Association of the Triglyceride-Glucose Index and Obesity Indicators with Multiple Chronic Diseases: A Longitudinal Cohort Study Based on CHARLS by Lan Y, Qi G, Li B, Sooranna SR, Chen D, Rao W, Lin Y, Pang Y

“…Yincai Lan,1,* Guangzi Qi,1,* Boya Li,1 Suren Rao Sooranna,2 Dongshun Chen,3 Wenlian Rao,3 Yinxia Lin,1 Yaqin Pang4– 7 1School of Public Health, Youjiang Medical University for Nationalities, Baise, Guangxi, 533000, People’s Republic of China; 2Life science and clinical research center, Youjiang Medical University for Nationalities, Baise 533000, Guangxi, China and Department of metabolism, digestion and reproduction, Imperial College London, Chelsea & Westminster Hospital, London, SW10 9NH, UK; 3School of Basic Medicine, Youjiang Medical University for Nationalities, Baise, Guangxi, 533000, People’s Republic of China; 4School of Medical Laboratory Medicine, Youjiang Medical University for Nationalities, Baise, Guangxi, 533000, People’s Republic of China; 5Key Laboratory of Environmental and Population Health Research, Ecological Aluminum Industrial Base of Guangxi Universities, Baise, Guangxi, 533000, People’s Republic of China; 6Key Laboratory for Environmental Pollution and Health Risk Assessment, Youjiang Medical University for Nationalities, Baise, Guangxi, 533000, People’s Republic of China; 7Modern Industrial College of Biomedicine and Great Health, Youjiang Medical University for Nationalities, Baise, Guangxi, 533000, People’s Republic of China*These authors contributed equally to this workCorrespondence: Yinxia Lin; Yaqin Pang, Email lin1837731@163.com; pangyaqin@126.comObjective: To explore the relationship between triglyceride glucose (TyG) and the obesity combined indexes and the occurrence of multiple chronic diseases (MCD), which will help to provide a basis for the prevention and treatment of this condition.Methods: 3037 participants in the China Health and Retirement Longitudinal Study, which was conducted from 2011 to 2015 were selected for this study. …”
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Atherogenic and Inflammatory Markers in Recent Small Subcortical Infarcts: Associations with Location, Morphology, and Short-Term Recurrence by Huang C, Geng J, Fan J, Tian B, Wang K, Zhang Y, Zhou X, Zhu X, Sun Z

“…This study aimed to investigate the associations between the atherogenic index of plasma (AIP), systemic immune-inflammation index (SII), and systemic inflammation response index (SIRI) with the occurrence and recurrence of RSSIs.Methods: Three hundred forty-two patients with RSSIs who met the eligibility criteria were included in the cross-sectional analysis. …”
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Early infantile epileptic encephalopathy type 16: the new clinical and genetic variant of TBC1D24 gene mutation by A. A. Kholin, I. D. Fedonyuk, O. P. Dovelman, N. N. Zavadenko, T. V. Kozhanova, E. A. Kholina, G. Sh. Khondkarian, E. S. Il`ina

“…Objective: to analyse the clinical and neurophysiological data from a case of early infantile epileptic encephalopathy type 16 in a child with homozygous mutation in TBC1D24 gene.Material and methods. Female child M. aged 1 year and 2 months, with identified mutations in TBC1D24 gene was examined. …”
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Investigating the Role and Underlying Mechanisms of 18β-Glycyrrhetinic Acid in the Therapy of Ulcerative Colitis Through Modulation of the PPAR-γ/NF-κB... by Zhu A, Qiu Q, Xu Z, Zhang Q, Sun F, Liu Y, Chen Z, Zhang Y, Yao J

“…Aijing Zhu,1,* Qingqing Qiu,1,* Zhengguang Xu,1,* Qilian Zhang,2 Fang Sun,1,3 Yanzhan Liu,1 Zeang Chen,1 Yanan Zhang,4 Jing Yao1,3 1School of Basic Medicine, Jining Medical University, Jining, 272067, People’s Republic of China; 2People’s Hospital Affiliated to Shandong First Medical University, Jinan, 271100, People’s Republic of China; 3Jining Key Laboratory of Pharmacology, Jining Medical University, Jining, 272067, People’s Republic of China; 4Department of Obstetrics, Affiliated Hospital of Jining Medical University, Jining, Shandong, 272029, People’s Republic of China*These authors contributed equally to this workCorrespondence: Jing Yao, Jining Medical University, School of Basic Medicine, Jining Medical University, Jining, 272067, People’s Republic of China, Tel +86 537-3616269, Email yjing_87@163.com Yanan Zhang, Affiliated Hospital of Jining Medical University, Department of Obstetrics, Affiliated Hospital of Jining Medical University, Jining, Shandong, 272029, People’s Republic of China, Tel +86 15153705143, Email yanan1202@163.comBackground: 18β-glycyrrhetinic acid (18β-GA), a triterpenoid saponin naturally occurring in Glycyrrhizae uralensis, has potent anti-inflammatory and antioxidant properties, but the therapeutic efficacy and precise mechanism of 18β-GA in ulcerative colitis (UC) remain unclear.Methods: To determine the therapeutic potential of 18β-GA, we constructed a dextran sodium sulfate (DSS)-induced UC model on a cohort of thirty-two female BALB/c mice and used mouse peritoneal macrophages to establish a co-culture system for in vitro experiments. …”
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Surgical Management of Anterior Urethral Stricture: A 23-year Single-Center Study by Guo Y, Ma N, Zhang J, Chen S, Liu P, Yang Z, Li Y

