Advancing Nanomedicine Through Electron Microscopy: Insights Into Nanoparticle Cellular Interactions and Biomedical Applications by Akhtar S, Zuhair F

“…However, challenges like sample preparation and artifacts persist, with rapid freezing methods, such as plunge-freezing particularly, high-pressure freezing, proving effective in preserving native cellular structures. …”
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PLS-DA model for accurate identification of Chinese cabbage leaf color based on multispectral imaging by Ziwei Xie, Jinghui Yan, Hao Liang, Xiaonan Yue, Xiangjie Su, Huixin Wei, Yin Lu, Xiaofei Fan, Wei Ma, Xiaomeng Zhang, Xiaoxue Sun, Dongfang Zhang, Jingrui Li, Jianjun Zhao, Mengyang Liu

“…In this study, we constructed a partial least squares discriminant analysis (PLS-DA) leaf color identification model and compared four classification methods for leaf color, namely red, green, and blue (RGB) channels, hue, saturation, and lightness (HSL) color space, multi-spectrum and data-fusion. …”
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The Manitoba Personalized Lifestyle Research (TMPLR) study protocol: a multicentre bidirectional observational cohort study with administrative health record linkage investigating... by Navdeep Tangri, Dylan Mackay, Rebecca C Mollard, Matthew Granger, Sharon Bruce, Heather Blewett, Jared Carlberg, Todd Duhamel, Peter Eck, Patrick Faucher, Naomi C Hamm, Ehsan Khafipour, Diana McMillan, Semone Myrie, Amir Ravandi, Meghan Azad, Peter JH Jones

“…The objective of The Manitoba Personalized Lifestyle Research study is to understand how these lifestyle factors interact with each other and with other factors, such as an individual’s genetics and gut microbiome, to influence health.Methods An observational study of adults, with extensive phenotyping by objective health and lifestyle assessments, and retrospective assessment of early life experiences, with retrospective and prospective utilisation of secondary data from administrative health records.Study population A planned non-random convenience sample of 840 Manitobans aged 30–46 recruited from the general population, stratified by sex (equal men and women), body mass index (BMI; 60% of participants with a BMI>25 kg/m2) and geography (25% from rural areas). …”
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Phase II study of concomitant radiotherapy with atezolizumab in oligometastatic soft tissue sarcomas: STEREOSARC trial protocol by Nicolas Penel, Dominique Vaur, Juliette Thariat, Alexandre Escande, Jennifer le Guevelou, Colin Debaigt, Esma Saada-Bouzid, Julien Viotti, Nazim Khalladi, David Thibouw, Marie Pierre Sunyach, Laurence Moureau-Zabotto, Mohamed Benchalal, Ovidiu Veresezan, Anne Ducassou, Cecile le Pechoux, Maria Jolnerovski, Celine Bazille, Raphael Serre, Christine Lovera

“…In order to shift the balance towards antitumour immunity by multisite irradiation, radiation could be combined with inhibitors of the immunosuppressive pathways.Methods and analysis STEREOSARC is a prospective, multicentric, randomised phase II, designed to evaluate the efficacy of SBRT associated with immunotherapy versus SBRT only. …”
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Obstacles for self-management practices among diabetes patients: A facility-based study from Coastal South India. [version 3; peer review: 2 approved] by Murali Mohan R, Rekha T, Balanarayana Suma, Nithin Kumar, Kausthubh Hegde, Bhaskaran Unnikrishnan, Prasanna Mithra, Ramesh Holla, Aysha Roushida Sahama M, Aadithya M Rao, Patil Nikitha

“…Background The management of diabetes mellitus (DM) extends beyond clinical care, with self-care being equally important to achieve optimal treatment outcomes and prevent complications. …”
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REMAP Periop: a randomised, embedded, multifactorial adaptive platform trial protocol for perioperative medicine to determine the optimal enhanced recovery pathway components in co... by Brian Williams, Jennifer Holder-Murray, Kathirvel Subramaniam, Kert Viele, Oscar C Marroquin, Scott Berry, Aman Mahajan, Luca La Colla, Charles Luke, Alison R Althans, Stephen A Esper, Joshua Knight, Joseph Derenzo, Ryan Ball, Shawn Beaman, Nicholas Schott, Elizabeth Lorenzi, Lindsay R Berry, Miranda Masters, Katie A Meister, Todd Wilkinson, William Garrard

“…Patients enrolled in the trial will be randomised to arms within both domains, with the possibility of adding additional domains in the future.Methods and analysis In the PONV domain, patients are randomised to optimal versus supraoptimal prophylactic regimens. …”
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The age of obesity onset affects changes in subcutaneous adipose tissue macrophages and T cells after weight loss by Jessica Murphy, Jessica Murphy, Jessica Murphy, José A. Morais, José A. Morais, Michael A. Tsoukas, Alexandra B. Cooke, Stella S. Daskalopoulou, Stella S. Daskalopoulou, Stella S. Daskalopoulou, Sylvia Santosa, Sylvia Santosa, Sylvia Santosa

