Digital Inclusion Pathways and Influencing Factors Among Older Adults in Outpatient Settings: A Grounded Theory Study by Chen Y, Yin Q, Zhou T, Gu S, Xie L, Xiao M, Wang L, Zhao Q

“…This study aims to investigate the experiences, attitudes, and perceptions of older adults in outpatient regarding smart healthcare service in order to develop an explanatory digital inclusion pathway and construct a comprehensive path model for older adults.Patients and Methods: We conducted semi-structured interviews with 27 older adults in outpatients in Chongqing, China to understand their experiences, attitudes, and perceptions of attending smart healthcare services through theoretical sampling. …”
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Long Non-Coding RNA EPB41L4A-AS1 Serves as a Diagnostic Marker for Chronic Periodontitis and Regulates Periodontal Ligament Injury and Osteogenic Differentiation by Targeting miR-2... by Li R, Huang Z, Chen M

“…Rui Li,1,* Zhibin Huang,2,* Mengmeng Chen3 1Department of Stomatology, Affiliated Hospital of Nantong University, Nantong, People’s Republic of China; 2Medical Room, Nantong College of Science and Technology, Nantong, People’s Republic of China; 3Department of Stomatology, The Fourth Hospital of Harbin, Harbin, People’s Republic of China*These authors contributed equally to this workCorrespondence: Mengmeng Chen, Department of Stomatology, The Fourth Hospital of Harbin, No. 119, Jingyu Street, Daowai District, Harbin City, Heilongjiang Province, 150026, People’s Republic of China, Tel +86 0451-88029850, Email chenmengm74@163.comBackground: Several long non-coding RNAs (lncRNAs) are dysregulated in chronic periodontitis (CP).Purpose: The study aimed to elucidate the molecular mechanisms and clinical significance of lncRNA EPB41L4A antisense RNA 1 (EPB41L4A-AS1) in CP.Patients and Methods: This study enrolled 101 patients with CP and 90 subjects with healthy periodontal tissues. …”
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Pattern of changes in morpho-densitometric parameters of magnocellular neurons of the hypothalamic paraventricular nucleus under restraint stress of different duration by K. B. Romanova, O. V. Hancheva, Yu. M. Kolesnyk

“…The aim of the work was to define the nature of changes in morpho-densitometric parameters of magnocellular neurons of the hypothalamic paraventricular nucleus in rats at 6, 15 and 21 weeks of restricted living space. Materials and methods. A total of 55 male Wistar rats aged 6-10 months were used and divided into 4 groups (1 – intact control, 10 rats; 2, 3 and 4 – experimental groups of 15 rats each, which were in conditions of restricted environmental space for 6, 15 and 21 weeks, respectively). …”
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Effect of perioperative ONS combined with intestinal microecology in patients with colorectal cancer: a randomized clinical trial by Xuanjun Liu, Weixu Mao, Guowei Zhao, Juan Liao, Qigang Li, Gan He

“…PurposeTo investigate the combined effects of oral nutritional supplement (ONS) and intestinal microecology on postoperative nutrition status, inflammatory response and intestinal flora regulation colorectal cancer (CRC) patients.MethodsThis prospective single-center randomized controlled trial (RCT) was conducted at Chongqing Yongchuan Hospital between December 2023 and December 2024. …”
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Enhancing adoptive cancer immunotherapy with Vγ2Vδ2 T cells through pulse zoledronate stimulation by Hong Wang, Mohanad H. Nada, Grefachew Workalemahu, Yoshimasa Tanaka, Craig T. Morita

“…Additionally, IL-15 increases the anti-tumor activity of murine αβ T cells in mice but its effect on the in vivo anti-tumor activity of human Vγ2Vδ2 cells has not been assessed.Methods Human Vγ2Vδ2 T cells were expanded by pulse or continuous zoledronate stimulation with IL-2 or IL-15. …”
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m6A-Methylated NUTM2B-AS1 Promotes Hepatocellular Carcinoma Stemness Feature via Epigenetically Activating BMPR1A Transcription by Li W, Zeng M, Ning Y, Lu R, Wei Y, Xu Z, Wei H, Pu J