“…We conducted a 23-year single-center retrospective study to evaluate the long-term surgical outcomes of anterior urethral strictures with different clinical characteristics and to study factors that contribute to stricture recurrence.Methods: A retrospective study was conducted on 145 male patients diagnosed with anterior urethral stricture, who underwent meatotomy, anastomotic urethroplasty (AU), penile skin flap urethroplasty (PFU), single-stage buccal mucosa grafting (SSU), or multistage buccal mucosa grafting (MSU) between April 2000 and August 2023. …”
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Extracting Cognitive Impairment Assessment Information From Unstructured Notes in Electronic Health Records Using Natural Language Processing Tools: Validation with Clinical Assess... by Wang KY, Mahesri M, Novoa-Laurentiev J, Bessette LG, York C, Zakoul H, Lee SB, Ngan K, Zhou L, Kim DH, Lin KJ

“…Suite 3030, Boston, MA, 02120, USA, Tel +1 (617) 278-0930, Fax +1 (617) 232-8602, Email jklin@bwh.harvard.eduPurpose: We aimed to develop a Natural Language Processing (NLP) algorithm to extract cognitive scores from electronic health records (EHR) data and compare them with cognitive function recorded by Centers for Medicare & Medicaid Services (CMS)-mandated clinical assessments in nursing homes and home health visits.Patients and Methods: We identified a cohort of Medicare beneficiaries who had either the Minimum Data Set (MDS) or Outcome and Assessment Information Set (OASIS) linked to EHR data from the Research Patient Data Registry (Mass General Brigham, Boston, MA) from 2010 to 2019. …”
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Association Between Central Sleep Apnea and Left Atrial Enlargement in Snoring Patients with Preserved Ejection Fraction by Sun X, Wang Y, Wu C, Gao Y

“…However, the relationship between CSA and left atrial size in individuals with preserved EF remains underexplored.Objective: This study aims to examine the relationship between left atrial size and CSA in snoring patients with preserved EF.Methods: An observational study was conducted involving 341 consecutive snoring patients from a cardiology department who underwent overnight polysomnography (PSG) and echocardiography. …”
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A Comparison of in-vitro Pharmacokinetics and Pharmacodynamics of Branded and Its Locally Produced Cefuroxime Sodium Against Staphylococcus and Escherichia Escherichia coli by Du M, Sun T, Wang X, Chi X, Xiao Y

“…Mengjiao Du,1,2,* Tingting Sun,1,2,* Xueting Wang,3,4 Xiaohui Chi,5 Yonghong Xiao2– 4 1Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan, Shandong, People’s Republic of China; 2Jinan Microecological Biomedicine Shandong Laboratory, Jinan, Shandong, People’s Republic of China; 3Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, The First Hospital of Zhejiang University School of Medicine, Hangzhou, Zhejiang, People’s Republic of China; 4Research Units of Infectious Disease and Microecology, Chinese Academy of Medical Sciences, Hangzhou, Zhejiang, People’s Republic of China; 5Department of Medical Laboratory, The Affiliated Yantai Yuhuangding Hospital of Qingdao University, Yantai, Shandong, People’s Republic of China*These authors contributed equally to this workCorrespondence: Xiaohui Chi, Department of Medical Laboratory, The Affiliated Yantai Yuhuangding Hospital of Qingdao University, Yantai, Shandong, People’s Republic of China, Email 15684003984@163.com Yonghong Xiao, Jinan Microecological Biomedicine Shandong Laboratory, Jinan, Shandong, People’s Republic of China, Email xiao-yonghong@163.comPurpose: To compare the in-vitro antibacterial effects of branded and its locally produced cefuroxime sodium against Staphylococcus ATCC29213, clinical strains of methicillin-sensitive Staphylococcus aureus (MSSA) 164342 and methicillin-sensitive coagulase-negative staphylococci (MSCNS) 117933, and Escherichia coli ATCC25922, and to provide a reference for their clinical use.Methods: An in-vitro antibacterial susceptibility test, time-kill curve and pharmacokinetics and pharmacodynamics (PK/PD) modeling was used in the comparison.Results: The minimum inhibitory concentrations (MIC) of the two types of cefuroxime sodium were identical against four bacterial strains; both types of cefuroxime sodium had MICs of 0.5 μg/mL, 8 μg/mL, 0.5 μg/mL, and 0.25 μg/mL against ATCC 29213, ATCC 25922, M164342 and MSCNS117933, respectively. …”
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Novel Loop-Structure-Based CD19/CD22 Dual-Target CAR-T Therapy for High-Risk Diffuse Large B-Cell Lymphoma Presenting with Hemophagocytic Lymphohistiocytosis: A Case Report by Ye Y, Li S, Guo Z, Zhao L, Zhou H, Zhong N, He M, Cao YJ, Liu L

