A space-gamified approach to examine muscle contraction behaviour in children and adolescents with spastic cerebral palsy: feasibility, acceptability and repeatbility by Jule Heieis, Jule Heieis, Jule Heieis, Ibrahim Duran, Ibrahim Duran, Eckhard Schönau, Eckhard Schönau, Christoph Fritzsche, Bettina Götz, Laura Kehe, Moritz Meier, Karoline Spiess, Wilhelm Bloch, Jörn Rittweger, Jörn Rittweger

“…We therefore examined feasibility and acceptability of a muscle testing protocol that is based on the muscle examinations of astronauts and in bed-rest studies in children and adolescents with CP (clinical trial registry number DRKS00031107).MethodsTwelve participants, aged between 8 and 18 years, with CP and age-matched able-bodied counterparts (Ctrl) have been included to the study. …”
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A predictive model for Epstein-Barr virus-associated hemophagocytic lymphohistiocytosis by Rui Huang, Rui Huang, Dan Wu, Dan Wu, Ling Wang, Ling Wang, Ping Liu, Ping Liu, Xiaoru Zhu, Xiaoru Zhu, Leqiu Huang, Leqiu Huang, Mengmeng Chen, Mengmeng Chen, Xin Lv, Xin Lv

“…The outcome of this study carries important clinical value for early diagnosis and treatment of EBV-HLH.MethodsA retrospective analysis was conducted on 60 patients diagnosed with EBV-HLH and 221 patients diagnosed with EBV-IM at our hospital between November 2018 and January 2024. …”
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A Study of Multimodality Imaging Features of Brown Tumor or Osteitis Fibrosa Cystica by Dhruv Patel, Abhijeet Ashok Salunke, Nandlal Bharwani, Ritesh Suthar, Umank Tripathi, M. Varun, Dipesh Dave, Keval Patel, Vikas Warikoo, Jebin Aron, Rahul Shah, Shashank J. Pandya

“…We performed paired t-tests on the blood investigation values and Visual Analog Scale (VAS) scores for all patients. …”
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The potential for dementia prevention in Brazil: a population attributable fraction calculation for 14 modifiable risk factorsResearch in context by Claudia K. Suemoto, Wyllians V. Borelli, Ismael L. Calandri, Laiss Bertola, Raphael M. Castilhos, Paulo Caramelli, Ricardo Nitrini, Sonia M.D. Brucki, Jerson Laks, Naaheed Mukadam, Gill Livingston, Cleusa P. Ferri

“…The three risk factors with the highest PAFs were less education (9.5%, 95% CI = 8.9–10.1), untreated visual loss (9.2%, 95% CI = 8.6–9.8), and midlife depression (6.3%, 95% CI = 5.8–6.8). …”
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Five-Year Follow-Up of a Slowly Resorbable Biosynthetic P4HB Mesh (Phasix) in VHWG Grade 3 Incisional Hernia Repair by L. M. Van den Dop, MD, M. M. J. Van Rooijen, MD, PhD, T. Tollens, MD, L. N. Jørgensen, MD, PhD, T. S. De Vries-Reilingh, MD, PhD, G. Piessen, MD, PhD, F. Köckerling, MD, PhD, M. Miserez, MD, PhD, M. Dean, MD, F. Berrevoet, MD, PhD, B. Dousset, MD, PhD, H. L. Van Westreenen, MD, PhD, F. Gossetti, MD, PhD, G. W. M. Tetteroo, MD, PhD, A. Koch, MD, PhD, M. F. Boomsma, MD, PhD, J. F. Lange, MD, PhD, J. Jeekel, MD, PhD

“…However, long-term outcomes after resorption are scarce. Methods:. Patients with VHWG grade 3 incisional midline hernia, who participated in the Phasix trial (Clinilcaltrials.gov: NCT02720042) were included by means of physical examination and computed tomography (CT). …”
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Head-to-head comparison of tau PET tracers [18F]PI-2620 and [18F]RO948 in non-demented individuals with brain amyloid deposition: the TAU-PET FACEHBI cohort by Matteo Tonietto, Oscar Sotolongo-Grau, Núria Roé-Vellvé, Santiago Bullich, Juan Pablo Tartari, Ángela Sanabria, Ainhoa García-Sánchez, Edilio Borroni, Christopher Galli, Esther Pérez-Martínez, Joan Castell-Conesa, Isabel Roca, Lluís Tárraga, Agustín Ruiz, Andrew W. Stephens, Mercè Boada, Gregory Klein, Marta Marquié, on behalf of the FACEHBI study group, on behalf of the AMYPAD consortium

“…In this work, we aimed to compare the in-vivo uptake of tau tracers [18F]PI-2620 and [18F]RO948 in the early stages of the AD continuum. Methods Data from the TAU-PET FACEHBI clinical trial (EUDRA-CT 2021–000473-83) were analyzed. …”
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Unravelling Metazoan and Fish Community Patterns in Yujiang River, China: Insights from Beta Diversity Partitioning and Co-Occurrence Network by Yusen Li, Dapeng Wang, Yuying Huang, Jun Shi, Weijun Wu, Chang Yuan, Shiqiong Nong, Chuanbo Guo, Wenjian Chen, Lei Zhou

