A Novel Triptolide Nano-Liposome with Mitochondrial Targeting for Treatment of Hepatocellular Carcinoma by Zhou L, Du Y, Shang Y, Xiang D, Xia X

“…In this study, we used triptolide (TP), a bioactive constituent in Tripterygium wilfordii Hook F, as a model drug to develop a novel nano-liposome drug delivery system for the treatment of liver tumours.Methods: We constructed a functionally-modified triptolide liposome (FA+TPP-TP-Lips) using the film-dispersion method and investigated its physicochemical properties, mitochondrial targeting of hepatic tumour cells, in vitro and in vivo anti-hepatic tumour activity and its mechanism.Results: The prepared FA+TPP-TP-Lips had a particle size of 99.28 ± 5.7 nm, a PDI of 0.20 ± 0.02, a zeta potential of 1.2 ± 0.08 mV, and an encapsulation rate of 74.37% ± 1.07%.FA+TPP-TP-Lips facilitates the cellular uptake of drug delivery systems and improves their targeted delivery to mitochondria. …”
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Effect of Simulation-Based Education of Adult BLS-CPR on Nursing Students’ Skills and Knowledge Acquisition by Bdiri Gabbouj S, Zedini C, Naija W

“…In this study, we aimed to assess the effect of a simulation-based education of adult basic life support cardiopulmonary resuscitation (BLS-CPR) on the acquisition of knowledge and skills among nursing students.Subjects and methods: This study used a post-test nonequivalent control group quasi-experimental design. …”
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A comprehensive study of the mechanical properties of rock-like materials for inelastic deformation model establishment by TRIMONOVA Mariia, STEFANOV Yuri, DUBINYA Nikita, BAKEEV Rustam

“…Numerical modeling of sample loading is performed through the finite difference method. Mathematical model parameters are adjusted to minimize the discrepancy between numerical modeling results and experimental data. …”
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Peri-implant bone behavior after single drilling technique versus undersized drilling technique of immediately loaded implant in posterior maxilla: a one-year prospective study by Mohamed Ahmed Galal Sadek, Mohamed Zaghlool Amer, Nesma El-Gohary, Heba Abo-Elfetouh Elsheikh

“…This study was directed to evaluate the peri-implant bone behavior of the undersized drilling technique versus the single drilling technique of immediately loaded dental implants inserted in the posterior maxilla. Patients and methods 32 patients were selected for prosthetic replacement of a missing maxillary posterior single tooth by an immediately loaded dental implant and divided randomly into two equal groups. …”
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Male adolescents’ attitude towards justifying wife beating: a study on 20 low and lower-middle-income countries by Nahid Hassan Nishan, M. Z. E. M. Naser Uddin Ahmed, Sayantan Chakraborty, Saidur Rahman Mashreky, Katja Gillander Gådin, Koustuv Dalal

“…Data analysis was conducted using Stata 17 software, applying weighting methods from the DHS Program to ensure the results accurately represented the target population. …”
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Factors Influencing Decision-Making Preferences Among Patients with Inflammatory Bowel Disease: A Cross-Sectional Study in China by Wang Y, Zhang S, Fang W, Yao Y, Yu Q, Zhao X, Zhang X

“…Yizhen Wang,1,2,* Shijing Zhang,1,2,* Wenjuan Fang,2 Yanli Yao,1 Qun Yu,1 Xia Zhao,1 Xinqiong Zhang1 1School of Nursing, Anhui Medical University, Hefei, Anhui, People’s Republic of China; 2Department of Gastroenterology, The First Affiliated Hospital of Anhui Medical University, Hefei, Anhui, People’s Republic of China*These authors contributed equally to this workCorrespondence: Xinqiong Zhang, School of Nursing, Anhui Medical University, Hefei, Anhui, People’s Republic of China, 230032, Email hixqzhang@163.comPurpose: This study aimed to evaluate the current status and the discrepancies between anticipated and actual involvement in decision-making roles among patients with inflammatory bowel disease, as well as to explore the factors that influenced actual decision-making participation.Patients and Methods: From December 2023 to June 2024, a convenience sampling method was employed to recruit patients with inflammatory bowel disease from the Department of Gastroenterology at a tertiary hospital in Anhui, China. …”
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Exploring Barriers and Facilitators to Early Rehabilitation in Post-Stroke Hand Dysfunction: A Qualitative Study by Qin X, Zou Q, He Y, Liu L, Zhao C

“…Exploring these factors is crucial for the formulation of strategies aimed at boosting patients’ motivation towards early rehabilitation and cultivating their proactive engagement.Aim: This study aimed to explore the barriers and facilitators to early rehabilitation in post-stroke hand dysfunction.Methods: This is a descriptive qualitative study. 15 patients with post-stroke hand dysfunction were selected using the purposive sampling method. …”
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Dose-Weighted Network Pharmacology: Evaluating Traditional Chinese Medicine Formulations for Lumbar Disc Herniation by Zhou C, Xiang T, Yu Y, Ma H, Liu C, Yang F, Yang L

“…The VIKOR method was used to assess the importance of therapeutic targets, with weights assigned based on both drug and disease perspectives. …”
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Deep learning detects retropharyngeal edema on MRI in patients with acute neck infections by Oona Rainio, Heidi Huhtanen, Jari-Pekka Vierula, Janne Nurminen, Jaakko Heikkinen, Mikko Nyman, Riku Klén, Jussi Hirvonen