“…Weight loss can modify adipose tissue immune cell composition, but whether these changes differ by obesity onset remains unknown.MethodsWe compared abdominal and femoral subcutaneous adipose tissue (SAT) immune cell percentages between people with CO and AO before and after moderate (~10%) weight loss. …”
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Low-concentration atropine (0.01%) on quantitative contrast sensitivity function in Chinese children with myopia by Yu-Hao Ye, Yi-Yong Xian, Fang Liu, Zhong-Lin Lyu, Xing-Tao Zhou, Jing Zhao

“…AIM: To investigate the effect of 0.01% low-concentration atropine (LA) on quantitative contrast sensitivity function (qCSF) in children with myopia. METHODS: This paired case-control study included 90 eyes of 58 children who were sex-, age-, and refraction-matched and equally divided into two groups: the 0.01% LA group had undergone 6mo use of daily 0.01% atropine and control group was naïve to LA. …”
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The Efficacy of Oral Dexamethasone in the Management of Symptomatic Irreversible Pulpitis Without Pulpotomy: A Non-Randomized Clinical Trial by Sara Chehab, Roula Abiad, Lara Nasr, Hala Sacre, Pascale Salameh, Reem Chamseddine, Romy Zouein, Louis Hardan, Naji Kharouf, Rim Bourgi, Roula El Hachem

“…The purpose of this clinical trial was to evaluate the effectiveness of an inferior alveolar nerve block (IANB) injection followed by oral dexamethasone administration in reducing the pain associated with symptomatic irreversible pulpitis (SIP) in mandibular molars, without performing conventional pulpotomy. Methods: A sample of 80 subjects suffering from acute pain due to SIP on a mandibular molar were assigned to the dexamethasone group, who received an IANB injection followed by one oral dose of 4 mg of dexamethasone during the emergency visit followed by one dose of 4 mg after 8 h, or the control group, who received a conventional pulpotomy. …”
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Relationship between cognitive impairments and psychopathological symptoms in female schizophrenia subsequent to 8 weeks treatment with antipsychotic drugs by Shuzhan Gao, Qing Xu, Yanlin Han, Jing Jiang, Fan Wu, Ting Peng, Chenxi Ling, Sulin Ni, Rongrong Zhang, Yidan Ming, Xuzhen Liu, Xijia Xu

“…Further exploration of the characteristics of female schizophrenia patients can offer valuable sex-related considerations for clinicians in diagnosis and interventions. Methods Our study involved 94 female patients with drug-naïve or drug-withdrawal schizophrenia who received antipsychotic drug for 8 weeks, along with 71 age-matched female healthy controls. …”
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Vitamin D insufficiency and sleep disturbances in children with ADHD: a case-control study by Panpan Zhang, Panpan Zhang, Yang Liu, Yang Liu, Yan Ma, Yan Ma, Tingting Zhao, Tingting Zhao, Chan Zhang, Chan Zhang, Hao Sun, Hao Sun

“…Regrettably, no studies have looked at whether vitamin D insufficiency exacerbates sleep problems in ADHD children and further affects ADHD symptoms.ObjectiveThis study aimed to examine whether vitamin D insufficiency exacerbates sleep problems and ADHD symptoms in children aged 6–14 years.MethodsThis is a case-control study, 260 ADHD children (aged 6-14 years) were enrolled in, of whom 95 had vitamin D insufficiency and 165 had sufficiency. …”
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Increased concentration of tumour necrosis factor alpha in the plasma of glaucoma patients by Trenkić Marija, Jevtović-Stoimenov Tatjana, Bašić Jelena, Vasilijević Jelena, Ristić Dragana, Trenkić Milan, Veselinović Aleksandar, Cvetanović Marija

“…The aim of the study was to determine concentrations of tumor necrosis factor (TNF)-α in the plasma of patients with OAG and subjects without glaucoma and examine the correlation between the TNF-α concentration in plasma in glaucoma patients and specific clinical parameters. Methods. The study included 87 participants (87 eyes) divided into three groups: 35 subjects (35 eyes) with primary OAG (POAG) with elevated intraocular pressure (IOP) – hypertension glaucoma (HTG) (POAG-HTG), 23 subjects (23 eyes) with pseudoexfoliative OAG (XFG), and 29 subjects in the control group (healthy subjects) matched with the patient groups in terms of age and gender. …”
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Expression and clinical significance of FANCI gene in pan-cancer: a comprehensive analysis based on multi-omics data by Yunzheng Zhao, Yunzheng Zhao, Qingyu Li, Qingyu Li, Jiajun Li, Jiajun Li, YiFeng Cui, YiFeng Cui, Zhaoyang Lu, Zhaoyang Lu