“…However, whether m6A has oncofetal characteristics remains unknown.Methods: Gene expression in HCC tissues and cells was detected using qPCR. …”
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Comparative Genomic Analysis of Tigecycline Resistance Development in Clinical Acinetobacter baumannii Isolates by Li X, Liu J, Zhang X, Li J, Xuan L, Yuan S, Li J, Sun Y, Du X

“…The goal is to provide clinical insights into the development of tigecycline resistance in A. baumannii, with a focus on multidrug-resistant strains commonly associated with hospital-acquired infections.Methods: We conducted dynamic tracking of multidrug-resistant Acinetobacter baumannii (MDR-AB) infections in three patients to monitor changes in tigecycline sensitivity during antimicrobial therapy. …”
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Effect of Uncertainty-Aware AI Models on Pharmacists’ Reaction Time and Decision-Making in a Web-Based Mock Medication Verification Task: Randomized Controlled Trial by Corey Lester, Brigid Rowell, Yifan Zheng, Zoe Co, Vincent Marshall, Jin Yong Kim, Qiyuan Chen, Raed Kontar, X Jessie Yang

“…ObjectiveThis study aimed to determine the effects of black-box and uncertainty-aware AI advice on pharmacist decision-making and reaction time. MethodsRecruitment emails were sent to pharmacists through professional listservs describing a web-based, crossover, randomized controlled trial. …”
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Severe soft tissue injuries in multiple trauma patients—a challenge we can meet? A matched-pair analysis from the TraumaRegister DGU® by Nora Kirsten, Georg Maximilian Franke, Rolf Lefering, Tim Klüter, Matthias Weuster, Michael Müller, Sebastian Lippross, Andreas Seekamp, TraumaRegister DGU®, Stefanie Fitschen-Oestern

“…Concomitant soft tissue injuries represent a particular challenge, as they can lead to complications at any time of trauma care, hold a high risk of infection and often require multiple surgical interventions and interdisciplinary collaboration.MethodsThis retrospective, multicentric study used the TraumaRegister DGU® to examine the effect of open fractures and severe soft tissue injuries on outcome of multiple trauma patients. …”
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Quantitative Assessment of Psychological Stress Changes Before and After Ureteral Stent Placement: A Prospective Observational Study by Fu Y, Liang P, Gao X, Mo Z, Ruan Y, Pan J

“…This study aimed to quantitatively evaluate psychological stress changes before and after ureteral stent placement in order to better understand patients’ psychological needs during this common urological procedure.Methods: This prospective observational study with paired before-after measurements was conducted at Yangjiang Hospital of Traditional Chinese Medicine between November 2024 and March 2025. …”
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Study on the Regulated Cell Death of Hypertrophic H9c2 Cells Induced by Au:Ag Nanoparticles by Galindo-Padrón AG, Lorenzo-Anota HY, Rueda-Munguía M, García-Carrasco A, Gaitán López M, Vázquez-Garza E, Campos-González E, Lozano O, Cholula-Díaz JL

“…The main objective of this work is to explore the susceptibility of cells due to exposure to Au:Ag NPs in conditions representing cardiometabolic diseases.Methods: Au:Ag NPs were synthesized in different molar ratios (Au:Ag, 100:0, 75:25, 50:50, 25:75, 0:100) using starch as a capping and reducing agent. …”
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Therapeutic Potential of PDA@CeO2 in Suppressing Hepatic Stellate Cell Activation and Preventing Liver Fibrosis by Li HM, Zhang JY, Wang XQ, Ye LT, Ren B, Leng YH, Zhang JX, Yang Y, Jiang Q, Feng LL, Li Y, Yu JH

“…This study tests the hepatoprotective effects of PDA@CeO2 nanoparticles in scavenging ROS, inhibiting HSC activation, and delaying fibrosis, using 2D-SWE to assess treatment efficacy.Methods: In vitro, flow cytometry evaluated ROS levels in HSCs, scratch assays assessed migration, and α-SMA expression confirmed activation. …”
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Systemic Immune-Inflammation Index (SII) and Neutrophil-to-Lymphocyte Ratio (NLR): A Strong Predictor of Disease Severity in Large-Artery Atherosclerosis (LAA) Stroke Patients by Liu K, Yang L, Liu Y, Zhang Y, Zhu J, Zhang H, He Z

