Innovative machine learning-based prediction of early airway hyperresponsiveness using baseline pulmonary function parameters by Hua Yang, Xingru Zhao, Zhuochang Chen, Lihong Yang, Guihua Zhao, Chenxiao Xu, Jinyi Xu

“…This study explores the potential of baseline pulmonary function parameters, particularly small airway indices, in predicting AHR and develops a machine learning-based model to improve screening efficiency and reduce unnecessary BPT referrals.MethodsThis retrospective study analyzed baseline pulmonary function data and BPT results from Henan Provincial People’s Hospital (May to September 2024). …”
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The impact of anterior cruciate ligament deficiency severity on the outcomes of fixed-bearing unicompartmental knee arthroplasty: a retrospective study by Shuhan Jia, Di Long, Bo Zhang, Mingyang Sun, Fengji Liu, Yixuan Jiao, Guoan Wang, Bin Zhang

“…This study aimed to evaluate the impact of varying severities of ACLD on the clinical outcomes of FB-UKA. Methods This retrospective analysis included 81 patients (87 knees) who underwent FB-UKA for anteromedial osteoarthritis (AMOA). …”
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Efficacy of Bilateral Transverse Abdominis Plane Block and Ilioinguinal Iliohypogastric Nerve Block for Post Lower Segment Caesarean Section Pain Relief: A Randomised Clinical Stud... by Jigisha Bharatbhai Mehta, Gayatri Vasagadekar, Sara Mary Thomas

“…Aim: To compare the efficacy of bilateral Transverse Abdominis Plane block (TAP) and Ilioinguinal Iliohypogastric block (II-IH) for postcaesarean section pain relief. Materials and Methods: A randomised clinical study was conducted at Dhiraj Hospital, Piparia, Vadodara, Gujarat, India, on 60 pregnant women, aged between 18 to 45 years, who were posted for elective Lower Segment Caesarean Section (LSCS). …”
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Improving frailty documentation from admission to discharge: a quality improvement project in an elderly care ward by Thomas Kirwin, Carmel Halevy, Yass Hatahet, Jan Chiu, Iris Soteriou, Marcus Geyer, Ruth Mizoguchi, Iraida Safiulova

“…Key components of CGA, including Treatment Escalation Plans (TEPs), Universal Care Plans (UCPs), and the Abbreviated Mental Test Score (AMTS), have pivotal roles in recognising frailty, guiding appropriate management and ensuring holistic care from hospital to community settings. Methods: A retrospective analysis of documentation of three CGA parameters (TEP, UCP and AMTS) in clinical notes on admission to a Care of the Elderly Care ward was conducted over four cycles. …”
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Efficacy and Safety of Tranexamic Acid on Hidden Blood Loss in Osteoporotic Vertebral Compression Fractures Patients Treated with Percutaneous Kyphoplasty: A Prospective Randomized... by Lou Z, Jiang K, Xia S, Chen S, Jiang Y, Zhu J, Zhu J

“…HBL was calculated and compared on postoperative days 1 (POD1) and 3 (POD3). Visual analog scale (VAS) scores were also recorded preoperatively and during the follow-up. …”
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Comparison of surgical efficacy between direct anterior approach and posterolateral approach in the treatment of sarcopenia with femoral neck fractures by Zhaoyang Yin, Qin Hu, Bin Zhang, Jin Yi, Hailong Zhang, Jian Yin

“…This study aims to compare the effects of the DAA and the posterolateral approach (PLA) on the efficacy of TJA surgery in patients with FNF who also present with sarcopenia. Methods This study retrospectively analyzed the clinical data of patients with FNF who underwent total hip arthroplasty (THA) using either DAA or PLA from December 2019 to December 2022. …”
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Reliability of the electronic patient reported outcome measures for assessing xerostomia, dysphagia and quality of life in Spanish patients with head and neck cancer: a randomised... by Mario Lozano-Lozano, Maria Lopez-Garzon, Paula Cuadrado-Guerrero, Paula Postigo-Martin, Carolina Fernández-Lao, Isabel Tovar-Martín, Noelia Galiano-Castillo

“…We hypothesised notable reliability and equivalence between the two modalities. Methods A total of 24 patients (median age 63.00 years, undergone radiotherapy, either alone or in combination with surgery and/or chemotherapy, and suffering xerostomia) were randomised to either paper-based (PROM) or ePROM in a two-arm crossover design with a within-subject comparison of the two modalities (washout period 90 min). …”
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OncoPSM: an interactive tool for cost-effectiveness analysis using partitioned survival models in oncology trial by Xulong Qiu, Xulong Qiu, Jidi Chen, Jidi Chen, Muting Wang, Kaixin Zheng, Ruixiong Li

