Genetic Insights Into Lipid Traits and Lipid-Modifying Drug Targets in Pregnancy Complications: A Two-Sample Mendelian Randomization Study by Shao H, Xu C, Zhang C, Li L, Wu P, Chen Z, Guan R

“…This two-sample Mendelian Randomization (MR) study investigated the causal relationship between lipid traits and pregnancy complications and evaluated the impact of lipid-modifying drug targets.Methods: Genetic instruments for lipid traits and targets for lipid-modifying drugs were obtained from the Global Lipids Genetics Consortium. …”
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Dynamic Changes in ALFF and DC in Subthreshold Depression Before and After ICBT Intervention by Wang Y, Ying Y, Zhu Z, Wang L, Yang Y, Zhang L, Yu W, Liang Y, Zhang H, Ji Y, Pan Y

“…This study aimed to examine changes in intrinsic brain activity in SD and their further alterations after ICBT intervention.Patients and Methods: Twenty-five individuals with SD and 25 matched healthy controls (HC) were enrolled. …”
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Automatic Real-Time Detection and Diagnosis of Liver Tumor with Ultrasound by Wu CH, Sheu JC, Chou PL, Lee J, Nien HC

“…We aimed to develop deep learning (DL) models to automatically diagnose and detect hepatic lesions in a larger dataset, with HCC as the dominant malignancy.Methods: We enrolled patients diagnosed with hepatic tumors using abdominal ultrasound between January 2002 and December 2020 in a retrospective cohort with a diagnosis of malignant and benign lesions. …”
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IL-6/IL-6R Signaling Blockade Alleviates Chronic Allograft Rejection by Modulating Germinal Center B Cells and Allograft Inflammation in Murine Cardiac Transplantation by Xia R, Shi X, Zhang H, Zeng W, Yang Z, Xu J, Wang J, Miao Y, Liao T

“…In this study, we investigate the preventive efficacy and underlying mechanism of IL-6/IL-6R signaling blockade.Methods: The CR model in mice was constructed using allogeneic cardiac transplantation with CTLA4-Ig injection. …”
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Comparative efficacy and safety of nitinol vs. novel fully biodegradable occluders for transcatheter patent foramen ovale closure in migraine treatment: a retrospective cohort stud... by Rui-lin Li, Jing-juan Huang, Jie Ming, Ying Hao, Wei Wen, Yun-li Shen, Li Lin, Lin-xiang Lu

“…Nevertheless, the comparative effectiveness and safety of traditional nitinol vs. fully biodegradable occluders remain to be fully elucidated and warrant further investigation.Materials and methodsThis retrospective cohort study included 158 migraine patients with a confirmed patent foramen ovale (PFO) and a grade II–III right-to-left shunt (RLS) as determined by contrast-enhanced transthoracic echocardiography (cTTE), who underwent transcatheter PFO closure at Shanghai East Hospital, Tongji University, between October 2023 and January 2024. …”
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Distribution characteristics, source apportionment, and health risk assessment of metals and metalloids in PM2.5 in a southern city in 2019 by Yaxin QU, Suli HUANG, Chao WANG, Jie JIANG, Jiajia JI, Daokui FANG, Shaohua XIE, Xiaoheng LI, Ning LIU

“…ObjectiveTo assess the distribution characteristics of metals and metalloids in outdoor PM2.5 in a southern city of China, conduct source apportionment, and evaluate the associated health risks, thereby providing theoretical support for further pollution control measures. MethodsPM2.5 samples were collected in districts A, B, and C of a southern China city, and the concentrations of 17 metals and metalloids were detected by inductively coupled plasma-mass spectrometry (ICP-MS). …”
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Association between serum albumin and severe impairment of activities of daily living in patients with stroke: a cross-sectional study by Ranran Bi, Yupeng Shi, Manrong Li, Xiaochen Liu, Zhenchao Ma, Yiqing Huang, Bingyin Liang, Fang Cui

“…This study aims to provide further results.Materials and methodsThis study examined cross-sectional data from patients aged 18 years or older with a diagnosis of stroke confirmed by cranial CT or MRI within 24 h of admission, gathered from January 2020 to August 2022. …”
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Effect of Telemedicine-Supported Structured Exercise Program in Patients with Chronic Low Back Pain: Study Protocol for a Randomized Controlled Trial by Feng Y, Jia C, Liu H, Bao T, Wang C, Wang Z, Huang J, Jiang Y, Wang X, Zhang R, Zhang Y, Zhang S, Zhu S, He C

