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18401
Construction of a Novel Necroptosis-Related Signature in Rat DRG for Neuropathic Pain
Published 2025-01-01“…This study aims to identify a gene signature related to necroptosis in DRG that can predict neuropathic pain.Methods: The mRNA expression profiles associated with neuropathic pain (GSE24982 and GSE30691) were acquired from the Gene Expression Omnibus (GEO) database. …”
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18402
Muscone Ameliorates High-Altitude Hypoxia Gastrointestinal Stress via Modulation of Lactobacillus Murinus and Mitochondrial Metabolism
Published 2025-05-01“…The ameliorative effects of Lactobacillus murinus on acute gastrointestinal stress induced by high-altitude conditions were validated through various methods, such as HE staining, immunohistochemistry, transmission electron microscopy, ELISA, and flow cytometry. …”
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18403
Cost-effectiveness of Procalcitonin (PCT) guidance for antibiotics management of adult sepsis patients in the Egyptian context
Published 2024-10-01“…Procalcitonin (PCT) is a host response marker with high specificity for bacterial infections, unlike C-reactive protein (CRP) or white blood cell count (WBC), which represent the traditional methods of detecting inflammation and infection. Its dynamic profile and superior prognostic prediction make it invaluable for assessing response to antibiotic treatment and improving clinical care for sepsis patients. …”
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18404
Using Machine Learning to Predict Linezolid-Associated Thrombocytopenia
Published 2025-05-01“…Rao Wei,1,* Kexin Li,1,* Huaguang Wang,1 Xinbo Cai,1 Nian Liu,2 Zhuoling An,1 Hong Zhou1 1Pharmacy Department of Beijing Chao-Yang Hospital, Capital Medical University, Beijing, People’s Republic of China; 2Hematology Department of Beijing Chao-Yang Hospital, Capital Medical University, Beijing, People’s Republic of China*These authors contributed equally to this workCorrespondence: Zhuoling An, Pharmacy Department of Beijing Chao-Yang Hospital, Capital Medical University, Beijing, People’s Republic of China, Email anzhuoling@163.com Hong Zhou, Pharmacy Department of Beijing Chao-Yang Hospital, Capital Medical University, Beijing, People’s Republic of China, Email Zhhz0513@163.comObjective: Using artificial intelligence and machine learning to predict linezolid-induced thrombocytopenia helps identify related risk factors in patients.Methods: Between January 2020 and December 2023, 284 patients receiving linezolid from Beijing Chaoyang Hospital were enrolled. …”
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18405
Clinical-epidemiological characteristics delivery cases of tropic dengue fever
Published 2021-03-01“…Petersburg.Materials and methods. The obtained data of official registration of cases of diseases in the Department of accounting and registration of infectious and parasitic diseases of the city of St. …”
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18406
Analysis of production and financial potential as a basis for developing a strategy for modernizing the Russian economy
Published 2018-09-01“…In this connection, the authors focus on analyzing the factors constraining modernization processes, such as: a low level of capital accumulation, inadequate development of the financial services market, and uneven spatial accessibility of credit institutions.The methodological apparatus for analyzing the production and financial potential is based on the allocation of basic non-financial sectors of the economy and the financial market, using the methods of detailing, grouping, vertical and horizontal analysis, comparison and synthesis. …”
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18407
Prediction Model for Brain Metastasis in Patients With Metastatic Germ‐Cell Tumors
Published 2025-02-01“…We aimed to establish an effective and practical BM prediction model. Patients and Methods Between January 1990 and September 2017, 2291 patients with mGCT who were treated at Indiana University were identified. …”
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18408
Phytotea “ATINE” has beneficial effects on some neural, endocrine, immune, metabolic and biophysics variables in patients with maladaptation
Published 2025-06-01“…The parameters of metabolism, EEG, HRV, acupuncture, biophotonics, cholekinetics, immunity, microbiota as well as adaptation hormones was assessed using routine methods, and two equal groups were formed on this basis. …”
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18409
Empagliflozin-Pretreated MSC-Derived Exosomes Enhance Angiogenesis and Wound Healing via PTEN/AKT/VEGF Pathway
Published 2025-04-01“…Current treatment methods are limited and often ineffective in promoting wound repair. …”
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18410
Exploring the Potential of Chaihu-Danggui Tang in Breast Cancer Treatment Based on Network Pharmacology, Molecular Docking, and Experimental Validation
