Interleukin-1 Receptor-Associated Kinase-3 Aggravates Neuroinflammatory Injury After Intracerebral Hemorrhage via Activation NF-κB/IL-17A Pathway in Mice by Wang J, Li Y, Tan C, Shao J, Tang W, Kong Q, Sheng W, Ding Z, Li F, Piao J, Lv D, Hu L, Wang Q, Jiang X

“…Although previous studies have shown that IRAK3 is involved in immune responses, the potential effects of IRAK3 on ICH remain unclear.Methods: Collagenase IV–induced ICH mouse model. Western blotting was used to determine the expression of IRAK3 at different time points following ICH. …”
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The Application of Multifunctional Endoscope Transport Carts in Bedside Endoscopy in Intensive Care Unit Patients by Zhang M, Du J, Zhang Q, Qiao F, Ye L, Hu B, Tao S

“…Miao Zhang,1,2,* Jiang Du,1,2,* Qiongying Zhang,1,2 Fu Qiao,3 Liansong Ye,1,4 Bing Hu,1,4 Siyuan Tao3 1Department of Gastroenterology and Hepatology, West China Hospital, Sichuan University, Chengdu, Sichuan, People’s Republic of China; 2West China School of Nursing, Sichuan University, Chengdu, Sichuan, People’s Republic of China; 3Department of Infection Control, West China Hospital, Sichuan University, Chengdu, Sichuan, People’s Republic of China; 4Digestive Endoscopy Medical Engineering Research Laboratory, West China Hospital, Sichuan University, Chengdu, Sichuan, People’s Republic of China*These authors contributed equally to this workCorrespondence: Qiongying Zhang, Department of Gastroenterology and Hepatology, West China Hospital, Sichuan University, No. 37 Guoxue Alley, Wuhou District, Chengdu, Sichuan, 610041, People’s Republic of China, Email hxnjzqy@163.com Fu Qiao, Department of Infection Control, West China Hospital, Sichuan University, No. 37 Guoxue Alley, Wuhou District, Chengdu, Sichuan, 610041, People’s Republic of China, Email qiaofu2005@scu.edu.cnBackground: This study aimed to investigate whether the application of multifunctional endoscope transport carts, in bedside endoscopy in intensive care unit (ICU) patients, can improve the cleaning quality of the endoscopes.Methods: A total of 175 endoscopes, used for bedside endoscopy in ICU patients in a hospital in China during November 2023 to January 2024, were randomly classified into the control group (n=88) and the experimental group (n=87). …”
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A Health Literate Healthcare Organization Index System for China: Based on CiteSpace and Qualitative Analysis by Zhao S, Chen Y, Xia X, Zhou J, Wang X, Sun Q, Chang J, Ge J, Hu L, Lu R

“…Shenyu Zhao,1,* Yang Chen,2,* Xiyang Xia,2 Jing Zhou,2 Xiaoyu Wang,2 Qing Sun,1 Jiaqian Chang,2 Jiaying Ge,2 Lingmin Hu,2 Renjie Lu1,3 1Changzhou Third People’s Hospital, Changzhou Medical Center, Nanjing Medical University, Changzhou, Jiangsu, People’s Republic of China; 2Department of Reproduction, Changzhou Maternity and Child Health Care Hospital, Changzhou Medical Center, Nanjing Medical University, Changzhou, Jiangsu, People’s Republic of China; 3Changzhou Institute for Advanced Study of Public Health, Nanjing Medical University, Changzhou, Jiangsu, People’s Republic of China*These authors contributed equally to this workCorrespondence: Renjie Lu, Changzhou Third People’s Hospital, Changzhou Medical Center, Nanjing Medical University, Changzhou, Jiangsu, 213000, People’s Republic of China, Email renjie_lu@126.com Lingmin Hu, Department of Reproduction, Changzhou Maternity and Child Health Care Hospital, Changzhou Medical Center, Nanjing Medical University, Changzhou, Jiangsu, 213000, People’s Republic of China, Email hulingmin1986@126.comObjective: This study aims to analyze the current status and development trends of health literate healthcare organization (HLHO) worldwide, and preliminarily construct an index system suitable for HLHO in China.Methods: This study first utilized CiteSpace for bibliometric analysis to explore global research hotspots and trends in HLHO. …”
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Impact of the COVID-19 pandemic on hospital-based heart failure care in New South Wales, Australia: a linked data cohort study by Daniel McIntyre, Desi Quintans, Samia Kazi, Haeri Min, Wen-Qiang He, Simone Marschner, Rohan Khera, Natasha Nassar, Clara K. Chow

