NETs activate the GAS6-AXL-NLRP3 axis in macrophages to drive morphine tolerance by Qingyan Tian, Haiyue Guo, Mengyao Zhang, Kunmao Jiang, Fan Hu, Yan Xu, Li Wan, Xiaokai Zhou, Yinbing Pan, Wentao Liu, Chun-Yi Jiang

“…This study aims to explore the mechanisms underlying morphine tolerance from a novel perspective, with the ultimate goal of uncovering new insights and identifying promising therapeutic targets for its treatment. Methods C57BL/6J mice were used in the tail-flick test to evaluate morphine tolerance. …”
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Meta-analyses of the effects of high-intensity interval training in elite athletes — part II: relationships between the mean effects on various performance measures by Hans-Peter Wiesinger, Hans-Peter Wiesinger, Hans-Peter Wiesinger, Will G. Hopkins, Nils Haller, Nils Haller, Julia Blumkaitis, Tilmann Strepp, Thomas Leonhard Stöggl, Thomas Leonhard Stöggl

“…Here, we extend the analyses to relationships between mean changes of these measures and consider implications for understanding and improving HIIT that were not apparent in the previous analyses.MethodsThe data were mean changes from HIIT with highly trained endurance and elite other (mainly team sport) athletes in studies where two or more measures or predictors of performance were available. …”
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Effects of plant active substances in rheumatoid arthritis—a systematic review and network meta-analysis by Qiuwei Peng, Jian Wang, Kesong Li, Congming Xia, Chuanhui Yao, Qiuyan Guo, Xun Gong, Xiaopo Tang, Quan Jiang

“…The widespread use of these extracts as therapeutic measures for RA is problematic due to the lack of compelling evidence.ObjectiveOur research aims to assess the impact of plant active substances on RA by conducting a network meta-analysis.MethodsWe systematically searched four electronic databases—PubMed, EMBASE, the Cochrane Central Register of Controlled Trials, and Web of Science—from their inception to August 2024. …”
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The burden of refraction disorders in 204 countries and territories from 1990 to 2021: A systematic analysis from the global burden of disease 2021 by Yunhan Shen, Linyan Wang, Yuxin Cui, Bangxun Mao, Grace Loy Ming Hooi, Oluwatobi Idowu, Juan Ye, Tiansheng Zhu

“…This study aims to describe and predict the burden and regional distribution of refraction disorders using data from the 2021 Global Burden of Disease (GBD) study. Methods: This study utilized data from the Global Burden of Disease (GBD) 2021 on refraction disorders from 1990 to 2021. …”
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Effect of superficial cervical plexus nerve block with Ropivacaine or a combination of different adjuvants on perioperative analgesia and quality of postoperative recovery in patie... by Xiaoyu Kang, Caifen Li, Liuyu Lu, Xiaotong Qin, Yonghao Wang, Yang Lu, Li Ma, Shaoliang Zhu, Zheng Gong

“…Abstract Objective To investigate the effect of ultrasound-guided bilateral superficial cervical plexus nerve blocks with Ropivacaine or a combination of different adjuvants on perioperative analgesia and quality of postoperative recovery in patients undergoing radical thyroid cancer surgery under general anesthesia with nerve monitoring without muscarinic maintenance. Methods A total of 140 patients undergoing elective radical thyroid cancer surgery were randomly divided into four groups, with 35 cases in each group: general anesthesia alone group (Group C), general anesthesia + Ropivacaine group (Group R), general anesthesia + Ropivacaine combined with dexmedetomidine group (Group R1), and general anesthesia + Ropivacaine combined with dexamethasone group (Group R2). …”
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Differential effects of sound interventions tuned to 432 Hz or 443 Hz on cardiovascular parameters in cancer patients: a randomized cross-over trial by Anna Hohneck, Ánxelo Maia Rodríguez, Simone Weingärtner, Kirsten Merx, Felicitas Sarodnick, Fritjof von Gagern, Athanasios Mavratzas, Iris Burkholder, Gerhard Schumacher, Wolf-Karsten Hofmann, Ralf-Dieter Hofheinz

“…Abstract Background This study investigated whether a sound intervention tuned to 432 Hz (Hz) yields differential effects on cardiovascular parameters and psychological outcomes compared to 443 Hz, which is the concert pitch in German professional orchestras. Methods Using a randomized cross-over design, patients with cancer were recruited to receive both a 15-minute sound intervention with a body monochord tuned to 432–443 Hz. …”
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Metformin treatment for patients with hand osteoarthritis: protocol for the multicentre, randomised, placebo-controlled METRO trial by David J Hunter, Robin Christensen, Marius Henriksen, Henning Bliddal, Karen Ellegaard, Mikael Boesen, Tue Kragstrup, Filip K Knop, Anna Dossing, Kasper Staberg Madsen, Asbjørn S Poulsen, Rasmus Oscar