Published 2025-05-01“…In this study, we used network pharmacology, molecular docking, and experimental validation methods to investigate the core components, key targets, and possible mechanisms through which CHDGT may exert therapeutic effects in BC treatment.Methods: The Traditional Chinese Medicine Systems Pharmacology (TCMSP) was employed to obtain the active ingredient and targets of CHDGT. …”
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18411
NDVI estimation using Sentinel-1 data over wheat fields in a semiarid Mediterranean region
Published 2024-12-01“…The use of RF and SVR outperformed the curve-fitting methods with an RMSE equal to 0.12. The present findings revealed the high accuracy of the proposed approach to estimate the missing values of wheat fields NDVI values during the vegetation development period until heading and the senescence phase. …”
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18412
Formative Evaluation of Suicide Prevention Websites for Men: Qualitative Study with Men at Risk of Suicide and with Potential Gatekeepers
Published 2025-02-01“…Furthermore, we examined (4) additional ideas for effective communication about suicide prevention. MethodsWe conducted (1) individual videoconference interviews with 24 men to evaluate the website and (2) four focus groups with 8 gatekeepers in each group (32 participants) to evaluate the online education program. …”
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18413
Effectiveness of a Four-Stage Death Education Model Based on Constructivist Learning Theory for Trainee Nursing Students
Published 2025-03-01“…Yujing Yang,1,* Yue Li,2,* Jia Fu,3 Dan Guo,4 Jingjing Xue1 1Fundamental Nursing Teaching- Research Department, Fenyang College of Shanxi Medical University, Fenyang City, Shanxi Province, 032200, People’s Republic of China; 2Academic Affairs Office, Fenyang College of Shanxi Medical University, Fenyang City, Shanxi Province, 032200, People’s Republic of China; 3Department of Radiation Oncology, Shanxi Cancer Hospital, Taiyuan City, Shanxi Province, 030013, People’s Republic of China; 4Department of Research and Teaching, China Aerospace Science and Industry Corporation 731 Hospital, Beijing City, 100074, People’s Republic of China*These authors contributed equally to this workCorrespondence: Yujing Yang, Fundamental Nursing Teaching- Research Department, Fenyang College of Shanxi Medical University, No. 16 Xueyuan Road, Fenyang City, Shanxi Province, 032200, People’s Republic of China, Tel +86 18335846366, Email yangyj2024yj@163.comObjective: To explore the effectiveness of the four-step death education model based on constructivist learning theory in enhancing the death coping abilities and attitudes of trainee nurses and improving course satisfaction.Methods: Sixty-six trainee nurses from a tumour hospital in Shanxi Province were selected as the study subjects, and a class-experimental research design was adopted, in which the nursing students before the course implementation were taken as the control group and those after the course implementation were taken as the experimental group. …”
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18414
Harnessing Research Pressure: A Dual Chain Mediation Effects of Achievement Motivation and Research Anxiety on Innovative Behavior Under Challenge-Hindrance Research Stressors
Published 2025-04-01“…Grounded in the cognitive transactional theory of stress and adopting a “perception → psychology → behavior” research framework, this study develops a dual chain mediation model to explain the association between challenge-hindrance research stressors and researchers’ innovative behavior.Patients and Methods: A two-wave survey was conducted, collecting 887 valid responses from researchers across 30 provinces in China. …”
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18415
Efficient Detection of Stigmatizing Language in Electronic Health Records via In-Context Learning: Comparative Analysis and Validation Study
Published 2025-08-01“…ObjectiveWe aimed to investigate the efficacy of ICL in detecting stigmatizing language within EHRs under data-scarce conditions. MethodsWe analyzed 5043 sentences from the Medical Information Mart for Intensive Care–IV dataset, which contains EHRs from patients admitted to the emergency department at the Beth Israel Deaconess Medical Center. …”
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18416
The Role of Women’s Empowerment in Fertility Preferences and Outcomes: Analysis of the 2017 Indonesia Demographic and Health Survey
Published 2025-04-01“…This study examines the association between four dimensions of women’s empowerment and three fertility-related outcomes among married women aged 22 years and older in Indonesia. Methods We used cross-sectional data from 34,017 married women participating in the 2017 Indonesia Demographic and Health Survey (IDHS). …”
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18417
Peculiarities of dynamics of level of the acute phase C-reactive protein and its connection with the immune system of organism in patients, suffering the ulcer gastro-intestinal he...
