Effect of lncRNA H19 on Rats with Chronic Heart Failure Based on TGF-β1/Smad3 Signaling Pathway by WANG Lingyan, CAO Guojun, MEI Yang, ZHANG Bin, ZHOU Shijing

“…At the 1st, 4th, 7th, 10th, 13th and 16th day, the negative control group, the overexpression group and the combined overexpression group were injected intravenously with lncRNA H19 negative control plasmid at 5 mL/(kg·d), lncRNA H19 plasmid at 5 mL/(kg·d), lncRNA H19 plasmid at 5 mL/(kg·d) and miRNA-200a plasmid at 2 mL/(kg·d) in the tails respectively; the heart failure group and the sham surgery group were only injected with equal dose of normal saline, once a day. Two days after the last injection, color Doppler ultrasound was used to detect cardiac function indexes [left ventricular ejection fraction (LVEF), left ventricular fractional shortening (LVFS), left ventricular end-systolic dimension (LVESD), left ventricular end-diastolic dimension (LVEDD)]; Masson staining was used to detect myocardial fibrosis and collagen volume fraction (CVF); real-time fluorescence quantitative PCR was used to detect the transcription level of lncRNA H19 and miRNA-200a in myocardial tissue of rats; Western blot method was used to detect the protein expression level of TGF-β1 and Smad3 in myocardial tissue of rats.ResultsCompared with sham surgery group, the protein expression level of LVEDD, LVESD, TGF-β1, Smad3 and transcription level of miRNA-200a in the other four groups significantly increased, while the protein expression level of LVFS, LVEF and transcription level of lncRNA H19 significantly decreased (<italic>P</italic>&lt;0.05); compared with the heart failure group and the negative control group, the protein expression level of LVEDD, LVESD, TGF-β1, Smad3 and transcription level of miRNA-200a in the overexpression group and the combined overexpression group significantly decreased, while the protein expression level of LVFS, LVEF and transcription level of lncRNA H19 significantly increased (<italic>P</italic>&lt;0.05); compared with the overexpression group, the protein expression level of LVEDD, LVESD, TGF-β1, Smad3 and transcription level of miRNA-200a in the combined overexpression group significantly increased, while LVFS and LVEF significantly decreased (<italic>P</italic>&lt;0.05), and the transcription level of lncRNA H19 was not statistically different (<italic>P</italic>&gt;0.05). …”
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Diagnosis of Tuberculous Pericarditis in Zhejiang, China: A Diagnostic Prediction Model Based on LASSO Logistic Regression by Xu X, Liu X, Yang C, Cai L, Liu L, Chen T, Zhu H, Wei H

“…The aim of this study was to develop and validate a diagnostic prediction model suitable for primary healthcare institutions to predict the risk of TBP.Methods: We collected detailed medical histories, imaging examination results, laboratory test data, and clinical characteristics of patients and used the Least Absolute Shrinkage and Selection Operator (LASSO) technique combined with logistic regression analysis to construct a predictive model. …”
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Prognostic Value of the SII-PNI Score in Unresectable HCC Treated with Transcatheter Arterial Chemoembolization Combined with Lenvatinib and PD-1 Inhibitors by Wei SM, Zeng ZX, Pan RJ, Wu JY, Wu JY, Luo MC, Li YN, Li H, Liu DY, Ou XY, Zhang ZB, Zhou JY, Li B, Zhuang SW, Yan ML

“…Survival curves were estimated and compared using the Kaplan–Meier method with the Log rank test.Results: A total of 290 patients were included. …”
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Functional Outcome of Percutaneous K-wiring vs Closed Reduction and Plaster Casting in Treatment of Unstable Distal Radius Fractures: A Comparative Study by R Sahaya Jose, M Syed Moosa, N Kattu Bava

“…Subjects and methods: A prospective comparative study was conducted among 50 patients who presented to the emergency medicine department and to the orthopedics outpatient department (OPD) at our tertiary care center from July 2022 to October 2023. …”
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Optimizing Haploidentical Hematopoietic Stem Cell Transplantation: Enhancing Outcomes in Hematologic Malignancies in Resource-Limited Settings by Owattanapanich W, Karoopongse E, Kittivorapart J, Meeudompong U, Sathapanapitagkit N, Kungwankiattichai S, Vittayawacharin P, Jianthanakanon J, Donsakul N, Bundhit R, Kongsomchit C, Poonmee N, Luangtrakool P, Warindpong T, Chamsai S, Bintaprasit W, Atakulreka S, Kunacheewa C

“…Over the first year, eight patients with blood cancers, including acute leukemia and lymphoma, received this treatment. A specialized method was applied to reduce complications and improve success rates. …”
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Transhumanism and New Challenges in Political Theories by Matin Anjomrooz, Mohammad Khezri

