Deciphering the role of Wnt/β-catenin and miR-214 in knee osteoarthritis: molecular and clinical insights by Waad A. Samman, Esraa M. Mosalam, Esraa M. Mosalam, Dalia S. Saif, Mahmoud S. Abdallah, Mahmoud S. Abdallah, Abdel-Aziz A. Zidan, Amany Said Sallam, Shimaa Abdelsattar, Fatma Omar Khalil, Amany E. Elashkar, Somia Mokabel Mohamed, Mohamed Al-Ghannam, Hend E. Abo Mansour, Hend E. Abo Mansour

“…Our study aims to investigate the implication of Wnt/ β-catenin pathway in development of KOA by detection of the downstream target genes and their crosstalk with miR-214 in patients with KOA and to correlate that with the clinical findings.MethodsSixty participants were involved in the study. …”
Get full text

Effects of herbal medicines (Eunkyosan/Yin qiao san and Samsoeum/Shen su yin) for treating the common cold: A randomized, placebo-controlled, multicenter clinical trial by Kwan-Il Kim, Minna Hong, Yang-Chun Park, Beom-Joon Lee, Kitae Kim, Byoung Kab Kang, Jun-Yong Choi

“…This study aimed to evaluate the effectiveness and safety of EKS and SSE for treating the common cold. Methods: A randomized, patient-assessor-blind, placebo-controlled, parallel, and multicenter clinical trial was conducted. …”
Get full text

CHANGES IN CALPROTECTIN LEVEL, ITS RELATIONSHIP TO THE CLINICAL AND LABORATORY PARAMETERS OF DISEASE ACTIVITY AND SIGNIFICANCE FOR PREDICTING THE THERAPEUTIC RESPONSE IN RHEUMATOID... by A. O. Pchelintseva, A. P. Zhornyak, N. G. Ionichenok, E. Yu. Panasyuk, A. E. Ilyina, I. A. Andrianova, E. E. Gubar, E. S. Tsvetkova, M. V. Cherkasova, E. N. Aleksandrova, L. N. Denisov, E. L. Nasonov

“…To assess RA activity, tender and swollen joint count, pain, patient’s and physician’s assessment of global disease activity on 100-mm visual analogue scale and DAS28 were used. Functional status was evaluated by HAQ and RAPID3. …”
Get full text

Effectiveness of Local Wound Infiltration with Morphine, Ketorolac, and Bupivacaine Compared to Bupivacaine Alone Following Tibial Osteotomy in Pediatric Patients: A Randomized Con... by Piyanuch Musikachart, Thanase Ariyawatkul, Jidapa Wongcharoenwatana, Nath Adulkasem, Perajit Eamsobhana

“…Primary outcomes were Visual Analog Scale (VAS) pain scores measured every 4 hours during the first 48 hours after surgery. …”
Get full text

Prevalence and risk factors for antenatal anxiety in the first trimester among Chinese pregnant women by Li Zhang, Yan Zhang, Jin Liu, Yan Yu, Junzhe Cheng, Yumeng Ju, Mi Wang, Bangshan Liu, Shuyin Xu, Mengqi Xu, Yilin Peng, Jintao Xiong, Xuemei Qin, Zhuo Peng, Weiguo Mao, Meiqun Xiao

Get full text

Julius Kruopis – the pioneer of applied statistics in Lithuania by Vilijandas Bagdonavičius, Vydas Čekanavičius, Rūta Levulienė, Pranas Vaitkus

“…Kruopis related to the application of statistical methods in reliability theory and survival analysis.  …”
Get full text

SUBSTANTIATION FOR PRINCIPLES OF AESTHETIC STOMATOLOGY by I.K. Lutskaya

“…Different methods of dental bleaching are to be considered as well as minor dissection (microabrasion) and grinding the prismless layer off the enamel surface. …”
Get full text

TRANSFORMATION OF CHAN-BUDDHIST MOTIFS IN MONASTERY POETRY OF THE SONG DYNASTY (GENDER ASPECT) by Anna V. Ryzhkova

“…To achieve this goal, several methods were used – hermeneutic, historical and cultural, historical and literary, comparative methods as well as semantic and poetical analysis. …”
Get full text