Published 2021-07-01“…This category of patients was distributed in accordance to methods of treatment of coexistent cardio-vascular pathology: Group A – 20 patients, who took hypotensive therapy in accordance to standard scheme, Group B – 15 patients, who took a «double» therapy. …”
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18418
On influence of structural features on stress-strain state of a reinforced concrete floor slab
Published 2022-06-01“…The development of stress values and transverse vertical displacements directly depended on the support conditions of the floor slab.Limitation of transverse horizontal displacements on the support by any of the selected methods made it possible to reduce stresses by 3.47 - 3.78 times, deflections by 1.5 - 1.52 times, stresses - up to 11.9 times, wребро deflections - 1.18–1.53 times.Creating an end rib or limiting movement with an additional horizontal connection had almost the same effect.The transverse horizontal displacements of the lower face of the longitudinal contour rib in the direction of the 𝑢ребро span which occurred in the floor slab, which did not have an end rib and limitation of displacements in the transverse direction, were in a parabolic relationship with the magnitudes of the vertical transverse forces.In a florr slab with limited displacements in the transverse direction or with an end rib, 𝑢ребро displacements were 3.88–4.32 times less, and at the ends they depended on the deformability of the bonds, i.e. when horizontal movement was prohibited, they were equal to zero. stresses acting on the lower edge of the flange in the transverse direction, in the region of the middle of the span in the floor slab with reinforcement prestressed to the maximum value, had positive values almost over the entire width of the flange and directly depended on the thickness of the slab in each section.Prestressing made it possible to reduce deflections by 4.02 - 4.37 times, wребро deflections by 1.09 - 5.59 times, and evenly distribute stresses along the length of the longitudinal contour rib, to make they are only tensile, close to zero along its entire length.The prestressing of the reinforcement of the maximum value made it possible to increase the horizontal rigidity of the longitudinal contour rib of the floor slab and limit its transverse 𝑢ребро movements.The transverse displacements that occurred near the support of the prestressed shell slab were 1.04 - 1.2 times less than in the shell slab with non-stressed reinforcement, on the rest of the span - slightly more, changing evenly, without sharp changes, unlike floor slabs with non-stressed reinforcement.Discussion and conclusion. …”
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18419
Impact of Pathological Grades of Metabolic Dysfunction-Associated Steatotic Liver Disease on Weight Loss Following Laparoscopic Sleeve Gastrectomy
Published 2025-07-01“…This study aimed to evaluate the effect of fatty liver severity on percentage of excess weight loss (%EWL) in patients undergoing laparoscopic sleeve gastrectomy (LSG).Methods: This retrospective cohort study included 226 patients with obesity who underwent LSG. …”
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18420
Effect of Plyometric Exercises of Lower Limb on Strength, Postural Control, and Risk of Falling in Stroke Patients
Published 2025-01-01“…<i>Materials and Methods:</i> This study involved 40 chronic left stroke patients randomly divided into two equal groups. …”
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