“…Sub-questions focus on the impact of transhuman technologies on notions of sovereignty, democracy, human rights, and national identity.Methods: This research employs an analytical-descriptive method, with a focus on content analysis of philosophical and political texts. …”
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Invasive Vagus Nerve Stimulation Activates Microglia α7nAChR to Reduce Striatal Neuroinflammation in Mouse Model of Parkinson's Disease and Its Mechanism by GENG Yao, WANG Ruiyu, ZHU Zhuang, SHEN Ying, ZHANG Kezhong

“…After a 1-week recovery period post-surgery, the PD model was induced by subcutaneous injection of MPTP saline solution (20 mg/kg) combined with intraperitoneal injection of probenecid (250 mg/kg) in the MPTP, VNS and Sham groups. The equal volume of normal saline was injected in the control group using the same method twice a week for 5 weeks. …”
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Propolis-Based Nanostructured Lipid Carrier of &amp;alpha;-Mangostin for Promoting Diabetic Wound Healing in Alloxan-Induced Mice by Suhandi C, Wilar G, Mohammed AFA, Mahmoud SA, Muchtaridi M, Shamsuddin S, Safuan S, Lesmana R, Hasan N, Zulhendri F, Wathoni N

“…In vitro release studies were conducted using a dialysis bag method and analyzed using kinetic models. Cytotoxicity was assessed using the WST-8 assay on NIH-3T3 fibroblast cells. …”
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The Role of Gene of the Tumor Necrosis factor-alfa G-308A Polymorphism in the Development of Congestive Heart Failure in Patients with Ischemic Heart Disease and Obesity by Kravchun P., Kadykova O., Ryndina N., Krapivko S.

“…Materials and research methods. Within the research a complex examination of 222 patients with IHD and obesity has been performed. …”
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mHealth Social Support Versus Standard Support for Diabetes Management in Safety-Net Emergency Department Patients: Randomized Phase-III Trial by Elizabeth Burner, Danielle Hazime, Michael Menchine, Wendy Mack, Janisse Mercado, Adriana Aleman, Antonio Hernandez Saenz, Sanjay Arora, Shinyi Wu

“… BackgroundMobile health (mHealth) is a low-cost method to improve health for patients with diabetes seeking care in safety-net emergency departments, resulting in improved medication adherence and self-management. …”
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Exploring the Mechanism of Lianqiao Jinbei Decoction Inhibiting HER2-Positive Breast Cancer Based on Network Pharmacology and Experimental Verification by Li D, Liu X, Fan H, Dong J, Wei L, Guo N, Wang Z, Du Z, Liu J, Zhao X, Tian X, Han C, Yao X

“…Dehui Li,1,&amp;ast; Xukuo Liu,2,&amp;ast; Huanfang Fan,3 Jingfei Dong,4 Liying Wei,3 Na Guo,3 Zhengrong Wang,3 Zhihua Du,3 Jiao Liu,2 Xiaohui Zhao,2 Xiaotong Tian,2 Changhui Han,3 Xujiong Yao5 1Department of Oncology II, The First Affiliated Hospital of Hebei University of Chinese Medicine (Hebei Province Hospital of Chinese Medicine), Key Laboratory of Integrated Chinese and Western Medicine for Gastroenterology Research, Hebei Industrial Technology Institute for Traditional Chinese Medicine Preparation, Shijiazhuang, Hebei Province, People’s Republic of China; 2Graduate School, Hebei University of Chinese Medicine, Shijiazhuang, Hebei Province, People’s Republic of China; 3Department of Oncology II, The First Affiliated Hospital of Hebei University of Chinese Medicine (Hebei Province Hospital of Chinese Medicine), Shijiazhuang, Hebei Province, People’s Republic of China; 4Department of Medical Laboratory, The First Affiliated Hospital of Hebei University of Chinese Medicine (Hebei Province Hospital of Chinese Medicine), Shijiazhuang, Hebei Province, People’s Republic of China; 5Department of Pathology, The First Affiliated Hospital of Hebei University of Chinese Medicine (Hebei Province Hospital of Chinese Medicine), Shijiazhuang, Hebei Province, People’s Republic of China&amp;ast;These authors contributed equally to this workCorrespondence: Dehui Li, Department of Oncology II, The First Affiliated Hospital of Hebei University of Chinese Medicine (Hebei Province Hospital of Chinese Medicine), Key Laboratory of Integrated Chinese and Western Medicine for Gastroenterology Research, Hebei Industrial Technology Institute for Traditional Chinese Medicine Preparation, 389 Zhongshan East Road, Shijiazhuang, Hebei Province, 050000, People’s Republic of China, Email 258289951@qq.comPurpose: Through network pharmacological prediction and in vitro experimental verification, the mechanism of action of Lianqiao Jinbei Decoction (LJD) in inhibiting HER2-positive breast cancer cells was clarified, providing experimental evidence for its treatment of HER2-positive breast cancer.Methods: Network pharmacology method was used to construct the potential target network of LJD in the treatment of HER2+ breast cancer. …”
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Quality of Care and Outcomes of Inpatients with COPD: A Multi-Center Study in China by Wang F, Wang M, Chen X, Song A, Zeng H, Chen J, Wang L, Jiang W, Jiang M, Shi W, Li Y, Zhong H, Chen R, Liang Z

