switchgrass germplasm by Shiva Om Makaju, Shiva Om Makaju, Shiva Om Makaju, Hari Bahadur Chhetri, Chanaka Roshan Abeyratne, Mirko Pavicic, Hari Poudel, Jazib Ali Irfan, Jazib Ali Irfan, Anita Giabardo, Katrien M. Devos, Katrien M. Devos, Katrien M. Devos, Daniel Jacobson, Ali Mekki Missaoui, Ali Mekki Missaoui, Ali Mekki Missaoui

“…This study introduces a Drought Adaptation Index (DAI), derived from Best Linear Unbiased Prediction (BLUP), as a method to assess drought resilience in switchgrass (Panicum virgatum L.). …”
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A naked-eye biosensing system based on one-pot RPA-CRISPR/Cas12a driver G4-hemin self-assembly for Mycobacterium tuberculosis by Ting Yuan, Ting Yuan, Jianbo Yuan, Jianbo Yuan, Jian Huang, Jian Huang, Nana Li, Nana Li, Huan Cai, Yan Yang, Juan Li, Rui Chen, Xun Min, Xun Min

“…Clinical validation using 104 patient samples demonstrated high concordance with standard diagnostic methods. This approach combines the advantages of recombinase polymerase amplification (RPA), CRISPR/Cas12a specificity, and G4-hemin DNAzyme-based colorimetric signal amplification, enabling simple, equipment-free visual detection. …”
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