Whole Transcriptome-Based ceRNA Regulatory Network Analysis of Radiation-Induced Esophageal Epithelial Cell Injury by Lin H, Feng Y, Liu H, Zhang J, Zhang X, Ying X, Shi Y, Tan H, Tu W

“…This study aimed to investigate the effects of ionizing radiation on human esophageal epithelial cells and explore the role of the ceRNA network in this injury.Methods: Cellular phenotype experiments assessed the effects of ionizing radiation on human esophageal epithelial cells. …”
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Anatomical and morphological features of the heart of a domestic dog (Canis Lupus Familiaris L., 1758) by M. R. Ragulya, L. P. Goralskyi, I. M. Sokulskyi, N. L. Kolesnik, B. V. Gutyj

“…For the work, complex morphological research methods were used: anatomical, histological, organo-, histo- and cytometric, statistical, thanks to which new data on the peculiarities of the macro-, histo- and cytomorphometric characteristics of the morphological structures of the heart in the studied animals were presented. …”
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Effects of Prophylactic Infusion of Equivalent Doses of Norepinephrine and Phenylephrine in Preventing Spinal Anesthesia-Induced Hypotension During Cesarean Delivery on Fetal and M... by Mao J, Lin K, Liu X, Liu J, Liang G, Sheng Z

“…We aimed to compare the effects of norepinephrine and phenylephrine at equivalent doses on fetal and maternal outcomes, and assess their efficacy at the 90% effective dose (ED90).Methods: A total of 100 parturients scheduled for cesarean delivery were randomly allocated to receive either 0.10 μg/kg/min norepinephrine (Group NE) or 0.60 μg/kg/min phenylephrine (Group PE) to prevent spinal anesthesia-induced hypotension. …”
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A Nomogram Based on Fibrinogen-to-Neutrophil Ratio as a Novel Predictor of Lymph Node Metastasis in Patients with Cervical Cancer and Type 2 Diabetes Mellitus by Kuang H, Yang D, Lin R, Tang Y, Luo Y, Wang S, Xia T, Lou G, Chen H

“…In this regard, we propose the fibrinogen-to-neutrophil ratio (FNR) as an innovative and promising biomarker for evaluating pelvic lymph node metastasis in cervical cancer patients with type 2 diabetes.Methods: The study was conducted on 141 patients diagnosed with cervical cancer and concomitant type 2 diabetes, who were treated at the First Affiliated Hospital of Xiamen University. …”
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Gender-Related Characterization of Acne in Chinese: A Multiple-Center Cross-Sectional Survey on 13085 Cases by Zhu T, Ge Y, Zhang J, Chen Y, Zhong H, Yang L, Zhang J, Li K, Yang S

“…Other gender-related characteristics of acne have not been well elucidated yet.Objective: We compared characteristics of skin lesions, severity and risk factors of acne between males and females in Chinese.Methods: Investigator-administered questionnaire was used to collect demographic data, clinical feature and risk factors of acne from May 2020 to August 2021. …”
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A Pan-Cancer Analysis of Natriuretic Peptide Receptor 3 (NPR3) with Clinical Cohort and in vitro Validation by Liu Y, Liu J, Li Y, Zhao Z, Lyu D, Dong K, Wei M, Huang R, Lu B, Pan X

“…This study aimed to comprehensively analyze NPR3’s role across multiple cancers, focusing on its potential as a prognostic biomarker, particularly in kidney cancer.Methods: A comprehensive pan-cancer study of NPR3 was conducted using 20 different databases and datasets. …”
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Adeno‐Associated Virus 8 and 9 Myofibre Type/Size Tropism Profiling Reveals Therapeutic Effect of Microdystrophin in Canines by Matthew J. Burke, Braiden M. Blatt, James A. Teixeira, Dennis O. Pérez‐López, Yongping Yue, Xiufang Pan, Chady H. Hakim, Gang Yao, Roland W. Herzog, Dongsheng Duan