“…Yuan Ye,1,* Shuhong Li,2,* Zhi Guo,1,* Lijun Zhao,2 Huanhuan Zhou,1 Nan Zhong,1 Mingxin He,1 Yu J Cao,2 Liqiong Liu1 1Department of Hematology, Affiliated Nanshan Hospital of Shenzhen University, Shenzhen, Guangdong, 518052, People’s Republic of China; 2State Key Laboratory of Chemical Oncogenomics, Shenzhen Key Laboratory of Chemical Genomics, Peking University Shenzhen Graduate School, Shenzhen, Guangdong, 518055, People’s Republic of China*These authors contributed equally to this workCorrespondence: Liqiong Liu, Department of Hematology, Affiliated Nanshan Hospital of Shenzhen University, Shenzhen, Guangdong, 518052, People’s Republic of China, Email llqwsp@hotmail.com Yu J Cao, State Key Laboratory of Chemical Oncogenomics, Shenzhen Key Laboratory of Chemical Genomics, Peking University Shenzhen Graduate School, Shenzhen, Guangdong, 518055, People’s Republic of China, Email joshuacao@pku.edu.cnObjective: To investigate the efficacy and safety of novel loop-structure-based CD19/CD22 dual-target chimeric antigen receptor T-cell (CD19/CD22 BS LoopCAR-T) therapy in high-risk diffuse large B-cell lymphoma (DLBCL) presenting with hemophagocytic lymphohistiocytosis (HLH).Methods: We analyzed the clinical data of a high-risk DLBCL patient presenting with HLH treated with CD19/CD22 BS LoopCAR-T at the Affiliated Nanshan Hospital of Shenzhen University in December 2023.Results: The patient, a 59-year-old female, was diagnosed with myelodysplastic syndromes with multilineage dysplasia in October 2022. …”
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Impact of HIV Pretreatment Drug Resistance on Secondary Transmission Through Treatment Dropout: A Prospective Population-Based Study in Southwestern China by Chen Y, Xu X, Chen H, Zhang X, Zhu Q, Liang S, Xing H, Liao L, Feng Y, Shao Y, Ruan Y, Lan G, Li J

“…The study aimed to assess the relationship between pretreatment drug resistance (PDR) and ART dropout, as well as the relationship between HIV treatment dropout and HIV secondary transmission.Methods: This study included all eligible participants from a local surveillance database in southwestern China between 2014 and 2021. …”
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Forecasting Hospitalization for Adult Asthma Patients in Emergency Departments Based on Multiple Environmental and Clinical Factors by Xi H, Zhang Y, Li W, Zhang C, Sun Y, Ji H, He Z, Chang C

“…Assessing the need for hospitalization of patients with complex comorbidities remains a significant challenge.Research Question: This study aims to develop models that integrate various environmental and clinical factors to predict the hospitalization of adult asthma patients in EDs and to interpret these models.Study Design and Methods: A retrospective analysis was conducted utilizing data from asthma patients at a single ED from 2016 to 2023; the data included demographics, vital signs, illness severity, laboratory test results, and comorbidities, along with environmental variables. …”
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Mechanism of the Traditional Chinese Medicine Simiao Biejia Decoction Improves the Diabetes Mellitus-Induced Erectile Dysfunction in Rats by Liu Y, Sun D, Xing D, Rui Y, Jin Y, Wang P, Cai B, Li C, Gao C, Cui Y, Jin B

“…This study aimed to investigate the effects and mechanisms of SMBJ in a rat model of DMED using network pharmacology, proteomics, and molecular docking.Methods: A rat model of DMED was established, and SMBJ granules were administered (0, 7.1, 14.2, and 28.4 mg/kg/d, respectively) for 4 weeks. …”
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O ESPAÇO VERDE DO BAIRRO ESTÁ ASSOCIADO AO AUMENTO DA CONEXÃO À NATUREZA EM ADULTOS E IDOSOS by Helena Moreira, Luís Quaresma, Graça Pinto, José Martinho, Ronaldo Gabriel, Andreia Teixeira

