IL-8 Downregulation Mediates the Beneficial Effects of Infection-Induced Fever on Breast Cancer Prognosis by Li H, Liang X, Ma J, Liu Q, Lin Y, Tang J, Ren Z, Liang Z

“…However, the key cytokines and the underlying mechanisms through which fever exerts its anti-tumor effects remain unclear.Patients and Methods: A total of 794 breast cancer patients were recruited between 2008 and 2017, with follow-up extending until October 31st, 2023. …”
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MiRNAs and Neutrophil-Related Membrane Proteins from Plasma-Derived Extracellular Vesicles for Early Prediction of Organ Dysfunction and Prognosis in Septic Patients by Ye R, Wei Y, Li J, Xu M, Xie H, Huang J, Deng L, Li C

“…We sought to investigate the profile of extracellular vesicles (EVs)-mediated communication between plasma and polymorphonuclear neutrophils (PMNs) in sepsis, and to elucidate whether miRNAs and PMN-related membrane proteins from plasma-derived EVs (plasma-EVs) are associated with sepsis-induced organ dysfunction and prognosis.Methods: PMN-derived EVs (PMN-EVs) were isolated from the blood samples of healthy controls (N=3) and patients with septic shock (N=3) after ICU admission. …”
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Hypoxia-induced genome-wide DNA demethylation by DNMT3A and EMT of cancer cells by Biswanath Chatterjee, Pritha Majumder, Chun-Chang Chen, Jing-Ping Wang, Po-Hsuan Su, Hung-Cheng Lai, Ching-Chen Liu, Hsin-Nan Lin, Chen-Hsin A. Yu, Hanna S. Yuan, Che-Kun James Shen

“…Previously, the mammalian DNA methyltransferases (DNMTs) have been shown to possess redox- and Ca++- dependent active DNA 5mC demethylation activities in addition to the cytosine methylation activity. Methods In this study, we have carried out experiments using a range of molecular, cellular, and genome editing approaches including cell culturing, CRISPR/Cas9-editing, si- or sh-RNA-mediated knockdown, quantitative RT-PCR, western blotting, ChIP-qPCR, Na-bisulfite sequencing, EMT and lung colonization assays in conjunction with DNA methylome and DNMT3A ChIP-Seq analyses, Results We found that active DNA demethylation activity of DNMT3A is essential for hypoxia-induced EMT of the SW480 colon cancer cells, its global genomic DNA demethylation, and promoter DNA demethylation/transcriptional activation of EMT-associated genes including TWIST1 and SNAIL1. …”
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Autonomic Nervous Regulation was Associated with Sleep Quality Among Peritoneal Dialysis Patients by Huang B, Qian Y, Gao Y, Chen Z, Zhang L, Mao H, Xing C, Ren H, Wang J

“…However, the relationship between autonomic nervous system activity and sleep remains inadequately elucidated.Methods: This cross-sectional study enrolled adult maintenance PD patients in our center. …”
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Integration of single-cell sequencing and drug sensitivity profiling reveals an 11-gene prognostic model for liver cancer by Qunfang Zhou, Jingqiang Wu, Jiaxin Bei, Zixuan Zhai, Xiuzhen Chen, Wei Liang, Jing Meng, Mingyu Liu

“…Methods We downloaded single-cell sequencing data from GSE189903, grouped cells by cluster markers, and classified epithelial cells into adjacent non-tumor, normal, and tumor cells. …”
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Identification of Epigenetic Alteration of the IFI44L Gene in B Cells of Sjogren’s Syndrome as a Clinical Biomarker and Molecular Significance by Zhang K, Luo Z, Yao X, Lu D, Hong T, Zhu X, Chen M, Wang X

“…This study investigated gene expression and epigenetic changes in IFI44L, analyzing its correlation with disease activity and clinical indicators.Methods: Differentially expressed genes (DEGs) were identified from the GSE199868 dataset, while IFN-I-related genes were collected from GeneCards. …”
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High BMP7 Expression May Worsen Airway Disease in COPD by Altering Epithelial Cell Behavior by Dong W, Xie M, Ming C, Li H, Xu X, Cui L, Wang W, Li Y

“…Previous research has shown that BMP7 is highly expressed in the airway epithelia of patients with COPD, but its role in airway disease has not been fully elucidated.Methods: A lung tissue cohort and a sputum cohort were included in the study. …”
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Cinobufagin Suppresses Lipid Peroxidation and Inflammation in Osteoporotic Mice by Promoting the Delivery of miR-3102-5p by Macrophage-Derived Exosomes by Geng Z, Sun T, Yu J, Wang N, Jiang Q, Wang P, Yang G, Li Y, Ding Y, Zhang J, Lin G, Zhao Y

“…This research aims to ascertain the bone-protective properties of cinobufagin and investigate underlying mechanisms.Methods: Mice were ovariectomized to establish an osteoporosis model, followed by intraperitoneal injections of cinobufagin and cinobufagin-treated RAW.264.7-derived exosomes for therapy. …”
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Gubi Decoction Ameliorates Porous Cartilage Endplate in an Intervertebral Disc Degeneration Model Mouse Through Inhibition of NF-κB Activity and Pyroptosis by Yao S, Li Y, Ruan H, Wu L, Zeng H

