Evaluation of a Novel eHealth Tool for Pulmonary Rehabilitation in People With Chronic Obstructive Pulmonary Disease: Randomized Controlled Pilot and Feasibility Trial by Åsa Karlsson, Pernilla Sönnerfors, Sara Lundell, Annika Toots, Karin Wadell

“…Moreover, this study aims to evaluate clinical outcome measures to prepare for a future larger trial. MethodsA multicenter, parallel-group randomized controlled pilot and feasibility trial was conducted in 6 primary health care centers. …”
Get full text

Association between clinical and MRI‐detected imaging findings for people with midfoot pain, a cross‐sectional study by Jill Halstead, Carmen Martín‐Hervás, Elizabeth M. A. Hensor, Anne‐Maree Keenan, Philip G. Conaghan, Dennis McGonagle, John B. Arnold, Jennifer Jones, Anthony C. Redmond

“…This study aimed to describe bone, joint and soft tissue changes and to explore associations between MRI‐detected abnormalities and clinical symptoms (pain and disability) in a group of adults with midfoot pain, but who were radiographically negative for osteoarthritis. Methods Community‐based participants with midfoot pain underwent an MRI scan of one foot and scored semi‐quantitatively using the Foot OsteoArthritis MRI Score (FOAMRIS). …”
Get full text

Gantry-based pencil beam scanning proton therapy for uveal melanoma: IMPT versus proton arc therapy by Hang Qi, Lei Hu, Sheng Huang, Yen-Po Lee, Francis Yu, Qing Chen, Yunjie Yang, Minglei Kang, Huifang Zhai, Milo Vermeulen, Andy Shim, Peter Park, Xuanfeng Ding, Jun Zhou, David H. Abramson, Jasmine H. Francis, Charles B. Simone, Christopher A. Barker, Haibo Lin

“…Abstract Background This study reports the single-institution clinical experience of multifield pencil beam scanning (PBS) intensity-modulated proton therapy (IMPT) and dosimetric comparison to proton arc for uveal melanoma (UM) in a regular PBS gantry room. Methods Eleven consecutive UM patients were treated with IMPT to 50 Gy in 5 fractions. …”
Get full text

Labor induction at 41+0 gestational weeks or expectant management for the nulliparous woman: The Finnish randomized controlled multicenter trial by Katariina Place, Leena Rahkonen, Aydin Tekay, Kirsi Väyrynen, Maija‐Riitta Orden, Marja Vääräsmäki, Jukka Uotila, Kati Tihtonen, Kirsi Rinne, Kaarin Mäkikallio, Seppo Heinonen, Heidi Kruit

“…Management practices of late‐ and post‐term pregnancies vary, and the optimal time point for intervention by labor induction is yet to be determined. Material and methods This randomized controlled trial of 381 nulliparous women with unripe cervices compared labor induction at 41+0 gestational weeks (early induction) with expectant management and labor induction at 41+5 to 42+1 gestational weeks (expectant management). …”
Get full text

Analysis of HMGCS2 Expression and TG Lipidomics in the Perirenal Adipose Tissue of Obese Diabetic Nephropathy Mice by Yuhong Huang, Miao Zeng, Mengxue Yang, Xiaodi Zheng, Lulu Jin, Rui Zhang, Yueyue Wu, Fei Li, Bo Yang, Jun Liu

“…This study was designed to elucidate the contribution of Hmgcs2 in the pathogenesis of obese diabetic kidney disease mice. Methods 12‐week‐old db/db (diabetic) and db/m (control) mice were fed high‐fat or normal diets, respectively. …”
Get full text

How does dispersal shape the genetic patterns of animal populations in European cities? A simulation approach by Savary, Paul, Tannier, Cécile, Foltête, Jean-Christophe, Bourgeois, Marc, Vuidel, Gilles, Khimoun, Aurélie, Moal, Hervé, Garnier, Stéphane

“…Besides, we assessed how the spatial distribution of urban green spaces (UGS) and peri-urban forests acts on these patterns. Methods: We simulated multi-generational genetic processes in virtual populations of animal species occupying either UGS or forest areas (both considered as a virtual species habitat) within and around 325 European cities. …”
Get full text

Retinal progenitor cells (jCell) for retinitis pigmentosa by Jing Yang, Jing Yang, Baruch D. Kuppermann, David Liao, Mitul C. Mehta, Chinhui Hsiang, Chinhui Hsiang, Steven Menges, Steven Menges, David S. Boyer, Henry Klassen, Henry Klassen

“…Each dose group contained equal numbers of subjects from Cohorts 1 and 2.ResultsIntravitreal RPC injection was well tolerated and associated with mostly transient mild to moderate adverse events. …”
Get full text

