Differentiations in Illness Duration, Thyroid-Stimulating Hormone, Glucose and P300 Latency Between Drug-Naïve Unipolar and Bipolar Depression: A Comparative Cross-Sectional S... by Li C, Yang L, Zhang Q, Zhang Y, Li R, Jia F, Wang L, Ma X, Yao K, Tian H, Liu Z, Zhuo C

“…The present study aimed to investigate whether demographic, clinical, and biochemical parameters can help differentiate drug-naïve BD from UD.Methods: Drug-naïve patients with UD and BD were recruited from Shandong Mental Health Center. …”
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Predictive Value of IDEAL-IQ and DWI Imaging Biomarkers for P53 Mutations in Hepatocellular Carcinoma by Wang D, Yin H, Li X, Zhou S, Wang YC

“…Dongdong Wang,1,* Huijia Yin,2,* Xiaoming Li,1 Shuwei Zhou,3 Yuan-Cheng Wang3 1Department of Radiology, Zhengzhou People’s Hospital and The Fifth Clinical Medical College of Henan University of Chinese Medicine, Zhengzhou, People’s Republic of China; 2Department of MR, The First Affiliated Hospital of Xinxiang Medical University, Weihui, People’s Republic of China; 3Department of Radiology, Zhongda Hospital, Nurturing Center of Jiangsu Province for State Laboratory of AI Imaging and Interventional Radiology, School of Medicine, Southeast University, Nanjing, People’s Republic of China*These authors contributed equally to this workCorrespondence: Yuan-Cheng Wang, Department of Radiology, Zhongda Hospital, Nurturing Center of Jiangsu Province for State Laboratory of AI Imaging and Interventional Radiology, School of Medicine, Southeast University, Nanjing, 210009, People’s Republic of China, Tel +86 25 83272121, Fax +86 25 83311083, Email yuancheng_wang@seu.edu.cnPurpose: To investigate the application of imaging biomarkers, including R2*, Fat Fraction (FF) and apparent diffusion coefficient (ADC) values, obtained through Iterative Decomposition of water and fat with Echo Asymmetry and Least-squares estimation for Imaging Quantification (IDEAL-IQ) and DWI techniques, in differentiating P53-mutated and non-mutated HCC.Patients and Methods: This retrospective study included patients with pathologically confirmed HCC between January 2019 and July 2024. …”
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Identification of a Missense Mutation in the FLNC Gene from a Chinese Family with Restrictive Cardiomyopathy by Dong J, Zhang W, Chen Q, Zha L

“…By using WES, we attempted to identify the genetic cause of an RCM family and clarify the clinical diagnosis of the patient and then provide a personalized treatment plan.Materials and Methods: Blood samples were obtained from the proband and his healthy parents. …”
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Effects of Stretching and Resistance Training on Psychophysical Awareness: A Pilot Study by Giovanni Esposito, Rosario Ceruso, Pietro Luigi Invernizzi, Vincenzo Manzi, Gaetano Raiola

“…Such findings offer practical implications for coaches seeking to optimize flexibility training by integrating alternative methods that promote both physical and perceptual adaptations.…”
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Gender and age effects on the incidence and severity of chemotherapy-induced neuropathic pain: a propensity score matching analysis by Andreas A. Argyriou, Roser Velasco, Foteini Kalofonou, Pantelis Litsardopoulos, Montse Alemany, Dimitrios Rikos, Haralabos P. Kalofonos, Jordi Bruna

“…Abstract Objective To determine whether the clinical phenotype of chemotherapy-induced neuropathic pain (CINP) varies based on the gender and age of patients. Methods Retrospective, file-based analysis of cancer patients who received any conventional standard of care chemotherapy and were referred to assess the extent of painful chemotherapy-induced peripheral neurotoxicity (CIPN). …”
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Associations Between Psychosocial Influence, Positive Thinking, and Vaccine Attitudes in Patients with Schizophrenia During the COVID-19 Pandemic by Li DJ, Wang WC, Chou FHC, Hsu ST, Hsieh KY, Lin GG, Wu PJ, Liu CL, Wu HC, Huang JJ