“…Consequently, further research is warranted to clarify the impact of telemedicine-supported structured exercise programs on patients with CLBP.Patients and Methods: This randomized controlled trial will include patients with CLBP who have not received exercise therapy in the past three months. …”
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Human Neural Stem Cells Reduce Hypoxia-Ischemic Neurological Impairment Through the Regulation of Inflammatory M1/M2 Microglias in Rats by Ding YB, Zhao Y, Chen BY, Wang Q, Wang ZY, Luan Z, Yi B

“…Ya-Bing Ding,1,2,* Yuan Zhao,1– 3,* Bing-Yu Chen,1 Qian Wang,1 Zhao-Yan Wang,1 Zuo Luan,1,2 Bin Yi4 1Department of Pediatrics, The Sixth Medical Center of PLA General Hospital, Beijing, People’s Republic of China; 2Department of Pediatrics, The Second School of Clinical Medicine, Southern Medical University, Guangzhou, People’s Republic of China; 3Department of Neonatology, Children’s Hospital of Shanxi, Women Health Centre of Shanxi, Taiyuan, People’s Republic of China; 4Department of Pediatrics, Gansu Provincial Maternity and Child-Care Hospital, Lanzhou, People’s Republic of China*These authors contributed equally to this workCorrespondence: Zuo Luan, Department of Peadiatric, The Sixth Medical Center of PLA General Hospital, Beijing, 100048, People’s Republic of China, Tel +86-18600310270, Fax +86-1066958303, Email luanzuodoctor@126.com Bin Yi, Gansu Provincial Maternity and Child-care Hospital, Lanzhou, Gansu, 730000, People’s Republic of China, Email www.0931@163.comObjective: This study aims to investigate the therapeutic efficacy and migration of human neural stem cell (hNSC) therapy in a rat model of moderate to severe Hypoxic-ischemic encephalopathy (HIE).Methods: hNSCs were transplanted into the brain ventricle of HIE-induced rats. …”
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The Mechanism of Sijunzi Decoction Suppresses Gastric Cancer Metastasis via the m6A Methyltransferase METTL14 Based on Untargeted Metabolomics Studies and Network Pharmacology Anal... by Li X, Zhao L, Wang J, Ma T, Zhou J, Bian Y, Guo J

“…However, additional research is necessary to comprehend the mechanisms beneath the therapeutic potential of SJZ in gastric cancer.Objective: This research endeavored to analyze how SJZ treats gastric cancer using network pharmacology and experimental validation.Methods: Liquid chromatography coupled with tandem mass spectrometry (LC-MS/MS) and network pharmacology were applied to systemically clarify the mechanism of SJZ against gastric cancer. …”
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Aggregation of Stress Granules Induced by Hypoxia and Lipopolysaccharide via PKR-p-eIF2α Pathway and 4EBP1 Pathway Inhibits the Inflammatory Response in Peri-Implantitis by Li S, Ma C, Fan C, Liu Y, Li J, Yin B, Zhong L, Bai N, Li Z

“…Shuang Li,1,2,* Chunling Ma,3,* Chun Fan,4 Yanshan Liu,5 Jian Li,2,6 Baoheng Yin,1,2 Lingmei Zhong,7 Na Bai,1,2 Zhiyuan Li3 1Department of Prosthodontics, The Affiliated Hospital of Qingdao University, Qingdao, Shandong, People’s Republic of China; 2School of Stomatology, Qingdao University, Qingdao, Shandong, People’s Republic of China; 3Medical Research Center, The Affiliated Hospital of Qingdao University, Qingdao, Shandong, People’s Republic of China; 4Department of Periodontology, The Affiliated Hospital of Qingdao University, Qingdao, Shandong, People’s Republic of China; 5Department of Maxillofacial Surgery, The Affiliated Hospital of Qingdao University, Qingdao, Shandong, People’s Republic of China; 6Department of Oral Implantology, The Affiliated Hospital of Qingdao University, Qingdao, Shandong, People’s Republic of China; 7Department of Pulmonary and Critical Care Medicine, The Affiliated Hospital of Qingdao University, Qingdao, Shandong, People’s Republic of China*These authors contributed equally to this workCorrespondence: Zhiyuan Li, Email zyli0120@163.com Na Bai, Email na.bai@qdu.edu.cnObjective: To investigate whether stress granules (SGs) exist in peri-implantitis (PI) and to explore the formation mechanism and role of SGs in the response of human gingival fibroblasts (hGFs) to hypoxia or LPS.Methods: Gingival tissues were collected from patients with PI and from healthy individuals. …”
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Growth Differentiation Factor-15 as a Potential Biomarker for Renal Involvement in POEMS Syndrome by Huang Y, Chen J, Yao Y, Zhang L, Li Y, Li J