“…Purpose: The current study examines the associations between residential green space, PA, and CN in subjects between the ages of 18 and 75 years. Methods: The sample included 194 individuals, 61 men (41.42±15.37 years) and 133 women (39.93±15.60 years). …”
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Community-Based Approaches to Healthy Aging: Lessons from Japanese Blue Zones by Hiroko Oe, Kai Weeks, Sitsada Sartamorn

“…The study employed qualitative fieldwork methods including semi-structured interviews with 60 residents aged 65 and above, equally divided between the two study sites. …”
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Comprehensive Analysis of Programmed Cell Death-Related Genes in Diagnosis and Synovitis During Osteoarthritis Development: Based on Bulk and Single-Cell RNA Sequencing Data by Zhou J, Jiao S, Huang J, Dai T, Xu Y, Xia D, Feng Z, Chen J, Li Z, Hu L, Meng Q

“…Diverse programmed cell death (PCD) pathways are closely linked to the pathogenesis of OA, but few studies have explored the relationship between PCD-related genes and synovitis.Methods: The transcriptome expression profiles of OA synovial samples were obtained from the Gene Expression Omnibus (GEO) database. …”
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Risk factors for complicated community-acquired pneumonia in Egyptian children: a hospital-based 6-month study by Abla S. Mostafa, Amr Mahmoud Abdel Khaleq, Yasser Hassan Mohammed, Erini Farid Fawzy

“…Aim To identify and elucidate risk factors that predispose children diagnosed with community-acquired pneumonia (CAP) to develop local pulmonary complications (complicated community-acquired pneumonia) in our Egyptian community. Methods One-hundred pediatric cases with CAP were involved in a case–control study, where cases were classified into 2 groups depending on the absence (41 cases) or the presence (59 cases) of local pulmonary complications. …”
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Ultrasound and Clinicopathological Characteristics of Papillary Thyroid Carcinoma Predict the Coexistence of TERT Promoter and BRAFV600E Mutations by Yu M, Zhang C, Wang Z, Lv S, Sun Y, Zhao W, Li L, Kong Q, Liu K, Wang S

“…This study aimed to develop preoperative and postoperative predictive models for coexisting mutations based on ultrasound and clinicopathological characteristics to stratify prognostic risks and guide clinical decision-making.Methods: Retrospective analysis of the ultrasound and clinicopathological characteristics of 120 patients with a surgical pathology of PTC with TERT promoter and BRAFV600E gene testing results in the Affiliated Hospital of Jining Medical University from December 2020 to December 2023. …”
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Predicting In-Hospital Mortality in Myocardial Infarction: A Nomogram-Based Retrospective Analysis of the MIMIC-IV Database by Peng S, Chen Q, Ke W, Wu Y

“…We aimed to develop and validate a predictive model for in-hospital mortality in myocardial infarction patients.Methods: LASSO regression analysis, univariate analysis, and multivariate logistic analysis were used to construct the nomogram in the training set, followed by model comparison, internal validation, and sensitivity analysis.Results: The analysis comprised 4688 patients in total. …”
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Systemic Lupus Erythematosus Stimulates Chondrocyte Pyroptosis to Aggravate Arthritis via Suppression of NRF-2/KEAP-1 and NF-κB Pathway by Shen S, Fang X, Zhang H, Lang T, Fu F, Du Y, Xu T, Jin H, Tong P, Wu C, Hu C, Ruan H

“…The study aimed to investigate the impact of SLE exacerbation on arthritis using the MRL/lpr mouse model, which closely mimics human SLE manifestations.Methods: In the present study, we evaluated the impact of SLE onset on knee joint degeneration by comparing arthritic phenotype and complex molecular alterations between 6 female 14-week-old MRL/lpr mice, which manifest SLE, and MRL/MpJ mice, which remain unaffected.Results: Our results demonstrated that MRL/lpr mice exhibited a more severe arthritic phenotype compared to MRL/MpJ mice, characterized by elevated Osteoarthritis Research Society International (OARSI) scores (P < 0.01), disrupted extracellular matrix metabolism, impaired chondrocyte proliferation and increased apoptosis. …”
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Interleukin-1 Receptor-Associated Kinase-3 Aggravates Neuroinflammatory Injury After Intracerebral Hemorrhage via Activation NF-&kappa;B/IL-17A Pathway in Mice by Wang J, Li Y, Tan C, Shao J, Tang W, Kong Q, Sheng W, Ding Z, Li F, Piao J, Lv D, Hu L, Wang Q, Jiang X

“…Although previous studies have shown that IRAK3 is involved in immune responses, the potential effects of IRAK3 on ICH remain unclear.Methods: Collagenase IV–induced ICH mouse model. Western blotting was used to determine the expression of IRAK3 at different time points following ICH. …”
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