Spleen Volume Dynamics and Survival Outcomes in HCC Patients Undergoing Immune Checkpoint Inhibitors: A Retrospective Analysis by Fu X, Jiang S, Li Y, Guo Y, Gong B, Lou J, Li Y, Wang S, Sun Y, Ren Y, Chen Q, Yang L

“…This study investigated the prognostic impact of spleen volume (SV) on the survival in hepatocellular carcinoma (HCC) patients receiving immune checkpoint inhibitors (ICIs).Patients and Methods: This retrospective study included 224 HCC patients treated with ICIs, categorized into Higher and Lower SV groups by median SV and further into SV increased and Non-SV increased groups based on changes in SV at 3 months after ICIs. …”
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Narrow-Margin Treatment with Modified Mohs Microsurgery for Extramammary Paget’s Disease: A Retrospective Clinical Analysis by Yang J, Yan J, Luo H, Li L, Jiang L, Chen X, Wu L, Chai J, Xue H, Gan L, Liu Y, Chen J, Fei W, Bai Y, Zhu Q, Chen Z, Guo L, Chen Y

“…Jing Yang,1,* Jianna Yan,1,* Hao Luo,1 Liang Li,1 Long Jiang,1 Xuewen Chen,1 Ling Wu,1 Jingxiu Chai,1 Huan Xue,1 Leimeng Gan,1 Yeqiang Liu,2 Jia Chen,3 Wu Fei,2 Yun Bai,4 Quangang Zhu,5 Zhongjian Chen,5 Lehang Guo,6 Yuchong Chen1 1Department of Surgery, Shanghai Skin Disease Hospital Affiliated to Tongji University, Shanghai, People’s Republic of China; 2Department of Pathology, Shanghai Skin Disease Hospital Affiliated to Tongji University, Shanghai, People’s Republic of China; 3Department of Rheumatology and Immunology, Shanghai Skin Disease Hospital Affiliated to Tongji University, Shanghai, People’s Republic of China; 4Department of Central Laboratory, Shanghai Skin Disease Hospital Affiliated to Tongji University, Shanghai, People’s Republic of China; 5Department of Pharmacy, Shanghai Skin Disease Hospital Affiliated to Tongji University, Shanghai, People’s Republic of China; 6Department of Ultrasonography, Shanghai Skin Disease Hospital Affiliated to Tongji University, Shanghai, People’s Republic of China*These authors contributed equally to this workCorrespondence: Yuchong Chen, Department of Dermatologic Surgery Division, Shanghai Skin Disease Hospital Affiliated to Tongji University, Shanghai, People’s Republic of China, Email 973309637@qq.comBackground: To investigate the clinical efficacy of narrow-margin modified Mohs microsurgery (mMMS) in the treatment of extramammary Paget’s disease (EMPD).Methods: A retrospective cohort review was conducted on 52 patients with EMPD who were treated at the Skin Disease Hospital of Tongji University in Shanghai between 2017 and 2023. …”
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Real-World Efficacy and Safety of Anti-PD-1 Antibody Plus Apatinib and Temozolomide for Advanced Acral Melanoma by Zhang J, Tian H, Mao L, Li C, Wei X, Gu J, Wang X, Zhou L, Lian B, Tang B, Yan X, Li S, Cui C, Chi Z, Sheng X, Guo J, Si L

“…The aim of this retrospective study was to evaluate the efficacy and safety of the triplet regimen for advanced AM in the real-world setting.Methods: The data of patients with advanced AM who received anti-PD-1 antibody plus apatinib and temozolomide at Peking University Cancer Hospital and Institute between September 2019 and December 2023 were analyzed. …”
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Predictive Potential of CRTP5 and SII for Coronary Artery Severity and Myocardial Fibrosis in Patients with NSTE-ACS: An Exploratory Biomarker Study by Ji J, Qiao M, Ding Y, Wei X, Wan D, Wu L, Liu H