“…In this study, we investigated factors influencing vaccine attitudes in patients with schizophrenia and explored the interactions among these factors.Methods: Cross-sectional, self-report surveys were conducted among Taiwanese patients with schizophrenia to collect data on vaccine attitudes and associated variables. …”
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Role of Peripheral Blood Regulatory T Cells and IL-2 in the Collateral Circulation of Acute Ischemic Stroke by Zhang S, Rao C, Wen M, Zhang X, Zha Z, Gu T, Zhu L, Yu C

“…The objective of this investigation was to explore the link between peripheral regulatory T cells (Tregs), interleukin-2 (IL-2), and the status of collateral circulation.Methods: Between September 2023 and May 2024, the study incorporated 117 AIS patients from the neurology department, with 60 identified as having good collateral status (GCS) and 57 with poor collateral status (PCS). …”
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The Inhibitory Effect of the Active Ingredients in the Bushen Huoxue Formula on the IL-17A Signaling Pathway and Its Alleviating Effect on Osteoarthritis by Wang X, Zhang Y, Chang X, Wen X, Tian F, Yu H, Li Y

“…In this study, we employed network pharmacology alongside in vitro and in vivo experiments to elucidate the molecular mechanism by which BSHXF treats OA.Methods: Based on the TCMSP database, active components of BSHXF were screened, and OA-related targets were retrieved from GeneCard and DisGeNET to construct a “component-target-pathway” network using Cytoscape. …”
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Machine Learning Radiomics for Predicting Response to MR-Guided Radiotherapy in Unresectable Hepatocellular Carcinoma: A Multicenter Cohort Study by Su K, Liu X, Zeng YC, Xu J, Li H, Wang H, Du S, Wang H, Yue J, Yin Y, Li Z

“…Machine learning-based radiomics was utilized to predict responses in these patients.Methods: This retrospective study included 118 hCC patients who received MR-guided hypofractionated radiotherapy. …”
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Anemarrhena asphodeloides Bunge-Fritillaria Cirrhosae Bulbus Herb Pair Alleviates Ovalbumin-Induced Asthma by Regulating Arachidonic Acid Pathway by Tian X, Cui Q, Wei J, Zhang Q, Zhang H, Yang M, Xing Y, Niu Y, Li W, Wang N, Jin Y, Du Y

“…This study aimed to investigate how ZC affects asthma and its mechanism.Methods: Asthma model rats were sensitized by ovalbumin. …”
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Optimizing Radiation Dose and Image Quality in Stroke CT Protocols: Proposed Diagnostic Reference Levels for Multiphase CT Angiography and Perfusion Imaging by Robert Forbrig, Christoph G. Trumm, Paul Reidler, Wolfgang G. Kunz, Konstantinos Dimitriadis, Lars Kellert, Johannes Rückel, Thomas Liebig, Robert Stahl

“…We therefore present dosimetry data, while also considering image quality, for a large, unselected patient cohort. Methods: A retrospective single-center study of 1790 patients undergoing the extended stroke protocol with three scanners (2× dual-source, DSCT; 1× single-source, SSCT) between 07/21 and 12/23 was conducted. …”
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The Effects of Novel Thymoquinone-Loaded Nanovesicles as a Promising Avenue to Modulate Autism Associated Dysregulation by Restoring Oxidative Stress in Autism in Mice by Eissa N, Alwattar JK, Jayaprakash P, Chkier D, Ahmed AO, Ahmed A, Rizwan R, Mujeeb S, Rahal M, Sadek B

“…Moreover, a novel TQ-loaded nanovesicle drug delivery system was optimized and utilized to enhance the bioavailability of TQ in the central nervous system.Methods: Through a battery of standard behavioral tests, primary parameters such as social behavior, locomotor activity, and anxiety levels were assessed following systemic administration with TQ (10mg/kg, i.p). …”
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Neoadjuvant chemoradiation and surgical excision versus definitive radiotherapy for locally advanced cervix uteri carcinoma: in terms of early and late complications and locoregion... by Hisham Khalifa, Mohamed Ayaty, Reham Oreaba, Reem Emad, Mohamed Salama, khaled Elsebahy, Wael A. Wahab Ghoniem