“…This study aimed to examine heart failure care during the pandemic in New South Wales (NSW). Methods Analysis of hospital utilisation among patients aged ≥ 18 years with a primary diagnosis of heart failure conducted using linked administrative health records from hospital admission, emergency department, non-admitted services, and mortality data collections. …”
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Clinical efficacy of 177Lu-DOTATATE peptide receptor radionuclide therapy in thyroglobulin-elevated negative iodine scintigraphy: A “not-so-promising” result compared to GEP-NETs... by Sandip Basu, Rahul Parghane, Chinna Naik

“…The selected patients were analyzed for the following parameters: (i) the patient characteristics, (ii) the metastatic burden, (iii) study of PRRT cycles and activity, (iv) response assessment (undertaken by three-parameter scale: symptomatic including Karnofsky/Lansky Performance scoring, biochemical and scan features) employing predefined criteria (detailed in methods), and (v) Grade III/IV hematological or renal toxicity. …”
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Understanding Mental Health Service Perceptions in Chinese Americans with Type 2 Diabetes and Co-Occurring Mental Health Challenges Living in New York City: A Qualitative Study by Liu J, Cao J, Shi Y, Jiang Y, Ruan J, Wu B, Tsai W, Hu L

“…This study aimed to provide an in-depth exploration of mental health care perceptions in this population.Patients and Methods: Two focus group discussions involving 12 participants were conducted in Mandarin. …”
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The Association Between Medication Adherence and Health-Related Quality of Life in Patients with COPD: A Cross-Sectional Study by Saja MF, Younis AS, Alzahrani LA, Alkhlassi IN, Aldakhil LS, Albayyat RM, Alnasser NA, Alokla KS, Alghamdi LA, Rashed AN, Azer SA

“…This study aimed to measure medication adherence and its impact on HRQoL in patients with COPD.Patients and Methods: This cross-sectional observational study included patients with COPD from two health centers in Riyadh, Saudi Arabia. …”
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Supported Telemonitoring and Glycemic Control in People with Type 2 Diabetes: The Telescot Diabetes Pragmatic Multicenter Randomized Controlled Trial. by Sarah H Wild, Janet Hanley, Stephanie C Lewis, John A McKnight, Lucy B McCloughan, Paul L Padfield, Richard A Parker, Mary Paterson, Hilary Pinnock, Aziz Sheikh, Brian McKinstry

“…There were few adverse events and these were equally distributed between the intervention and control groups. …”
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Qing’e Pills Ameliorates Osteoporosis by Regulating Gut Microbiota and Th17/Treg Balance in Ovariectomized Rats by Hao F, Guo M, Zhao Y, Zhu X, Hu X, Zhu W, Mei C, Zhou N, Qin K, Zhu H, Li W

“…However, the mechanism of its immune action remains unclear.Methods: QEP components were identified via HPLC. …”
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Abnormal CSF-Specific OCBs in Neuronal Surface Antibody-Associated Autoimmune Encephalitis Differentiating from Viral Encephalitis by Qiao S, Zhang C, Li H, Zhou T, Wang A, Zhang S

“…Additionally, the study aimed to assess the impact of cerebrospinal fluid (CSF) oligoclonal bands (OCBs) on the severity and prognosis of NSAE.Patients and Methods: This retrospective analysis included patients with NSAE, encompassing NMDAR-E, LGI1-E, and GABABR-E, alongside individuals with VE. …”
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Effects of Electroacupuncture and Mecobalamin for Utidelon-Induced Peripheral Neuropathy in Breast Cancer Patients: A Randomized Controlled Clinical Trial by Lu C, Shen Q, Deng D, Zhang Y, Wang P, Shao X, Deng Y, Bao W, Chen W, Li G

“…This study aims to evaluate the clinical effects of electroacupuncture (EA) and Mecobalamin (MeCbl) in treating Utidelone-induced peripheral neuropathy (UIPN), providing preliminary evidence to optimize clinical management strategies.Methods: A total of 60 eligible breast cancer patients with UIPN were randomly assigned in a 1:1 ratio to either the EA group or the MeCbl group. …”
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Analysis and 15-Year Projections of the Global Burden of Tension-Type Headache by Sex from 1990 to 2021: A Systematic Review of GBD 2021 Data by Xu H, Qin X, Zhao G, Feng Z, You S

