Effects of vagus nerve stimulation on daily function and quality of life in markedly treatment-resistant major depression: Findings from a one-year, randomized, sham-controlled tri... by A. John Rush, Charles R. Conway, Scott T. Aaronson, Mark S. George, Patricio Riva-Posse, David L. Dunner, John Zajecka, Mark T. Bunker, João Quevedo, Rebecca M. Allen, Gustavo Alva, Heather Luing, Ziad Nahas, Lucian Manu, Jeffrey I. Bennett, Brian J. Mickey, Jonathan Becker, Yvette Sheline, Cristina Cusin, James W. Murrough, Kevin Reeves, Peter B. Rosenquist, Ying-Chieh (Lisa) Lee, Shannon Majewski, Jeffrey Way, Bryan Olin, Harold A. Sackeim

“…The WHODAS 2.0 (P = 0.304) and EQ-5D visual analog scale (P = 0.125) failed to reveal between-group differences. …”
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Validating the SONG-PKD Pain Instrument, a Core Outcome Measure for Pain in ADPKD by Rosanna Cazzolli, Angela Ju, Patrizia Natale, Armando Teixeira-Pinto, Martin Howell, Allison Jaure, Ronald D. Perrone, Eva Burnette, Niek F. Casteleijn, Arlene Chapman, Jonathan C. Craig, Sarah Eastty, Ron T. Gansevoort, Tess Harris, Marie C. Hogan, Shigeo Horie, Bertrand Knebelmann, Richard Lee, Karine Manera, Reem A. Mustafa, Richard Sandford, Gopala K. Rangan, Bénédicte Sautenet, Andrea K. Viecelli, Yeoungjee Cho

“…There was a high convergence of SONG-PKD Pain with the Brief Pain Inventory-Short Form (BPI-SF; 0.84, 95% CI: 0.80–0.87) and a visual analog scale (VAS; 0.84, 95% CI: 0.81–0.87). …”
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The incorporation of MALDI mass spectrometry imaging in studies to identify markers of toxicity following in utero opioid exposures in mouse fetuses by Dustyn Barnette, Amy L. Inselman, Pravin Kaldhone, Grace S. Lee, Kelly Davis, Sumit Sarkar, Pritpal Malhi, J. Edward Fisher, Joseph P. Hanig, Richard D. Beger, E. Ellen Jones

“…Matrix-assisted laser desorption/ionization mass spectrometry imaging (MALDI MSI) is a dynamic approach capable of generating 2D ion images to visualize the distribution of an analyte of interest across a tissue section.MethodsGiven the importance of lipid metabolism and neurotransmitters in the developing central nervous system, this study incorporates MALDI MSI to assess lipid distributions across mouse gestational day (GD) 18 fetuses, with and without observable NTDs following maternal exposure on GD 8 to morphine (400 mg/kg BW) or the NTD positive control valproic acid (VPA) (500 mg/kg BW).ResultsAnalysis of whole-body mouse fetuses revealed differential lipid distributions localized mainly in the brain and spinal cord, which included several phosphatidylcholine (PC) species such as PCs 34:1, 34:0, and 36:2 localized to the cortex or hippocampus and lyso PC 16:0 across all brain regions. …”
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Modeling the distribution of the invasive snail Physella acuta in China: Implications for ecological and economic impact by Yingxuan Yin, Anyuan Xu, Xiaowen Pan, Qing He, Aoxun Wu, Linya Huang, Yinjuan Wu, Xuerong Li

“…Gaining insight into their geographical spread in China under current and future climate scenarios is crucial for effective monitoring and control strategies against this invasive species. Methods: Global distribution data of P. acuta were collected and screened using “ENMtool”; environmental variables were screened based on contribution of environmental variables, jackknife test and variable correlation analysis using MaxEnt 3.4.1 and GraphPad Prism 8; “kuenm” package in R 4.0.4 software was used to calculate and adjust model parameters; the optimized MaxEnt model was used to predict the potential distribution range of P. acuta in China under different climate scenarios; ArcGIS 10.7 was used to process and visualize the results. …”
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Key motor and non-motor features in early dementia with Lewy bodies by Anna Planas-Ballvé, Anna Planas-Ballvé, José Rios, Lourdes Ispierto, Mireia Gea, Laia Grau, Marta Jiménez, Cynthia Cáceres, Sílvia Martínez, Katrin Beyer, Ramiro Álvarez, Pau Pastor, Dolores Vilas, Dolores Vilas