Effect of Platelet-rich Fibrin on Soft-tissue and Hard-tissue Healing following Surgical Extraction of Mandibular Third Molar: A Prospective Interventional Study by Sudip Chakraborty, Chayan Kundu, Samiran Ghosh, Richi Burman, Avishek De Sarkar, Gourab Mandal, Somak Saha

“…Results: Twenty-six patients were included in the final analysis. They were equally divided into the interventional group (group I, with PRF) and the control group (group II, without PRF). …”
Get full text

Confirmation of Tuberculous Meningitis Using Metagenomic Next-Generation Sequencing: A Case Report by Liu C, Cai Y, Yuan K, Lu M, Deng Y, Chen X, Ye L, Cui S, Lyu J, Ling Y

“…Changyu Liu,1,* Yihan Cai,2,* Kaixuan Yuan,1 Mengdi Lu,1 Yangxi Deng,1 Xiaoli Chen,1 Long Ye,1 Shanzhao Cui,1 Jingwen Lyu,1,3 Yong Ling1 1Department of Clinical Laboratory Medicine, Guangdong Provincial People’s Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou, Guangdong, 510000, People’s Republic of China; 2Department of Clinical Laboratory Medicine, Xiaolan People’s Hospital of Zhongshan (The Fifth People’s Hospital of Zhongshan), Zhongshan, Guangdong, 528415, People’s Republic of China; 3State Key Laboratory of Genetic Engineering and Collaborative Innovation Center for Genetics and Development, School of Life Sciences, Human Phenome Institute, Fudan University, Shanghai, 200433, People’s Republic of China*These authors contributed equally to this workCorrespondence: Jingwen Lyu, Email lvjingwen66@163.com Yong Ling, Email lingyong@gdph.org.cnBackground: Tuberculous meningitis (TBM) remains a significant clinical challenge due to limitations in traditional diagnostic methods, such as cerebrospinal fluid (CSF) analysis and tuberculosis culture, which often have long turnaround times and low sensitivity and specificity. …”
Get full text

Diphtheria in Russia in the 21st Century by N. M. Maximova, T. N. Yakimova, S. S. Markina, K. A. Yatskovsky, S. E. Aduguzelov

“…The aggregation of data in the work were used the methods of parametric statistics. Results and discussion. …”
Get full text

Mycobacterium tuberculosis Detection in Diverse Clinical Specimens by GeneXpert MTB/RIF: A Large-Scale Retrospective Study by Li H, Li Z, Cui X, Liu X, Zhao J, Zhang Y, Wang C, Li B, Fan Y, Han J, Xia Y, Xiong Z, Zou X, Zhu Y, Li M, Lu B, Cao B

“…Haibo Li,1,2,* Ziyao Li,1– 4,* Xiaojing Cui,1,2 Xinmeng Liu,1,2,5 Jiankang Zhao,1,2 Yulin Zhang,1,2 Chunlei Wang,1,2 Binbin Li,1,2 Yanyan Fan,1,2 Jiajing Han,1,2,5 Yudi Xia,1,2 Zhujia Xiong,1,2 Xiaohui Zou,1,2 Yue Zhu,1,2 Mengxue Li,1,2,5 Binghuai Lu,1– 3,5 Bin Cao1– 7 1Laboratory of Clinical Microbiology and Infectious Diseases, Department of Pulmonary and Critical Care Medicine, Center of Respiratory Medicine, National Clinical Research Center for Respiratory Diseases, National Center for Respiratory Medicine, New Cornerstone Science Laboratory, China-Japan Friendship Hospital, Beijing, People’s Republic of China; 2National Center for Respiratory Medicine; State Key Laboratory of Respiratory Health and Multimorbidity; National Clinical Research Center for Respiratory Diseases; Institute of Respiratory Medicine, Chinese Academy of Medical Sciences; Department of Pulmonary and Critical Care Medicine, Center of Respiratory Medicine, China-Japan Friendship Hospital, Beijing, People’s Republic of China; 3Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing, People’s Republic of China; 4Changping Laboratory, Beijing, People’s Republic of China; 5China-Japan Friendship School of Clinical Medicine, Peking University, Beijing, People’s Republic of China; 6Tsinghua University-Peking University Joint Center for Life Sciences, Tsinghua University, Beijing, People’s Republic of China; 7Department of Respiratory Medicine, Capital Medical University, Beijing, People’s Republic of China*These authors contributed equally to this workCorrespondence: Binghuai Lu; Bin Cao, Laboratory of Clinical Microbiology and Infectious Diseases, Department of Pulmonary and Critical Care Medicine, China-Japan Friendship Hospital, No. 2 East Yinghua Street, Chaoyang District, Beijing, 100029, People’s Republic of China, Tel/Fax +86-010-84206256, Email zs25041@126.com; caobin_ben@163.comPurpose: Mycobacterium tuberculosis (MTB) infection poses a significant global health challenge, with conventional diagnostic methods like acid-fast smear and culture techniques exhibiting limitations in sensitivity and efficiency. …”
Get full text