“…Jinrui Ji,1,2,* Mu Qiao,3,4,* Ya’nan Ding,1,2,* Xiaoyun Wei,1,2,* Dongyu Wan,1,2,* Lei Wu,1,2,* Hengliang Liu1,2,* 1Clinical Medical Department, Faculty of Medicine, Henan University of Traditional Chinese Medicine, Zhengzhou, 450000, People’s Republic of China; 2Department of Cardiology, People’s Hospital of Henan University of Traditional Chinese Medicine, Zhengzhou, 450000, People’s Republic of China; 3Department of Cardiology, Seventh People’s Hospital of Zhengzhou, Zhengzhou, 450000, People’s Republic of China; 4Department of Cardiology, Zhengzhou Cardiovascular Institute, Zhengzhou, 450000, People’s Republic of China*These authors contributed equally to this workCorrespondence: Hengliang Liu, Department of Cardiology, People’s Hospital of Henan University of Traditional Chinese Medicine, Zhengzhou, 450000, People’s Republic of China, Email hnzzjjr@163.comPurpose: Findings from this research aim to enhance clinical assessments of coronary artery disease severity and myocardial fibrosis (MF).Methods: A total of 523 eligible non-ST-segment elevation acute coronary syndromes (NSTE-ACS) patients were included. …”
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Effectiveness of isoniazid preventive treatment among patients on antiretroviral treatment in Southeast Nigeria: A retrospective cohort study by Chukwuma David Umeokonkwo, Bello Segun, Patrick Nguku, Muhammad Shakir Balogun, Peter Nsubuga, Lilian Bulage, Adanna Anthonia Umeokonkwo, Olufunmilayo Ibitola Fawole

“…The log-rank ratio was used to compare the equality of the survival function. Results: Six hundred and sixty-one patients were recruited for the study with a mean age of 38.5±9.6 years. …”
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IN VITRO STUDY OF SUPERFICIAL ENAMEL LAYER OF PERMANENT TEETH DURING STAGE OF SECONDARY MINERALIZATION by G.M. Grigorenko, L.A. Khomenko, G.V. Sorochenko, L.M. Kapitanchuk

“…The remaining 10 samples were randomly divided into two equal groups (6 months and 12 months) and placed into two boxes that were filled with artificial saliva (T. …”
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Glioma-Associated Mesenchymal Stromal/Stem Cells Derived Exosomal miR-191 Promotes the Proneural-to-Mesenchymal Transition in Glioblastoma Cells via PTEN/PI3K/AKT Signaling by Lv P, Zhang Y, Zhao Z, Wu W, Zhou Y, Liu Z, Wang H, Jiang X, Li S, Yan P, Huang X, Xiang W, Fu P

“…This study aimed to explore the effects and mechanisms of GaMSCs-derived exosomal miRNA-191-5p on the PMT of glioblastoma.Methods and Results: Conditioned medium from three independently established GaMSCs lines (GaMSCs-CM) significantly enhanced the tumorigenicity of glioma cells. …”
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Protective Effect of Resveratrol on Exercise-induced Kidney Injury in Rats by Regulating Keap1-Nrf2 Signaling Pathway by Haitao ZHOU, Ge HU, Jing ZHANG, Qiyun ZHOU, Fei QIN

“…Objective: To investigate the protective mechanism of resveratrol on exercise-induced kidney injury in rats. Methods: Thirty-two 7-week-old SPF-grade male SD rats were randomly assigned to four groups: control group (CONT, n=8), resveratrol group (RESV, n=8), exercise-induced kidney injury model group (EIKIM, n=8), and resveratrol-treated exercise-induced kidney injury group (REIKIM, n=8). …”
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Cifoplastia con silicona (elastoplastia) versus cifoplastia tradicional con cemento para fracturas vertebrales osteoporóticas. ¿Esta nueva técnica reduce las complicaciones? by R. Luque, D. Garríguez, P. Checa Betegon, M. Sanchez, M. Olvera, J.L. Perez Gonzalez, I. Dominguez Esteban

“…However, long-term results in terms of pain relief and quality of life are similar, making both treatments equally valid.…”
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Acupuncture Modulates Spatiotemporal Neuronal Dynamics in Mild Cognitive Impairment: A Protocol for Simultaneous EEG-fMRI Study by Li YQ, Chen ZW, He H, Liu YW, Ye F, Yang ZQ, Li DH, Bao QN, Zhang XY, Zhong WQ, Wu KX, Yao J, Xu P, Yang SQ, Wang ZW, Yin ZH, Liang FR

