Enhancing safety with an AI-empowered assessment and monitoring system for BSL-3 facilities by Yi-Ling Fan, Ching-Han Hsu, Ju-Yu Wu, Ying-Ying Tsai, Wei J. Chen, Min-Shi Lee, Fang-Rong Hsu, Lun-De Liao

“…Laboratory management failures can pose significant hazards. Methods: An external system captured images of personnel entering a laboratory, which were then analyzed by an AI-based system to verify their compliance with personal protective equipment (PPE) regulations, thereby introducing an additional layer of protection. …”
Get full text

Dilatation of the main pulmonary artery in patients with isolated pulmonary stenosis: Arteriopathy or hemodynamic consequence? by Pietro Paolo Tamborrino, Michela Miglianti, Dario Freitas, Camelia Demetrescu, Christopher Rush, Claudia Montanaro, Alessandra Frigiola

“…The aim of our study was to detect the incidence of mPA dilatation and aneurysm in patients with isolated PV stenosis and the association with PV function. Methods: In this single-center retrospective observational study, all patients with a diagnosis of isolated PV stenosis referred to our center were enrolled. …”
Get full text

Change in choroid thickness and vascularity index associated with accommodation and aberration after small-incision lenticule extraction by Dan Cheng, Yi-Lin Qiao, Xue-Ying Zhu, Kai-Ming Ruan, Heng-Li Lian, Mei-Xiao Shen, Shu-Lin Wang, Li-Jun Shen, Yu-Feng Ye

“…AIM: To explore choroidal thickness (CT) and choroidal vascularity index (CVI) changes around the macula and optic nerve head (ONH) using swept-source optical coherence tomography (SS-OCT) after small-incision lenticule extraction (SMILE) and evaluate their associations with accommodation and aberrations. METHODS: Participants were divided into more myopic group (43 eyes) and less myopic group (33 eyes) according to refractive error. …”
Get full text

Acetyl-L-Carnitine as an Add-On Treatment in Fibromyalgia Syndrome: A Retrospective Analysis on 183 Patients, According to the Generalized Linear Mixed Model for Longitudinal Data by Vittorio Schweiger, Libera Villagrossi, Francesco Taus, Leonardo Gottin, Eleonora Bonora, Marco Anderloni, Giustino Varrassi, Luca Polati, Marta Nizzero, Alvise Martini, Enrico Polati

“…Fibromyalgia Syndrome (FMS) is characterized by chronic widespread pain, sleep disturbances, fatigue and cognitive impairment. <b>Methods</b>. In this retrospective study, we analyzed data collected between 2017 and 2022 regarding Acetyl-L-Carnitine (ALC) as an add-on treatment in 183 adult patients with FMS according to the 2016 ACR (American College of Rheumatology) criteria and patients’ pain lasting for over three months. …”
Get full text

Lack of pre-movement facilitation as neurophysiological hallmark of fatigue in patients with Parkinson's disease: A single pulse TMS study by Antimo Buonocore, Celeste Cafaro, Ciro De Luca, Giovanna Vermiglio, Giovanna Sepe, Giuseppe Rocco, Marco Aiello, Andrea Soricelli, Michele Papa, Carlo Cavaliere, Giovanni Cirillo

“…Recent evidence suggests that deficits in cortical motor preparation processes may contribute to PD-related fatigue. Methods: This study investigated premovement facilitation (PMF), a marker of corticospinal excitability during motor preparation, in 20 healthy subjects (HS) and 28 PD patients, subdivided into those with fatigue (PDwF, n = 14) and without fatigue (PDwoF, n = 14). …”
Get full text

Utilization of magnification devices in Vietnam’s dental practice and education: an online survey by Minh-Hieu Nguyen Tran, Anh Huynh Bui, Lan-Anh Hoang Le, Thuy-Trang Thi Huynh, Phuong-Doan Phan, Thuan-Loc Tran, Nguyen-Tra-Mi Le, Thu-Tra Nguyen, Hoang-Vinh Le, Dai-Phong Lam, Quoc-Viet Lam, Tran-Lan-Khue Pham, An-Tran Pham, Van-Khoa Pham

“…This study aimed to assess magnification device utilization in Vietnamese dental practice and education, with a pioneering focus on 3D-DOMs. Methods An online, questionnaire-based observational survey was conducted from October to December 2024. …”
Get full text

Levels of physical activity in a large international cohort of patients with systemic lupus erythematosus by Laurent Arnaud, Matteo Piga, Manuel Francisco Ugarte-Gil, Christelle Sordet, Philippe Mertz, Luc Pijnenburg, Marina Rinagel, Lou Kawka, Sophie Geneton, Julien Blaess, Timothée Mischler, Juan C Sarmiento-Monroy

