Effect of Esketamine on Cognitive Recovery After Propofol Sedation for Outpatient Colonoscopy: A Randomized Clinical Trial by Liu D, Gao X, Zhuo Y, Cheng W, Yang Y, Wu X, Yang H, Yao Y

“…This study investigated the effects of esketamine on multiple dimensions of recovery, particularly cognition, in patients undergoing colonoscopy with propofol-based sedation.Patients and Methods: We conducted this randomized, double-blinded, placebo-controlled trial from January 6, 2023, to May 20, 2024, at two hospitals in China. …”
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Inhibition of the MRSA Biofilm Formation and Skin Antineoplastic Activity of Ethyl Acetate Roots and Aerial Parts Extracts from <i>Geum urbanum</i> L. by Lyudmila Dimitrova, Maya M. Zaharieva, Lilia Tserovska, Milena Popova, Vassya Bankova, Hristo Najdenski

“…<b>Objectives:</b> The aim of our study was to evaluate the antibiofilm potential of ethyl acetate roots (EtOAcR) and aerial parts (EtOAcAP) extracts from the perennial Bulgarian plant <i>Geum urbanum</i> L. against methicillin-resistant <i>S. aureus</i> (MRSA) NBIMCC 8327. <b>Methods</b>: The effects of both extracts on the expression of biofilm-related genes, <i>ica</i>A and <i>ica</i>D, were investigated. …”
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Association and Comparison of Systemic Inflammation Indicators and Myocardial Injury After Noncardiac Surgery in Older Patients by Meng B, Zhang K, Liu C, Yao S, Li Z, Lou J, Fu Q, Liu Y, Cao J, Mi W, Li H

“…Bingbing Meng,1,2,&ast; Kai Zhang,1,2,&ast; Chang Liu,2,3 Siyi Yao,1,2 Zhao Li,1,2 Jingsheng Lou,1,2 Qiang Fu,1,2 Yanhong Liu,1,2 Jiangbei Cao,1,2 Weidong Mi,1,2,4 Hao Li1,2,4 1Medical School of Chinese People’s Liberation Army (PLA), Beijing, People’s Republic of China; 2Department of Anesthesiology, The First Medical Center, Chinese People’s Liberation Army General Hospital (PLAGH), Beijing, People’s Republic of China; 3Nankai University, Tianjing, People’s Republic of China; 4National Clinical Research Center for Geriatric Diseases, Chinese PLA General Hospital, Beijing, People’s Republic of China&ast;These authors contributed equally to this workCorrespondence: Weidong Mi; Hao Li, Department of Anesthesiology, The First Medical Center, Chinese People’s Liberation Army General Hospital (PLAGH), 28th Fuxing Road, Haidian District, Beijing, 100853, People’s Republic of China, Email wwdd1962@aliyun.com; lihao301@126.comObjective: To identify the association between preoperative inflammatory state and myocardial injury after noncardiac surgery (MINS) in older patients using systemic inflammation indicators neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), and systemic immune-inflammation index (SII) and to compare their clinical predictive values.Methods: This study included patients aged ≥ 65 years who underwent noncardiac surgery between January 2017 and August 2019. …”
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Engaging Community-Dwelling Older Adults in Research: Qualitative Substudy of Factors Impacting Participation by Bryah Boutilier, Grace Warner, Brianna Wolfe, Sorayya Askari, Elaine Moody, Parisa Ghanouni, Tanya Packer

“…The substudy aimed to identify motivations that influence older adults’ engagement in research and barriers to their participation. MethodsData collection involved qualitative semistructured interviews with 27 older adults, with a mean age of 77 (SD 5.4), who had completed a comprehensive assessment. …”
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Diagnostic and prognostic significance of detecting mutations in the <i>BRAF, TERT, RAS, RET/PTC, PAX8/PPARG</i> in the material of fine needle aspiration biopsy thyroid nodules in... by A. A. Musaelyan, S. V. Lapin, V. D. Nazarov, E. S. Kozorezova, S. L. Vorobyev, S. V. Orlov

“…In group 2, using the genetic panel sensitivity and specificity were equal: 36.4 and 93.9 %, respectively. positive and negative predictive values were 66.7 and 81.6 %, respectively. …”
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Associations Between Health Literacy and Chronic Disease Prevalence Among Employees in Chinese Petroleum Companies: A Cross-Sectional Study by Ma H, Su Y, Zhao S, Wang Y, Wei X, Qu H