“…This study aimed to evaluate the quality of care and outcomes among inpatients with COPD and to identify prognostic factors relate to healthcare quality indicators.Methods: A multi-center, retrospective longitudinal study was conducted. …”
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Prediction of methylphenidate treatment response for ADHD using conventional and radiomics T1 and DTI features: Secondary analysis of a randomized clinical trial by Mingshi Chen, Zarah van der Pal, Maarten G. Poirot, Anouk Schrantee, Marco Bottelier, Sandra J.J. Kooij, Henk A. Marquering, Liesbeth Reneman, Matthan W.A. Caan

“…Methods: We performed a secondary analysis of a randomized clinical trial (ePOD-MPH), involving 47 stimulant-naive ADHD participants (23 boys aged 11.4 ± 0.4 years, 24 men aged 28.1 ± 4.3 years) who underwent 16 weeks of treatment with MPH. …”
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Advanced Characterization of Vitreous Hyperreflective Dots via OCT-Derived Metrics: A Cross-Sectional Study by William Rojas-Carabali, Jinghan Lin, Paola Saboya-Galindo, Eunice Jin Hui Goh, Joewee Boon, Carlos Cifuentes-González, Rupesh Agrawal

“…Abstract Introduction The use of optical coherence tomography (OCT) as a potential tool for the measurement of vitreous inflammation has been previously described as a more objective and reproducible method when compared to historically known subjective scales. …”
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Pupil responses to melanopsin-isolating stimuli as a potential diagnostic biomarker for glaucoma. by Jonathan Denniss, Riccardo Cheloni, Joel T Martin, Manuel Spitschan

“…<h4>Purpose</h4>To test whether differences in pupil responses to melanopsin-isolating spectral stimuli in glaucoma may be useful as a diagnostic biomarker.<h4>Methods</h4>Spectral stimuli were presented to 20 glaucoma and 15 age-similar healthy control participants. …”
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Development of Moringa Leave Extract Nanoemulsions: Effect of Ethanol Concentration and Sonication Toward the Stability by Harimurti Sabtanti, Febriyani Dwi, Primasari Sukamdi Dyani, Widada Hari, Amid Azura

“…The experiment was performed in four sets of 96% ethanol concentration (5%, 10%, 15%, and 20%) and three sonication periods (30, 60, and 90 minutes). The freeze-and-thaw method was utilized to evaluate the stability of the nanoemulsions. …”
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Boosting Deep Reinforcement Learning with Semantic Knowledge for Robotic Manipulators by Lucía Güitta-López, Vincenzo Suriani, Jaime Boal, Álvaro J. López-López, Daniele Nardi

“…Our architecture combines KGEs with visual observations, enabling the agent to exploit environmental knowledge during training. …”
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ROLE OF INTAOPERATIVE ULTRASOUND INVESTIGATION IN SURGICAL TREATMENT OF THYROID CARCINOMA (A REVIEW OF LITERATURE) by Yu. V. Alymov, V. N. Sholokhov, S. O. Podvyaznikov

“…The paper details utility of intraoperative ultrasound investigation as a method of obtaining information about localization of nonpalpable tumor nodes, cancer extension, reduction the possibility of non-radical surgical treatment and unnecessary extension of surgical treatment in patients with thyroid cancers, characterized with regional lymph nodes involvement.…”
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Ｒesearch on Design Synthesis Methodology in Supporting of Bio-inspired Design Solution Generation by CHEN Ji-yi, MA Jin, HU Jie, QI Jin, PENG Ying-hong

“…Thirdly，the evaluation process based on the fuzzy TOPSIS comprehensive evaluation method further evaluates the quality of suggested solutions to acquire committed design solutions. …”
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A Review and Prospect of the Studies on Fishermen's Livelihood by CAI Xinyi, GUO Jianke, ZHU Yingyu, GUO Yue

“…However, there are still some problems in the related research, such as the weakness of basic theory research, the unitary research content, the visual angle and method, etc., in the future, the research on fishermen's livelihood theory exploration and multidisciplinary integration, the comparison and quantitative description of multi-scale fishermen's livelihood problems, ocean development and sustainable analysis of fishermen's livelihood, the relationship between people and sea and fishermen's livelihood resilience, and the development environment of fishermen's livelihood in China under the background of rural revitalization and construction can be strengthened.…”
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