“…However, traditional survey methods often fail to comprehensively capture species diversity, particularly for low-abundance taxa. …”
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Association between remnant cholesterol (RC) and endometriosis: a cross-sectional study based on NHANES data by Zeru Chen, Ruixuan Li, Jiajie Guo, Xiaorong Ye, Yang Zhou, Mingzhu Cao

“…Consequently, looking into and clarifying the connection between RC and EMs was the primary goal of this study. Methods Following the screening of participants from the NHANES dataset spanning 2001 to 2006, a total of 1,840 individuals were incorporated into this research. …”
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Venous Sinus Stenting Using a Ledge‐Reducing Catheter, 0.088‐in. Catheter‐Extender With an External Single Point of Control: Technique and Multicenter Clinical Experience by Oded Goren, Fabio Settecase, George Luh, Tareq Kass‐Hout, Rami Morsi, Coleman O. Martin, Ahmad K. Almekkawi, Nicholas A. Telischak, Matthew D. Alexander, Michael G. Abraham, Sivani Lingam, Ramesh Grandhi, M. Shazam Hussain, Tudor G. Jovin, Priyank Khandelwal, Thanh T. Nguyen, Piers Klein, Joey D. English, Mohamad K. Abdalkader

“…In this study, we describe the MS technique for VSS and our multicenter clinical experience. Methods We retrospectively reviewed consecutive patients who underwent VSS with the MS from 2022 to 2023 for intracranial hypertension and/or pulsatile tinnitus at 13 sites. …”
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Examining the evolution and impact of OTC vending machines in Global Healthcare Systems by Ammar Abdulrahman Jairoun, Sabaa Saleh Al-Hemyari, Moyad Shahwan, Sahab Alkhoujah, Faris El-Dahiyat, Ammar Ali Saleh Jaber, Sa'ed H. Zyoud

“…Data analysis included bibliometric indicators such as publication counts, citation trends, and co-authorship networks, which were visualized using VOSviewer software (version 1.6.20) to highlight key research themes and collaboration patterns. …”
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Epidemiological trends of hepatitis C incidence and death in Mainland China between 2004 and 2018 and its predictions to 2030 by Guo Tian, Yang Zheng, Yinghua He, Can Chen, Xiaobao Zhang, Yuxia Du, Shigui Yang, Tianan Jiang, Lanjuan Li

“…Temporal-spatial scanning analysis was conducted to visualize the grading of hepatitis C incidence in mainland China. …”
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Varied cellular abnormalities in thin vs. normal endometrium in recurrent implantation failure by single-cell transcriptomics by Xiaoying Fu, Xiaoyan Guo, Han Xu, Yini Li, Bihui Jin, Xirong Zhang, Chongyi Shu, Yuhang Fan, Yiqi Yu, Yuqing Tian, Jiao Tian, Jing Shu

“…Scanning and transmission electron microscopy were employed to visualize ultrastructural details of the endometrial tissue, while hematoxylin and eosin staining facilitated the examination of tissue morphology and cellular composition. …”
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Effect of fusion and arthroplasty for cervical degenerative disc disease in patients with physically demanding occupations by Harjot Uppal, MBA, George Abdelmalek, MD, Neil Patel, MD, Daniel Coban, MD, Stuart Changoor, MD, Nikhil Sahai, MD, Kumar Sinha, MD, Ki Hwang, MD, Arash Emami, MD

“…Functional outcomes were measured using the Visual Analog Scale for neck and arm pain (VAS-neck, VAS-arm) and the Neck Disability Index (NDI), with attention to timelines for returning to full-time work. …”
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Mean Arteriolar Diameter Measured from Wide-Field Swept-Source OCT Angiography: A Highly Sensitive Indicator for Mean Arterial Pressure by Yuchen Li, Yuyao Qu, Hanze Zhang, Yue Bian, Langxuan Yuan, Jingbo Hu, Shengrui Xu, Xiayu Xu, PhD, Jianqin Lei, MD

“…Eligible eyes had a corrected visual acuity of 20/25 or better and an intraocular pressure (IOP) not exceeding 21 mmHg. …”
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Predicting the risk of postoperative avascular necrosis in patients with talar fractures based on an interpretable machine learning model by Jian Zhang, Jian Zhang, Jian Zhang, Jihai Xu, Jihai Xu, Jiapei Yu, Jiapei Yu, Jiapei Yu, Hong Chen, Hong Chen, Xin Hong, Songou Zhang, Xin Wang, Xin Wang, Chengchun Shen, Chengchun Shen, Chengchun Shen