“…However, its specific role in this workforce is not well understood.Objective: This study investigates the associations between health literacy and the prevalence and number of chronic diseases among employees in a Chinese petrochemical company.Methods: In March 2022, a cross-sectional survey collected 39,491 valid responses from employees of a large petrochemical company in Shandong Province, China. …”
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Sericin-Assisted Green Synthesis of Gold Nanoparticles as Broad-Spectrum Antimicrobial and Biofilm-Disrupting Agents for Therapy of Bacterial Infection by Cai R, Cheng Q, Zhao J, Zhou P, Wu Z, Ma X, Hu Y, Wang H, Lan X, Zhou J, Tao G

“…Therefore, it is critical to develop simple and effective strategies to kill bacteria and remove biofilms.Methods: The present study used sericin as a reducing and stabilizing agent to synthesize sericin-gold nanoparticles (Ser-Au NPs) and tested its colloidal stability under different pH and salt concentration conditions. …”
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DIAGNOSIS OF CAROTID PARAGANGLIOMA: MULTIDISCIPLINARY ASPECTS by I. V. Stepanov, M. S. Ol’shanskiy, D. Yu. Kharitonov, V. V. Dmitriev, A. V. Podoprigora, A. S. Shcherbinin

“…Objective: to enhance the efficiency of diagnosis and treatment of  carotid paragangliomas, by introducing of a multidisciplinary approach into clinical practice.Material and methods. A total of 15 cases of paragangliomas have been followed up for 10 years. …”
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SIRT2 Promotes NLRP3-Mediated Microglia Pyroptosis and Neuroinflammation via FOXO3a Pathway After Subarachnoid Hemorrhage by Sun JQ, Sheng B, Gao S, Liu XZ, Cui Y, Peng Z, Chen XX, Ding PF, Zhuang Z, Wu LY, Hang CH, Li W

“…Jia-Qing Sun,1,5,&ast; Bin Sheng,2,5,&ast; Sen Gao,2,5,&ast; Xun-Zhi Liu,2,5 Yue Cui,4,5 Zheng Peng,2,5 Xiang-Xin Chen,2,5 Peng-Fei Ding,3,5 Zong Zhuang,2,5 Ling-Yun Wu,2,5 Chun-Hua Hang,1– 5 Wei Li2– 5 1Department of Neurosurgery, Nanjing Drum Tower Hospital, Drum Tower Hospital Clinical College, Xuzhou Medical University, Nanjing, People’s Republic of China; 2Department of Neurosurgery, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, People’s Republic of China; 3Department of Neurosurgery, Nanjing Drum Tower Hospital Clinical College of Nanjing Medical University, Nanjing, People’s Republic of China; 4Department of Neurosurgery, Nanjing Drum Tower Hospital Clinical College of Nanjing University of Chinese Medicine, Nanjing, People’s Republic of China; 5Neurosurgery Institute of Nanjing University, Nanjing, People’s Republic of China&ast;These authors contributed equally to this workCorrespondence: Chun-Hua Hang; Zong Zhuang, Department of Neurosurgery, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Nanjing, 210006, People’s Republic of China, Tel +86 25 83106666-11902 ; +86 25 83106666-11901, Email hang_neurosurgery@163.com; zhuangzong@njglyy.comPurpose: This study primarily elucidating the specific mechanism of SIRT2 on neuroinflammation and microglial pyroptosis in a mouse model of SAH.Patients and Methods: CSF were collected from 57 SAH patients and 11 healthy individuals. …”
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Routine Laboratory Markers-Based Machine Learning Model for Predicting Severe Kawasaki Disease in Pediatric Patients by Wu M, Chen J, Gao Y, Chen H, Li W

“…This study introduces a novel machine learning approach for the early prediction of SKD in pediatric populations, utilizing routinely collected laboratory parameters.Methods: We extracted patients’ age, sex, and 67 standard laboratory markers from the clinical records of 1,466 patients diagnosed with KD at the Children’s Hospital of Nanjing Medical University. …”
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Peran Gembala Sidang Dalam Mengajar Dan Memotivasi Untuk Melayani Terhadap Pertumbuhan Rohani Pemuda by Talizaro Tafonao