“…However, many CEA tools are not specifically tailored to address the intricate cost composition resulting from the complex treatment regimens in oncology trials.MethodsWe extracted data from Kaplan-Meier (KM) curves, reconstructed individual patient data (IPD) using an iterative KM algorithm, and fitted parametric survival functions to the IPD data. …”
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Modifying reaction time tasks parameters in the automated IntelliCage identifies heightened impulsivity and impaired attention in the 3xTg-AD model of Alzheimer’s disease by Jessica M. Judd, Wendy Winslow, Ian McDonough, Faizan Mistry, Ramon Velazquez, Ramon Velazquez, Ramon Velazquez

“…Each of the four corners of a cage contains doors to manipulate access to water, visual LED cues, and a valve allowing administration of an air puff. …”
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Silk Biowaste Protein Mediated Silver Nanoparticles Synthesis and Analysis of Anti-Inflammatory, Wound Healing, Antidiabetic, Antioxidant, Tyrosinase Inhibition, and Antibacterial... by Das G, Shin HS, Yang IJ, Nguyen LTH, Patra JK

“…Gitishree Das,1,2 Han-Seung Shin,2 In-Jun Yang,3 Ly Thi Huong Nguyen,3,4 Jayanta Kumar Patra1,2 1Research Institute of Integrative Life Sciences, Dongguk University-Seoul, Goyangsi, 10326, Republic of Korea; 2Department of Food Science & Biotechnology, College of Life Science and Biotechnology, Dongguk University-Seoul, Goyangsi, 10326, Republic of Korea; 3Department of Physiology, College of Korean Medicine, Dongguk University, Gyeongju, 38066, Republic of Korea; 4Department of Pathology, University of Alabama at Birmingham, Birmingham, AL, 35294, USACorrespondence: Jayanta Kumar Patra, Dongguk University-Seoul, Goyangsi, 10326, Republic of Korea, Email jkpatra@dongguk.eduBackground: Silk, a natural biowaste protein from silkworm cocoons called sericin, has promising properties as a biomaterial for several biomedical applications, owing to its excellent biocompatibility, biodegradability, hydrophilicity, and reactivity.Purpose: The synthesis of AgNPs using these biowaste protein materials is more efficient, environmentally friendly, and cost-effective.Methods: In this study, a novel approach was developed to synthesize silver nanoparticles (Scn-AgNPs) using sericin as a reducing agent and to study their anti-inflammatory, wound healing, antidiabetic, antioxidant, tyrosinase inhibitory, and antibacterial mechanisms of action.Results: The initial production of Scn-AgNPs was established by a visual color change to brown, followed by UV-visible spectroscopy, which showed a solid absorption band at 422 nm due to surface plasmon resonance. …”
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Survival Prediction of Esophageal Cancer Using 3D CT Imaging: A Context-Aware Approach With Non-Local Feature Aggregation and Graph-Based Spatial Interaction by Fuce Guo, Chen Huang, Shengmei Lin, Yongmei Dai, Qianshun Chen, Shu Zhang, Xunyu XU

“…In the current study, we aimed to develop an effective EC survival risk prediction using only 3D computed tomography (CT) images.The proposed model consists of two essential components: 1) non-local feature aggregation module(NFAM) that integrates visual features from tumor and lymph nodes at both local and global scales, 2) graph-based spatial interaction module(GSIM) that explores the latent contextual interactions between tumors and lymph nodes.The experimental results demonstrate that our model achieves superior performance compared to state-of-the-art survival prediction methods, emphasizing its robust predictive capability. …”
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Vertebral Column Decancellation for Correcting Cervicothoracic Kyphotic Deformity in Patients With Ankylosing Spondylitis by Han Yu, Qi Wang, Yiming Fan, Dengbin Qi, Tianhao Wang, Bing Li, Yi Huang, Ze Wang, Chao Xue, Guoquan Zheng

“…The purpose of the present study was to retrospectively analyze and evaluate the effect of VCD on cervicothoracic kyphotic deformity in patients with AS. Methods Records of eight patients with cervicothoracic kyphotic deformity who underwent VCD at C7 in our institution were retrospectively reviewed. …”
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The clinical efficacy of auricular acupuncture in the treatment of frequent episodic tension-type headache: a single-blind randomized controlled trial by Xiaxia Jin, Ziwen Xu, Tao Gao, Gaofeng Wang, Wendi Dong, Junyi Jin, Yongmei Yan

“…Purpose This study aimed to compare the efficacy and safety of auricular acupuncture and sham acupuncture in treating FETTH. Methods This was a randomized controlled trial. Participants with FETTH were randomly assigned in a 1:1 ratio to receive auricular acupuncture or sham acupuncture for 4 weeks, with follow-up lasting for up to 24 weeks. …”
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Clinical and biochemical characteristics of patients with acromegaly and normal or increased prolactin levels by Yuliya A. Kukushkina, Irena A. Ilovayskaya