“…Growth differentiation factor-15 (GDF-15) is related with renal function, but few studies have focused on it in renal impairment of POEMS syndrome.Objective: To evaluate the potential of circulating GDF-15 concentration as a biomarker for renal function in POEMS syndrome.Methods: 150 Chinese patients, diagnosed with POMES syndrome, were enrolled and divided into three subgroups according to their chemotherapy stage. …”
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Development and Validation of Predictive Models for Inflammatory Bowel Disease Diagnosis: A Machine Learning and Nomogram-Based Approach by Dong R, Wang Y, Yao H, Chen T, Zhou Q, Zhao B, Xu J

“…This study aimed to develop predictive models for diagnosing IBD, Crohn’s disease (CD), and Ulcerative colitis (UC) by combining two approaches: machine learning (ML) and traditional nomogram models.Methods:  Cohorts 1 and 2 comprised data from the UK Biobank (UKB), and the First Hospital of Jilin University, respectively, which represented the initial laboratory tests upon admission for 1135 and 237 CD patients, 2192 and 326 UC patients, and 1798 and 298 non-IBD patients. …”
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Multinational cross-sectional study and meta-analysis on radicular grooves, C-shaped canals, and taurodontism in mandibular first premolars across 20 countries by Fatma Pertek Hatipoğlu, Güldane Magat, Mohmed Isaqali Karobari, Glynn Dale Buchanan, Maira Kopbayeva, Nessrin Taha, Rafael Fernández-Grisales, Olga Bekjanova, Peter Luu, Sebastian Bürklein, Abdulbaset Mufadhal, Xenos Petridis, María Fernanda Mora, Surendar Sugumaran, Safaa Allawi, Anja Ivica, Wen Yi Lim, Abdulrahman Fadag, Rohan Jagtap, Tomasz Kulczyk, Suha Alfirjani, Paulo J. Palma, Ömer Hatipoğlu

“…This study aimed to investigate the prevalence and regional variations of C-shaped canals, RGs, and taurodontism across 20 countries using CBCT imaging and meta-analytic methods. A multicenter, cross-sectional study analyzed CBCT datasets from 6,000 participants (12,000 teeth) distributed equally across 20 countries. …”
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DONOR-TRANSMITTED CORONARY ATHEROSCLEROSIS by B. L. Mironkov, V. V. Chestukhin, R. Sh. Saitgareev, V. M. Zakharevich, V. N. Poptsov, A. Ya. Kormer, G. A. Akopov, T. A. Khalilulin, A. M. Golts, A. R. Zakiryanov, V. V. Golubitsky, N. Yu. Zakharevich, S. V. Gautier

“…To estimate opportunities, prospects and safety of using heart transplants from aged donors who are at high risk of coronary atherosclerosis.Materials and methods. Over the period from March 1987 to May 2014450 heart transplantations (HTx) were performed in V.I.Shumakov Federal Research Center of Transplantology and Artifi cial Organs. …”
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A modified Delphi consensus statement on the role of biopsy in small renal masses by Darryl E. Bernstein, Hannah Warren, Joseph Santiapillai, Geraldine Fox, William H. Wildgoose, Grant D. Stewart, Jim Armitage, Pieter Le Roux, Frank X. Keeley Jr, Nicholas Campain, Ben Challacombe, Hazel Warburton, Carlotta Palumbo, Riccardo Campi, Stjin H. J. Muselaers, Miles Walkden, Steve Bandula, Dominic Yu, Michael Gonsalves, My‐Anh Tran‐Dang, Nazanin Etessami, Pedro Oliveira, Anna Calio, Soha El‐Sheikh, Tze Wah, Axel Bex, Ravi Barod, Kurinchi Gurusamy, Maxine G. B. Tran