“…Our prior studies have highlighted the therapeutic potential of Gubi decoction (GBD) in alleviating knee osteoarthritis, however, but the specific mechanism of GBD in treating IVDD is not clear.Objective: To ascertain the clear mechanism of GBD for enhancing its therapeutic efficacy in treating lVDD, through comparison of its effects across different doses of GBD and clinical positive control drugs using a mouse IVDD model.Methods: In this study, 8-week-old male mice were treated with lumbar spine instability (LSI) surgery to construct IVDD model mice. …”
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Downregulation of EB1 impedes Cx43 localization and cardiac conduction after hypothermic ischemia-reperfusion in rats by Chunlei Wen, Rongfeng Yang, Jing Yi, Ying Cao, Yuting Song, Li An, Zijun Wang, Hong Gao

“…This study aims to investigate the role and mechanisms of EB1 in hypothermic ischemia-reperfusion arrhythmia. Methods 4–6 week old male Sprague-Dawley (SD) rats were randomly assigned to four groups with a control group receiving no treatment. …”
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Association Between High Jugular Bulb and Sudden Sensorineural Hearing Loss: A Computed Tomography Based Study by Wanting Y, Rafiq M, Wu J, Jin L, Liu G, Cheng C

“…Yang Wanting,1,* Muhammad Rafiq,2,3,* Juan Wu,4 Long Jin,4 Gang Liu,5 Chunsong Cheng2,3 1Department of Otolaryngology, First Clinical Medical College of Anhui University of Traditional Chinese Medicine, Hefei, Anhui, 23003, People’s Republic of China; 2Jiangxi Key Laboratory for Sustainable Utilization of Chinese Materia Medica Resources, Lushan Botanical Garden, Chinese Academy of Sciences, Jiujiang, Jiangxi Province, 332900, People’s Republic of China; 3Lushan Xinglin Institute for Medicinal Plants, Jiujiang Xinglin Key Laboratory for Traditional Chinese Medicines, Jiujiang, Jiangxi Province, 332900, People’s Republic of China; 4Department of Otolaryngology, First Affiliated Hospital of Anhui University of Traditional Chinese Medicine, Hefei, Anhui, 230031, People’s Republic of China; 5School of Clinical Medicine, Anqing Medical College, Anqing, Anhui, 246000, People’s Republic of China*These authors contributed equally to this workCorrespondence: Gang Liu, Email 1015799606@qq.com Chunsong Cheng, Email chengcs@lsbg.cnObjective: To explore the correlation between high jugular bulb (HJB) and sudden sensorineural hearing loss (SSNHL) by collecting and analyzing data from patients diagnosed with sudden sensorineural hearing loss (SSNHL) accompanied by HJB.Methods: A total of 62 patients with acute deafness admitted to the Otolaryngology ward of the First Affiliated Hospital of Anhui University of Chinese Medicine from October 2023 to June 2024 were included. …”
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An innovative Hearing AED alarm system shortens delivery time of automated external defibrillator – A randomized controlled simulation study by Chih-Yu Chen, Jeffrey Che-Hung Tsai, Shao-Jen Weng, Yen-Ju Chen

“…The aim of this study is to determine if this novel Hearing AED alarm system shortens the AED delivery time. Methods: This was a randomized controlled simulation study. …”
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Gold and Silver Nanoparticles Efficiently Modulate the Crosstalk Between Macrophages and Cancer Cells by Adamecz DI, Veres É, Papp C, Árva H, Rónavári A, Marton A, Vizler C, Gácser A, Kónya Z, Igaz N, Kiricsi M

“…Since it is fairly unknown how the promising anticancer agents, silver (AgNPs) and gold nanoparticles (AuNPs) affect the bidirectional communication and reprogramming in the tumor stroma, we examined the behavior, the tumor-supporting functions, and the expression of polarization and functional marker genes of TAMs to reveal how these are modulated upon interaction with nanoparticle-exposed cancer cells.Methods: We established co-cultures of murine immortalized J774 or primary bone marrow-derived macrophages with 4T1 breast cancer cells treated with AuNPs or AgNPs or with none of the nanoparticles. …”
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Unveiling PANoptosis in Acute Kidney Injury: An Integrative Multi-Dimensional Approach to Identify Key Biomarkers by Wang N, Zhang L, Xu Z, Xu Q, Lu Y, Niu P, Yan L, Wang L, Cao H, Shao F

“…While this process has been implicated in various inflammatory conditions, its specific role in AKI remains unclear.Methods: The role of PANoptosis in AKI was investigated using single-cell RNA sequencing (scRNA-seq) and bulk transcriptomic data. …”
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Influence of additional risk factors on the antihypertensive efficacy of eprosartan and telmisartan in patients with essential hypertension by V. V. Syvolap, O. V. Vizir-Tronova