Protective Effects of GalNac-Modified Red Blood Cell-Derived Extracellular Vesicles Against Liver Diseases by Huang X, Yang J, Hu Y, Li S, Cai Z, Li C, Qin W, Zhang G

“…Xiaofang Huang,1,2 Jie Yang,3 Yuanyuan Hu,1 Shuai Li,1 Zhijian Cai,4,5,* Chen Li,1,* Weidong Qin,1,2,* Gensheng Zhang3,6,* 1Department of Critical Care Medicine, Qilu Hospital of Shandong University, Jinan, Shandong, People’s Republic of China; 2Key Laboratory of Cardiovascular Remodeling and Function Research, Chinese Ministry of Education, Chinese Ministry of Health and Chinese Academy of Medical Sciences, Qilu Hospital of Shandong University, Jinan, Shandong, People’s Republic of China; 3Department of Critical Care Medicine, Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, Zhejiang, People’s Republic of China; 4Institute of Immunology, Zhejiang University School of Medicine, Hangzhou, Zhejiang, People’s Republic of China; 5Department of Orthopedics, The Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, Zhejiang, People’s Republic of China; 6Key Laboratory of Multiple Organ Failure (Zhejiang University), Ministry of Education, Hangzhou, Zhejiang, People’s Republic of China*These authors contributed equally to this workCorrespondence: Gensheng Zhang, Department of Critical Care Medicine, Second Affiliated Hospital of Zhejiang University School of Medicine, 88 Jiefang Road, Hangzhou, 310009, People’s Republic of China, Email genshengzhang@zju.edu.cnObjective: The high morbidity and mortality of liver diseases warrant the development of more effective therapeutic methods. …”
Get full text

The Incidence of a New Coronavirus Infection in Medical Workers and the Evaluation of the Effectiveness of Individual Technologies for their Protection at Different Stages of the P... by E. I. Sisin, A. A. Golubkova, I. I. Kozlova, N. A. Ostapenko, O. A. Ezhova, D. I. Marapov, T. A. Platonova, A. V. Deryabina

“…The incidence of new coronavirus infection in ,medical worckers as well as the chances of getting sick, were equal to those in the adult population (OR 1.1), while the frequency of clinical forms of infection with lung involvement was even lower than in the population (P=95.7‰). …”
Get full text

Improving the Physico-mechanical Properties of Extruded Rice Based on Mixed Rice-quinoa Flours Using Pickering Emulsion-filled Gel Containing Beta-carotene by Maryam Davtalab, Sara Naji-Tabasi, Mostafa Shahidi

“…Pickering emulsion is one of the encapsulation methods suitable for encapsulating lipophilic compounds like β-carotene. …”
Get full text

Independent Association of Sleep Apnea-Specific Hypoxic Burden and Sleep Breathing Impairment Index with Thyroid Function in Obstructive Sleep Apnea: A Retrospective Study by Zhou Y, Shi Y, Zhu S, Cao Z, Xie Y, Lu C, Niu X, Ma L, Wang Z, Su Y, Xia Z, Yuan Y, Yang J, Lu R, Feng Y, Ren X, Hou W

