Modified Zuo Gui Wan Ameliorates Ovariectomy-Induced Osteoporosis in Rats by Regulating the SCFA-GPR41-p38MAPK Signaling Pathway by Song C, Yan Q, Ma Y, Li P, Yang Y, Wang Y, Li W, Wan X, Li Y, Zhu R, Liu H, Zhang Z

“…We aimed to validate the anti-OP effect of MZGW and explore its underlying mechanism.Methods: An ovariectomy (OVX) rat model in vivo and a RANKL-induced osteoclasts (OCs) model in vitro were established. …”
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The Predictive Effects of Atherogenic Indices and Remnant Cholesterol on Gestational Diabetes Mellitus Risk by Cheng Y, Song J, Zhao L, Yin J, Lu X, Zhao Y, Sun G

“…Yao Cheng,1,* Jieping Song,2,* Lei Zhao,1,* Jieyun Yin,3 Xinfeng Lu,4 Yun Zhao,1 Guoqiang Sun1 1Obstetrics Department, Maternal and Child Health Hospital of Hubei Province, Wuhan, Hubei, People’s Republic of China; 2Medical Genetics Center, Maternal and Child Health Hospital of Hubei Province, Wuhan, Hubei, People’s Republic of China; 3Department of Epidemiology and Health Statistics, School of Public Health, Medical College of Soochow University, Suzhou, Jiangsu, People’s Republic of China; 4Medical Record Department, Maternal and Child Health Hospital of Hubei Province, Wuhan, Hubei, People’s Republic of China*These authors contributed equally to this workCorrespondence: Guoqiang Sun, Obstetrics Department, Maternal and Child Health Hospital of Hubei Province, Tongji Medical College, Huazhong University of Science and Technology, Wuluo Road No. 745, Hongshan District, Wuhan, 430070, People’s Republic of China, Email sunguoqiang@hbfy.com Yun Zhao, Obstetrics Department, Maternal and Child Health Hospital of Hubei Province, Tongji Medical College, Huazhong University of Science and Technology, Wuluo Road No. 745, Hongshan District, Wuhan, 430070, People’s Republic of China, Email zhao020060@163.comPurpose: This study aimed to investigate the predictive effects of atherogenic indices and remnant cholesterol on the risk of GDM.Patients and Methods: This observational study was conducted based on the Hospital’s clinical information system. …”
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Analysis of the results of treatment of patients with malignant tumors of the salivary glands by V. T. Vayradyan, A. M. Mudunov, V. D. Ermilova, R. I. Azizyan, I. A. Zaderenko, S. B. Aliyeva, E. L. Dronova

“…Objective: improve results of the treatment of patients with malignant salivary gland neoplasm (MSGN).Materials and methods. Analysis of 417 patients suffering from MSGN treated in the Federal State Budgetary Institution “N.N. …”
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Diagnostic Accuracy of the Alice NightOne Single-Belt Monitor for Obstructive Sleep Apnea and Reliability of Wireless Data Transfer by Peng M, Zhang Y, Zhao R, Li J, Zhang X, Deng L, Zhao L, Zhou B, Wang X, Dong X, Han F

“…MaoHuan Peng,1,* YuanYuan Zhang,2,* Rui Zhao,3 Jing Li,1 XueLi Zhang,1 LiHua Deng,4 Long Zhao,1 Bing Zhou,1 XinRu Wang,1 XiaoSong Dong,1 Fang Han1 1Department of Sleep Medicine, Peking University People’s Hospital, Beijing, People’s Republic of China; 2Department of General Practice, Peking University People’s Hospital, Beijing, People’s Republic of China; 3Department of Pulmonary and Critical Care Medicine, Peking University People’s Hospital, Beijing, People’s Republic of China; 4Department of Geriatrics, Peking University People’s Hospital, Beijing, People’s Republic of China*These authors contributed equally to this workCorrespondence: XiaoSong Dong, Department of Sleep Medicine, Peking University People’s Hospital, Beijing, 100044, People’s Republic of China, 100044, Email dongxiaosong@pkuph.edu.cnObjective: To validate the performance of a single-belt type 3 portable monitor Alice NightOne for diagnosis of obstructive sleep apnea and its reliability in remote data transmission.Methods: Our study included two parts: in-laboratory Alice NightOne (ANO) monitoring (ANOlab) and home sleep apnea testing (HSAT) using ANO (ANOhome). …”
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Biodegradable Electrospun PLGA Nanofibers-Encapsulated Trichinella Spiralis Antigens Protect from Relapsing Experimental Autoimmune Encephalomyelitis and Related Gut Microbiota Dys... by Sabljić L, Radulović N, Đokić J, Stojanovic DB, Radojević D, Glamočlija S, Dinić M, Golić N, Vasilev S, Uskoković P, Sofronić-Milosavljević L, Gruden-Movsesijan A, Tomić S

