Population Pharmacokinetic/Pharmacodynamic Study of Linezolid in Hospital-Acquired Pneumonia Patients with Renal Insufficiency by Xu J, Chen X, Zhang Q, Zhuang Z, Yuan Y, Duan L, Shi L, Zhu C, Li J, Lu J, Yu Y, Tang L

“…The objective of this study was to compare the outcomes of linezolid versus teicoplanin in HAP patients with renal insufficiency and to explore optimal dosage strategy for linezolid.Methods: The retrospective study enrolled adult patients treated with intravenous linezolid or teicoplanin at Suzhou Municipal Hospital between July 2018 and August 2023. …”
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The Association Between Medication Adherence, Internalized Stigma and Social Support Among Outpatients with Major Depressive Disorder in a Malaysian Hospital: A Cross-Sectional Stu... by Halim R, Kaur M, Syed Mokhtar SS, Chemi N, Sajatovic M, Tan YK, Siau CS, Ng CG

“…This study aimed to investigate poor adherence prevalence and the demographic and clinical factors associated with poor medication adherence among patients with MDD.Methods: This cross-sectional survey recruited participants using universal sampling from a major hospital in Selangor, Malaysia. …”
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Factors Influencing Mechanical Ventilation and Inpatient Palliative Care Utilization in Patients With Chronic Obstructive Pulmonary Disease by Kao LT, Yang CC, Wu YC, Ko SC, Liang YS, Liao KM, Ho CH

“…In this study, we aimed to investigate inpatient palliative care utilization among hospitalized patients with COPD requiring mechanical ventilation and examine the associated risk factors and clinical outcomes.Patients and Methods: A retrospective nested case-control study was conducted using population-based claims datasets from 2017 to 2021. …”
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Mechanism of Qingdai in Alleviating Acute Lung Injury by Inhibiting the JAK2/STAT3 Signaling Pathway by Qi L, Wang S, Guo T, Qi Z, Wu S, Gao D, Yan Z, Tan B, Yang A

“…This investigation demonstrated QD alleviated LPS-induced ALI in mice and exerted anti-inflammatory effects by inhibiting the JAK2/STAT3 signaling pathway.Methods: The active compounds of QD were identified through UPLC-LTQ-Orbitrap-MS/MS. …”
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Distinct Roles of HHLA2 and PD-L1 in the Immune Cell and Prognosis of Hepatocellular Carcinoma by Wang CH, Chen SL, Yang X, Wu T, Liu LL, Yun JP

“…This study aims to elucidate the expression patterns of HHLA2 and PD-L1 in HCC, their associations with tumor-infiltrating lymphocytes (TILs), and their impact on clinical outcomes.Methods: Immunohistochemistry (IHC) was employed to evaluate HHLA2 and PD-L1 expression in 547 HCC tissue samples. …”
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Assessment of Diagnostic Knowledge and the Management of Bell’s Palsy Among Primary HealthCare Physicians in Saudi Arabia by Al Jaber MY, Al Shammari A, Al Subaie FT, Alhowaish Z, Al Harbi MM, AlNaaim SA

“…Particular emphasis was placed on identifying critical knowledge gaps that may affect clinical decision-making, especially in corticosteroid dosing and standardized diagnostic approaches.Patients and Methods: A cross-sectional observational study was conducted in Al-Ahsa, Saudi Arabia. …”
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Sex-Biased CD3ζ 3ʹ-UTR SNP Increased Incidence Risk in Aplastic Anemia by Guo L, Zhang Y, Liu X, Xiao Y, Luo W, Fang S, Li Y, Lai J, Li Y, Li B

“…In this study, our aim was to analyze whether CD3ζ 3ʹ-UTR SNPs were associated with AA susceptibility and had influence on CD3ζ protein level and provide new research data for exploring the pathogenesis of aplastic anemia.Patients and Methods: We screened the genotypes of SNPs in 101 healthy individuals and 91 AA patients by PCR-RFLP and sequencing. …”
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Associations of Protein Classes With Cross-Reactivity and Cross-Sensitization in Furry Animal Allergens: A Component-Resolved Diagnostics Study by Lu J, Zhu H, Yang Q, Xu Y, Huang Z, Sun B