“…In finding the answers of this study, researchers used quantitative research methods with descriptive research type. After conducted field research and data processing using SPSS 19 program with the result are: First, Based on correlation analysis (r) Spearmen model, then obtained correlation analysis results that there is correlation between the influence of the role of pastor in teaching with spiritual growth of youth GKII Shalom Kalasan of 0.461. …”
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The Chain Mediating Role of Hope and Posttraumatic Growth Between Social Support and Psychological Distress Among Lung Cancer Patients by Huang JG, Xu CH, Shi YM, Jiang J, Huang FM, Xu LL

“…Jin-Gui Huang,1,&amp;ast; Chen-Han Xu,2,&amp;ast; Yu-Mei Shi,1 Juan Jiang,3 Feng-Mei Huang,1 Ling-Li Xu4 1Department of Medical Oncology, Chongqing University Cancer Hospital, Chongqing, 400030, People’s Republic of China; 2College of Computer Science, Chongqing University, Chongqing, 400000, People’s Republic of China; 3Department of Gastroenterology, Chongqing University Cancer Hospital, Chongqing, 400030, People’s Republic of China; 4Department of Human Resources, Chongqing University Cancer Hospital, Chongqing, 400030, People’s Republic of China&amp;ast;These authors contributed equally to this workCorrespondence: Ling-Li Xu, Department of Human Resources, Chongqing University Cancer Hospital, No. 181, Hanyu Street, Shapingba District, Chongqing, 400030, People’s Republic of China, Tel +86 15823276672, Email 15823276672@163.comPurpose: This research was designed to explore whether hope and posttraumatic growth (PTG) played a mediating role between social support and psychological distress in patients diagnosed with lung cancer.Patients and Methods: A hospital-based cross-sectional study was carried out on 502 lung cancer patients. …”
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Exploring Nursing Students&rsquo; Awareness and Willingness to Participate in Multi-Site Practice: A Cross-Sectional Study by Li F, Huang Q, Xiong L, Lei C, Mou S, Zhou Y, Liang R, Yu H, Zhang H, Ren X, Shi Q

“…For example, will inadequate laws and regulations, occupational safety issues or excessive work load affect their willingness?Methods: This cross-sectional study was conducted across eight provinces in China, involving 1014 nursing students who participated in an online survey between October and November 2021.Results: Among the 1014 nursing students surveyed, 61.74% were introduced to multi-site practice through their educational institutions, 75.25% expressed support for multi-site practice, and 53.75% indicated a willingness to engage in multi-site practice. …”
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Efficacy and Safety of Hepatic Artery Infusion Chemotherapy Combined with Donafenib and Camrelizumab in the Treatment of Patients with Unresectable Hepatocellular Carcinoma: A Retr... by Wu C, Fu Z, Pan L, Li J, Zhou Y, Sun R, Gou Y, Zhao Y, Wang Z, Qiu Y, Huang P

“…Chenrui Wu,1,&amp;ast; Zixuan Fu,1,&amp;ast; Long Pan,1 Jiachu Li,2 Yin Zhou,3 Ruirui Sun,1 Yang Gou,1 Yaowu Zhao,1 Zhouyan Wang,1 Yuhao Qiu,1 Ping Huang1 1Department of Hepatobiliary Surgery, First Affiliated Hospital of Chongqing Medical University, Chongqing, People’s Republic of China; 2Department of Oncology, First Affiliated Hospital of Chongqing Medical University, Chongqing, People’s Republic of China; 3Department of Radiology, First Affiliated Hospital of Chongqing Medical University, Chongqing, People’s Republic of China&amp;ast;These authors contributed equally to this workCorrespondence: Ping Huang, Department of Hepatobiliary Surgery, The First Affiliated Hospital of Chongqing Medical University, No. 1, Youyi Road, Yuzhong District, Chongqing, 400016, People’s Republic of China, Email huangping4069@163.comPurpose: To evaluate the efficacy and safety of hepatic artery infusion chemotherapy with oxaliplatin, fluorouracil, and leucovorin (FOLFOX-HAIC) combined with donafenib and camrelizumab in patients with unresectable hepatocellular carcinoma (uHCC).Patients and Methods: This retrospective study analyzed clinical data from 49 uHCC patients treated with FOLFOX-HAIC, donafenib tablets, and camrelizumab at the First Affiliated Hospital of Chongqing Medical University between November 1, 2021, and November 30, 2024. …”
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Study of heart rate variability in healthy humans as a function of age: considerations on the contribution of the autonomic nervous system and the role of the sinoatrial node by David A. Jorge Tasé, David A. Jorge Tasé, Leopoldo Garavaglia, Magdalena M. Defeo, Isabel M. Irurzun