Comparison of Mallampati test in supine and upright positions with and without phonation in predicting difficult laryngoscopy and intubation in age groups 3-10 years. by P. Awasthi, S. Gautam, A. Malik, V. Singh, M. Kohali, S. Jafa, J. Agarwal

“…Aims and Objectives are To evaluate the ef- fect of phonation on Mallampati test in supine and upright position and correlation of it with laryngoscopic view using Cormack and Lehane score and difficulty in endotracheal intubation. Material and methods In this prospective study, 100 patients aged 3-12 years were recruited. …”
Get full text

Renoprotective Effects of Hydroxychloroquine and Folinic Acid via ET-1 and NLRP3 Modulation in Reducing Tubular Injury in A Rabbit Model of Methanol-induced Acute Kidney Injury by Prayuda Prayuda, I Gde Raka Widiana, Ketut Suega, Yenny Kandarini, Ni Wayan Winarti, Bambang Purwanto

“…This study evaluated their therapeutic effects in a rabbit model of methanol-induced AKI. METHODS: The animals subjects were randomly assigned to four groups: control group receiving aquabidest, folinic acid group receiving 2 mg/kg body weight (BW) intraperitoneal folinic acid, hydroxychloroquine group receiving 30 mg/kg BW oral hydroxychloroquine phosphate, and combination group receiving both folinic acid and hydroxychloroquine at the same dosages. …”
Get full text

Randomized Clinical Trial of Surgical vs. Percutaneous vs. Hybrid Revascularization in Multivessel Coronary Artery Disease: Residual Myocardial Ischemia and Clinical Outcomes at On... by Vladimir Ganyukov, Nikita Kochergin, Aleksandr Shilov, Roman Tarasov, Jan Skupien, Wojciech Szot, Aleksandr Kokov, Vadim Popov, Kirill Kozyrin, Olga Barbarash, Leonid Barbarash, Piotr Musialek

“…We evaluated, in a randomized clinical trial, residual myocardial ischemia (RI) and clinical outcomes of MV-CAD revascularization using coronary artery bypass grafting (CABG), hybrid coronary revascularization (HCR), or MV-PCI. Methods. Consecutive MV-CAD patients (n = 155) were randomized (1 : 1 : 1) to conventional CABG (LIMA-LAD plus venous grafts) or HCR (MIDCAB LIMA-LAD followed by PCI for remaining vessels) or MV-PCI (everolimus-eluting CoCr stents) under Heart Team agreement on equal technical and clinical feasibility of each strategy. …”
Get full text

Measurement invariance of HIV-related stigma scales among men who have sex with men (MSM) and non-MSM populations: implications for comparative studies in China by Tianyue Mi, Xueying Yang, Guanghua Lan, Shan Qiao, Zhiyong Shen, Yuejiao Zhou, Xiaoming Li

“…This study examines the measurement invariance of internalized, anticipated, and enacted HIV-related stigma scales between MSM and non-MSM populations in China.MethodsData were derived from two studies: a prospective cohort study with 193 MSM and 579 non-MSM, and a cross-sectional survey of 402 MSM. …”
Get full text

Impact of male peer‐led outreach on uptake of HIV testing among male partners of pregnant women in Uganda: a randomized trial by Faith Naddunga, Michelle A. Bulterys, Agnes Nakyanzi, Deborah Donnell, Juliet Kyomugisha, Juliet E. Birungi, Paul Ssendiwala, Rogers Nsubuga, Timothy R. Muwonge, Joshua Musinguzi, Sue Peacock, Connie L. Celum, Andrew Mujugira, Monisha Sharma

“…We evaluated the impact of male peer outreach to increase HIV testing among partners of pregnant women in Uganda. Methods We conducted a randomized trial in Kampala, Uganda, enrolling an equal number of pregnant women with and without HIV from public ANC clinics who were randomized 1:1 to intervention or standard‐of‐care (SOC) with delayed intervention after 1 month. …”
Get full text

Bahir Dar Child Development Cross-Sectional Study, Ethiopia: study protocol by Alemayehu Worku, Yemane Berhane, Lian V Folger, Anne CC Lee, Krysten North, Nebiyou Fasil, Kalkidan Yibeltal, Fred Van Dyk, Firehiwot Workneh, Theresa I Chin, Sarah K G Jensen, Unmesha Roy Paladhi, Betelhem Haimanot Abate, Atsede Teklehaimanot, Tizita Lemma Melka, Moriah E Thomason, Terrie Inder, Patricia Ellen Grant

“…This study aims to characterise the typical development of healthy children and factors that influence child development in Bahir Dar, Ethiopia.Methods and analysis The Bahir Dar Child Development Study is a cross-sectional study implemented in two health centres, Shimbit and Abaymado and in Felege Hiwot Comprehensive Specialized Hospital (FHCSH) in Bahir Dar, Amhara, Ethiopia. …”
Get full text