“…This study aimed to verify the predictive value of the clinical parameters such as systemic immune-inflammation index (SII) and neutrophil-to-lymphocyte ratio (NLR) for the severity in Large Artery Atherosclerosis (LAA) stroke patients.Methods: The SII is defined as platelet × (neutrophil count/lymphocyte count), the NLR is defined as neutrophil count/lymphocyte count. …”
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Chaihuang Qingfu Pills Protect Against Acute Pancreatitis—Associated Acute Lung Injury Through MMP9-NLRP3-Pyroptosis Pathway by Xiao W, Shi H, Tian Y, Chen F, Xie Y, Han X, Zhang X, Cao Y, Liu W, Zhu Y, Liu Y, Jiang Y

“…However, its role in SAP-ALI and the underlying mechanisms remain unclear.Methods: 92 AP patients were enrolled to observe the protective effect of CHQF on AP-ALI. …”
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Robot-assisted laparoscopic ureteropelvic junction plasty in children using the da Vinci Xi robotic system: a Russian first experience by V. V. Sizonov, A. G. Makarov, S. M. Pakus, D. G. Kvaratskhelia, E. V. Orlova, S. G. Piskunova, M. I. Kogan

“…To conduct a comprehensive analysis of the experience in performing RALP in pediatric patients using the da Vinci Xi robotic platform. Materials & methods. Between July and October 2024, a total of 14 robot-assisted laparoscopic pyeloplasties (RALP) were successfully performed. …”
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Liver Function Abnormalities in Patients with Chlamydia psittaci Pneumonia: A Multicenter Retrospective Study by Fang C, Xu L, Lu J, Li Y, Zhao Z

“…In this study, we aimed to elucidate the characteristics of liver function changes and the factors influencing liver injury in patients with Chlamydia psittaci pneumonia, providing a reference for clinical treatment.Methods: The clinical data of patients with Chlamydia psittaci pneumonia admitted to three tertiary Grade A hospitals in Guangdong Province, China, from January 2020 to February 2025 were retrospectively collected. …”
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LncRNA PTS-1 Protects Against Osteoarthritis Through the miR-8085/E2F2 Axis by Ma C, Chen Q, Wei YF, Chen SW, Liu H, Xin F, Ren YX

“…This study focuses on lncRNA PTS-1, a novel lncRNA, to explore its function and regulatory mechanisms in OA progression.Methods: The expression profile of lncRNAs was assessed using RNA sequencing and qRT-PCR. …”
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Isokinetic peak torque and flexibility changes of the hamstring muscles after eccentric training: Trained versus untrained subjects by Amr Almaz Abdel-aziem, Elsadat Saad Soliman, Osama Ragaa Abdelraouf

“…Objective: The aim of this study was to examine the effect of eccentric isotonic training on hamstring flexibility and eccentric and concentric isokinetic peak torque in trained and untrained subjects. Methods: Sixty healthy subjects (mean age: 21.66 ± 2.64) were divided into three equal groups, each with 20 voluntary participants. …”
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In vitro Activity of Eravacycline and Risk Factors for Carbapenem-Resistant Acinetobacter Baumannii Infections in Patients with Respiratory Diseases: A Retrospective Cohort Study by Guan J, Wang Z, Dong Y, Wang J, Ren Y, Lu Z, Hu S, Duan X

“…In contrast, Eravacycline (ERV), a novel fluorocycline, exhibits potent activity against multidrug-resistant Gram-negative pathogens and may help mitigate these limitations.Patients and Methods: A retrospective analysis was conducted on 1071 CRAB isolates obtained from 524 respiratory patients at Shaanxi Provincial People’s Hospital in 2024. …”
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The Impact of Non-Thyroidal Illness Syndromes on The Prognosis and Immune Profile in Severe Fever with Thrombocytopenia Syndrome Patients by Wu H, Mu Y, Liu Y, Zhang R, Xu Y, Zhang Y, Zhao C, Zhang W, Lin L, Chen Z

“…This study aims to evaluate the impact of NTIS on the prognosis of SFTS patients and to explore the relationship between thyroid hormones (THs) and immune cell profiles.Methods: Adult patients admitted to Yantai Qishan Hospital for SFTS from January 2023 to December 2023 with no prior history of thyroid disease were retrospectively recruited. …”
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