“…However, whether timely controlled delivery of ESL1 antigens in vivo, as in natural infections, could enhance its therapeutic potential for MS is still unknown.Methods: To test this, we encapsulated ESL1 antigens into biodegradable poly (lactide-co-glycolic) acid (PLGA) nanofibers by emulsion electrospinning as a delivery system and assessed their release dynamics in vitro, and in an animal MS model, experimental autoimmune encephalomyelitis (EAE), induced 7 days after PLGA/ESL1 subcutaneous implantation. …”
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Knowledge, attitudes, and factors associated with the utilization of youth-friendly sexual and reproductive health services among teenagers and young adults in Kigali City, Rwanda by Julienne Nyirarukundo, Venuste Musugire, Boniface Nsengiyumva, Joella Mukashyaka, Zephanie Nzeyimana

“…This study determined knowledge, attitudes, and factors associated with the utilization of youth-friendly sexual and reproductive health services among teenagers and young adults. Methods This was a quantitative cross-sectional survey in which data were collected from July 8 to 22, 2024. …”
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Clinical Outcomes of Hospitalized Immunocompromised Patients With COVID-19 and the Impact of Hyperinflammation: A Retrospective Cohort Study by Zhang X, Han X, Li C, Cui J, Yuan X, Meng J, Han Z, Han X, Chen W, Xiong J, Xie W, Xie L

“…We aimed to illustrate the inflammation profile and clinical outcomes of hospitalized immunocompromised patients with COVID-19.Methods: We conducted a retrospective study using a multicenter database and included adult hospitalized patients with Corona virus disease 2019 (COVID-19) in China’s late 2022 COVID-19 wave. …”
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Identification of EARS2 as a Potential Biomarker with Diagnostic, Prognostic, and Therapeutic Implications in Colorectal Cancer by Wang L, Deng X, Tang J, Gong Y, Bu S, Li Z, Liao B, Ding Y, Dai T, Liao Y, Li Y

“…This study identifies key genes associated with lactic acid metabolism and explore their impact on CRC.Patients and Methods: This study utilized data from The Cancer Genome Atlas, Gene Expression Omnibus, other public databases, and our institutional resources. …”
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A Phase I Study to Evaluate the Safety, Tolerability, Pharmacokinetics of BGT-002, a Novel ATP-Citrate Lyase Inhibitor, in Healthy Chinese Subjects by Liu Y, Yu C, Zhang Y, Xie Z, Wang Y, Qian H, Liang L, Liu Y, Chen Q, Jia J, Yan S, Lai X, Li W, Li J, Zhang Y, Nan F, Yu C

“…., Shanghai, People’s Republic of China*These authors contributed equally to this workCorrespondence: Fajun Nan; Chen Yu, Email fjnan@simm.ac.cn; cyu@shxh-centerlab.comObjective: This Phase I study evaluated the safety, tolerability, pharmacokinetics (PK) and pharmacodynamics (PD) of BGT-002, a novel ATP-citrate lyase (ACLY) inhibitor, in healthy Chinese adults.Methods: This study included three parts: Part I (single-ascending-dose study), Part II (multiple-ascending-dose study), and Part III (food effect study). …”
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Prediction of Pathologic Response in Unresectable Hepatocellular Carcinoma After Downstaging with Locoregional and Systemic Combination Therapy by Yang C, Chen Y, Sheng L, Wang Y, Zhang X, Yang Y, Ronot M, Jiang H, Song B