“…However, little is known about the fibre type and fibre size tropism of AAV in large mammals. Methods We evaluated fibre type‐ and size‐specific transduction properties of AAV8 and AAV9 in 17 dogs that received systemic gene transfer (dose 1.94 ± 0.52 × 1014 vg/kg; injected at 2.86 ± 0.30 months; harvested at 20.79 ± 3.30 months). …”
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The Mediation Role of Insulin Resistance and Chronic Systemic Inflammation in the Association Between Obesity and NAFLD: Two Cross-Sectional and a Mendelian Randomization Study by Huang X, Chen Q, Su Q, Gong J, Wu L, Xiang L, Li W, Chen J, Zhao H, Huang W, Du S, Ye W

“…Xiaoyin Huang,1,* Qianni Chen,2,* Qingling Su,1,* Jiamin Gong,1 Liqin Wu,2 Liangguang Xiang,3 Wanxin Li,1 Jun Chen,1 Hongwei Zhao,4 Wuqing Huang,1 Shanshan Du,5 Weimin Ye1,5,6 1Department of Epidemiology and Health Statistics, Fujian Medical University, Fuzhou, People’s Republic of China; 2Department of Ultrasonography, Fuqing City Hospital Affiliated to Fujian Medical University, Fuqing, People’s Republic of China; 3Department of General Surgery, Fuqing City Hospital Affiliated to Fujian Medical University, Fuqing, People’s Republic of China; 4Division of Occupational and Environmental Health, University of Utah, Salt Lake City, UT, USA; 5Institute of Population Medicine, Fujian Medical University, Fuzhou, People’s Republic of China; 6Department of Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden*These authors contributed equally to this workCorrespondence: Shanshan Du, Institute of Population Medicine, Fujian Medical University, Fuzhou, People’s Republic of China, Tel +86 591 2286 9594, Email dushanshan1007@163.com Weimin Ye, Department of Epidemiology and Health Statistics, Fujian Medical University, Fuzhou, People’s Republic of China, Tel +86 591 2286 2023, Fax +86 591 2286 2510, Email ywm@fjmu.edu.cnPurpose: We aimed to identify the association between obesity and nonalcoholic fatty liver disease (NAFLD) and to quantify the mediating effects of insulin resistance (IR) and chronic inflammation through observational studies and Mendelian randomization (MR).Patients and Methods: In the current study, three IR-related indicators and three indicators of inflammation were included. …”
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Synergistic Induction of Immunogenic Cell Death by Biomineralized Manganese and Bisphosphonates Enhances Anti-PD-L1 Therapy in Triple-Negative Breast Cancer by Zhang X, Liu N, Wei M, Yang C, Lin Y, Zeng Y, Li Y, Zhou L, Li T, Zheng Q, Yu H, Zhang J, Gu Y, Xia N, Li S

“…Strategies to synergistically enhance ICD induction and elucidate the underlying molecular mechanisms remain to be fully explored.Methods: We analyzed the mode of apoptosis and immunogenicity of cancer cells post-treatment using Western blotting, flow cytometry, and confocal microscopy. …”
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Performance of specific CMIP6 GCMs for simulating the historical rainfall and temperature climatology of Lake Tana sub-basin, Ethiopia by Tadele Melese Lebeza, Temesgen Gashaw, Haimanote Kebede Bayabil, Pieter R. van Oel, Abeyou W. Worqlul, Yihun T. Dile, Abebe Demissie Chukalla

“…Through wide-ranging evaluation methods using the Comprehensive Rating Index (CRI) and Taylor diagram, our study contributes by highlighting the top performing GCMs across different temporal scales for precipitation, Tmax and Tmin separately. …”
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The Joint Association of Sleep Quality and Outdoor Activity with Asthma and Allergic Rhinitis in Children: A Cross-Sectional Study in Shanghai by Lu R, Zhang Y, Chen Y, Lyu J, Li R, Kang W, Zhao A, Ning Z, Hu Y, Lin X, Tong S, Lu Z, Li S