“…However, comprehensive analyses and predictive studies on the global TTH burden stratified by gender are currently lacking.Aim: This study utilized data from the Global Burden of Disease (GBD) Study to analyze the global burden of tension - type headache by sex from 1990 to 2021 and conducted a 15 - year projection (up to 2036).Methods: We conducted a systematic review of GBD 2021 data, employing Joinpoint regression analysis and decomposition analysis to assess TTH incidence, prevalence, YLDs, and DALYs. …”
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Multifunctional Indomethacin Conjugates for the Development of Nanosystems Targeting Cancer Treatment by Thiruchenthooran V, Świtalska M, Maciejewska G, Palko-Łabuz A, Bonilla-Vidal L, Wietrzyk J, Souto EB, Sánchez-López E, Gliszczyńska A

“…Therefore, this study aimed to develop a nanosystem with reduced toxicity and risk of side effects for the delivery of IND for cancer treatment.Methods: IND was encapsulated in nanostructured lipid carriers (NLC) in the form of a phospholipid conjugate, where a covalent bond exists between the drug and phosphatidylcholine skeleton. …”
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Treatment with Ceftazidime-Avibactam for Lower Respiratory Tract Infections Caused by the Multidrug-Resistant Gram-Negative Bacteria in the Intensive Care Unit by Pan J, Kong H, Geng Z, Liang M, Yu S, Fang X

“…This study aimed to evaluate the clinical characteristics of patients with LRTIs caused by MDR-GNB who were treated with CAZ-AVI in the ICU, and to investigate the independent risk factors for mortality.Patients and Methods: This single-center retrospective study included patients with LRTIs treated with CAZ-AVI in the respiratory ICU of a tertiary hospital in Anhui Province between December 2022 and November 2024. …”
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Characterizing Duodenal Immune Microenvironment in Functional Dyspepsia: An AutoML-Driven Diagnostic Framework by Zhang X, Fan X, Hu X, Qian Z, Li J, Wu W, Chen L, Wu S, Ma L, Yang C, Zhang T, Su X, Wei W

“…Recent studies suggest that duodenal immune activation plays a pivotal role in its development.Methods: Mendelian randomization analysis using genome-wide association studies (GWAS) and expression quantitative trait loci (eQTL) data identified genes associated with FD. …”
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Development and Validation of a Dynamic Online Nomogram for Predicting Inpatient Fall Risk: A Cohort Study by Jiang S, Zhao F, Liang Y, Wang S, Xu Q, Wang R, Wu T, Yang H

“…Su Jiang,1,* Feng Zhao,2,* Yan Liang,2 Sulei Wang,2 Qiuyue Xu,3 Ruilin Wang,4 Tianchen Wu,2 Hui Yang3 1Department of Rehabilitation Medicine, The Affiliated Taizhou People’s Hospital of Nanjing Medical University, Taizhou, 225300, People’s Republic of China; 2Department of Neurology, Nanjing Hospital of Chinese Medicine Affiliated to Nanjing University of Chinese Medicine, Nanjing, 210012, People’s Republic of China; 3School of Nursing, Nanjing University of Chinese Medicine, Nanjing, 210023, People’s Republic of China; 4College of Acupuncture, Moxibustion and Orthopedics, Hubei University of Chinese Medicine, Wuhan, 430000, People’s Republic of China*These authors contributed equally to this workCorrespondence: Hui Yang, School of Nursing, Nanjing University of Chinese Medicine, No. 138 of Xianlin Road, Qixia District, Nanjing, 210023, People’s Republic of China, Tel +86 25 85811993, Email yanghuiyhcc@163.com Tianchen Wu, Department of Neurology, Nanjing Hospital of Chinese Medicine Affiliated to Nanjing University of Chinese Medicine, No. 157 Daming Road, Qinhuai District, Nanjing, 210012, People’s Republic of China, Tel +86 25 5227 6666, Email wutianchenwtc@126.comObjective: This study aimed to develop and validate a dynamic online nomogram for predicting inpatient fall risk using data from a Dryad database cohort to strengthen fall prevention strategies and enhance patient safety in hospital settings.Methods: We analyzed data from a cohort study conducted at Fukushima Medical University Hospital, with external validation using an independent dataset from Taizhou People’s Hospital (2019– 2023, n=2000). …”
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Prediction of Acute Kidney Injury for Critically Ill Cardiogenic Shock Patients with Machine Learning Algorithms by Zhang X, Xiong Y, Liu H, Liu Q, Chen S