“…Chongtu Yang,1,2,* Yidi Chen,1,2,* Liuji Sheng,1,2 Yanshu Wang,1,2 Xiaoyun Zhang,3 Yang Yang,4 Maxime Ronot,5 Hanyu Jiang,1,2 Bin Song1,2,6 1Department of Radiology, West China Hospital, Sichuan University, Chengdu, People’s Republic of China; 2Functional and Molecular Imaging Key Laboratory of Sichuan Province, West China Hospital, Sichuan University, Chengdu, Sichuan, People’s Republic of China; 3Division of Liver Surgery, Department of General Surgery, West China Hospital, Sichuan University, Chengdu, People’s Republic of China; 4Cancer Center, West China Hospital, Sichuan University, Chengdu, Sichuan, People’s Republic of China; 5Department of Radiology, Hôpital Beaujon (Université de Paris), Clichy, France; 6Department of Radiology, Sanya People’s Hospital, Sanya, Hainan, People’s Republic of China*These authors contributed equally to this workCorrespondence: Hanyu Jiang; Bin Song, West China Hospital, Sichuan University, Chengdu, Sichuan, 610041, People’s Republic of China, Email hanyu_jiang@foxmail.com; songlab_radiology@163.comBackground: The combination of locoregional and systemic therapy may achieve remarkable tumor response for unresectable hepatocellular carcinoma (HCC).Objective: We aimed to investigate the correlation between radiologic and pathologic responses following combination therapy, evaluate their prognostic values, and to establish a non-invasive prediction system for pathologic response.Methods: This single-center retrospective study included 112 consecutive patients with HCC who underwent locoregional and systemic combination therapy followed by liver resection or transplantation. …”
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Postoperative Adverse Outcomes in Patients With Frailty Undergoing Urologic Surgery Among American Patients: A Propensity-Score Matched Retrospective Cohort Study by Hsu CW, Chang CC, Lam F, Liu MC, Yeh CC, Chen TL, Lin CS, Liao CC

“…Our purpose is to evaluate the association between the mFI-5 and postoperative mortality and complications among patients undergoing urologic surgery.Methods: This retrospective cohort study used the American College of Surgeons National Surgical Quality Improvement Program database from 2015 to 2020. …”
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Multi-Omics Analysis and Validation of Cell Senescence-Related Genes Associated with Non-Alcoholic Fatty Liver Disease by Gong J, Qin Z, Xiao Y, Li J, Wang Q, Lei L, Li J

“…Jianhua Gong,1– 3,* Zhijie Qin,3,* Yihao Xiao,3,* Jixue Li,3 Qing Wang,3 Liping Lei,4 Jiangfa Li3 1Department of Hepatobiliary and Pancreatic Surgery, The First College of Clinical Medical Science, China Three Gorges University, Yichang, Hubei, 443003, People’s Republic of China; 2Department of Hepatobiliary and Pancreatic Surgery, Yichang Central People’s Hospital, Yichang, Hubei, 443003, People’s Republic of China; 3Department of Hepatobiliary and Pancreatic Surgery, The First Affiliated Hospital of Guilin Medical University, Guilin, Guangxi, 541001, People’s Republic of China; 4Department of geriatric medicine, The First Affiliated Hospital of Guilin Medical University, Guilin, Guangxi, 541001, People’s Republic of China*These authors contributed equally to this workCorrespondence: Jianhua Gong, Department of Hepatobiliary and Pancreatic Surgery, The First College of Clinical Medical Science, China Three Gorges University, Yichang Central People’s Hospital, No. 183 Yiling Ave, Yichang, Hubei, 443003, People’s Republic of China, Tel +86-13886703242, Email 38891488@qq.com Jiangfa Li, Department of Hepatobiliary and Pancreatic Surgery, The First Affiliated Hospital of Guilin Medical University, Guilin, Guangxi, 541001, People’s Republic of China, Tel +86-18907839510, Email 247546160@qq.comObjective: To assess causal links between senescence-related genes and non-alcoholic fatty liver disease (NAFLD) using summary-data Mendelian randomization (SMR) and colocalization analyses.Methods: Our study examined the relationship between senescence and NAFLD by integrating DNA methylation, gene expression, and protein quantitative trait loci (mQTL, eQTL, and pQTL) data. …”
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The Higher Incidence of Liver Injury in HCC Patients Compared to Other Malignancies During Immune-Checkpoint Inhibitor Therapy is Primarily Due to Tumor Progression by Wang Y, Liu L, Zhao M, Chen W, Chen Y, Zhao X