“…Ruoyu Lu,1,* Ye Zhang,1,* Yiting Chen,1 Jiajun Lyu,1 Rong Li,1 Wenhui Kang,1 Anda Zhao,1,2 Zidi Ning,1 Yabin Hu,3 Xiaya Lin,4 Shilu Tong,3 Zhaohui Lu,3 Shenghui Li1,5 1School of Public Health, Shanghai Jiao Tong University School of Medicine, Shanghai, People’s Republic of China; 2Huadong Hospital, Fudan University, Shanghai, People’s Republic of China; 3National Children’s Medical Center, Shanghai Children’s Medical Center, School of Medicine, Shanghai Jiao Tong University, Shanghai, People’s Republic of China; 4Hainan Branch, Shanghai Children’s Medical Center, School of Medicine, Shanghai Jiao Tong University, Sanya, Hainan Province, People’s Republic of China; 5MOE-Shanghai Key Laboratory of Children’s Environmental Health, Shanghai Jiao Tong University School of Medicine, Shanghai, People’s Republic of China*These authors contributed equally to this workCorrespondence: Zhaohui Lu, National Children’s Medical Center; Shanghai Children’s Medical Center, School of Medicine, Shanghai Jiao Tong University, 1678 Dongfang Road, Pudong District, Shanghai, 200127, People’s Republic of China, Tel +86-18930830796, Email luzhaohui@sjtu.edu.cn Shenghui Li, School of Public Health, Shanghai Jiao Tong University School of Medicine, 227 South Chongqing Road, Huangpu District, Shanghai, 200025, People’s Republic of China, Tel +86-21-63846590, Email lsh9907@163.com; submission9907@163.comPurpose: Aiming to investigate the combined association of sleep quality and outdoor activity with the risk of asthma and allergic rhinitis in children.Patients and Methods: 16,936 children from kindergartens and primary schools in 13 administrative districts of Shanghai, China were involved in the analyses. …”
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Impact of Relaxation and Music Intervention on Psychological and Gastrointestinal Health in Military Recruits: A Prospective Study by Liu J, Liu T, Lu H, Zhao X, Ma S, Song F, Qiao N, Cheng W, Qi X

“…This prospective before-after study aimed to explore whether progressive muscular relaxation training combined with music intervention, which is potentially beneficial for psychological conditions, can improve gastrointestinal symptoms.Methods: A total of 623 recruits’ effective questionnaires before and after intervention were collected. …”
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Unveiling the Temporal Dynamics and Molecular Regulation Profiles of Neutrophil Extracellular Traps Following Spinal Cord Injury by Li J, Chang C, Li Y, Cui S, Bai J, Zhang C, Wang X, Li K, Jian F

“…This study aimed to explore the temporal dynamics and key regulatory genes of NET formation in SCI to identify therapeutic targets.Methods: We integrated two transcriptomic datasets from the GEO database to identify differentially expressed NETs-related genes (NRGs) in SCI. …”
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Prognostic Value of Spontaneous Potential in Left Atrial Posterior Wall Isolation and Radiofrequency Ablation for Non-Paroxysmal Atrial Fibrillation by Chen ZY, Zhong YH, Gong KZ, Chen XH, Xu Z, Zhang FL

“…Zhi-Yang Chen,1,2,* Yu-Hong Zhong,1,3,* Ke-Zeng Gong,1 Xue-Hai Chen,1 Zhe Xu,1 Fei-Long Zhang1 1Department of Cardiology, Fujian Medical University Union Hospital; Fujian Heart Medical Center, Fujian Institute of Coronary Heart Disease; Fujian Clinical Medical Research Center for Heart and Macrovascular Disease, Fuzhou, 350001, People’s Republic of China; 2Department of Cardiology, Zhangzhou Yuanshan Hospital, Zhangzhou, 363100, People’s Republic of China; 3Department of Cardiology, Huian County Hospital, Quanzhou, 362100, People’s Republic of China*These authors contributed equally to this workCorrespondence: Fei-Long Zhang, Department of Cardiology, Fujian Medical University Union Hospital; Fujian Heart Medical Center, Fujian Institute of Coronary Heart Disease; Fujian Clinical Medical Research Center for Heart and Macrovascular Disease, No. 29 Xinquan Road, Gulou District, Fuzhou, 350001, People’s Republic of China, Tel +86 10 8888888, Fax +86 10 6666666, Email cardizhang@163.comObjective: This study aimed to examine the long-term effects of left atrial posterior wall spontaneous potential (SP) in patients with non-paroxysmal atrial fibrillation (AF) who underwent pulmonary vein isolation (PVI) combined with left atrial posterior wall isolation (PVI+BOX) ablation.Methods: Clinical data were retrospectively collected from 140 patients with symptomatic non-paroxysmal atrial fibrillation (NPAF) who underwent first-time radiofrequency ablation between 2022 and 2023. …”
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Correlations Between TyG-Related Indices and Bone Health: A Cross-Sectional Study of Osteoporosis in a Rural Chinese Population by Jia F, Lu Y, Wen H, Tu J, Ning X, Wang J, Li P