“…Aim: To identify hallmarks of clinical and biochemical parameters in patients with acromegaly and normal or increased prolactin level. Methods: We performed a single center, single sample retrospective, observational cohort uncontrolled non-interventional study in 306 patients (70 men and 236 women) with acromegaly examined from July 2021 to June 2024, 50 of them with a pituitary microadenomas and 256 with macroadenomas. …”
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Influence of Irrigant Activation Techniques on External Root Temperature Rise and Irrigation Penetration Depth in 3D-Printed Tooth Model: An In Vitro Study by Ali Addokhi, Ahmed Rahoma, Neveen M. A. Hanna, Faisal Alonaizan, Faraz Farooqi, Shimaa Rifaat

“…Thus, this study aimed to investigate the temperature rise during different irrigation activation techniques at various time intervals and evaluate the efficacy of these techniques in removing biofilm-mimicking hydrogel BMH of a simulated root canal system in 3D-printed tooth models. <b>Methods:</b> Ten extracted human mandibular premolars, prepared to size 40/0.04 taper, and a hundred 3D-printed resin premolars with simulated main (0.25 mm) and lateral canals (0.15 mm at 3, 7, 11 mm from apex) were used; 50 of them were filled with biofilm-mimicking hydrogel (BMH). …”
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Induction heating combined with antibiotics or SAAP-148 effectively reduces biofilm-embedded Staphylococcus aureus on a fracture-related implant mimic by Marielle Verheul, Anne A. Wagenmakers, Rob G. H. H. Nelissen, Peter H. Nibbering, Bart G. Pijls

“…In addition, we assessed the ability of antibiotics, the antimicrobial peptide SAAP-148, and bacteriophage (phage) ISP to enhance the efficacy of NCIH, thereby allowing the use of lower temperatures during NCIH. Methods: Clinical isolates of methicillin-resistant and methicillin-sensitive S. aureus (methicillin-resistant S. aureus (MRSA), methicillin-sensitive S. aureus (MSSA)) were cultured for seven days on Ti-6Al-7Nb (mimicking fracture plates) discs to obtain mature biofilms. …”
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Evaluating the MPM III and SAPS III prognostic models in a war-affected, resource-limited setting: a prospective study from the Gaza Strip by Belal Aldabbour, Ahmed J. H. Elhissi, Hamza Abudaqqa, Jaser Alqrinawi, Mohammed Badran, Mohammed Sulaiman, Yousef Alsoos, Yousef Altartour, Mohammed Abulebda, Mohammed Muhaisen, Omar Alsafadi, Zuhair Assaf

“…The intense conflict in the Gaza Strip presents an opportunity to evaluate the performance of local ICUs and validate the performance of the MPM and SAPS models within a resource-limited and highly stressed healthcare system. Methods A prospective study conducted from October to December 2024 included all patients admitted to ICUs in three of the four critical care units operating in the Gaza Strip. …”
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Oral health status, oral hygiene behaviors, and caries risk assessment of individuals with special needs: a comparative study of Pakistan and Saudi Arabia by Osama Khattak, Farooq Ahmad Chaudhary, Shahzad Ahmad, Muhammad Amber Fareed, Shazia Iqbal, Asma Shakoor, Mohammed Nadeem Baig, Haifa Ali Almutairi, Rakhi Issrani, Azhar Iqbal

“…This study aims to: (1) assess the oral health status of disabled individuals in Pakistan and Saudi Arabia, (2) evaluate their oral hygiene knowledge and behaviors, and (3) determine their caries risk using the Caries Management by Risk Assessment (CAMBRA) protocol. Methods A cross-sectional study was conducted on 189 participants aged 13 years and older, including both young people and adults with hearing, visual, or intellectual disabilities from Pakistan and Saudi Arabia between September 2023 and April 2024. …”
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Prognostic analysis of sepsis-induced myocardial injury patients using propensity score matching and doubly robust analysis with machine learning-based risk prediction model develo... by Pan Guo, Pan Guo, Li Xue, Fang Tao, Kuan Yang, YuXia Gao, Chongzhe Pei

“…This study aimed to evaluate the prognostic impact of SIMI and develop validated predictive models using advanced machine learning (ML) algorithms for identifying SIMI in critically ill sepsis patients.MethodsData were sourced from the Medical Information Mart for Intensive Care IV (MIMIC-IV, v3.0) database. …”
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Susceptibility-weighted MR imaging (SWI) of basal ganglia iron deposition in the early and advanced stages of Parkinson's disease by A. G. Trufanov, A. A. Yurin, A. B. Buriak, S. A. Sandalov, M. M. Odinak, I. V. Litvinenko

“…The accumulation of iron is visualized as an area of reduced signal intensity on SWI, and its estimation in accordance with the SPIN program has accordingly a smaller value. …”
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