“…The primary endpoint is the between-group difference in least squares means for the change in the Visual Analogue Scale (VAS) finger joint pain scores between the metformin and placebo groups at 16 weeks. …”
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Neurophysiological findings in Attention Deficit Hyperactivity Disorder, a Pandora’s box with therapeutic implications by Montserrat Gerez-Malo, Armando Tello, Maria Jimena Martin-Salas, Lauro Castanedo, Arturo Mendizábal, Oscar Meneses Luna, Leslie Quintanar, Carlos Acosta

“…This study aimed to identify dysfunctional mechanisms behind ADHD symptoms and test if targeting these dysfunctions can improve clinical outcomes. Methods: 230 children with ADHD diagnosis studied with hypothesis-related variables from electroencephalogram (EEG) visual inspection and quantitative z-scored power, coherence and ratios, and from event-related brain potentials (ERPs) z-sored P50, N100, N200, P300 latencies amplitudes and ratios. …”
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Efficacy of repetitive transcranial magnetic stimulation for smoking cessation: a systematic review and meta-analysis by Youssef A. Ismail, Omar K. Habib, Yahya El-Banan, Raneem Ramadan, Mohamed O. Henidak, Mohamed E. El-Badry, Ahmed R. Rabea, Amira A. Fouad, Salsapeel I. El-Tahlawy, Rahma M. El-Shawa, Mohamed Atef, Rahma A. Abd El-Kader, Abdullah El-Lawendy, Mariam El-Morsy, Mariam S. El-Rayes, Hanem El-Hasanen, Moaz Abouelmagd

“…Objective To evaluate the efficacy of rTMS in smoking cessation, its impact on abstinence rates, nicotine dependence, and craving. Methods We conducted a comprehensive search across multiple databases (PubMed, Scopus, Web of Science, Cochrane, PsycINFO, and Clinicaltrials.gov) from inception to August 2024. …”
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Anterior lumbar interbody fusion with a novel osteoinductive allograft – Mid-term clinical and radiographic outcomes by Charlie R. Faulks, Dean T. Biddau, Michael D. Selby, Ralph J. Mobbs, Gregory M. Malham

“…We aimed to evaluate the clinical and radiographic outcomes of patients who underwent ALIF with a novel osteoinductive demineralised bone allograft (DBA) due to the paucity of peer reviewed literature. Methods: Includes 112 consecutive patients from 3 senior spine surgeons (multi-centre) undergoing stand-alone ALIF with osteoinductive DBA (Allovance® Crunch Plus) between January 1, 2019 and January 1, 2022. …”
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Anterior cervical discectomy and fusion in treating acute myelopathy caused by Brucella cervical spondylitis: a case series by Long Chen, Tao Zhang, Xing-yu Chen, Yi-zhe Wang, Xing-guo Tan, Da-shuai Huang, Yan-peng Lu, Song-kai Li

“…This study aims to begin to investigate the clinical characteristics of acute cervical myelitis caused by Brucella infection and to evaluate the profile of clinical benefit of anterior cervical discectomy and fusion (ACDF) for this condition.Methods This retrospective case series included 6 patients who underwent surgical treatment for acute cervical spinal cord impairment due to Brucella infection at our institution between January 1, 2013, and January 1, 2023. …”
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Multimodal Analgesia Approach in Acute Low Back Pain Management: A Phase III Study of a Novel Analgesic Combination of Etoricoxib/Tramadol by Miguel A. Zuqui-Ramírez, Victor M. Belalcazar-López, Adelfia Urenda-Quezada, Alejandro González-Rebatu y González, José G. Sander-Padilla, Laura A. Lugo-Sánchez, Ileana C. Rodríguez-Vázquez, Kevin F. Rios-Brito, María M. Arguedas-Núñez, Emmanuel Canales-Vázquez, Jorge González-Canudas

