Usp18 Mediates D-Dopachrome Tautomerase-Induced Astrocytic Inflammation After Spinal Cord Injury by Zhang X, Hou Y, Cai R, Zhou Y, He B, Cao Z, Li A, Song H, Wang Y, Jiang H, Qi L, Wang Y

“…Whether D-DT activates astrocytic inflammation via regulation of Usp18 deserves further study.Methods: SCI model was prepared by cord contusion at T8-T10 of rats. …”
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Changes of natriuresis and prediction of cardiovascular events in patients with type 2 diabetes and decompensated heart failure over therapy with sodium-glucose cotransporter 2 inh... by O. A. Abdullaev, A. G. Arutyunov, D. P. Vereshchak, E. V. Tavlueva, V. A. Konik, N. A. Bylova, D. V. Puzenko, N. P. Kulagina, I. R. Nurieva, T. V. Zanina, G. P. Arutyunov

“…To evaluate the influence and changes of clinical and water-electrolyte parameters on the risk of cardiovascular events in the early period after decompensated heart failure (HF) in patients with type 2 diabetes (T2D), taking into account the influence of standard diuretic therapy and diuretic therapy in combination with sodium-glucose cotransporter 2 (SGLT-2) inhibitors.Material and methods. The study included 119 patients with type 2 diabetes and class III-IV HF. …”
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Impact of Pan-Immune Inflammation Value on Short-Term Outcomes and Long-Term Prognosis in Patients with Type A Aortic Dissection by Cai H, Shourav, Shao Y, Shuangling S, Duan C, Zhang C, Wu QC

“…This study aims to investigate the relationship between preoperative PIV and both short-term and long-term outcomes in patients with acute TAAD.Methods: This retrospective study included acute TAAD patients who underwent surgical repair between September 2017 and December 2020. …”
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The Role of Applying Metagenomic Next-Generation Sequencing (mNGS) in Periprosthetic Joint Infection with Sinus Tract: A Retrospective Study by Yuan X, Wang Q, Ding H, Li H, Fang X, Zhang W, Huang Z

“…We evaluated mNGS’s role in diagnosing and guiding treatment for PJI with sinus tracts.Methods: This retrospective analysis included 52 PJI patients (2019– 2024). …”
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Development and Validation of the CHD-PEBBS: A Scale to Assess Perceived Exercise Benefits and Barriers in Coronary Heart Disease Patients by Liu Y, Feng L, Wang L, Li H, Tu H, Li X, Zhang X, Zhang L, Yang M, Sun X, Huang T, Xiong Y

“…There is a lack of validated tools to assess coronary heart disease (CHD) patients’ exercise perception.Purpose: The aim of this study is to develop a scale assessing CHD patients’ perceived exercise benefits and barriers (CHD-PEBBS) and test its reliability and validity.Methods: A total of 205 CHD patients were recruited for a cross-sectional survey. …”
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Perspectives on Enhanced Measurement-Based Care Among Healthcare Providers, Adults, Adolescent Patients with Major Depressive Disorder and Pediatric Family Members: A Multicenter O... by Zhang H, Sun P, Wang X, Yang X, He Y, Yang T, Su Y, Fu Y, Li Q, Sun J, Liu J, Murphy JK, Michalak EE, Lam RW, Chen J, Fang Y

“…This study aimed to identify the barriers and facilitators of enhanced MBC (eMBC) in the outpatient setting to clarify the eMBC utilization dilemma.Methods: Between September 2022 and June 2023, we collected the opinions of healthcare providers, adult and adolescent patients, and family members of adolescent patients via online surveys. …”
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СРАВНЕНИЕ ВЛИЯНИЯ ДЛИТЕЛЬНОЙ ТЕРАПИИ, ОСНОВАННОЙ НА КАРВЕДИЛОЛЕ И БИСОПРОЛОЛЕ, НА МЕТАБОЛИЧЕСКИЕ ПАРАМЕТРЫ И ЭРЕКТИЛЬНУЮ ФУНКЦИЮ У БОЛЬНЫХ АРТЕРИАЛЬНОЙ ГИПЕРТОНИЕЙ И ИЗБЫТОЧНОЙ МАС... by S. Y. Martsevich, S. N. Tolpygina