“…Abstract Objectives Following external beam radiation therapy (EBRT) with concurrent chemotherapy, we analyzed the benefits of surgical resection for locally advanced cervical carcinoma in terms of the frequency and severity of complications and disease-free survival, including cases of adjuvant hysterectomy after failure of resolution post-brachytherapy. Patient and methods Retrospective analysis was utilized to determine the eligibility of 145 cases treated at the National Cancer Institute between January 2015 and June 2021. …”
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Association Between Metabolic Syndrome and Cardiac Autonomic Nervous Function and Cardiorespiratory Fitness in Older Adults: A Retrospective Observational Study with Propensity Sco... by Cui N, Li Q, Cheng J, Xing T, Shi P, Wang Y, Luo M, Dun Y, Liu S

“…The present study aimed to investigate the association between MetS and HRRs at 1, 2, 3 and 6 minutes after exercise and cardiorespiratory fitness (CRF) in Chinese dwelling older adults.Methods: This retrospective, observational study consecutively enrolled participants aged 60 years or older who underwent physical examinations in Shenzhen District Yantian People’s Hospital from September 2019 to July 2021. …”
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Increased Risk of Dermatomyositis in Patients with Psoriasis: A Retrospective Cohort Study by Chen M, Tian N, Cui R, Zhang H, Wang Q, Tong Q, Chen Z, Wang YH, Wei JC, Dai SM

“…Miao Chen,1,* Na Tian,1,* Ran Cui,1 Hua Zhang,1 Qian Wang,1 Qiang Tong,1 Zhiyong Chen,1 Yu-Hsun Wang,2 James Cheng-Chung Wei,3– 6,* Sheng-Ming Dai1,* 1Department of Rheumatology and Immunology, Shanghai Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, People’s Republic of China; 2Department of Medical Research, Chung Shan Medical University Hospital, Taichung, Taiwan; 3Shanxi Bethune Hospital, Shanxi Academy of Medical Sciences, Third Hospital of Shanxi Medical University, Tongji Shanxi Hospital, Taiyuan, People’s Republic of China; 4Department of Allergy, Immunology & Rheumatology, Chung Shan Medical University Hospital, Taichung, Taiwan; 5Graduate Institute of Integrated Medicine, China Medical University, Taichung, Taiwan; 6Institute of Medicine/Department of Nursing, Chung Shan Medical University, Taichung, Taiwan*These authors contributed equally to this workCorrespondence: Sheng-Ming Dai, Department of Rheumatology and Immunology, Shanghai Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, People’s Republic of China, Email shengmingdai@163.com James Cheng-Chung Wei, Institute of Medicine, Chung Shan Medical University, Taichung, Taiwan, Email jccwei@gmail.comPurpose: This study aimed to investigate the risk of dermatomyositis among patients with psoriasis in a large population.Patients and Methods: Individuals aged ≥ 20 years with records in the TriNetX database from January 1, 2002 to December 31, 2022 were included. …”
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Burden of Carbon Monoxide Poisoning in Asian Countries From 1990 to 2021 and Its Projection Until 2030: An Analysis of the Global Burden of Disease Study 2021 by Xie J, Wu C, Zhao Z, Cao Z, Jin X

“…This study seeks to assess the burden of CO poisoning in Asia from 1990 to 2021 utilizing data from the Global Burden of Disease Study (GBD) 2021.Methods: Data on the burden of CO poisoning across 49 Asian countries were extracted from GBD 2021. …”
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Efficacy of a Web-Based Stress Management Intervention for Beginning Teachers on Reducing Stress and Mechanisms of Change: Randomized Controlled Trial by Hanna Heckendorf, Dirk Lehr

“…In addition, this study was the first to explore problem-solving ability and emotion regulation skills as potential mechanisms of change within an iSMI grounded in transactional stress theory. MethodsParticipants were 200 highly stressed beginning teachers (Perceived Stress Scale score of >21) undergoing German teacher induction randomized to either an intervention group (IG) with guidance or a waitlist control group. …”
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Determinants of Healthcare Professionals’ Knowledge on Age-Related Macular Degeneration Risk Factors in Ethiopia by Alemu DS, Munaw MB, Bekele MM, Asmare Kindie C, Ayele FA, Limenih MA