“…This study evaluated the efficacy and safety between two fixed-dose combinations (FDC): etoricoxib/tramadol compared to paracetamol/tramadol for the management of acute low back pain (LBP) in a 7-day treatment. Methods We conducted a phase IIIb, prospective, randomized, and multicenter study in patients with acute LBP treated with etoricoxib 90 mg/tramadol 50 mg (one packet of granules diluted in 100 ml of water, once a day [QD], for 7 days) or paracetamol 975 mg/tramadol 112.5 mg (one tablet of 325 mg/37.5 mg, three times a day [TID], for 7 days) to assess the efficacy (in terms of pain and disability improvement) and safety. …”
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Neuroprotective effects of healthful plant-based diets on retinal structure: insights from a large cohort by Qian Zhu, Xiaoxin Liu, Yuan Qu, Yan Jiang, Xinyi Liu, Yu Xiao, Kangjia Lv, Yupeng Xu, Kun Liu

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Age features of myocardial remodeling in men with ischemic chronic heart failure and renal dysfunction by D. A. Lashkul

“…The aim of research is to study the age features of the formation of different types of myocardial remodeling in men with ischemic chronic heart failure and renal dysfunction. Materials and methods. To investigate the age characteristics of cardiac remodeling in men with ischemic chronic heart failure and renal dysfunction structural and functional remodeling of left ventricular myocardium was studied in 277 men (mean age 58,1±9,3 years) using Doppler echocardiography. …”
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[Translated article] Risk factors for complications in total hip arthroplasty by L.A. Hoyos-Velasco, J.C. Palacio, W.P. Stangl, C.L. Chacón-Castillo, V. Palacio-Aragón, J.P. Pulgarín

“…The objective of this study is to identify the risk factors associated with local and systemic complications in patients treated with total hip arthroplasty. Methods: Observational, analytical, retrospective cohort study, which included 304 participants treated with total hip replacement. …”
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Rengalin, a Novel Drug for Treatment of Cough in Children. Intermediate Data on Multicentre, Comparative Randomized Clinical Trial by N. A. Geppe, E. G. Kondyurina, A. N. Galustyan, T. E. Pak, N. B. Baltserovich, O. V. Zhiglinskaya, A. V. Kamaev, S. G. Lazareva, S. L. Laleko, I. M. Melnikova, E. V. Mikhailova, O. A. Perminova, A. U. Sabitov, Yu. M. Spivakovsky

“…The aim of the multicenter, comparative, randomized clinical trial was to estimate the efficacy and safety of rengalin in the treatment of cough in patients with acute respiratory infection (ARI) of the upper respiratory tract. Methods. One hundred forty six patients at the age of 3 to 17 years (the average age of 8.2+3.6 years) from 14 medical centres of Russia were observed. …”
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Factores de riesgo para complicaciones en artroplastia total de cadera by L.A. Hoyos-Velasco, J.C. Palacio, W.P. Stangl, C.L. Chacón-Castillo, V. Palacio-Aragón, J.P. Pulgarín

“…The objective of this study is to identify the risk factors associated with local and systemic complications in patients treated with total hip arthroplasty. Methods: Observational, analytical, retrospective cohort study, which included 304 participants treated with total hip replacement. …”
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Safety and efficacy of amnion-derived mesenchymal stem cells (AM01) in patients with steroid-refractory acute graft-versus-host disease after allogeneic haematopoietic stem cell tr... by Hiroki Nishikawa, Shunsuke Ohnishi, Hiroshi Hayashi, Rika Okamoto, Kenichi Yamahara, Toshiyuki Isoe, Norihiro Sato, Akiko Hamada, Toshihiro Soma, Masaya Okada, Satoshi Yoshihara, Kyoko Yoshihara, Kazuhiro Ikegame, Hiroya Tamaki, Katsuji Kaida, Takayuki Inoue, Yuko Ohsugi, Hiroaki Iijima, Daigo Hashimoto, Takanori Teshima, Hiroyasu Ogawa, Yoshihiro Fujimori

“…This study will aim to evaluate the safety and efficacy of amnion-derived MSCs (AM01) in patients with steroid-refractory aGVHD.Methods and analysis This study will be a multicentre, single-arm, open-label trial (an interventional study). …”
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Ophiopogon japonicus (L. f.) Ker Gawl. extract treats dry eye disease via anti-inflammatory, antioxidant, and goblet cell-stimulating effects by Guoliang Li, Rui Feng, Jiayi Yu, Boliang Li, Yanni Luo, Hongyi Luo, Cheng Zhang, Guanghong Zhang, Jianglong Li, Chao Qu

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Relative peripheral refractive errors in Chinese children with myopic anisometropia by Yu-Ting Tong, Yu-Qin Du, Shan-Shan Ge, Li Chen, Xiao-Qi Ma, Yu-Juan Guo, Yue-Hua Zhou

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