“…Aim — to compare the antihypertensive efficacy, effect on blood glucose, uric acid, index of insulin resistance levels, lipid profile and effect on erectile function of long-term therapy, based on carvedilol and bisoprolol in patients with AH 1−2 deg. and overweight/obesity.Materials and methods. Type of research: clinical, multicenter, randomized, open, comparative, stepped, in two parallel groups. …”
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Efficacy and Safety of Bushen Jiedu Tongluo Decoction in Active Rheumatoid Arthritis: Study Protocol for a Multi-Center, Randomized, Double-Blind, Controlled Trial by He Y, Shen J, Wu H, Chen L, Zhou Q, Wang Q, Guo Y, Wu F, Pan X

“…Therefore, we designed a multi-center, randomized, double-blind, placebo-controlled study, to scientifically evaluate the clinical efficacy and safety of BSJDTL for active RA.Methods: This was a multi-center, randomized, double-blind placebo-controlled trial. …”
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COMPARATIVE EVALUATION OF THE LABORATORY STUDY RESULTS OF THE ADHESION STRENGTH OF A-SILICONE LINING MATERIAL IN THE PRODUCTION OF TWO-LAYER REMOVABLE PROSTHESES by I. Yanishen, P. Zapara, О. Fedotova

“…However, it was found that the index of the bond strength of the "PM-S" with the plastic "Pallopress" is equal to (5.5 ± 0.3) kgf / cm2, which is significantly (p <0,05) higher than the contact the material is "Villacryl H Plus" - (5.1 ± 0.2) kgf / cm2. …”
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Effect of Resistance Training on Hepatic Bile Acid, beta-Klotho Protein and Expression of Farnesoid X Receptor, Fibroblast Growth Factor 15 and Fibroblast Growth Factor Receptor 4... by Mehri Gholipour, Najme Rezaeian, Mohammad Karimi, Sadegh Cheragh-Birjandi

“…This research was carried out to study the effect of eight weeks of resistance training on liver bile acid (BA), beta klotho protein (KLB) and the expression of farnesoid X receptor (FXR), fibroblast growth factor 15 (FGF15) and fibroblast growth factor receptor 4 (FGFR4) in male rats with non-alcoholic fatty liver disease. Materials and Methods: In this study, 16 male Wistar rats (age, six-weeks and weight, 120-160 gr) after induction of NAFLD conditions, with six weeks of high-fat diet were randomly divided into two equal groups (n=8 in each group) of Control (C), and resistance training (R). …”
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Adenovirus Nanoparticles Displaying RBD Induce a Protective Immune Response Against BA.5 in Mice by Mo C, Wang Z, Liu D, Yang X, Zhang Q, Ye L, Yuan S, Deng S, Lai Z, Huang D, Yang Y, Xu D, Yuan J, Zhu Y, Liu H, Zhou C, Liao X, Li X, Liu W, Zhou R, Tian X

“…Hexon is the major capsid protein, and multiple hypervariable regions (HVRs) have been used for displaying exogenous antigens and inducing a strong antibody responses.Methods: We utilized SpyCatcher/SpyTag technology to incorporate SpyTag into HVR2, 4, and 7 of the hexon of the bivalent vaccine strain rAd3/7, respectively, to construct recombinant Ad, rAd3/7-SpyTag. …”
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Prognostic Implications of Red Blood Cell Distribution Width to Albumin Ratio in Myelofibrosis: A 10-Year Multicenter and Retrospective Study by Zeng T, Zheng Z, Qian H, Liu L, Shi X, Shao Y, Huang Z, Li R, Wen B, Han Q, Feng Q, Tu L, Bao X, Tong H, Jin J, Huang J