“…The aim of this study is to determine the effect of additional risk factors on blood pressure parameters, cardiovascular remodeling and the state of vegetative balance of the heart rhythm in patients with stage II essential hypertension (EH) under treatment with eprosartan and telmisartan. Materials and methods. The study included 100 patients with stage II essential hypertension (EH), 1–2 degrees with a low and moderate risk of developing cardiovascular complications. …”
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Non-Luminal Disease Score for Everolimus in Patients with Hormone Receptor‑positive and Human Epidermal Growth Factor Receptor 2-Negative Advanced Breast Cancer: A Mult... by Tan Y, Jiang H, Tian X, Ma F, Wang J, Zhang P, Xu B, Fan Y, Zhao W

“…Yujing Tan,1,* Hanfang Jiang,2,* Xinzhu Tian,1,* Fei Ma,1 Jiayu Wang,1 Pin Zhang,1 Binghe Xu,1 Ying Fan,1 Weihong Zhao3 1Department of Medical Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, 100021, People’s Republic of China; 2Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Department of Breast Oncology, Peking University Cancer Hospital & Institute, Beijing, 100142, People’s Republic of China; 3Department of Medical Oncology, Chinese PLA General Hospital, Beijing, 100853, People’s Republic of China*These authors contributed equally to this workCorrespondence: Ying Fan; Weihong Zhao, Email fanying@cicams.ac.cn; zhaowh0818@163.comPurpose: This study aims to explore the role of the non-luminal disease score (NOLUS) for everolimus in patients with hormone receptor-positive and human epidermal growth factor receptor 2-negative (HR+/HER2-) advanced breast cancer (ABC).Methods: NOLUS has previously been established as an algorithm: NOLUS (0– 100) = − 0.45 × ER(%) − 0.28 × PR(%) + 0.27 × Ki67(%) + 73. …”
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Identification and Evaluation of Lipocalin-2 in Sepsis-Associated Encephalopathy via Machine Learning Approaches by Hu J, Chen Z, Wang J, Xu A, Sun J, Xiao W, Yang M

“…Identifying and screening key genes responsible for SAE, as well as exploring potential targeted therapies, are vital for improving the management of sepsis and advancing precision medicine.Patients and Methods: Single-cell RNA sequencing (scRNA-seq) was administrated to identify cell subpopulations related to poor prognosis in septic patients. …”
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Nanoformulations Downregulating METTL16 Combined with mRNA Tumor Vaccines Suppress Triple-Negative Breast Cancer and Prevent Metastasis by Wang R, Zhang Y, Du S, Li Y, Ren Y, Lin J

“…The integration of this formulation with emerging mRNA tumor vaccines aimed to effectively inhibit the growth and metastasis of TNBC.Research Methods: Using microfluidic technology, efficient siRNA encapsulation in lipid nanoparticle (LNP) yielded LNP/siMETTL16 and selective organ-targeting LNP/siMETTL16 (SORT-LNP/siMETTL16). …”
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Telehealth Modality Preferences for Video and Voice-Only Visits Among US Clinicians and the Public: Cross-Sectional, Web-Based Survey Study by Rachel C Forcino, Julie K Johnson, Glyn Elwyn

“…ObjectiveWe aimed to identify telehealth modality preferences (voice vs video) among clinicians and the populations they serve and explore the barriers to telehealth use from clinician and public perspectives. MethodsWe conducted 2 independent, cross-sectional, web-based surveys. …”
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Hypoxic Burden and T90% as Predictive Indicators of Cardiovascular Risk and Myocardial Ischemia in Patients with Obstructive Sleep Apnea by Zeng W, Wu S, Liu Z, Yuan L, Chen B, Rong Y

“…Wenmei Zeng,1,* Sulong Wu,2,* Zhuofan Liu,1 Long Yuan,1 Bilin Chen,1 Yan Rong1 1Department of Pulmonary and Critical Care Medicine, Shenzhen Qian Hai She Kou Free Trade Zone Hospital, Shenzhen, 518067, People’s Republic of China; 2Department of Emergency Intensive Care Medicine, Shenzhen Qian Hai She Kou Free Trade Zone Hospital, Shenzhen, 518067, People’s Republic of China*These authors contributed equally to this workCorrespondence: Yan Rong, Department of Pulmonary and Critical Care Medicine, Shenzhen Qian Hai She Kou Free Trade Zone Hospital, No. 36, Gongye 7th Road, Nanshan District, Shenzhen, 518067, People’s Republic of China, Tel +86-13622230015, Email shanshuisahala@163.comPurpose: This study analyzed the role of hypoxic burden and the percentage of time with blood oxygen saturation below 90% (T90%) in assessing the myocardial ischemia and cardiovascular risk in obstructive sleep apnea (OSA) patients using portable sleep monitors.Patients and Methods: We conducted a prospective observational study of hospitalized OSA patients diagnosed by portable sleep monitors at a single tertiary center in Southern China from January 2022 to March 2024. …”
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