“…This investigation seeks to clarify the expression profiles, prognostic relevance, and diagnostic capabilities of FANCI across multiple malignancies, along with its links to immune cell infiltration, genetic alterations, protein-protein interactions, and functional roles.MethodsBy utilizing data from The Cancer Genome Atlas (TCGA) and Genotype-Tissue Expression (GTEx) databases, we conducted a comprehensive analysis of FANCI mRNA expression using R software and visualized the results with the ggplot2 package. …”
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Conservative treatment versus hip arthroscopy in patients with femoroacetabular impingement: a multilevel meta-analysis of randomized controlled trials by Nikolai Ramadanov, Jonathan Lettner, Maximilian Voss, Robert Hable, Robert Prill, Dobromir Dimitrov, Roland Becker

“…The aim of this multilevel meta-analysis of randomized controlled trials (RCTs) was to evaluate the outcomes of FAI patients treated conservatively compared with those treated with hip arthroscopy (HAS). Methods: A systematic literature search of PubMed, CENTRAL of the Cochrane Library, Epistemonikos, and Embase databases was conducted up to 30 June 2024. …”
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Deep Learning and Edge Computing in Agriculture: A Comprehensive Review of Recent Trends and Innovations by Apri Junaidi, Siti Zaiton Mohd Hashim, Mohd Shahizan Bin Othman, Mohd Murtadha Bin Mohamad, Hitham Alhussian, Said Jadid Abdulkadir, Maged Nasser, Yunusa Adamu Bena

“…Traditional inspection methods are labor-intensive and error-prone, highlighting the need for automated, intelligent solutions. …”
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Directly anterior approach for total hip arthroplasty with an acetabular structural bone graft for developmental dysplasia of the hip (Crowe III and IV): a concise 5-year follow-up... by Lijia Pei, Ben Liu, Yifan Wu, Yuanhang Wang, Wenhao Sun, Wenju Chang, Xinshe Zhou

“…Abstract Background This study evaluated the results of total hip arthroplasty (THA) via the direct anterior approach (DAA) in the lateral decubitus position combined with acetabular reconstruction via a bulk autograft for patients with developmental dysplasia of the hip (Crowe III and IV). Patients and methods A retrospective study was conducted to analyse 16 patients (16 hips) with Crowe type III and IV developmental dysplasia of the hip (DDH) who underwent THA from June 2016 to July 2021. …”
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Clinical profile, associated events and safety of vericiguat in a real‐world cohort: The VERITA study by Mario Galván Ruiz, Miguel Fernández de Sanmamed Girón, María delVal Groba Marco, Lorena Rojo Jorge, Claudia Peña Saavedra, Elvira Martín Bou, Rubén Andrade Guerra, Eduardo Caballero Dorta, Antonio García Quintana

“…Abstract Aims The aim of this study was to determine the clinical profile, associated events and safety of vericiguat in a real‐world cohort of patients with heart failure with reduced ejection fraction (HFrEF). Methods This study is a prospective and observational cohort study of patients with HFrEF and recent HF worsening episodes requiring intravenous therapy who initiated vericiguat in an HF outpatient clinic. …”
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Association between triglyceride–glucose index and mortality in critically ill patients with atrial fibrillation: a retrospective cohort study by Rong Ding, Erjing Cheng, Miao Wei, Liya Pan, Lu Ye, Yi Han, Xuan Zhang, Chao Xue, Jiannan Gong, Hui Zhao

“…This study aimed to investigate the association between the TyG index and all-cause mortality in this high-risk population. Methods We identified critically ill patients with AF from the Medical Information Mart for Intensive Care IV (MIMIC-IV) database and categorized them into tertiles based on their TyG index levels. …”
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Radiomics Signature of Aging Myocardium in Cardiac Photon-Counting Computed Tomography by Alexander Hertel, Mustafa Kuru, Johann S. Rink, Florian Haag, Abhinay Vellala, Theano Papavassiliu, Matthias F. Froelich, Stefan O. Schoenberg, Isabelle Ayx

“…Detecting structural changes in aging left-ventricular myocardium may help predict cardiovascular risk. <b>Methods</b>: In this retrospective, single-center, IRB-approved study, 90 patients underwent ECG-gated contrast-enhanced cardiac CT using dual-source PCCT (NAEOTOM Alpha, Siemens). …”
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Comparative Genomics of Rhamnolipid Synthesis and Monoaromatic Hydrocarbon Tolerance Genes in Environmental Pseudomonas aeruginosa strains [version 2; peer review: 2 approved] by Sandro B. Martel-Torres, Camila Castillo-Vilcahuaman, ROGER A. PALOMINO HUARCAYA, Susana M. Gutiérrez Moreno, Fernando A. Merino Rafael

“…This study aimed to investigate the rhl and mla systems in six strains isolated from hydrocarbon-contaminated sites in Peru. Methods Six Pseudomonas aeruginosa strains were evaluated in this study. …”
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