“…The red cell distribution width to albumin ratio (RAR), a novel biomarker indicative of inflammation, has emerged as a strong prognostic indicator in the general population but remains unexplored in MF.Methods: We retrospectively enrolled 504 consecutive MF patients from 7 hematological centers over a 10-year period. …”
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Abstract 062: N20 Potential And Imaging Biomarkers Of Functional Recovery In Acute Ischemic Stroke Patients And EVT by Alicia Martinez Piñeiro, Giuseppe Lucente, María Hernandez‐Perez, Jordi Cortés, Andrea Arbex, Meritxell Gomis Cortina, Laura Dorado Bouix, Natalia Pérez de la Ossa, Alba Ramos‐Fransi, Miriam Almendrote, Carlos Castaño, Sebastián Remollo, Maria Rosa García Sort, Patricia Cuadras Collsamata, Mónica Millán, Antoni Dávalos

“…This secondary study aims to describe the association between the N20 response and imaging biomarkers of ischemic penumbra, infarct volume and collateral flow. Methods Presence and amplitude of the N20 response was recorded before EVT. …”
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Evaluation of Environmental Effects of Applied Pesticides on Canola (Brassica napus L.), Sugar Beet (Beta vulgaris L.), and Potato (Solanum tuberosum L.) Fields in Ali Abad Katool... by Zahra Deilam, Hossein Kazemi, Maral Niazmoradi, Javid Gherekhloo

“…This study investigated the environmental effects of pesticides used in canola, sugar beet, and potato fields in Aliabad Katool County (Golestan province), during 2021-2022.Materials and MethodsFor this purpose, 21 canola fields, six potato fields, and five sugar beet fields were randomly selected and information related to pesticide spraying, field area, crop rotation, and crop yield with continuous monitoring, face-to-face interviews, and completed questionnaires was collected from farmers. …”
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Mechanism of magnesium sulfate suppressing vascular calcification in rats with chronic renal failure through TLR4/NF-κB pathway by Dong Li-ming, Li Yin-hui, Li Li

“…ObjectiveTo explore the effect of magnesium sulfate on vascular calcification （VC） in rats with chronic renal failure （CRF） through the pathway of Toll-like receptor 4 （TLR4）/nuclear transcription factor-κB （NF-κB）.MethodsA total of 50 Sprague-Dawley （SD） rats were randomized into five groups of control， model， magnesium sulfate-L （25% magnesium sulfate， 2 mL）， magnesium sulfate-H （25% magnesium sulfate， 4 mL） and magnesium sulfate-H+PDTC （25% magnesium sulfate， 4 mL+NF-κB inhibitor PDTC， 100 mg/kg） （<italic>n</italic>=10 each）. …”
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The Role of L-Sorbose Metabolism in Enhancing Fitness and Virulence in Escherichia coli Under Acidic Conditions by Qiu T, Chen X, Deng X, Zhang G, Wen S, Wu J, Sun D, Li T, Yan B, Dai M, Zhong LL, Tian GB

“…While metabolic flexibility is critical for E. coli fitness to host environments, the role of secondary carbon sources like L-Sorbose remains poorly characterized.Methods: The functional importance of L-Sorbose metabolism in E. coli CFT073 was investigated under acidic conditions simulating gastrointestinal and urinary tract environments. …”
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Transcriptomic Changes and Pathological Mechanisms in Familial and Sporadic Idiopathic Restless Legs Syndrome: Implications for Inflammation and Cell Adhesion Molecules by He XR, Song JM, Zhao JP, Zhang J, Feng JT, Chen SQ, Zhou ZY, Wang HM, Zhang Y, Feng Y, Wu YC, Zhu XY

“…The study aims to investigate transcriptomic changes and underlying pathological mechanisms in familial and sporadic idiopathic RLS to uncover potential contributors to its pathogenesis.Patients and Methods: This study included 37 RLS patients, 39 unrelated healthy controls and 19 healthy relatives of RLS patients with a positive family history. …”
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A Nomogram for Diagnosing Ventilator-Associated Pneumonia Using Circulating Inflammation Indicators in ICU Patients by Yang J, Bao W, Wang H, Zhou J, Hu Q, Wang Y, Li Y