“…Relevance statement Our automated method for detecting relevant MRI findings was efficiently trained and might be easily deployed in practice to study clinical applicability. …”
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Causal Effect of Obstructive Sleep Apnea on Sick Sinus Syndrome: A Bidirectional Mendelian Randomization Study by Chen W, Pan W, Ling L, Jiang B, Zhang Y, Su X, Jiang T, Lin J

“…This study aims to investigate the potential causal relationship between OSA and the development of SSS.Methods: To evaluate the association between OSA and SSS, we utilized a bidirectional two-sample Mendelian randomization (MR) method. …”
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INTESTINAL PARASITOSES IN ADULT DOGS AND CATS KEPT IN SHELTERS FOR STRAY ANIMALS by V. B. Yastreb, V. M. Shaytanov

“…Fecal samples were delivered to the lab in special plastic containers and examined on the same day by Kalantaryan method using flotation solution of sodium nitrate. …”
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Socio-Economic Disparities in Pediatric Viral Gastroenteritis: A Comparative Study of Clinical Outcomes and Management in Hospitalized Children with Rotavirus, Adenovirus, and Noro... by Ioana Arbanas, Gabriela Coja, Alice Bilotta, Raluca-Ileana Lixandru, Oana Patran, Laura Bleotu, Oana Falup-Pecurariu

“…All children that have met the previously mentioned criteria, presenting positive stool samples (immunochromatography method) for Rotavirus, Adenovirus or Norovirus were included in the study. …”
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Patients’ Satisfaction of Health Care System Reform Plan in Educational-Medical Centers of Rasht City in North of Iran, 2018 by Samid Bahari Jokandan, Ataollah Asadi Louyeh, Zahra Majd Teimoori, Ehsan Kazem Nezhad Leili, Ezzat Paryad

“…Objective: This study aimed to investigate the satisfaction of hospitalized patients in educational and medical centers of Rasht City, Iran with the “Health Care System Reform Plan” in 2019. Materials and Methods: The present study is an analytical cross-sectional study. …”
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Strategi komunikasi pembangunan Andromeda Learning Center dalam mengembangkan pariwisata berbasis masyarakat di Yogyakarta by Habib Diki Setiawan, Benni Setiawan

“…Informants were selected and determined using the purposive judgment method. Data collection used in-depth interview and non-participant observation methods. …”
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Effect of benign prostatic hyperplasia surgery on ejaculatory function by M. P. Dianov, P. S. Kyzlasov, A. G. Martov, P. N. Korolev, V. A. Perepechay, V. V. Khvorov

“…However, the choice of method rarely considers its effect on ejaculatory function.Objectives. …”
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Effect of ARG1 Gene (rs2781666) Polymorphism on Plasma Arginase Activity and Bronchial Asthma Prevalence and Severity by Al-Ghunmieen EM, Shatanawi A, Al-Akhras FM, Al Oweidat K, Alzayadneh EM

“…Furthermore, increased serum arginase activity has been reported in patients with asthma, suggesting an association with bronchial asthma phenotypes.Purpose: To determine the frequency of ARG1 rs2781666 polymorphism among Jordanians, we compared plasma arginase activity and ARG1 rs2781666 polymorphism in asthmatic patients and non-asthmatic volunteers, and analyzed the distribution of rs2781666 genotypes among asthma severity groups.Patients and Methods: Four hundred and twenty-four asthmatic and non-asthmatic Jordanian subjects visiting the Jordan University Hospital were genotyped for ARG1 rs2781666 polymorphism using the polymerase chain reaction-restriction fragment length polymorphism method and were examined for serum arginase activity using an arginase activity assay.Results and conclusions: There was a significant association between ARG1 rs2781666 G/T polymorphism and bronchial asthma frequency and severity. …”
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The impact of different angiotensin II receptor blockers on the stiffness of the large arteries and effectiveness of therapy by O. L. Rekovets, Yu. M. Sirenko, O. O. Torbas

“…In recent years, the method of determining the Cardio-Ankle Vascular Index (CAVI) has been introduced into clinical practice, which can be used to determine changes in the stiffness of the large arteries regardless of changes in blood pressure (BP). …”
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Machine Learning Prognostic Model for Post-Radical Resection Hepatocellular Carcinoma in Hepatitis B Patients by Zhu D, Tulahong A, Abuduhelili A, Liu C, Aierken A, Lin Y, Jiang T, Lin R, Shao Y, Aji T

“…This study sought to develop and validate a machine learning-based prognostic model to predict survival outcomes in patients with HBV-related HCC following radical resection, with the potential to inform personalized treatment strategies.Patients and Methods: This study retrospectively analyzed clinical data from 146 patients at Xinjiang Medical University and 75 patients from The Cancer Genome Atlas (TCGA) database. …”
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Primary Biliary Cholangitis and Seropositive Rheumatoid Arthritis: A Two-Sample Mendelian Randomization Study by Deng Z, Lei W, Kuang X, Liu X, Tai W

“…Inverse variance weighting (IVW) was the primary analysis method, complemented by Bayesian weighted MR (BWMR), robustly adjusted profile scores (MR-RAPS), MR-Egger, and weighted median approaches. …”
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Determination of the MEC90 of Oxycodone for Preventing Perioperative Shivering in Pregnant Patients Undergoing Caesarean Delivery with Neuraxial Anaesthesia: A Biased-Coin up-and-D... by Lu X, Chen K, Xuan Y, Shen M, Lei W, Huang Y, Sun J

“…This study aimed to determine the optimal dose (90% minimum effective concentration [MEC90]) of intraoperative oxycodone to prevent shivering during caesarean section.Methods: This study was designed by the biased-coin up-and-down method. …”
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