Introduction by Merve Bedir

“…Chair Design Informatics, research program Computation and Performance aims to improve the performance of buildings by using computational methods for model generation and analysis, decision-making and design communication, in an interdisciplinary context. …”
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Perfluorohexyloctane ophthalmic solution for dry eye disease: pooled analysis of two phase 3 clinical trials by Ahmad M. Fahmy, Jennifer S. Harthan, David G. Evans, Jack V. Greiner, Joseph Tauber, John D. Sheppard, Sonja Krösser, Jason L. Vittitow

“…This study evaluated treatment effects of perfluorohexyloctane ophthalmic drop (formerly NOV03) in the pooled dataset from 2 pivotal clinical trials in patients with DED associated with MGD, both in the overall population and in patient subgroups based on sex, age, and baseline severity of eye dryness.MethodsPooled data from 2 similarly designed, phase 3, randomized controlled trials (GOBI, MOJAVE) were analyzed. …”
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Efficacy and safety of diacerein in patients with knee osteoarthritis by L. I. Alekseeva, N. G. Kashevarova, E. A. Taskina, E. P. Sharapova, S. G. Anikin, T. A. Korotkova, E. A. Strebkova

“…There was a statistically significant reduction in visual analog scale pain on walking just 1 month after therapy initiation (57.1±9.7 and 44.7±13.9 mm; p<0.0001) and a further significant improvement throughout the 6-month therapy. …”
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Efficacy of MCU-based and 3D-FEA for Improving Cervical Spondylosis by Meigui KE, Ruixu XU, Ningying HUANG, Hai GUO, Xinghui YAN, Nanxi WU, Sidong DOU

“…Objective:Based on the Muli-Cervical Unit(MCU)and three-dimensional finite element analysis(3D-FEA),this study explored whether the"Tuo tian zhuang"exercise in the Southern Shaolin Yi Jin Jing can improve the efficacy of electroacupuncture in the treatment of cervical spondylosis.Methods:Patients who met the inclusion criteria for cervical spondylosis of cervical type were randomized assigned by age stratification into control group and experimental group. …”
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Prevalence and risk factors for lameness in dairy cattle on selected farms located in Dessie and Kombolcha, Northeast Ethiopia by Hasen Ahimed Mekonin, Abadi Amare Reda, Abadi Amare Reda, Alula Alemayehu Assen, Alula Alemayehu Assen, Awol Mohammed Assen, Awol Mohammed Assen

“…A cross-sectional study was conducted from May 2022 to February 2023 to estimate the prevalence and identify associated risk factors of lameness in 433 dairy cows across 37 selected farms located in Dessie and Kombolcha, Northeast Ethiopia.MethodsThe selected animals were examined for lameness using a five-point visual locomotion scoring technique during daily outdoor access on a solid walking surface in the designated refreshment areas. …”
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A study on the effect of platelet-rich plasma (PRP) to promote bone fusion in lateral interbody fusion of the lumbar spine using artificial bone by Hiroshi Noguchi, Toru Funayama, Kosuke Sato, Masao Koda, Hiroshi Takahashi, Kousei Miura, Hiroshi Kumagai, Masashi Yamazaki

“…Objective This study assessed whether PRP enhances intervertebral bone fusion in LLIF surgery using β-tricalcium phosphate artificial bone. Methods The current study was a prospective, randomized, controlled trial. …”
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Local Infiltration Analgesia with Ropivacaine Improves Postoperative Pain Control in Ankle Fracture Patients: A Retrospective Cohort Study by Bao-Liang Li, Xizhe Liu, Lihua Cui, Wenqian Zhang, Hui Pang, Mingshan Wang, Hai-Qiang Wang

“…The primary outcome indicator was visual analogue scale (VAS) from 8 hours to 48 hours after surgery. …”
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A telomere-associated molecular landscape reveals immunological, microbial, and therapeutic heterogeneity in colorectal cancer by Yinmeng Zhang, Jiawei Fan, Jiahui Zhao, He Zhu, Yan Xia, Hong Xu

“…Whole-slide histopathological images (WSIs) and immunohistochemical (IHC) staining were utilized to visualize immune features, including tertiary lymphoid structures (TLSs), across subgroups. …”
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Health-Related Quality of Life with Cervical Cancer and Precancer: A Cross-Sectional Study in Yunnan Province, China by Min Zhao, Meng-Jiao Zhang, Lian-Ju He, Chun-Mei Zuo, Song-Rui Ding, Allison Rabkin Golden, Le Cai

“…This study investigates socioeconomic and clinical variations in HRQoL of women with cervical precancerous lesions and cervical cancer in Yunnan Province, China. Methods: The present study employed a cross-sectional survey design. …”
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Patient-reported outcomes and radiographic progression in patients with rheumatoid arthritis in sustained remission versus low disease activity by Annette H M van der Helm-van Mil, Pascal H P de Jong, Marijn Vis, Selinde V J Snoeck Henkemans, Agnes E M Looijen

“…Objective To compare clinical and patient-reported outcomes (PROs) over 5 years between patients with rheumatoid arthritis (RA) in sustained remission (sREM), sustained low disease activity (sLDA) or active disease (AD) in the first year after diagnosis.Methods All patients with RA from the treatment in the Rotterdam Early Arthritis CoHort trial, a multicentre, stratified, single-blinded trial with a treat-to-target approach, aiming for LDA (Disease Activity Score (DAS) ≤2.4), were studied. …”
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Gender-related differences in clinical presentation, electrocardiography signs, laboratory markers and outcome in patients with acute pulmonary embolism by Obradović Slobodan, Džudović Boris, Rusović Siniša, Subota Vesna, Obradović Dragana

