Evaluation of the efficacy and safety of a combination of chondroitin sulfate and glucosamine sulfate for knee and hip osteoarthritis in real clinical practice by A. E. Karateev, Yu. V. Barysheva, Ya. V. Belokon, T. Yu. Bolshakova, Yu. Yu. Grabovetskaya, E. A. Dolzhenkova, L. N. Eliseeva, O. B. Ershova, E. V. Zonova, I. Yu. Chernova, A. O. Isakanova, M. N. Kirpikova, V. T. Komarov, E. V. Kryukova, A. I. Kulikov, D. I. Lakhin, L. A. Levasheva, L. V. Masneva, L. V. Menshikova, Yu. V. Mishina, S. V. Norina, Yu. N. Pashkovsky, A. V. Petrov, A. G. Rusanov, A. V. Sarapulova, K. A. Svodtseva, O. V. Semagina, A. N. Sudakova, S. N. Tkachenko, M. M. Toporkov, S. K. Tutelyan, G. R. Fadienko, O. S. Filonenko, O. P. Fomina, A. S. Chernov

“…The investigators estimated changes in pain on movement by a 0 to 10 verbal pain scale, general health (GH) by a 0–10 visual analogue scale), the Lequesne index, the need for NSAIDs, and patient satisfaction with treatment and its tolerance.Results and discussion. …”
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Opioid versus opioid-free analgesia after surgical discharge: protocol for a systematic review and meta-analysis by Charbel El-Kefraoui, Ghadeer Olleik, Marc-Aurele Chay, Araz Kouyoumdjian, Philip Nguyen-Powanda, Fateme Rajabiyazdi, Uyen Do, Alexa Derksen, Tara Landry, Alexandre Amar-Zifkin, Agnihotram V. Ramanakumar, Marc-Olivier Martel, Gabriele Baldini, Liane Feldman, Julio F Fiore Jr

“…When trials report outcomes for a common domain (eg, pain intensity) using different scales, we will convert effect sizes to a common standard metric (eg, Visual Analogue Scale). Minimally important clinical differences reported in previous literature will be considered when interpreting results. …”
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Key Decision‐Making in Post‐Failed Internal Fixation of Intertrochanteric Fractures Hip Arthroplasty: A Multicenter Retrospective Study on Fracture Healing's Impact on Femoral Comp... by Jiexin Huang, Jiagu Huang, Haiqi Ding, Jianhua Lyu, Changyu Huang, Yang Chen, Qijin Wang, Hongyan Li, Baijian Wu, Ying Huang, Minghui Yang, Xinyu Fang, Wenming Zhang

“…Additionally, a decision tree model was developed to visually represent and explore the relationship between fracture healing status and the selection of femoral components. …”
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18F-NaF PET/CT in Presumed Aseptic Pseudarthrosis after Spinal Fusion: Correlation with Findings at Revision Surgery and Intraoperative Cultures by Yacine El Yaagoubi, Jean-Edouard Loret, Eric Lioret, Clément Thomas, Adrien Simonneau, Laurent Vinikoff, Caroline Prunier-Aesch, Alain Chetanneau, Laurent Philippe, Maja Ogielska, Louis Bernard

“…Results In the revision surgery group (n=18), visual assessment by 18F-NaF PET/CT revealed that all 22 cages with an increased 18F-NaF uptake around intercorporal fusion material had mobility at revision surgery, whereas none of the fused patients (n=5) showed uptake around cage/intervertebral disk space. …”
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The Golden Year? Early Intervention Yields Superior Outcomes in Chronic Pelvic Pain with Pudendal Neuralgia: A Comparative Analysis of Early vs. Delayed Treatment by Alexandru Ciudin, Albert Carrion, Rosa Regue, Alfredo Rodriguez, Eduardo Garcia-Cruz, Diana Finkelstein, Claudia Mercader, Cristian Toma, Razvan Popescu, Cristian Persu, Sergi Colom, Narcis Camps, Ramon Serrate, María José Ribal

“…Outcomes were assessed using the Visual Analog Scale (VAS), Spanish Pain Questionnaire (CDE–McGill), and the SF-12 health survey. …”
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Interactive effects of atmospheric oxidative pollutants and heat on circulatory disease mortality by Wenli Wang, Wenli Wang, Yang Chen, Ruoyu Li, Ruoyu Li, Linsheng Yang, Yu Jiang, Yu Jiang, Jianjun Xiang, Jianjun Xiang, Jing Wu, Jing Wu, Jing Li, Jing Li, Baoying Liu, Baoying Liu, Huaying Lin, Chuancheng Wu, Chuancheng Wu