“…ObjectiveThe objective of our study was to characterize early-stage dementia with Lewy bodies (DLB) focusing on motor and non-motor symptoms.MethodsThis cross-sectional study prospectively included newly diagnosed DLB patients within 3 years of cognitive symptom onset. …”
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Geometrical Features of Subbasal Corneal Whorl-like Nerve Patterns in Dry Eye Disease by Ziqing Feng, MD, Kang Yu, MD, Yupei Chen, MS, Gengyuan Wang, MS, Yuqing Deng, MD, Wei Wang, MD, Ruiwen Xu, MD, Yimin Zhang, MD, Peng Xiao, PhD, Jin Yuan, MD, PhD

“…Participants: The study included 29 healthy subjects (51 eyes) and 62 DED patients (95 eyes). Methods: All subjects underwent comprehensive ophthalmic examinations, dry eye tests, and in vivo confocal microscopy to visualize the whorl-like corneal nerve at the inferior whorl (IW) region and the straight nerve at the central cornea. …”
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Exploring family physicians’ mental health referrals via centralized referral systems in Quebec, Canada: a qualitative descriptive study by Jessica Spagnolo, Marie Beauséjour, Marie-Josée Fleury, Jean-François Clément, Claire Gamache, Lyne Couture, Carine Sauvé, Shane Knight, Christine Gilbert, Richard Fleet, Helen-Maria Vasiliadis

“…Methods: A qualitative descriptive study with 20 participants working in the healthcare sector was conducted. …”
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The efficacy and safety of glycosaminoglycan-peptide complex in patients with knee osteoarthritis and comorbidity: a multicenter prospective study by L. I. Alekseeva, E. A. Taskina, N. G. Kashevarova, E. P. Sharapova, E. A. Strebkova, S. G. Anikin, N. V. Chichasova, T. A. Raskina, E. V. Zonova, E. N. Otteva, E. I. Shmidt, S. P. Yakupova, I. B. Vinogradova, O. N. Ivanova, V. A. Lila, B. V. Zavadovsky, P. A. Shesternya, A. M. Lila

“…Objective: to evaluate the efficacy and safety of glycosaminoglycan-peptide complex (GPC, Rumalon) used in patients with knee osteoarthritis (OA) and comorbidities (hypertension and/or type 2 diabetes mellitus (T2DM).Patients and methods: A 10-month multicenter (13 centers from 10 subjects of the Russian Federation) prospective study included 179 patients with Stages II–III primary tibiofemoral knee OA and comorbidity, a walking pain intensity of ≥40 mm on a visual analogue scale (VAS), and a need for nonsteroidal anti-inflammatory drugs (for at least 30 days in the previous 3 months). …”
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Efficacy and safety of ozone injection into the intervertebral foramen for treating patients with chronic, intractable postherpetic neuralgia: a one-year follow-up study by Jiang-Lin Wang, Jiang-Lin Wang, Hai-Li Li, Xiang-Bo Liu, Jia-Gui Zhao, Dong Huang, Cheng Wu, Jia-Shuang Wang, Jia-Shuang Wang, Jun Chen, Jun Chen

“…Here, we reported the efficacy and safety of a standardized therapeutic approach with CT-guided intervertebral foramen injection of ozone (IVFO) in patients with chronic intractable thoracic and lumbar (PHN) (n = 56) who had been tolerant or insensitive to first-line drugs, such as gabapentin (GBP) or pregabalin.MethodsVisual analogue scale (VAS), quantitative sensory testing (von Frey filaments only), and infrared thermography were used to identify and quantify the pain intensity, area of mechanical hyperalgesia, and skin temperature in the included patients with PHN before and after IVFO treatment. …”
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The effect of topical TRanexamic Acid versus placebo on acute postoperative pain following Distal Radius fracture fixation: protocol for a randomised controlled trial at a quaterna... by Ryan Paul, Atefeh Noori, Christian Veillette, Darius Luke Lameire, Aazad Abbas, Jonathan Persitz, Heather Baltzer, Emily Collett, Andrea Chan