Retinal biomarkers for the risk of Alzheimer’s disease and frontotemporal dementia by Ruihan Wang, Jiajie Cai, Yuzhu Gao, Yingying Tang, Hui Gao, Linyuan Qin, Hanlin Cai, Feng Yang, Yimeng Ren, Caimei Luo, Shiyu Feng, Hongbo Yin, Ming Zhang, Chunyan Luo, Qiyong Gong, Xiong Xiao, Qin Chen

“…Our aim was to identify retinal biomarkers for the risk of AD and FTD in populations without dementia and explore underlying brain structural mechanisms.MethodsWe included a total of 3,0573 UK Biobank participants without dementia, ocular disorders, and diabetes who underwent baseline retinal optical coherence tomography (OCT) imaging. …”
Get full text

Identification of genetic mechanisms of non-isolated auditory neuropathy with various phenotypes in Chinese families by Yang Cao, Xiaolong Zhang, Lan Lan, Danyang Li, Jin Li, Linyi Xie, Fen Xiong, Lan Yu, Xiaonan Wu, Hongyang Wang, Qiuju Wang

“…This study focuses on two mitochondrial function-related genes which result in non-isolated AN, FDXR and TWNK, providing a summary and enrichment analysis of genes associated with non-isolated AN to elucidate the genotype-phenotype correlation and underlying mechanisms. Methods Seven independent Chinese Han patients with mutations in FDXR and TWNK underwent comprehensive clinical evaluations, genetic testing, and bioinformatics analyses. …”
Get full text

Large-Scale Cortical Network Analysis and Classification of MI-BCI Tasks Based on Bayesian Nonnegative Matrix Factorization by Shiqi Yu, Bin Mao, Yuanhang Zhou, Yunhong Liu, Chanlin Yi, Fali Li, Dezhong Yao, Peng Xu, X. San Liang, Tao Zhang

“…Here, we combined EEG source reconstruction and Bayesian nonnegative matrix factorization (NMF) methods to construct large-scale cortical networks of left-hand and right-hand MI tasks. …”
Get full text

Do neonatal intensive care unit (NICU) health workers know about retinopathy of prematurity (ROP)? A qualitative study at a Regional Referral Hospital in Uganda by Henry Muwonge, Innocent Ayesiga, Primrose Magala, Tom Didimus Ediamu, Hana El Diwany, Ian LY Yeung, Alex Wasomoka, Phillip Musoke, Elias Musiime, Abraham Tumwesigye, Pius Atwau, Noreen Atwijukire, Iddi Ndyabawe, Anne Mpaire Musika, Himanshu I Patel, Aeesha NJ Malik, Ibrahim Bwaga, Sheba Gitta Nakacubo

“…However, there is limited information available on health workers’ perspectives regarding ROP in Uganda.Methods This qualitative study explored health workers’ experiences regarding ROP in the neonatal intensive care unit (NICU) at Hoima Regional Referral Hospital. …”
Get full text

Network pharmacology-based approach to research the effects and mechanisms of Salvia Miltiorrhiza injection against idiopathic pulmonary fibrosis by Liangyu Chen, Liangyu Chen, Haobo Lin, Haobo Lin, Haobo Lin, Linmang Qin, Linmang Qin, Linmang Qin, Guangfeng Zhang, Guangfeng Zhang, Guangfeng Zhang, Peisheng Chen, Zebo Jiang, Pan Xu, Donghui Huang, Xiao Zhang, Xiao Zhang

“…This study aims to investigate the therapeutic effects and mechanisms of SM injection in treating IPF.MethodsActive components and targets of SM were acquired from the Traditional Chinese Medicine Systems Pharmacology (TCMSP) database, while IPF-associated genes were obtained from the DisGeNET database. …”
Get full text

Validation of the traditional Chinese version of the Sinus and Nasal Quality of Life Survey (SN-5) for children by Wan-Yu Lai, David J. Kay, Chang-Ching Wei, Fen-Wei Huang, Kai-Li Liang, Hung-Rong Yen

“…We translated the SN-5 into traditional Chinese and evaluated validity and reliability. Methods: From December 2016 to December 2017, healthy volunteers and children with persistent sinonasal symptoms were enrolled. …”
Get full text

Mapping Antarctic Blue Ice Areas With Sentinel-2A/B Images and LightGBM Model by Xiaolong Teng, Jiahui Xu, Xiangbin Cui, Guitao Shi, Zhengyi Hu, Qingyu Gu, Bailang Yu, Jianping Wu, Yan Huang

“…While satellite remote sensing is effective in mapping BIAs, traditional methods rely on limited spectral bands and linear models with inherent limitations. …”
Get full text