“…This study aims to evaluate the synergistic effects of ozone (O₃), oxidant (Ox), and nitrogen dioxide (NO₂) with temperature and heat waves, and to explore their impact on circulatory disease mortality, providing evidence to support public health interventions.MethodsBased on the mortality, meteorological, and environmental protection data of residents in Fuzhou City from January 1, 2016, to December 31, 2022, we employed a generalized additive model (GAM) and a distributed lag nonlinear model (DLNM) to assess the effects of atmospheric oxidative pollutants interacting with temperature and heat waves on the risk of death from circulatory diseases, where temperature includes the daily maximum temperature and diurnal temperature range (DTR). …”
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Effectiveness of bright light therapy and combination with myopic defocus for controlling myopic eye growth in schoolchildren: study protocol for a randomised controlled trial (pha... by Dennis Yan-yin Tse, Rachel Ka Man Chun, Chi Ho To, Ian G Morgan, Jinxiao Lian, Carly SY Lam, Wai-Ching Lam, Christopher Kai Shun Leung, Lai Ming Ho, Ying Hon, Billy Kin Kwok Cheung, Desmond Man Kit Lam, Andy Chi Wai Kong, Thomas C Lam

“…Introduction Myopia and its complications can lead to irreversible visual impairment and even blindness, making this a worldwide public health concern for the 21st century. …”
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Atrial fibrillation and clinical outcomes 1 to 3 years after myocardial infarction by Satoshi Yasuda, Christopher B Granger, David B Brieger, Shaun G Goodman, Karolina Andersson Sundell, Tabassome Simon, Dirk Westermann, Anthony P Carnicelli, Ruth Owen, Mauricio G Cohen, Katarina Hedman, Stuart J Pocock, Jose Carlos Nicolau

“…After multivariable adjustment, patients with AF had lower self-reported quality-of-life scores (EQ-5D UK-weighted index, visual analogue scale, usual activities and pain/discomfort) than those without AF. …”
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Brain functional alternation in patients with systemic sclerosis: a resting-state functional magnetic resonance imaging study by Xinyu Tong, Huilin He, Shihan Xu, Rui Shen, Zihan Ning, Xiaofeng Zeng, Qian Wang, Dong Xu, Zuo-Xiang He, Xihai Zhao

“…This study aimed to investigate the resting state (RS) functional alternations of SSc patients and the potential influenced factors. Methods Forty-four SSc patients (mean age, 46.3 ± 11.4 years; 40 females) and 19 age and sex comparable healthy volunteers (mean age, 42.6 ± 11.3 years; 16 females) were recruited and underwent RS functional MR imaging (fMRI) and neuropsychological assessments. …”
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Hyperuricemia predicts adverse clinical outcomes after arthroscopic microfracture of osteochondral lesions of the talus by Yuanqiang Li, Zhenyu Wang, Guo Zheng, Lin Ma, Xin Xin Li, Yan Liang, Xinyu Xie, Xiaolin Zhang, Chengsong Yuan, Wan Chen

“…Clinical characteristics recorded and analyzed included Visual Analog Scale (VAS score), American Orthopaedic Foot & Ankle Society score (AOFAS), and 36-Item Short Form Health Survey score (SF-36). …”
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Charting progress in learning health systems: A systematic review of 5 years of definitions, models, and frameworks by Louise A. Ellis, Georgia Fisher, Maree Saba, Genevieve Dammery, Kate Churruca, Samantha Spanos, Carolynn L. Smith, Bianca Forrester, Yvonne Zurynski, Jeffrey Braithwaite

“…Extracted data were examined using thematic and visual network analyses, and practical examples of how the domains of an LHS can be actualized in health settings were synthesized. …”
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Factors influencing, and associated with, physical activity patterns in dogs with osteoarthritis-associated pain by Christina Stevens, Elizabeth Kawecki-Wright, Avery Rowlison de Ortiz, Andrea Thomson, Savannah Aker, Erin Perry, Emily Haupt, Alejandra Mondino, Masataka Enomoto, Margaret E. Gruen, Margaret E. Gruen, B. Duncan X. Lascelles, B. Duncan X. Lascelles, B. Duncan X. Lascelles, B. Duncan X. Lascelles

“…Functional linear modeling (FLM) is an approach for analyzing and visualizing high-frequency longitudinal data such as physical activity and can be used to assess the influence of factors on activity patterns. …”
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Low density of intratumoral M1-macrophage infiltration may correlate with worse prognosis in low-grade early-stage uterine endometrioid carcinoma by Michiko Nagamine, Hiroshi Ogi, Maki Hirai, Ikoi Omatsu, Sanzo Moriwaki, Saya Shibata, Satoru Yasukawa, Kaori Yoriki, Motohiro Kojima, Taisuke Mori, Kyoko Itoh, Eiichi Konishi

“…Our objective was to explore the differences in tumor immune microenvironment (TIME) between recurrent and cured low-grade early-stage endometrioid carcinoma cases. Methods: We retrospectively examined the TIME in recurrent (n = 11) and non-recurrent (cured, n = 10) cases of low-grade, early-stage endometrioid carcinoma. …”
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Research trends and hotspots of acupuncture therapy for obesity from 2004 to 2023: A bibliometric analysis by Jinkun Wang, Kangdi Cao, Zhaoyi Chen, Tianli Lyu, Qiuyu Xia, Lu Liu, Bin Li