“…Jiancai Lu,1,* Huiqing Zhu,2,* Qingqing Yang,1 Yunjian Xu,1 Zhifeng Huang,1 Baoqing Sun1 1Department of Clinical Laboratory, National Center for Respiratory Medicine, National Clinical Research Center for Respiratory Disease, State Key Laboratory of Respiratory Disease, Guangzhou Institute of Respiratory Health, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong, 510120, People’s Republic of China; 2Department of Clinical Laboratory, Huizhou Central People`s Hospital, Huizhou, Guangdong, 516001, People’s Republic of China*These authors contributed equally to this workCorrespondence: Baoqing Sun; Zhifeng Huang, Department of Clinical Laboratory, National Center for Respiratory Medicine, National Clinical Research Center for Respiratory Disease, State Key Laboratory of Respiratory Disease, Guangzhou Institute of Respiratory Health, the First Affiliated Hospital of Guangzhou Medical University, 151 Yanjiang Road, Guangzhou, Guangdong, 510120, People’s Republic of China, Tel +86 020 81568020, Email sunbaoqing@vip.163.com; zfhuang_gzhmu@163.comObjective: This study aimed to investigate the molecular sensitization patterns of cats, dogs, and horses in patients with cat and/or dog sensitization and the IgE cross-reactivity with other furry animals.Methods: In 95 patients diagnosed with allergic diseases and sensitized to cats and/or dogs (confirmed by specific Immunoglobulin E (sIgE) ≥ 0.35 kUA/L to crude cat and/or dog dander extracts), sIgE levels of cat components (Fel d 1/2/4), dog components (Can f 1/2/3/5), horse dander (Equ c 1), as well as allergens from cow, guinea pig, mouse, rat, rabbit, and chicken, were measured. …”
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A Monocyte-Driven Prognostic Model for Multiple Myeloma: Multi-Omics and Machine Learning Insights by Xie L, Gao M, Tan S, Zhou Y, Liu J, Wang L, Li X

“…Nevertheless, the overall pattern of immune cells and MM pathogenesis within the bone marrow tumor microenvironment (BM-TME) remains underexplored.Methods and Results: Firstly, we performed Mendelian Randomization analysis for 731 immunocyte phenotypes and MM, identifying 21 immune traits significantly associated with increased MM risk (OR> 1, PFDR< 0.05). …”
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High Prevalence of Diabetic Retinopathy in an Outpatient Podiatry Clinic and Associated Barriers to Ophthalmic Care by Larimer-Picciani AM, Brown RB, Ruan H, Jones CE, DeBlasio RN, Burns PR, Williams AM, Waxman EL

“…This study assesses the prevalence of DR in a podiatric clinic while also investigating participant-reported barriers to routine ophthalmic follow-up.Methods: We conducted a cross-sectional study that included patients age ≥ 18 (n=62) receiving diabetic foot care at an outpatient podiatric clinic in 2021 and 2022. …”
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The Frequency of CYP2C19*2 Gene Polymorphisms in Burkina Faso Patients Treated with Clopidogrel by Kagambèga YD, Ouattara AK, Ouédraogo TWC, Traoré L, Yaméogo NV, Simpore J

“…This study aimed to assess the frequency of the CYP2C19*2 (rs4244285, 681 G>A1) polymorphism among patients with cardiovascular diseases undergoing clopidogrel therapy.Patients and Methods: This cross-sectional study recruited a total of seventy-three (73) patients from the Cardiology Department of the Centre Hospitalier Universitaire Yalgado Ouédraogo (CHU-YO) between January and June 2023. …”
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Association between infant feeding practices, COVID-19 related cognitive factors, and postpartum depression during the COVID-19 pandemic: a cross-sectional online study in Thailand by Wichukorn Suriyawongpaisal, Punpawee Kittikul, Eun Young Lee, Li-Yin Chien, Yan-Shing Chang, Kelly Pereira Coca, Doungjai Buntup, Seo Ah Hong

“…., COVID-19-vaccination-related belief and COVID-19-related knowledge and attitude) with infant feeding practices and their associations with PPD during the COVID-19 pandemic in Thai postpartum mothers. Methods A cross-sectional online survey was conducted among 840 postpartum mothers whose infants were less than or equal to 6 months old. …”
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Evaluation of a content-based image retrieval system for radiologists in high-resolution CT of interstitial lung diseases by Benjamin Böttcher, Marly van Assen, Roberto Fari, Philipp L. von Knebel Doeberitz, Eun Young Kim, Eugene A. Berkowitz, Felix G. Meinel, Carlo N. De Cecco

“…Abstract Background This retrospective study aims to evaluate the impact of a content-based image retrieval (CBIR) application on diagnostic accuracy and confidence in interstitial lung disease (ILD) assessment using high-resolution computed tomography CT (HRCT). Methods Twenty-eight patients with verified pattern-based ILD diagnoses were split into two equal datasets (1 and 2). …”
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Association of Serum Ferritin Levels With Obstructive Sleep Apnea in Overweight/Obese US Populations: A Population-Based Study From the NHANES by Zhang Y, Zhou P, Xu C, Su H, Li R, Sun L, Yang Y