“…This study aimed to explore the association between TyG indices and OP in a low-income rural Chinese population.Methods: This cross-sectional study was conducted in rural Tianjin, China, in 2020. …”
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Compare the Effects of 0 mg/kg, 0.1 mg/kg, 0.3 mg/kg and 0.5 mg/kg Esketamine on Emergence Agitation After Tonsillectomy and Adenoidectomy in Children: A Randomized Control Trial by Jiang P, Liu W, Peng Q, Feng Y, Wang D, Luo K, Huang S

“…This study investigated the effects of pre-anesthesia sedation of esketamine at 0mg/kg (Control group), 0.1mg/kg, 0.3mg/kg and 0.5mg/kg on EA in children.Methods: 164 children aged 3– 10 years, with American Society of Anesthesiologists (ASA) class I–II were included. …”
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Clinical Value of Complement C3a, C5a, and sC5b-9 in Evaluating the Severity of Patients with Severe Fever with Thrombocytopenia Syndrome by Chen T, Liu Y, Liu Y, Hu N, Dai Y, Zhu C, Han Y, Jin K, Li J

“…This article aims to evaluate the validity of complement C3a, C5a, and sC5b-9 in predicting the severity and clinical outcomes in SFTS.Patients and Methods: Patients diagnosed with SFTS at the First Affiliated Hospital with Nanjing Medical University from March to November 2021 were enrolled in this retrospective analysis. …”
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Exploring the Mechanism of Qinzhuliangxue Mixture for Treating Skin Lesions in Atopic Dermatitis: Insights from Network Pharmacology and Experimental Validation by Qiao Y, Yin H, Zhang H, He Q, Li Y, Sun L, Wang J, Li X, Koh WX, Pottakorn A, Chu Z, Xiang Y

“…The hospital preparation-Qinzhuliangxue mixture (QZLX) has shown potential in alleviating skin lesions in AD patients; however, its underlying mechanisms remain largely unexplored.Methods: QZLX’s key compounds and their targets in AD skin lesions were screened by network pharmacology, and gene enrichment analysis was performed. …”
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Comparative Effectiveness of Different Frequencies of Spinal Cord Stimulation for the Treatment of Patients with Failed Back Surgery Syndrome: Systematic Review and Network Meta-An... by Qin YY, Zhang CP, Tang SS, Wu JP, Zhu LX, Li YH, Xu F

“…This first network meta-analysis (NMA) compared the effectiveness and superiority of different SCS frequencies for FBSS.Material and Methods: Adhering to PRISMA guidelines, we searched PubMed, Web of Science, Embase, and CENTRAL for RCTs. …”
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Prevalence, Risk Factors, and Clinical Outcomes with Advanced HIV Disease Among People with Newly Diagnosed HIV During the “Treat-All” Era: A Retrospective Coho... by Jin J, Pan S, Chen J, Yin J, Ba H, Hou H, Zhang Y, Ma K

“…This study investigated the prevalence, characteristics, risk factors, and clinical outcomes of advanced HIV disease (AHD) in newly diagnosed HIV-positive individuals in China during the “treat-all” period.Patients and methods: We performed a retrospective cohort study on newly diagnosed adult ART-naive people with HIV (PWH) in Xi’an from 2016 to 2022. …”
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