“…However, no studies have investigated the detailed mechanisms underlying this effect.Methods: This randomized controlled neuroimaging trial will enroll 60 patients with MCI, who will be randomly assigned to one of two groups: a real acupuncture (RA) group or a sham acupuncture (SA) group. …”
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Targeted Next-Generation Sequencing in Pneumonia: Applications in the Detection of Responsible Pathogens, Antimicrobial Resistance, and Virulence by Liu B, Bao Z, Chen W, Xi X, Ge X, Zhou J, Zheng X, Zhang P, Deng W, Ding R, Zhou M, Fang J

“…We aimed to explore the applicability of tNGS in the co-detection of the responsible pathogens, antimicrobial resistance (AMR) genes, and virulence genes in patients with pneumonia.Methods: A prospective study was conducted among patients with suspected pneumonia at Ruijin Hospital from March 1 to May 31, 2023. …”
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Effect of Different Doses of Intrathecal Nalbuphine as Adjuvant to Hyperbaric Bupivacaine on Characteristics of Subarachnoid Block in Pelvic and Lower Limb Orthopaedic Surgeries: A... by Anupama Kumari, Shraddha Jogani, Nilesh Shah, Sara Mary Thomas

“…Patients with American Society of Anaesthesiologists (ASA) I/II status were randomly allocated into two equal groups of 20 each. Group-R received 0.75% hyperbaric ropivacaine 3.5 mL+0.1 mL normal saline (total 3.6 mL) and Group-L received 0.5% hyperbaric levobupivacaine 3.5 mL+0.1 mL normal saline (total 3.6 mL). …”
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Second Victim Syndrome Among Healthcare Professionals: A Systematic Review of Interventions and Outcomes by Ong TSK, Goh CN, Tan EKYE, Sivanathan KA, Tang ASP, Tan HK, Ng QX

“…This systematic review aimed to synthesize the evidence on the outcomes of available interventions targeting SVS.Methods: We systematically searched MEDLINE, Embase, and the Cochrane Library databases, covering all records up to July 7, 2024. …”
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Effects of exercise intensity on soleus muscle myostatin and follistatin levels of hyperglycaemic rats (Efectos de la intensidad del ejercicio sobre la miostatina y folistatina de... by Sepideh Azhir, Eidy Alijani, Sergio Francisco Martínez Huenchullán, Hamid Amni, Julien Baker, Farid Farhani

“…The total distance covered per session in MICT and HIIT was equal. 48 hours following the last training session, rats were anesthetized and soleus muscles were excised. …”
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TRAP1 Improves Diabetic Retinopathy by Preserving Mitochondrial Function by Li Y, Xu W, Zhao G, Guo Y, Wang L, Du Q, Fei Y, Hu X, Hu H, Chen L, Xu Y

“…Tumor necrosis factor-associated protein 1 (TRAP1), a mitochondrial chaperone regulating stress responses, remains unexplored in DR pathogenesis.Methods: We established in vivo and in vitro models of DR. …”
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Investigation into the Efficacy of Formic Acid Fumigation for Inactivating Clinically Isolated Filamentous Fungi by Yuan K, Tian B, Zhan A, Chen Z, Ye L, Ling Y, Liu S, Bai X, Zhao Y

“…We aim to develop an efficient inactivation protocol for molds and provide valuable insights into laboratory techniques for fungal inactivation.Methods: Initially, 238 clinical isolates from 23 species of molds were evaluated for the inactivation efficacy of formic acid, formaldehyde, and peracetic acid. …”
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Chinese Massage (Tuina) Attenuates Knee Osteoarthritis by Modulating Autophagy-Related Cytokines: A Multidisciplinary Methodological Investigation by Wang Z, Zhao C, Li M, Zhang L, Diao J, Wu Y, Yang T, Shi M, Lei Y, Wang Y, Li M, Bian Y, Zhou Y, Xu H