“…Destaye Shiferaw Alemu,1,* Minychil Bantihun Munaw,2 Matiyas Mamo Bekele,2 Chalie Asmare Kindie,3 Fisseha Admassu Ayele,3 Miteku Andualem Limenih1,* 1Department of Epidemiology and Biostatistics, Institute of Public Health, College of Medicine and Health Sciences, Comprehensive Specialized Hospital, University of Gondar, Gondar, Amhara National Regional State, Ethiopia; 2Department of Optometry, School of Medicine, College of Medicine and Health Sciences, Comprehensive Specialized Hospital, University of Gondar, Gondar, Amhara National Regional State, Ethiopia; 3Department of Ophthalmology, School of Medicine, College of Medicine and Health Sciences, Comprehensive Specialized Hospital, University of Gondar, Gondar, Amhara National Regional State, Ethiopia*These authors contributed equally to this workCorrespondence: Destaye Shiferaw Alemu, Department of Epidemiology and Biostatistics, Institute of Public Health, College of Medicine and Health Sciences, University of Gondar, P.O.Box: 196, Gondar, Ethiopia, Tel +251938316951, Email destayest@gmail.comPurpose: The aim of this study was to assess knowledge of healthcare professionals on risk factors of age-related macular degeneration and to identify factors that affect their level of knowledge.Patients and Methods: A cross-sectional study design was employed to collect data from 607 healthcare professionals in Gondar City from August 1 to 30, 2024. …”
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Effects of Ciprofol and Propofol General Anesthesia on Postoperative Recovery Quality in Patients Undergoing Ureteroscopy: A Randomized, Controlled, Double-Blind Clinical Trial by Shi S, Wu J, Wu Y, Han X, Dai H, Chen X, Sun Z, Wang F

“…Shuqi Shi,1,2,* Jimin Wu,1,* Yini Wu,1 Xin Han,1 Hong Dai,1 Xuedong Chen,3 Zhangnan Sun,4 Faxing Wang1,2 1Department of Anesthesiology, Lishui People’s Hospital, Wenzhou Medical University Lishui Hospital, The First Affiliated Hospital of Lishui University, Lishui, People’s Republic of China; 2Oujiang Laboratory (Zhejiang Lab for Regenerative Medicine, Vision and Brain Health), Wenzhou Medical University, Wenzhou, Zhejiang, People’s Republic of China; 3Department of Urology, Lishui People’s Hospital, Wenzhou Medical University Lishui Hospital, The First Affiliated Hospital of Lishui University, Lishui, People’s Republic of China; 4Department of Anesthesiology, The Second Hospital of Hebei Medical University, Shijiazhuang, Hebei, People’s Republic of China*These authors contributed equally to this workCorrespondence: Faxing Wang, Department of Anesthesiology, Lishui People’s Hospital, Wenzhou Medical University Lishui Hospital, The First Affiliated Hospital of Lishui University, No. 15, Dazhong Street, Lishui, Zhejiang Province, 323000, People’s Republic of China, Email wfx2023@wmu.edu.cn Zhangnan Sun, Department of Anesthesiology, The Second Hospital of Hebei Medical University, Shijiazhuang, Hebei, 050000, People’s Republic of China, Email 28703077@hebmu.edu.cnObjective: This study compares postoperative recovery quality between Ciprofol and Propofol, providing a reference for the clinical application of anesthetics.Methods: We randomized 112 patients undergoing ureteroscopic surgery into two groups: the Ciprofol group (Group C), with an induction dose of 0.4 mg/kg and a maintenance dose of 0.8– 1.5 mg/(kg·h), and the Propofol group (Group P), with an induction dose of 2 mg/kg and a maintenance dose of 4– 10 mg/(kg·h). …”
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TRANSUMBILICAL LAPAROSCOPIC CHOLECYSTECTOMY VERSUS STANDARD 4-PORT LAPAROSCOPIC CHOLECYSTECTOMY – RESULTS FROM PROSPECTIVE RANDOMIZED TRIAL AND 7 YEARS OF FOLLOW-UP by G. Ganchev, A. Saroglu, A. Julianov

“…The aim of this study is to compare the results of our own modification of transumbilical cholecystectomy versus standard 4-port cholecystectomy in patients with uncomplicated gallstone disease. METHODS: 80 patients (14 male, 66 female) at a mean age of 35±2,5 years (range 18-80) were randomly assigned to either standard 4-port cholecystectomy (n=40) or transumbilical cholecystectomy (n=40). …”
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