“…The primary outcome is acute postsurgical pain as measured by the visual analogue scale (VAS). Pain outcomes will be between postoperative days 0 to 7, and at 2 and 6 weeks postsurgery. …”
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A pilot study of intraoperative melphalan to prevent recurrent PVR: the IOMPVR study by Carlos A. Moreira-Neto, Jose S Pulido, Luca Bongiovanni de Miranda Gonçalves, Gabriel Nunes Cavalcanti, Acacio Souza Lima, José de Paula Barbosa Neto, Daniel Lavinsky, Talita Virginia Fernandes de Oliveira, Fernando Ejii Ogata, Lucas Zago Ribeiro, Luiz Fernando Teixeira, Flavia Borelli Gomes do Nascimento, Luiz H. Lima, Octaviano Jr. Magalhães, Michel Eid Farah, Maurício Maia

“…The logarithm of the minimum angle of resolution best-corrected visual acuity improved from the mean ± standard deviation preoperatively of 2.11 ± 0.22 to 0.89 ± 0.37 at 30 and to 0.84 ± 0.42 at 90 days postoperative (P < 0.001). …”
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‘A good decision is the one that feels right for me’: Codesign with patients to inform theoretical underpinning of a decision aid website by Kelly Kohut, Kate Morton, Karen Hurley, Lesley Turner, The CanGene‐CanVar Patient Reference Panel, Caroline Dale, Susan Eastbrook, Rochelle Gold, Kate Henwood, Sonia Patton, Reshma Punjabi, Helen White, Charlene Young, Julie Young, Elizabeth Bancroft, Lily Barnett, Sarah Cable, Gaya Connolly, Beth Coad, Andrea Forman, Helen Hanson, Grace Kavanaugh, Katherine Sahan, Katie Snape, Bethany Torr, Rosalind Way, Elizabeth Winchester, Alice Youngs, The International Lynch Decision Aid Stakeholder Panel, Diana Eccles, Claire Foster

“…The aim of an innovative workshop described here was to engage with the people who will use the PtDA regarding the theoretical underpinning and logic model outlining our hypothesis of how the PtDA would lead to more informed decision‐making. Methods Short presentations about psychological and behavioural theories by an expert were interspersed with facilitated, small‐group discussions led by patients. …”
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Down-regulation of colon mucin production induced by Eimeria pragensis infection in mice by Yulia Dwi Setia, Yulia Dwi Setia, Mio Kokubo-Tanaka, Ryusei Tanaka, Akemi Yoshida, Eiji Nagayasu, Parnian Ahmadi, Parnian Ahmadi, Parnian Ahmadi, Ayako Yoshida, Ayako Yoshida, Haruhiko Maruyama

“…In the present study, we investigated the pathogenesis and the mechanisms underlying goblet cell down-regulation in the early phase of infection.MethodsMale C57BL/6 mice were orally infected with 300 oocysts. …”
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Real-time augmented feedback for gait training: are gait responses affected by the choice of target parameter? by Mathilde Legrand, Mathilde Legrand, Mathilde Legrand, Florette Grenet, Olivia Hochstrasser, Olivia Hochstrasser, Andreas Luft, Andreas Luft, Roger Gassert, Roger Gassert, Roger Gassert, Olivier Lambercy, Olivier Lambercy, Chris Easthope Awai

“…BackgroundAugmented visual feedback (AVF) is a promising approach for gait rehabilitation after stroke. …”
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Quantitative insights into stroke recovery utilizing delayed vessel ratio from color-coded multiphase computed tomography angiography by Yu Lin, Yu Lin, Yu Lin, Xiaoxiao Zhang, Zhen Xing, Xiefeng Yang, Qingwen Tong, Shaomao Lv, Jinan Wang, Jinan Wang, Dairong Cao, Dairong Cao, Dairong Cao, Dairong Cao