“…All the patients confirmed PE by visualized thrombus on the multidetector computed tomography with pulmonary angiography (MDCTPA), ECG and echocardiographic examination at admission. …”
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Open surgery and minimally invasive repair of acute Achilles tendon rupture: stratified outcomes based on immobilization duration in a prospective cohort study by Yuan Cao, Xiuzhi Li, Zengzhen Cui, Yang Lv, Gao Si

“…This prospective cohort study aimed to compare clinical outcomes of OS and MIS for AATR repair and evaluate the impact of immobilization duration (0, 2, or 4 weeks) on postoperative rehabilitation. Methods A total of 474 patients undergoing surgical repair for acute AATR were stratified into six groups based on surgical approach (OS: 265 cases; MIS: 209 cases) and immobilization duration (0, 2, or 4 weeks). …”
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Barriers and Facilitators to the Preadoption of a Computer-Aided Diagnosis Tool for Cervical Cancer: Qualitative Study on Health Care Providers’ Perspectives in Western Cameroon by Magali Jonnalagedda-Cattin, Alida Manoëla Moukam Datchoua, Virginie Flore Yakam, Bruno Kenfack, Patrick Petignat, Jean-Philippe Thiran, Klaus Schönenberger, Nicole C Schmidt

“… BackgroundComputer-aided detection and diagnosis (CAD) systems can enhance the objectivity of visual inspection with acetic acid (VIA), which is widely used in low- and middle-income countries (LMICs) for cervical cancer detection. …”
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Clinical Value of Continuous Fascia Iliaca Compartment Block in Perioperative Management of Elderly Patients with Intertrochanteric Fracture: A Propensity Score-Matched Retrospecti... by Xu G, Deng Y, Gao H, Wang B, Wang G, Ma J

“…This study investigated the efficacy of continuous fascia iliaca compartment block (CFICB) in perioperative management.Methods: A retrospective analysis was conducted on elderly patients (≥ 65 years) with intertrochanteric fractures treated between January 2020 and December 2023. …”
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Antimicrobial peptides for treatment of patients with herpes virus-associated chronic prostatitis by E. V. Kulchavenya, S. Yu. Shevchenko, A. A. Baranchukova

“…To determine the efficacy of cytokines-antimicrobial peptides complex in therapy of patients with herpes virus-associated chronic prostatitis.Materials & methods. The pilot, open, prospective, non-comparative study included 23 patients who were followed up for CP for a mean of 9.7 ± 4.2 years. …”
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Proteomic and metabolomic analysis of serum in women infected with COVID-19 during late pregnancy by Yi Zheng, Jinyu Ning, Jiang Zhu, Honglin Zhu, Zhihua She, Pei Cai

“…IntroductionTo investigate the alterations of serum proteins and metabolomics in women infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) at the end of pregnancy and their potential effects on fetal development.MethodsThe corona virus disease 2019 (COVID-19) group (n=31) included women in the third trimester diagnosed with SARS-CoV-2 infection and who delivered, while the control group (n=30) comprised uninfected women in the same gestational period. …”
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Integrated pan-cancer analysis of ADM’s role in prognosis, immune modulation and resistance by Yunhuan Liu, Caicun Zhou

“…This called for a pan-cancer analysis of ADM, investigating its expression, genomic alterations, prognostic value, immune associations, and relations with drug sensitivity to provide insights into its potential as a therapeutic target and biomarker.MethodsADM expression data from normal and tumor tissues was retrieved and analyzed through HPA and Timer 2.0 online platforms. …”
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Progressive Response of Repeated Treatment with High-Concentration (179 mg) Capsaicin Patch in Peripheral Neuropathic Pain After Surgical or Traumatic Nerve Injury: Findings from t... by Michael A. Überall, Christian Simanski, Mike Zellnig, Mariëlle Eerdekens, Sylvia Engelen, Myriam Heine, Fabienne Percot, Rita Freitas, Lucia Garcia Guerra, Tamara Quandel

“…Results The mean average daily pain intensity (API) decreased from 52.5 mm on the visual analog scale (VAS) at baseline to 21.5 mm at month 12 in patients receiving four HCCPs. …”
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Efficiency of surgical treatment of neovascular glaucoma: a retrospective analysis by A. V. Zolotarev, E. V. Karlova, M. V. Radaikina, A. A. Kuz'mina, O. V. Ryzhkova

“…The timely treatment of the underlying disease with Anti-VEGF and LC of the retina allows the patient to maintain visual functions, and increases the effectiveness of NVG surgery.…”
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Commercially available antiseptics show high in vitro efficacy against pathogens most commonly associated with canine and feline infectious keratitis by Hinrich Tönjes Wolff, Ana Cristina Piroth, Hilke Oltmanns, Jessica Meißner, Jutta Verspohl, Holger Andreas Volk, Claudia Busse

“…After incubation, plates were visually examined for bacterial growth. Tests were carried out in triplicate.ResultsMBCs in PBS for polyhexanide ranged 0.8–1.6 mg/L for S. pseudintermedius and 1.6–3.2 mg/L for P. aeruginosa and Str. canis. …”
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