“…Using Citespace, VOSviewer, and Bibliometrix, we analyzed and visualized the publications, countries, institutions, authors, journals, and keywords from various angles. …”
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Contemporary carotid artery stenting practices and peri-procedural outcomes in different European countries: ROADSAVER study multicentric insights by Stefan Müller-Hülsbeck, Zsolt Vajda, Piotr Odrowąż-Pieniążek, Zoltán Ruzsa, Roel Beelen, Aleksandar Gjoreski, Koen Deloose, Sérgio Castro, Benjamin Faurie, Alejandro Tomasello Weitz, Arne Schwindt, Paweł Latacz, Antonio Orgaz Pérez-Grueso, Vladimir Cvetić, Ralf Langhoff, Sasko Kedev, all ROADSAVER study investigators

“…Trial registration Clinicaltrials.gov identifier: NCT03504228. Visual Abstract…”
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Free-breathing, non-contrast, three-dimensional whole-heart coronary magnetic resonance imaging for the identification of culprit and vulnerable atherosclerotic plaque by Reza Hajhosseiny, Adam Hartley, Graham Cole, Camilla Munoz, Amarjit Sethi, Rasha Al-Lamee, Saud Khawaja, Sameer Zaman, James Howard, Deepa Gopalan, Ben Ariff, Raffi Kaprielian, Radhouene Neji, Karl P. Kunze, Amit Kaura, Claudia Prieto, Ramzi Khamis, René M. Botnar

“…Objectives: To validate iT2prep-BOOST in patients with non-ST-segment elevation myocardial infarction (NSTEMI). Methods: 41 patients with suspected NSTEMI were recruited. …”
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Long-term safety and effectiveness of canakinumab in patients with monogenic autoinflammatory diseases: results from the interim analysis of the RELIANCE registry by Tilmann Kallinich, Juergen Rech, Ivan Foeldvari, Norbert Blank, Frank Weller-Heinemann, Gerd Horneff, Ioana Andreica, Joerg Henes, Jasmin B Kuemmerle-Deschner, Florian Meier, Frank Dressler, Michael Borte, Markus Hufnagel, Birgit Kortus-Götze, Prasad T Oommen, Tobias Krickau, Aleš Janda, Catharina Schuetz, Michael Fiene, Julia Weber-Arden

“…Objective Interim analysis of the RELIANCE registry, an on-going, non-interventional, open-label, multicentre, prospective study evaluating the long-term safety, dosing regimens and effectiveness of canakinumab in patients with cryopyrin-associated periodic syndromes (CAPS), familial Mediterranean fever (FMF), tumour-necrosis factor receptor-associated periodic syndrome (TRAPS) or mevalonate-kinase deficiency (MKD)/hyperimmunoglobulin-D syndrome (HIDS).Methods From September 2017 for patients with CAPS, and June 2018 for patients with FMF, TRAPS or MKD/HIDS, the registry enrolled paediatric (aged ≥2 years) and adult patients (aged ≥18 years) receiving canakinumab as part of their routine medical care. …”
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Use of technetium-99m-pyrophosphate single-photon emission computed tomography/computed tomography in monitoring therapeutic changes of RNA interference therapeutics in patients wi... by Yi-Hsin Hung, An-Li Yu, Yi-Chieh Chen, Cheng-Hsuan Tsai, Mao-Yuan Su, Chia-Tung Shun, Hsueh-Wen Hsueh, Jimmy Jyh-Ming Juang, Ming-Jen Lee, Ping-Huei Tseng, Chia-Hua Hsu, Sung-Tsang Hsieh, Chi-Lun Ko, Kon-Ping Lin, Wen-Chung Yu, Mei-Fang Cheng, Chi-Chao Chao, Yen-Hung Lin

“…First and second 99mTc-PYP SPECT/CT data, including visual grading, planar heart to contralateral lung (H/CL) ratio, and volumetric heart to lung (H/L) ratio were assessed. …”
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Metabolic response to burn injury: a comprehensive bibliometric study by Yixu Li, Yixu Li, Yifan Liu, Sujie Xie, Sujie Xie, Yushu Zhu, Yushu Zhu, Xinran Ding, Xinran Ding, Wei Zhang, Wei Zhang, Shuyuan Xian, Shuyuan Xian, Guosheng Wu, Guosheng Wu, Hanlin Sun, Hanlin Sun, Jiale Yan, Bingnan Lu, Yuntao Yao, Weijin Qian, Yuwei Lu, Yiting Yang, Dayuan Xu, Dayuan Xu, Runzhi Huang, Runzhi Huang, Shizhao Ji, Shizhao Ji

“…Ultimately, we conducted an extensive review of the literature, synthesizing the findings to clarify the present understanding within our field of study.MethodsWe obtained 8,823 scientific publications on burn injury and metabolism from the core Web of Science (WOS) database collection. …”
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Characterisation of combined abiotic and biotic stresses effects on lettuce plants via a multi-analysis approach by Roberta Bulgari, Roberta Bulgari, Jouhaina Riahi, Riccardo Cecire, Riccardo Cecire, Luisella Celi, Mery Malandrino, Gica Stefanescu Miralles, Gica Stefanescu Miralles, Lorenzo Comba, Luca Alfarano, Luca Alfarano, Massimo Pugliese, Massimo Pugliese

“…These findings pave the way to the development of proactive, reliable, and effective methods for stress detection in lettuce cultivation, also including non-destructive optical approaches.…”
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