“…Xiaofei Zhang,1,* Yonghong Xiong,2,* Huilan Liu,3 Qian Liu,4 Shubin Chen5 1Department of Gerontology, China Aerospace Science & Industry Corporation 731 hospital, Beijing, People’s Republic of China; 2Department of Cardiology, Beijing Feng Tai Hospital, Beijing, People’s Republic of China; 3Department of Nephrology, Zhongnan Hospital of Wuhan University, Wuhan, People’s Republic of China; 4Department of Cardiology, Wuhan Children’s Hospital, Tongji Medical College, Huazhong University of Science & Technology, Wuhan, People’s Republic of China; 5Department of Intensive Care Unit, China Aerospace Science & Industry Corporation 731 hospital, Beijing, People’s Republic of China*These authors contributed equally to this workCorrespondence: Qian Liu, Department of Cardiology, Wuhan Children’s Hospital, Tongji Medical College, Huazhong University of Science & Technology, No. 100 of Xianggang Road, Jiangan District, Wuhan, 430015, People’s Republic of China, Tel +86027-82433350, Email qian_liu1124@126.com Shubin Chen, Department of Intensive Care Unit, China Aerospace Science & Industry Corporation 731 hospital, No. 3 Zhen Gang Nan Li, Yun Gang Town, Feng Tai District, Beijing, 100074, People’s Republic of China, Tel +86010-68374065, Email 18610074016@163.comBackground: The aim of this study was to use five machine learning approaches and logistic regression to design and validate the acute kidney injury (AKI) prediction model for critically ill individuals with cardiogenic shock (CS).Methods: All patients who diagnosed with CS from the MIMIC-IV database, the eICU database, and Zhongnan hospital of Wuhan university were included in this study. …”
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Adjuvant Lenvatinib for High-Risk CNLC IIb/IIIa Hepatocellular Carcinoma After Curative Hepatectomy: A Prospective Exploratory Study by Sun HC, Huang ZY, Wen T, Liu L, Zhu XD, Zhang E, Li C, Zhang X, Wang J, Fan J, Zhou J

“…This study aimed to evaluate the efficacy and safety of lenvatinib as adjuvant therapy for HCC.Methods: In this open-label, single-arm, prospective, multicenter Phase II clinical study, a total of 51 hCC patients with China Liver Cancer (CNLC) stage IIb/IIIa (ie tumor number ≥ 4 or vascular invasion, equivalent to BCLC B/C) who underwent R0 resection 4– 6 weeks after curative surgery were enrolled. …”
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ESTIMATION OF EFFICACY OF THE THREATMENT PREVENTIVE COMPLEX IN PATIENTS WITH GENERALIZED PERIODONTITIS, WORKING IN CONDITIONS OF GREENHOUSES UNDER THE INFLUENCE OF PESTICIDES ON SE... by T. D. Zabolotnyj, N. N. Bandrivska, V. T. Dyryk

“…The material and research methods. A complex treatment of inflammatory diseases of periodontal tissues was conducted for 120 workers of greenhouses with generalized periodontitis (71 patient of the main group and 49 persons of the control group). …”
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Mechanisms of Zanthoxyli Pericarpium-Zingiberis Rhizoma in the Treatment of Gastric Cancer Based on Network Pharmacology and Experimental Validation by Gu Q, Duan S, Tibenda JJ, Gou B, Huang S, Chen G, Ning N, Du Y, Liu W, Nan Y, Yuan L

“…As the core combination of the traditional prescription “Dajianzhong Tang”, the medicinal pair of Zanthoxyli Pericarpium and Zingiberis Rhizoma (ZP-ZR) has shown unique advantages in tumor treatment.Purpose: To explore the mechanism of action of ZP-ZR in the treatment of GC using network pharmacology, bioinformatics analysis and in vitro experimental validation, and to provide a theoretical basis for subsequent experimental studies.Patients and Methods: Subsequently, the effects of ZP-ZR on the proliferative ability of gastric cancer HGC-27 and AGS cell lines were verified by CCK-8, apoptosis, cycle and colony formation assays. …”
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