Cobalt Chloride-simulated Hypoxia Promoted Ossification of the Posterior Longitudinal Ligament Through the HIF1A–BMP4 Axis by Shihao Lu, Junbin Liu, Junzhe Sheng, Aochen Xu, Zichuan Wu, Chen Xu, Jiabin Yuan, Yang Liu

“…This study investigates the effects of cobalt chloride (CoCl2), which simulates an in vitro hypoxic microenvironment, on OPLL and explores its potential mechanisms, aiming to enhance our understanding of the pathogenesis of OPLL. Methods: Ligament cells were extracted from patients with OPLL and normal posterior longitudinal ligament (PLL) tissues, confirming their mesenchymal stem cell (MSC)-like properties. …”
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Relationship between Hyponatremia and Peripheral Neuropathy in Patients with Diabetes by Yongze Zhang, Chuanchuan Li, Lingning Huang, Ximei Shen, Fengying Zhao, Cailin Wu, Sunjie Yan

“…This study was aimed at investigating the relationship between low serum sodium level and DPN in Chinese patients with type 2 diabetes mellitus. Methods. A retrospective study was performed on 1928 patients with type 2 diabetes between 2010 and 2018. …”
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Health-related quality of life and productivity burden for non-professional caregivers of adults with rare diseases: a real-world study by Ben Johnson, Gregor Gibson, Daniel Baskerville, Giorgio Castellano, Jonathan de Courcy, Halima Iqbal, James Piercy, Angela Williams, Rafael Pinedo-Villanueva, Angela Rylands

“…Patients’ mean (SD) EuroQol visual analogue scale (EQ VAS) score was 50.9 (23.3) and mean EQ-5D utility was 0.460 (0.350). …”
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Cost utility analysis of acute rehabilitation approaches in the management of traumatic anterior shoulder dislocation by Henry Nwankwo, James Mason, Martin Underwood, Helen Parsons, Aminul Haque, David Torgerson, Chetan Modi, Rebecca S. Kearney

“…Aims: We aimed to conduct a cost-utility analysis comparing one session of advice, supporting materials, and option to self-refer to physiotherapy with the same advice and materials, plus an additional programme of physiotherapy for people with a first-time, traumatic anterior shoulder dislocation. Methods: We conducted an economic evaluation within a randomized controlled trial from the UK NHS and personal social services (PSS) perspective. …”
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The effect of listening to music and drawing on coping with dysmenorrhea complaints in nursing students: randomized controlled trial by Burcu Küçükkaya, Şükran Başgöl

“…Abstract Aim To examine the effect of listening to music and drawing on coping with dysmenorrhea complaints of nursing students. Methods The study was a double-blind, three parallel-group randomized controlled trial conducted between August 2023 and May 2024 at Bartın University, Faculty of Health Sciences, Department of Nursing. …”
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Construction of dynamic ceRNA regulatory networks in osteogenesis during fracture healing based on transcriptomic analysis by Shuhang Guo, Shen Wang, Shaoxun Yuan, Xinyi Gu, Jin Deng, Chen Huang, Xinyi Zeng, Qingguo Lu, Xiaofeng Yin

“…This study aimed to investigate the key molecules involved in fracture healing and their potential competing endogenous RNA (ceRNA) regulatory mechanisms within the first 28 days post-fracture using bioinformatics methods. The experiment was conducted on 15 adult male SD rats, with tibia callus tissue samples collected at days 0, 3, 7, 14, and 28 (n = 3) post-fracture. …”
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Real-World Outcomes of Allogeneic Immunosafe Plasma Rich in Growth Factors Eye Drops for Refractory Ocular Surface Diseases: A Prospective Observational Study by Rosa Alvarado-Villacorta, Jesús Merayo-Lloves, Ronald M. Sánchez-Ávila, Belén Alfonso-Bartolozzi, Carlos Lisa, Luis Fernández-Vega-Cueto, José F. Alfonso, Eduardo Anitua

“…We aimed to evaluate the safety and clinical outcomes of allogeneic is-ePRGF therapy for refractory OSD in real-world practice. Methods A single-center cohort was conducted involving consecutive patients with severe OSD nonresponsive to conventional therapy. …”
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Midterm Outcomes Following Conversion of Failed Ankle Arthrodesis to Total Ankle Arthroplasty, Including Patients With a Deficient Fibula by George Lian MD, William Ip MD, Andrea Hankins, Michele Guillen, Carol Parise PhD