“…Abstract Objective To understand the variable utilisation of diagnostic biopsy for small renal masses (SRM) across the urology community, we worked with expert clinicians and patients to produce a consensus statement on the role of biopsy and to identify research gaps. Methods In phase I, qualitative interviews were performed to identify potential statements on the role of biopsy and research gaps. …”
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Molecular Monitoring of RUNX1-RUNX1T1 Transcript Level in Acute Myeloblastic Leukemias on Treatment by LL Girshova, EG Ovsyannikova, SO Kuzin, EN Goryunova, RI Vabishchevich, AV Petrov, DV Motorin, DV Babenetskaya, VV Ivanov, KV Bogdanov, IV Kholopova, TS Nikulina, YuV Mirolyubova, YuA Alekseeva, AYu Zaritskii

“…To estimate the dynamics of the RUNX1-RUNX1T1 level and relevant clinical manifestations during the monitoring of various stages of the program therapy and after its completion. Methods. The article presents a description of 10 cases of AML with isolated RUNX1-RUNX1T1 expression (n = 4) and the expression in combination with different molecular and cytogenetic abnormalities (n = 6). …”
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Closing the Sex-Based Differences in Stroke Care: Insights from a Large Telestroke Network on Treatment and Postacute Management by Soledad Pérez-Sánchez, Ana Barragán-Prieto, Juan Bautista Loscertales, Juan Antonio Cabezas Rodríguez, Elena Zapata-Arriaza, Laura Amaya Pascasio, Andrés Hermosín Gómez, Miguel Ángel Gamero García, Benito Galeano, Javier Fernández, Blanca Pardo Galiana, Ana Domínguez Mayoral, Leire Ainz Gómez, Jose Fernández Navarro, Cristina del Toro, Manuel Medina, Reyes de Torres, Pablo Baena, Francisco Moniche, Roberto Valverde Moyano, Patricia Martínez, Alejandro González, Joan Montaner

“…We investigated whether women are attended in a similar way to men in the telestroke network with specialized stroke physicians. Methods: A prospective registry of ischemic strokes recorded in the centralized Andalusian telestroke network was analyzed, focusing on sex differences. …”
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Advanced Doppler Ultrasound Insights: A Multicenter Prospective Study on Healthy Skin by Priscila Giavedoni, Jorge Romaní, Francisco de Cabo, Francisco Javier García-Martínez, Mónica Quintana-Codina, Esther Roè-Crespo, Irene Fuertes de Vega, Xavier Soria-Gili, Rafael Aguayo-Ortiz, Patricia Garbayo-Salmons, Gonzalo Castillo, David Vidal-Sarró, Jordi Mollet, Laura Serra, Carlos Gonzalez, Emilio López-Trujillo, Miquel Just, Marc Combalia, Sebastian Podlipnik, Josep Malvehy, Ximena Wortsman

“…<b>Objective:</b> This study aimed to evaluate the visible vessels of healthy skin using Doppler ultrasound. <b>Methods:</b> Prospective multicenter study using Doppler ultrasound to analyze healthy skin. …”
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Real-Life Clinical Use and Outcomes of Fusion Imaging-Guided Percutaneous Microwave Ablation of Hepatocellular Carcinoma: Experience from Two Italian Centers by Pierpaolo Biondetti, Francesco Cicchetti, Gaetano Valerio Davide Amato, Velio Ascenti, Niccolò Finardi, Jacopo Tintori, Francesco Ugo Iovino, Carolina Lanza, Salvatore Alessio Angileri, Pierluca Torcia, Anna Maria Ierardi, Giacomo Vignati, Lorenzo Giovanni Monfardini, Gianpaolo Carrafiello

“…This study reports real-life outcomes of USFI-guided microwave ablation (MWA) for HCC in two Italian centers. <b>Materials and Methods:</b> In this multicentric retrospective study, 56 patients with 73 poorly or non-visible HCC nodules underwent USFI-guided percutaneous MWA with no visibility or poor visibility on B-mode US. …”
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