“…This work provides further insights into the contribution of the SAN and the ANS to the cardiac rhythm in humans.MethodsWe analyzed a total of 205 HRV time series of healthy subjects. …”
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The Clinical Value of the Combined Detection of Systemic Immune-Inflammation Index (SII), Systemic Inflammation Response Index (SIRI), and Prognostic Nutritional Index (PNI) in Ear... by Zheng J, Zheng L, Wang X, Mao X, Wang Q, Yang Y, Mo D

“…The study delves into novel hematological inflammatory markers, such as systemic immune-inflammation index (SII), systemic inflammation response index (SIRI), and prognostic nutritional index (PNI), to explore their potential applications in early diagnosis of GC.Methods: From October 2020 and August 2024, 1339 GC patients admitted to our hospital were enrolled in this study. …”
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Advances in Machine Learning for Mechanically Ventilated Patients by Xu Y, Xue J, Deng Y, Tu L, Ding Y, Zhang Y, Yuan X, Xu K, Guo L, Gao N

“…ML can optimize patient management, improving clinical decisions, patient outcomes, and resource use.Objective: This review aims to summarize the current applications, challenges, and future directions of machine learning in managing mechanically ventilated patients, focusing on prediction models for extubation readiness, oxygenation management, ventilator parameter optimization, clinical prognosis, and pulmonary function assessment.Methods: Multiple databases, including PubMed, Web of Science, CNKI and Wanfang Data were systematically searched for studies on machine learning in mechanical ventilation management. …”
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Wenqing Yin Attenuates the Allergic Contact Dermatitis Response by Inhibiting the JAK2/STAT1 and MAPK Signaling Pathways by Ren M, Li S, Li S, Tan Z, Shi J

“…Wenqing Yin (WQY) is a classic prescription commonly used to treat ACD in China and Japan, and this study aims to explore the pharmacological effect and therapeutic mechanism of WQY to treat ACD.Methods: The pharmacological effect of WQY were investigated using a mouse model caused by 2,4-dinitrofluorobenzene, and the Th1 and Th2 cells numbers in spleen were measured. …”
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Co-Delivery of Dacarbazine and miRNA 34a Combinations to Synergistically Improve Malignant Melanoma Treatments by Ding B, Li M, Zhang J, Zhang X, Gao H, Gao J, Shen C, Zhou Y, Li F, Liu A

“…This study developed a promising strategy for tumor-targeted co-delivery of Dacarbazine (DTIC) and miRNA 34a-loaded PHRD micelles (Co-PHRD) for combination treatment of MM.Methods: To construct the dual drug-loaded delivery system Co-PHRD, poly (L-arginine)-poly (L-histidine)-polylactic acid (PLA) was employed as a building block. …”
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Prognostic Value of Peripheral Blood nCD64 Index, mHLA-DR, and CD14+monocyte Percentage in Different Infection Status in COVID-19 Patients by Zhu M, Cheng J, He L, Li C, Shi B, Jin M, Yu J, Huang J

“…Mingli Zhu,1,&amp;ast; Jianghao Cheng,1,2,&amp;ast; Lingyan He,1,&amp;ast; Chaodan Li,1 Bin Shi,1 Meitong Jin,1 Jianhua Yu,3 Jinsong Huang3 1Open Laboratory, Hangzhou Xixi Hospital Affiliated to Zhejiang Chinese Medical University, Hangzhou, Zhejiang, People’s Republic of China; 2Laboratory Medicine, Zhejiang Cancer Hospital, Hangzhou, Zhejiang, People’s Republic of China; 3Department of Infectious Diseases, Hangzhou Xixi Hospital Affiliated to Zhejiang Chinese Medical University, Hangzhou, Zhejiang, People’s Republic of China&amp;ast;These authors contributed equally to this workCorrespondence: Jianhua Yu, Email yujhmc@126.com Jinsong Huang, Email huangjinsongyz@126.comObjective: To explore the value of the neutrophil CD64 (nCD64) index, monocytic HLA-DR (mHLA-DR), and the percentage of CD14+ monocytes in the prognosis of Coronavirus disease 2019 (COVID-19).Methods: Fifty-seven COVID-19 patients from December 2022 to November 2023 were divided into two groups: non-severe group (mild or moderate cases) and severe group (severe or critical cases). …”
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