“…Yanuo Zhou,1,2,* Yewen Shi,1,2,* Simin Zhu,1,2,* Zine Cao,3 Yushan Xie,1,2 Chendi Lu,1,2 Xiaoxin Niu,1,2 Lina Ma,1,2 Zitong Wang,1,2 Yonglong Su,1,2 Zihan Xia,1,2 Yuqi Yuan,1,2 Jiayi Yang,1,2 Rui Lu,1,2 Yani Feng,1,2 Xiaoyong Ren,1,2 Wei Hou1,2 1Department of Otorhinolaryngology-Head and Neck Surgery, The Second Affiliated Hospital of Xi’an Jiaotong University, Xi’an, People’s Republic of China; 2Shaanxi Provincial Key Laboratory for Precision Diagnosis and Treatment of Otorhinolaryngology, The Second Affiliated Hospital of Xi’an Jiaotong University, Xi’an, People’s Republic of China; 3Department of Otorhinolaryngology Head and Neck Surgery, The Affiliated Children Hospital of Xi’an Jiaotong University, Xi’an, People’s Republic of China*These authors contributed equally to this workCorrespondence: Xiaoyong Ren, Department of Otorhinolaryngology-Head and Neck Surgery, The Second Affiliated Hospital of Xi’an Jiaotong University, NO. 157 Xi Wu Road, Xi’an, Shaanxi Province, People’s Republic of China, Email cor_renxiaoyong@126.com Wei Hou, Department of Otorhinolaryngology-Head and Neck Surgery, The Second Affiliated Hospital of Xi’an Jiaotong University, NO. 157 Xi Wu Road, Xi’an, Shaanxi Province, People’s Republic of China, Email hw716@163.comPurpose: This study aimed to explore thyroid function changes in patients with obstructive sleep apnea (OSA) and analyze the relationships among the sleep apnea-specific hypoxic burden (SASHB), the sleep breathing impairment index (SBII), and the function during different sleep stages.Methods: This retrospective study included 452 patients with OSA who visited the Second Affiliated Hospital of Xi’an Jiaotong University between August 2017 and March 2024. …”
Get full text

Gene-environment interactions and colorectal cancer risk: A case-control study on xenobiotic metabolizing enzyme polymorphisms in the Jammu& Kashmir, India population by Gowhar Rashid, Gulzar A. Bhat, Tahseen Bilal Rather, Kulsum Akhter, Ishrat Parveiz, Irfan Maqbool, Syed Nisar Ahmad, Malik Tariq Rasool, Farooq Ahmad Jan, Syed Mudassar

“…The study included 246 histopathologically confirmed colorectal cancer (CRC) cases, and an equal number of matched controls based on age (±5 years), gender, and place of residence. …”
Get full text

Disease phenotypic and outcome of very-early onset inflammatory bowel disease in Asian children: an understudied population by Way-Seah Lee, Way-Seah Lee, Kee-Seang Chew, James-Guoxian Huang, James-Guoxian Huang, Pornthep Tanpowpong, Karen S. C. Mercado, Almida Reodica, Veena Logarajah, K. L. W. Hathagoda, Shaman Rajindrajith, Yoko Kin-Yoke Wong, Suporn Treepongkaruna, Marion Margaret Aw, Marion Margaret Aw

“…We studied disease phenotype, clinical characteristics, management and outcome of VEO-IBD in South and Southeast Asian children.Materials and methodsWe extracted data from a multicentre Asian pediatric (onset <18 years) IBD registry. …”
Get full text

Comparative Efficacy of Subcutaneous Versus Intravenous Interleukin 12/23 Inhibitors for the Remission of Moderate to Severe Crohn’s Disease: A Systematic Review and Meta-Analysis... by Nouran Alwisi, Rana Ismail, Hissa Al-Kuwari, Khalifa H. Al-Ansari, Mohammed A. Al-Matwi, Noor A. Aweer, Wejdan N. Al-Marri, Yousif Al-Kubaisi, Muneera Al-Mohannadi, Shahd Hamran, Suhail A. R. Doi, Habib H. Farooqui, Tawanda Chivese

“…For the maintenance of remission, only two studies had analyzable data, and they showed that subcutaneous interleukin 12/23 inhibitors were equal or better compared to intravenous administration. …”
Get full text

Oral health literacy and oral health status of a german adult population with migration background – findings from the MuMi Study by Berit Lieske, Christopher Kofahl, Katrin Borof, Kristin Spinler, Anna Poth, Demet Dingoyan, Thomas Beikler, Guido Heydecke, Ghazal Aarabi

“…Thus, future research should focus on tailored preventive measures for improving oral health literacy, thereby helping to strengthen equal opportunities in oral health in Germany.…”
Get full text