“…Zhen Wang,1,* Chi Zhao,1,2,* Mengmeng Li,1,2,* Lili Zhang,1,* Jieyao Diao,1 Yiming Wu,2 Tao Yang,2 Mingwei Shi,2 Yang Lei,2 Yu Wang,3 Miaoxiu Li,4 Yanqin Bian,5 Yunfeng Zhou,1 Hui Xu1,2 1College of Acupuncture and Massage, Henan University of Chinese Medicine, Zhengzhou, People’s Republic of China; 2Acupuncture and Massage Department, The Third Affiliated Hospital of Henan University of Chinese Medicine, Zhengzhou, People’s Republic of China; 3College of Computer Science, Xidian University, Xian, People’s Republic of China; 4College of Acupuncture and Massage, Shanghai University of Chinese Medicine, Shanghai, People’s Republic of China; 5Orthopaedic Research Laboratory, University of California, Davis, CA, USA*These authors contributed equally to this workCorrespondence: Hui Xu, Email 15036065036@163.comBackground: Tuina therapy has demonstrated its potential in modulating autophagy-related factors in knee osteoarthritis (KOA); however, its core therapeutic targets and specific mechanisms require systematic elucidation through interdisciplinary research.Objective: This study investigated the mechanism by which Tuina alleviates KOA progression using multidimensional approaches, including Mendelian randomization (MR), in vivo experiments, and machine learning.Methods: Genetic data from genome-wide association studies of 60 cytokines and KOA were analyzed using MR analysis to identify autophagy-related factors significantly associated with KOA. …”
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Role of Digoxin in Preventing Cigarette Smoke-Induced COPD via HIF-1α Inhibition in a Mouse Model by Zhang K, Zhou F, Zhu C, Yuan L, Li D, Wang J, Lu W

“…Therefore, in the present study, we chose digoxin as the inhibitor to investigate whether HIF-1α contributes to the progression in a mouse model of COPD and possible mechanism.Methods: The COPD model was established by cigarette smoke (CS) exposed; animals were intragastrically treated with vehicle or different doses of digoxin (0.02 mg/kg and 0.1 mg/kg). …”
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Uso de Moodle para fortalecer competencias ciudadanas en estudiantes de fisioterapia: un diseño pretest-postest (Use of Moodle to strengthen citizenship competencies in physiother... by Milena Boneth-Collante, Jorge Salazar-Rodríguez, Adriana Angarita-Fonseca

“…Objective: To improve citizenship competencies through a pedagogical strategy in the Moodle platform in students registered in the training courses of clinical/administrative physiotherapy practice at the University of Santander, Bucaramanga, Colombia. Methods: A pretest-posttest design was carried out. …”
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Xietu Hemu Prescription Improves Metabolic Dysfunction-Associated Steatotic Liver Disease: A Real-World Cohort Study by Xiang LL, Cao YT, Wang XX, Wang GX, Zhang YJ, Li RH, Qi F, Huai JX, Sun J, He XJ, Zhou XQ

“…Liu-lan Xiang,1,2,* Yu-tian Cao,1,2,* Xiao-xiao Wang,3,* Gao-xiang Wang,1,* Yu-juan Zhang,4 Rui-han Li,1,2 Fang Qi,5 Jia-xuan Huai,1,2 Jing Sun,1,2 Xiao-jin He,3 Xi-qiao Zhou1 1Department of Endocrinology, Affiliated Hospital of Nanjing University of Chinese Medicine, Jiangsu Province Hospital of Chinese Medicine, Nanjing, People’s Republic of China; 2The First Clinical Medical College of Nanjing University of Chinese Medicine, Nanjing, People’s Republic of China; 3Affiliated Hospital of Nanjing University of Chinese Medicine, Jiangsu Province Hospital of Chinese Medicine, Nanjing, People’s Republic of China; 4Department of Endocrinology, Seventh People’s Hospital of Shanghai University of Traditional Chinese Medicine, Shanghai, People’s Republic of China; 5Department of Geriatrics, Panjin Liao-Oil Field Gem Flower Hospital, Liaoning, People’s Republic of China*These authors contributed equally to this workCorrespondence: Xi-qiao Zhou, Email zhouxiqiao@njucm.edu.cn Xiao-jin He, Email xomaestro@163.comPurpose: This study aims to evaluate the efficacy of the Xietu Hemu prescription (XHP) in improving metabolic dysfunction-associated steatotic liver disease (MASLD) through a Real World Study approach.Methods: This was a single-center, prospective, real-world cohort study of 262 patients with MASLD who met the inclusion and exclusion criteria from November 2021 to November 2023 at Jiangsu Provincial Hospital of Traditional Chinese Medicine. …”
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