“…Yan Wang,1,* Liwei Liu,2,* Mengyu Zhao,1,* Wei Chen,3 Yu Chen,2 Xinyan Zhao1 1Liver Research Center, Beijing Friendship Hospital, Key Laboratory on Translational Medicine on Cirrhosis, National Clinical Research Center for Digestive Disease, Capital Medical University, Beijing, People’s Republic of China; 2Fourth Department of Liver Disease (Difficult & Complicated Liver Diseases and Artificial Liver Center), Beijing You’an Hospital, Capital Medical University, Beijing, People’s Republic of China; 3Department of Gastroenterology, Beijing Friendship Hospital, Beijing Key Laboratory for Precancerous Lesion of Digestive Disease, National Clinical Research Center for Digestive Disease, Beijing Digestive Disease Center, Capital Medical University, Beijing, People’s Republic of China*These authors contributed equally to this workCorrespondence: Xinyan Zhao, Liver Research Center, Beijing Friendship Hospital, Capital Medical University, Beijing Key Laboratory on Translational Medicine on Cirrhosis, National Clinical Research Center for Digestive Disease, 95 Yong-an Road, Xi-Cheng District, Beijing, 100050, People’s Republic of China, Email zhao_xinyan@ccmu.edu.cn Yu Chen, Fourth Department of Liver Disease (Difficult & Complicated Liver Diseases and Artificial Liver Center), Beijing You’an Hospital, Capital Medical University, No. 8, Xi Tou Tiao, Youanmen Wai, Fengtai District, Beijing, 100069, People’s Republic of China, Email chybeyond1071@ccmu.edu.cnBackground: The study explores the incidence and clinical features of immune-related liver injury (irLI) in hepatocellular carcinoma (HCC) patients compared to those with other malignancies receiving immune checkpoint inhibitors (ICIs).Methods: A retrospective analysis was conducted on patients treated with ICIs at Beijing Friendship Hospital. …”
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Impact of Gender, Age, and Obesity on Childhood Obstructive Sleep Apnea: A Cross-Sectional Study of 4,668 Children by Huang G, Wang Q, Chang L, Ye S, Liu J, Lu Y, Li T, Zhan X, Liang J, Cheng Y, Gu Q

“…This study aimed to explore how these factors influence OSA in pediatric patients.Patients and Methods: This cross-sectional study was conducted at the Sleep Center of the Children’s Hospital Affiliated with the Capital Institute of Pediatrics from January 2017 to May 2023. …”
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Zhongfeng Xingnao Liquid Ameliorated the Early Impairment of Intracerebral Hemorrhage by Inhibiting NF-κB/NLRP3 Axis in Rats by Yang H, Luo B, Du Y, Guo J, Zhang S, Wang P, Dai Y, Lu Y, Xu S

“…This study aims to elucidate the optimal timing for ZFXN administration within hours of symptom onset and its underlying mechanisms, focusing on NF-κB/NLRP3-mediated neuroinflammation.Methods: ICH was induced by injection of autologous arterial blood into the left caudal nucleus. …”
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Predictive Significance of Admission-Day Blood Routine-Derived Indices for 30-Day Mortality Risk in Elderly Patients with Bacterial Pneumonia by Huang X, Huang L, Zhao S, Yuan L, Wang X, Tang G, Yuan K, Xiao M