“…PurposeThis study aims to develop and validate an interpretable machine learning model for predicting avascular necrosis (AVN) following talar fracture, thereby aiding in personalized prevention and treatment.MethodsA retrospective cohort study included patients undergoing surgical intervention for talar fractures at Ningbo No.6 Hospital between January 2018 and December 2023. …”
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Optimizing Corticosteroid Sinonasal Irrigation Outcomes Through 3D Printing: A Randomized Pilot Clinical Trial by Zachary T. Root, Thomas J. Lepley, Kanghyun Kim, Aspen R. Schneller, Songzhu Zhao, Raymond Wen, Veronica L. Formanek, Sarah M. Sussman, Joseph S. Lee, Ahmad Odeh, Lai Wei, Kathleen M. Kelly, Bradley A. Otto, Kai Zhao

“…Patient‐reported outcome measures (Nasal Obstruction Symptom Evaluation, Sinonasal Outcome Test‐22, and Visual Analog Scale of nasal congestion) improved significantly among all groups. …”
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White matter hyperintensity tissue property spatial variations as a function of cognitive status in Parkinson’s disease by Mariyemuguli Reheman, Sagar Buch, Naying He, Pei Huang, Qiurong Yu, Xinhui Wang, Yu Liu, Youmin Zhang, Zhijia Jin, Yan Li, Peng Liu, Shengdi Chen, E. Mark Haacke, Fuhua Yan

“…Water content, T1, and T2* measures were derived from qMRI data and tissue property heatmaps and periventricular distance profiles were constructed for all groups to visualize location-dependent tissue alterations of WMH relative to the lateral ventricles. …”
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Randomised trial comparing weight loss through lifestyle and GLP-1 receptor agonist therapy in people with MASLD by Ahmad Moolla, Toryn Poolman, Nantia Othonos, Jiawen Dong, Kieran Smith, Thomas Cornfield, Sarah White, David W. Ray, Sofia Mouchti, Ferenc E. Mózes, Helena Thomaides-Brears, Stefan Neubauer, Jeremy F. Cobbold, Leanne Hodson, Jeremy W. Tomlinson

“…Impact and implications: Weight loss, through either lifestyle intervention or pharmacotherapy with GLP-1RA has an equally beneficial impact on the liver, and both strategies should be considered in the management of people with MASLD. …”
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Development and validation of a risk prediction model for premenopausal breast cancer in 19 cohorts by Kristen D. Brantley, Michael E. Jones, Rulla M. Tamimi, Bernard A. Rosner, Peter Kraft, Hazel B. Nichols, Katie M. O’Brien, Hans-Olov Adami, Amaia Aizpurua, Amy Berrington de González, William J. Blot, Tonje Braaten, Yu Chen, Jessica Clague DeHart, Laure Dossus, Sjoerd Elias, Renée T. Fortner, Montserrat Garcia-Closas, Inger T. Gram, Niclas Håkansson, Susan E. Hankinson, Cari M. Kitahara, Woon-Puay Koh, Martha S. Linet, Robert J. MacInnis, Giovanna Masala, Lene Mellemkjær, Roger L. Milne, David C. Muller, Hannah Lui Park, Kathryn J. Ruddy, Sven Sandin, Xiao-Ou Shu, Sandar Tin Tin, Thérèse Truong, Celine M. Vachon, Lars J. Vatten, Kala Visvanathan, Elisabete Weiderpass, Walter Willett, Alicja Wolk, Jian-Min Yuan, Wei Zheng, Dale P. Sandler, Minouk J. Schoemaker, Anthony J. Swerdlow, A. Heather Eliassen

“…Abstract Background Incidence of premenopausal breast cancer (BC) has risen in recent years, though most existing BC prediction models are not generalizable to young women due to underrepresentation of this age group in model development. Methods Using questionnaire-based data from 19 prospective studies harmonized within the Premenopausal Breast Cancer Collaborative Group (PBCCG), representing 783,830 women, we developed a premenopausal BC risk prediction model. …”
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Pathway Of Low Anterior Resection syndrome (LARS) relief after Surgery (POLARiS): protocol for an international, open-label, multi-arm, phase 3 randomised superiority trial within... by Deborah D Stocken, Charles H Knowles, Jared Torkington, David Jayne, Julie Hepburn, Laura Knight, Neil Corrigan, Julie Cornish, Katie Gordon, Ashley Douglas, Kate Wilson, Megan Dale, Julie Croft, Christina Lloydwin, Alexandra Harriet Coxon-Meggy, Judith White, Alun Meggy, Aaron Quyn, Emily Farrow, Kheng-Seong Ng, Hannah Mather, Huey Yi Chong, Betty Tan, Ralph Powell, Andrea Warwick

“…Participants entering the RCT will be randomised between OCM, TAI or SNM, all with equal allocation ratios.Cohort and RCT participants will be followed up for a 24-month period, completing a series of questionnaires measuring LARS symptoms and QoL, as well as clinical review for those in the RCT. …”
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