“…The aim of this study was to assess PA level and characteristics in a large international cohort of patients with SLE.Methods PA was assessed in metabolic equivalent of tasks (METs) using the International Physical Activity Questionnaire (IPAQ) and classified into three levels: low, moderate and high PA. …”
Get full text

Efficacy and safety of phacotrabeculectomy versus phacogoniotomy in advanced primary angle-closure glaucoma: study protocol for a multicentre non-inferiority randomised controlled... by Xiulan Zhang, Xi Zhang, Yi Zhang, Li Tang, Guangxian Tang, Hengli Zhang, Aiguo Lv, Huiping Yuan, Yunhe Song, Lin Xie, Lan Lu, Kun Hu, Xiaohong Liang, Xiaowei Yan, Yingzhe Zhang, Wulian Song, Meichun Xiao, Xiaohuan Zhao, Xiaomin Zhu, Xinbo Gao, Minwen Zhou, Sujie Fan

Get full text

Brolucizumab efficacy and safety single-arm descriptive trial in patients with persistent diabetic macular edema (BEST study): protocol for a single-centre, open-label, single-arm... by Jing Li, Dan Cao, Honghua Yu, Yunyan Hu, Yijun Hu, Ying Fang, Jiahui Zeng, Anyi Liang, Ziyi Huang, Chenxiao Shen, Huiyi Liao, Chunwen Zheng, Shuyi Ouyang

“…This single-centre, open-label, single-arm design clinical trial aims to evaluate the efficacy and safety of intravitreal brolucizumab 6 mg in Chinese subjects with persistent DME.Methods and analysis A total of 52 adult subjects with persistent DME will be recruited from Guangdong Provincial People’s Hospital. …”
Get full text

Distinct mechanisms of electroacupuncture and manual acupuncture in modulating hypothalamic GnRH–tanycyte unit function of polycystic ovary syndrome by Yu Wang, Yicong Wang, Yuning Chen, Wenhan Lu, Xiaoyu Tong, Jiajia Li, Wenhao Gao, Rui Huang, Wei Hu, Yi Feng

“…Gonadotropin-releasing hormone (GnRH) neurons are pivotal in regulating hypothalamic endocrine function, whereas tanycyte, a specialized glial cell type, potentially contribute to this process. Methods A dihydrotestosterone (DHT)-induced PCOS-like mouse model was used to investigate the effects of acupuncture. …”
Get full text

Spectrum of gynecologic malignancies in Northeastern Nigeria by Dauda A. Katagum, Uchenna S. Ezenkwa, Sunday E. Achanya, Aliyu I. Lawan, Dauda E. Suleiman, Mairo U. Kadaura, Abba Kabir, Adamu I. Adamu, Abubakar Kolomi Modu, Hadiza Usman, Sophia H. L. George, Matthew Schlumbrecht, Bala M. Audu

“…Here, four-year multi-institutional data on gynecologic cancers in northeastern Nigeria were examined to determine their distribution by age and subtype.Patient and MethodsThis is a cross-sectional descriptive study using available data on histologically diagnosed gynecologic cancers archived in the pathology departments and/or cancer registries of six tertiary hospitals in northeastern Nigeria over four years. …”
Get full text

Efficiency of cell-based assays in detecting AChR antibodies in myasthenia gravis sera with low antibody concentrations as determined by radioimmunoprecipitation assay by John S. Tzartos, Aigli G. Vakrakou, Katerina Karagiorgou, Vasiliki Zouvelou, Elisabeth Chroni, Valentina Damato, Francesca Beretta, Stavroula Salakou, Eirini Sfyroera, Dimitra Veltsista, Konstantinos Voumvourakis, Sotirios Giannopoulos, Georgios Tsivgoulis, Socrates Tzartos, Socrates Tzartos, Socrates Tzartos

“…ObjectivesWe investigated whether the acetylcholine receptor (AChR) cluster cell-based assay (CBA) is effective in detecting AChR antibodies in sera from myasthenia gravis (MG) patients with low antibody concentrations, as determined by radioimmunoprecipitation assay (RIPA).MethodsIn this retrospective diagnostic cohort study, 193 RIPA-positive sera from MG patients were analyzed. …”
Get full text

Outcomes in Catheter Ablation of Sustained Ventricular Tachycardia in Myocarditis Compared with Ischemic Heart Disease by Sheng Su, Le Li, Xi Peng, Likun Zhou, Zhuxin Zhang, Yulong Xiong, Zhenhao Zhang, Mengtong Xu, Yan Yao

“…For myocarditis patients with VT, CA might be equally effective.…”
Get full text

A harmonized dataset relating alternative farmer management practices to crop yield, soil organic carbon stock, nitrous oxide emissions, and nitrate leaching generated using IPCC m... by Roberta Calone, Angela Fiore, Guido Pellis, Maria Luz Cayuela, Gabriele Mongiano, Alessandra Lagomarsino, Simone Bregaglio