“…Xiaoling Huang,1,* Lihua Huang,2,* Shicai Zhao,1 Lingyan Yuan,3 Xing Wang,4 Guanghua Tang,4 Kaifen Yuan,5 Min Xiao4 1Department of Respiratory, Sichuan Provincial People’s Hospital East Sichuan Hospital & Dazhou First People’s Hospital, Dazhou, Sichuan, People’s Republic of China; 2Department of Infection Disease, The First Affiliated Hospital of Dali University, Dali, Yunnan, People’s Republic of China; 3Department of Endocrinology, First People’s Hospital of LuLiang County, Qujing, Yunnan, People’s Republic of China; 4Department of Laboratory Medicine, Sichuan Provincial People’s Hospital East Sichuan Hospital & Dazhou First People’s Hospital, Dazhou, Sichuan, People’s Republic of China; 5Department of General Medicine, The Second Affiliated Hospital of Kunming Medical University, Kunming, Yunnan, People’s Republic of China*These authors contributed equally to this workCorrespondence: Kaifen Yuan, Department of General Medicine, The Second Affiliated Hospital of Kunming Medical University, No. 374, Dianmian Avenue, Wuhua District, Kunming, Yunnan, 650000, People’s Republic of China, Email 2548733853@qq.com Min Xiao, Department of Laboratory Medicine Sichuan Provincial People’s Hospital East Sichuan Hospital & Dazhou First People’s Hospital, 522 Xiwai Tashi Road, Tongchuan District, Dazhou, Sichuan, 635000, People’s Republic of China, Email xiaominkv@163.comObjective: To investigate the prognostic value of hematological indices derived from routine blood tests in assessing 30-day mortality risk among elderly patients with bacterial pneumonia at the time of admission.Methods: This study was conducted in the Second Affiliated Hospital of Kunming Medical University. …”
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Anthrahydroquinone-2,6-Disulfonate Restores Lung Function in COPD Through Keap1/Nrf2 Pathway Activation by Li Z, Chen J, Zhang J, Li N, Yi Y, Lu H, Li M, Liu R, Chen Y, Liu X

“…This study aimed to investigate the therapeutic effects of AH2QDS on COPD by exploring its mechanisms involving the Keap1-Nrf2 pathway via in vivo and in vitro models.Methods: This study induced COPD-like pathology by using LPS in combination with CS / CSE, establishing both in vivo and in vitro models to evaluate the effects of AH2QDS on lung function, histopathology, oxidative stress markers, levels of inflammatory cytokines, and apoptosis. …”
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Effect of COVID-19 restriction measures on multidrug resistant tuberculosis case notifications and treatment outcomes at treatment centres in Uganda by Pamela Okwir Apio, Lydia Nakiyingi, Charles Batte, Pius Mukisa, John Mukisa, Monica Okwir Acen, Andrew Weil Semulimi, Achilles Katamba, Joan Nakayaga Kalyango

“…This study aimed to assess the effect of COVID-19 restriction measures on MDR-TB case notifications and treatment outcomes at treatment centres in Uganda. Methods This was a retrospective cohort study in which a total of 483 participants were enrolled—238 before (March 2018-February 2020) and 245 during (March 2020-February 2022) COVID-19 restrictions. …”
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A cost-effectiveness analysis of sotorasib as second-line treatment for patients with KRAS-G12C-mutated metastatic non-small cell lung cancer (mNSCLC) in Switzerland by Tämer El Saadany, Judith Lupatsch, Michael Mark, Michaela Barbier, Tarun Mehra, Matthias Schwenkglenks, Roger von Moos

“…Our analysis assessed the cost-effectiveness of sotorasib as a second-line treatment in Swiss patients with non-small cell lung cancer from the perspective of the Swiss statutory health insurance system. METHODS: A partitioned survival model based on the CodeBreak 200 trial was constructed with a time horizon of 10 years and a discount rate of 3% for costs and quality-adjusted life years (QALYs). …”
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ROS/pH Dual-Responsive Hydrogel Dressings Loaded with Amphiphilic Structured Nano Micelles for the Repair of Infected Wounds by Wang J, Lin Y, Fan H, Cui J, Wang Y, Wang Z

“…The toxins secreted by bacteria cause persistent inflammation and excessive oxidative stress, resulting in serious tissue damage and ultimately delay wound healing.Methods: Herein, a ROS/pH dual-responsive hydrogel dressing loaded with amphiphilic structured nano micelles was developed for efficiently promoting infected wound healing. …”
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