“…Jiajia Yang,1,&ast; Weiyuan Bao,2,&ast; Hongmei Wang,1 Jie Zhou,3 Qiang Hu,4 Ying Wang,1 Yuancheng Li5 1Department of Infection Management, The Affiliated Suzhou Hospital of Nanjing Medical University, Suzhou Municipal Hospital, Gusu School, Nanjing Medical University, Suzhou, 215008, People’s Republic of China; 2Department of Logistics Support, The Affiliated Suzhou Hospital of Nanjing Medical University, Suzhou Municipal Hospital, Gusu School, Nanjing Medical University, Suzhou, 215008, People’s Republic of China; 3Intensive care unit, The Affiliated Suzhou Hospital of Nanjing Medical University, Suzhou Municipal Hospital, Gusu School, Nanjing Medical University, Suzhou, 215008, People’s Republic of China; 4Department of Respiratory and Critical Care Medicine, The Affiliated Suzhou Hospital of Nanjing Medical University, Suzhou Municipal Hospital, Gusu School, Nanjing Medical University, Suzhou, 215008, People’s Republic of China; 5Institute of Dermatology, Chinese Academy of Medical Sciences and Peking Union Medical College, Jiangsu Key Laboratory of Molecular Biology for Skin Diseases and STIs, Nanjing, 210042, People’s Republic of China&ast;These authors contributed equally to this workCorrespondence: Ying Wang, Department of Infection Management, The Affiliated Suzhou Hospital of Nanjing Medical University, Suzhou Municipal Hospital, Gusu School, Nanjing Medical University, No. 242, Guangji Road, Suzhou, 215008, People’s Republic of China, Email wangy830224@sina.com Yuancheng Li, Institute of Dermatology, Chinese Academy of Medical Sciences and Peking Union Medical College, Jiangsu Key Laboratory of Molecular Biology for Skin Diseases and STIs, Nanjing, Jiangsu, 210042, People’s Republic of China, Email ycli@pumcderm.cams.cnPurpose: To construct a risk nomogram model of ventilator-associated pneumonia (VAP) patients with mechanical ventilation in the intensive care unit (ICU) based on peripheral blood inflammatory indicators and to evaluate its diagnostic value.Patients and Methods: A matched 1:2 case: control study was conducted. …”
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Intravoxel Incoherent Motion Improves the Accuracy of Preoperative Prediction of Vessels Encapsulating Tumor Clusters in Hepatocellular Carcinoma by Li M, Zhang G, Li J, Ren Y, Jin X, Ke Q, Guo C, Lv J, Lu H, Xu Y, Liang W, Quan X, Li X

“…Therefore, this study used preoperative IVIM to predict VETC pattern in HCC and performed preoperative noninvasive recurrence risk stratification.Patients and Methods: Patients with suspicious HCC were included prospectively. …”
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Fu-Fang-Qi-Di-Hua-Yu-Tang Improves Diabetic Macrovascular Disease via PI3K/AKT Pathway Regulation by Zhang S, Yan M, Liang P, Zhang Y, Liu J, Huang H, Li G, Wu H

“…Shizhao Zhang,1,&amp;ast; Mei Yan,2,&amp;ast; Pengpeng Liang,1 Ye Zhang,3 Jiamin Liu,1 Hai Huang,1 Guiyun Li,1 Hongyan Wu1,2 1Shenzhen Hospital, Shanghai University of Traditional Chinese Medicine, Shenzhen, 518000, People’s Republic of China; 2School of Clinical Medicine, Jiangxi University of Chinese Medicine, Nanchang, 330000, People’s Republic of China; 3Pediatrics (TCM), Shenzhen Maternity and Child Healthcare Hospital Co-Construction Hospital, Shenzhen, 518000, People’s Republic of China&amp;ast;These authors contributed equally to this workCorrespondence: Hongyan Wu, Email wu.hy@163.comObjective: This study aimed to investigate the active ingredients and mechanisms of Fu-Fang-Qi-Di-Hua-Yu-Tang (FFQD) in alleviating atherosclerosis and insulin resistance in diabetic macrovascular disease (DMD) mice.Methods: Chemical profiling of FFQD was performed using UPLC-Q-TOF-MS. …”
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