“…Background and objectiveThe color-coded multiphase computed tomography angiography (cmCTA) is an accredited technique that employs color-coding to visually depict the temporal dynamics of collateral blood flow in patients with acute ischemic stroke (AIS). …”
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Novel minimally invasive carpal tunnel release using a specialized surgical kit: a prospective multi-center case series by Hsuan-Fu Chen, Shun-Min Chang, Chih-Ming Kao, Yu-Lin Chen, Li-Ting Kao, Ya-Chuan Hsu, Yin-Chih Fu, Yan-Hsiung Wang, Wen-Chih Liu, Tien-Ching Lee

“…This study evaluates a novel minimally invasive surgical technique using a specialized instrument for carpal tunnel release. Methods In this prospective multi-center case series, 41 patients underwent minimally invasive carpal tunnel release using a novel surgical kit. …”
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Global trends in the use of artificial intelligence for urological tumor histopathology: A 20-year bibliometric analysis by Fazhong Dai, Yifeng He, Juan Duan, Kangjian Lin, Qian Lv, Zhongxiang Zhao, Yesong Zou, Jianhong Jiang, Zongtai Zheng, Xiaofu Qiu

“…This study conducted a 20-year bibliometric analysis to map global research trends and innovations in AI-driven urological pathology. Methods For this bibliometric analysis, literature from 2004 to 2024 was retrieved from the Web of Science Core Collection. …”
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Machine Learning Model Based on Prognostic Nutritional Index for Predicting Long‐Term Outcomes in Patients With HCC Undergoing Ablation by Nan Zhang, Ke Lin, Bin Qiao, Liwei Yan, Dongdong Jin, Daopeng Yang, Yue Yang, Xiaohua Xie, Xiaoyan Xie, Bowen Zhuang

“…ABSTRACT Aims To develop multiple machine learning (ML) models based on the prognostic nutritional index (PNI) and determine the optimal model for predicting long‐term survival outcomes in hepatocellular carcinoma (HCC) patients after local ablation. Methods From January 2009 to December 2019, we analyzed data from 848 primary HCC patients who underwent local ablation. …”
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Does the number of drain tubes influence the formation of postoperative spinal epidural hematoma following biportal endoscopic unilateral laminotomy for bilateral decompression (BE... by Zhuolin Zhong, Jingjing Ying, Shaohua Zhang, Kaili Cai, Xiaowei Jing, Zhengyu Xu, Lejian Jiang, Tianxin Wu, Guojun Wei, Qingfeng Hu

“…Demographic data were collected, including preoperative visual analog scale (VAS) scores for leg pain and preoperative blood pressure (BP). …”
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Indocyanine green fluorescence-guided surgery in the emergency setting: the WSES international consensus position paper by Belinda De Simone, Fikri M. Abu-Zidan, Luigi Boni, Ana Maria Gonzalez Castillo, Elisa Cassinotti, Francesco Corradi, Francesco Di Maggio, Hajra Ashraf, Gian Luca Baiocchi, Antonio Tarasconi, Martina Bonafede, Hung Truong, Nicola De’Angelis, Michele Diana, Raul Coimbra, Zsolt J. Balogh, Elie Chouillard, Federico Coccolini, Micheal Denis Kelly, Salomone Di Saverio, Giovanna Di Meo, Arda Isik, Ari Leppäniemi, Andrey Litvin, Ernest E. Moore, Alessandro Pasculli, Massimo Sartelli, Mauro Podda, Mario Testini, Imtiaz Wani, Boris Sakakushev, Vishal G. Shelat, Dieter Weber, Joseph M. Galante, Luca Ansaloni, Vanni Agnoletti, Jean-Marc Regimbeau, Gianluca Garulli, Andrew L. Kirkpatrick, Walter L. Biffl, ICG-Fluorescence Guided Emergency Surgery Consensus Participants, Fausto Catena

“…Aim This consensus paper provides evidence-based and expert opinion-based recommendations for the standardized use of ICG fluorescence imaging in emergency settings. Methods Using the PICO framework, the consensus coordinator identified key research areas, topics, and questions regarding the implementation of ICG fluorescence-guided surgery in emergencies. …”
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