“…Yang Zhang,1,* Pinglang Zhou,2,* Chuan Xu,3,* Hua Su,1 Rendong Li,1 Longhua Sun,2 Yihan Yang1 1Jiangxi Provincial Key Laboratory of Respiratory Diseases, Jiangxi Institute of Respiratory Diseases, The Department of Respiratory and Critical Care Medicine, The First Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, 330006, People’s Republic of China; 2The Department of Respiratory and Critical Care Medicine, The First Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, 330006, People’s Republic of China; 3Department of Thoracic Surgery, The First Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, Jiangxi, 330006, People’s Republic of China*These authors contributed equally to this workCorrespondence: Yihan Yang, Jiangxi Provincial Key Laboratory of Respiratory Diseases, Jiangxi Institute of Respiratory Diseases, The Department of Respiratory and Critical Care Medicine, The First Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, 330006, People’s Republic of China, Email yangyihan@email.ncu.edu.cn Longhua Sun, The Department of Respiratory and Critical Care Medicine, The First Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, 330006, People’s Republic of China, Email ndyfy05715@ncu.edu.cnObjective: To investigate the relationship between serum ferritin levels and OSA in overweight/obese individuals and assess the association between ferritin levels and all-cause mortality in overweight/obese female OSA patients.Methods: Cross-sectional (n = 4,809) and prospective (n = 832) data from overweight/obese adults from the 2005– 2008, and 2015-March 2020 NHANES cycles were analyzed. …”
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Microbiological Characteristics, Risk Factors, and Short-Term Mortality of Carbapenem-Resistant Enterobacteriaceae Bloodstream Infections in Pediatric Patients in China: A 10-Year... by Liang Y, Zhao C, Lu Y, Liao K, Kong Y, Hong M, Li L, Chen Y

“…The purpose of this study was to summarize etiological characteristics and identify risk factors relevant to CRE bloodstream infection (BSI) and short-term mortality among pediatric patients in China.Methods: In this study, we included 370 inpatients ≤ 17 years old with BSI caused by Enterobacteriaceae in China from January 2013 to December 2022. …”
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Construction and Brain Validation of circRNAs-miRNAs-mRNAs Regulatory Axis in Early-Onset Schizophrenia by Zhang X, Li Z, Li R, Wang X, Liu H, Du X, Gao Y, Liu S, Xu Y

“…This study aimed to investigate the regulatory patterns and brain validation of circular RNAs-microRNAs-messenger RNAs in early-onset schizophrenia.Methods: Differentially expressed circular RNAs and microRNAs were identified in blood samples from 32 patients with early-onset schizophrenia and 29 healthy controls. …”
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Zuogui Pill Promotes Neurovascular Regeneration and Corticospinal Tract Remodeling After Ischemic Stroke by Wu D, Yan X, Mei S, Hua H, Fei X, Xu X, Liu Y, Wu M, Zhu J, Li W

“…Zuogui pill (ZGP) has good efficacy in treating cerebral ischemia, but the mechanism remains unclear.Purpose: To investigate the effects of ZGP on angiogenesis, neurogenesis, corticospinal tract (CST) remodeling, and further evaluate its mechanisms of action in mice with ischemic stroke.Methods: Network pharmacology was used to analyze the active components, related targets, and mechanisms of ZGP’s action in promoting neurovascular regeneration after ischemic stroke. …”
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Epidemiology and classification of scapular fractures: a detailed survey on a large sample of patients by Matteo Cantore, MD, Davide Manni, MD, Vittorio Candela, MD, Jacopo Preziosi Standoli, PT, Alessandro Are, MD, Stefano Gumina, PhD, MD

“…Our aim was to retrospectively analyze a large number of patients to provide detailed epidemiological information about scapular fractures and to classify them with the latest classification system. Methods: Patients admitted for scapular fracture in two trauma centers over a 7-year period were enrolled. …”
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Nanomedicine-Based Ophthalmic Drug Delivery Systems for the Treatment of Ocular Diseases by Lin X, Zhou Y, Lv K, Wu W, Chen C

“…Conventional drug delivery methods—topical, local injection, and systemic administration—face challenges such as low bioavailability (< 5%), rapid clearance, and physiological barriers like the cornea and blood-retinal barrier (BRB). …”
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MANAGEMENT OF MAGNESIUM DEFICIENCY IN PREGNANT WOMEN: PHARMACOEPIDEMIOLOGIC STUDY by D. V. Blinov, U. V. Zimovina, E. M. Dzhobava

“…Objectives: to evaluate Mg deficiency incidence and management in a pregnant population monitored in Russian polyclinics. Materials and Methods: pregnant women (at any trimester) aged over 18 years were included. …”
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