“…Current methodologies from the Intergovernmental Panel on Climate Change (IPCC) forassessing the impacts of alternative farming practices on GHG emissions rely on global or country-specific coefficients. However, these methods often do not explicitly account for the combined effects of management practices on carbon and nitrogen cycles or productivity, as this is not required for national GHG inventories. …”
Get full text

Study protocol of a randomised controlled trial of prostate radiotherapy in high-risk and node-positive disease comparing moderate and extreme hypofractionation (PRIME TRIAL) by Vedang Murthy, Indranil Mallick, Abhilash Gavarraju, Shwetabh Sinha, Rahul Krishnatry, Tejshri Telkhade, Arunsingh Moses, Sadhna Kannan, Gagan Prakash, Mahendra Pal, Santosh Menon, Palak Popat, Venkatesh Rangarajan, Archi Agarwal, Sheetal Kulkarni, Ganesh Bakshi

“…We hypothesise that a five-fraction schedule of extreme hypofractionation will be non-inferior to a moderately hypofractionated regimen over 5 weeks in efficacy and will have acceptable toxicity and quality of life while reducing the cost implications during treatment.Methods and analysis This is an ongoing, non-inferiority, multicentre, randomised trial (NCT03561961) of two schedules for National Cancer Control Network high-risk and/or node-positive non-metastatic carcinoma of the prostate. …”
Get full text

Food intake and influencing factors among primary and secondary school students in rural areas covered by the nutrition improvement program by Wenshuo YOU, Peipei XU, Wei CAO, Mulei CHEN, Qian GAN, Hongliang WANG, Ruihe LUO, Titi YANG, Hui PAN, Jianfen ZHANG, Xiaoning WANG, Qian ZHANG, Juan XU

“…ObjectiveTo analyze the food intake of primary and middle school students in areas implementing the Rural Compulsory Education Student Nutrition Improvement Program in 2021 and its influencing factors. MethodsFollowing the principle of random sampling, in 2021, in 727 national pilot counties in 31 provinces (autonomous regions, municipalities) and the Xinjiang Production & Construction Corps, approximately 10% of primary and middle schools were selected in urban and rural areas, respectively. …”
Get full text

Direct high-precision radon quantification for interpreting high-frequency greenhouse gas measurements by D. Kikaj, E. Chung, A. D. Griffiths, S. D. Chambers, G. Forster, G. Forster, A. Wenger, P. Pickers, P. Pickers, C. Rennick, S. O'Doherty, J. Pitt, K. Stanley, D. Young, L. S. Fleming, L. S. Fleming, K. Adcock, E. Safi, T. Arnold, T. Arnold

“…Here we describe standardized approaches regarding (1) instrument maintenance, (2) quality control of the raw data stream, (3) determination and removal of the instrumental background, (4) calibration methods, and (5) response time correction (by deconvolution). …”
Get full text

The effectiveness and risks of Treating people with Idiopathic Pulmonary fibrosis with the Addition of Lansoprazole (TIPAL): study protocol for a randomised placebo-controlled mult... by Toby M Maher, A John Simpson, Anthony Cahn, David Thickett, Luke Vale, Allan B Clark, Nazia Chaudhuri, Ian Forrest, Lisa G Spencer, Christopher Ward, Stephen Jones, Ganesh Raghu, Andrew M Wilson, Helen Parfrey, Megan Jones, Matthew Hammond, Jaclyn Ann Smith, Shajahan Wahed

“…Patients are randomised equally to receive two capsules of lansoprazole or two placebo capsules, two times per day for 12 months. …”
Get full text

Negative association between serum calcium and glucocorticoid-induced hypertension in thyroid-associated ophthalmopathy patients treated with methylprednisolone by Ling Wang, Yushi Sun, Meng Zhang, Hairong He, Jingya Wang, Huayang Xu, Yang Hao, Wenqiang Zhang, Yawen Wang, Yawen Wang, Yawen Wang, Kelvin K. L. Chong, Kelvin K. L. Chong, Kelvin K. L. Chong, Hui Guo, Bingyin Shi, Yue Wang

Get full text

Mir-218-5p from Extracellular Vesicles of Endometrium in Patients with Recurrent Implantation Failure Impairs Pre-Implantation Embryo Development by Cai L, Lv M, Wei J, Liu C, Li Y, Liao Z, Li T, Zhang H, Xi L, Sui C

“…Our findings revealed that miR-218-5p disrupted mouse embryo development, and this effect could be reversed by engineered extracellular vesicles (E-EVs) containing anti-miR-218-5p.Methods: The percentage of blastocyst development and hatching rates, embryo morphology, and the total cell number were measured. …”
Get full text