“…This retrospective study examines the midterm follow-up of 21 patients treated for a conversion of failed ankle arthrodesis by a single surgeon using a standard technique with a single prosthesis, with a focus on the treatment of 5 patients with a deficient distal fibula. Methods: Between May 2010 and August 2019, 27 patients underwent conversion using a prosthesis with an intramedullary tibial component, 21 of which were available for the study. …”
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Indicators of rheumatoid arthritis disease activity. An association with a patient’s psychological status by V. V. Rybakova, Yu. A. Olyunin, E. V. Likhacheva, E. L. Nasonov

“…Objective: to study of the relationship between psychological factors and indicators of rheumatoid arthritis (RA) disease activity in patients who have been followed up for a long time after initiation of treat-to-target therapy.Patients and methods. The investigation enrolled 38 RA patients (29 women and 9 men) aged 33 to 80 years (mean age, 56.5±12.5 years) with a mean disease duration of 6.0±0.9 years. …”
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Engagement and Follower Growth: Social Media Strategies of Swiss Athletes at the Paris Olympics by Larssyn Staley, Florian Droux

“…This study investigates how athletic performance and social media behavior influence engagement and follower growth on Instagram among Swiss athletes during the Summer Olympic Games in Paris 2024. Methods The Instagram activity of the 128-member Swiss Olympic delegation to Paris 2024 was analyzed, focusing on posts made during the 2024 Olympics. …”
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Gender characteristics of the course of toxoplasmic encephalitis in HIV-infected patients by T.A. Veliieva, K.I. Bodnia, P.V. Nartov, І.M. Asoyan, V.D. Makarenko, I.V. Krokhmal

“…The purpose was to analyze the gender characteristics of TE in HIV-infected patients. Materials and methods. A retrospective analysis of the gender characteristics of the TE course was performed in 23 HIV-infected patients. …”
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Elevated Blink Rates Predict Mind Wandering: Dopaminergic Insights into Attention and Task Focus by Leigh M. Riby, Lewis Marr, Lynn Barron-Millar, Joanna Greer, Colin Joseph Hamilton, Deborah McGann, Jonathan Smallwood

“…This study sought to clarify the relationships between dopaminergic function and cognitive control during a task by utilizing EBR and EBV as proxy measures. Methods: Vertical electrooculogram and brain event-related potential (ERP) data were gathered from 24 adult participants while they performed a computerized cognitive task. …”
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The Importance of the Correlation between CCT and Corneal Curvature in Refractive Surgery by Mimoza Ismaili

“…Background: The aim of this study was to analyze the relationship between central corneal thickness (CCT) and corneal curvature (CC) in patients with refractive anomalies and emmetropes, in three different age groups. Methods and Results: The study included 330 respondents, with a total of 660 eyes, divided into two groups. …”
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Ecosystem service trade-offs and synergies based on the mechanical equilibrium model: A case study of the urban agglomeration on the northern slope of the Tianshan Mountains by Jiazhen Chen, Alimujiang Kasimu, Lina Tang, Fuqiang Han, Miyesier Jumai

“…Understanding the trade-offs and synergies of ESs is crucial for resolving conflicts among services, yet there is a lack of effective methods for comprehensively understanding the complex interactions among multiple ESs. …”
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Risk Prediction of Postoperative Renal Dysfunction Based on Preoperative Lipid Profiles in Renal Transplant Recipients: A Retrospective Cohort Study by Zhang H, Zhang H, Li R, Zhuo L, Liu L, Tan L, Li R, Zhang S

“…This study aimed to establish a risk prediction model using machine learning (ML).Methods: This retrospective cohort study recruited 345 RTRs and followed up for one year. …”
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Treatment Cessation in Patients with Diabetic Maculopathy under Intravitreal Anti-VEGF Therapy Following a Treat-and-Extend Protocol by Lucia Saucedo, PhD, Isabel B. Pfister, PhD, Christin Schild, PhD, Justus G. Garweg, MD, PhD

“…Methods: Baseline characteristics, best-corrected VA, OCT biomarkers over time, and injection details were collected from patients' medical records. …”
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GENETIC ASPECTS OF PANNICULITIS IN A RUSSIAN POPULATION: A PILOT STUDY by M. Yu. Krylov, O. N. Egorova, B. S. Belov

“…Numerous  clinical observations show that the human genetic background plays an important  role in predisposition to many diseases.Objective: to investigate a possible relationship of the polymorphisms in 19 A/G leptin (LEP) gene, in the interleukin (IL)-1  receptor antagonist (IL-1RA) gene VNTR (variable number of tandem repeats), and in the -174G/C IL-6 gene to the risk of developing the clinical phenotypes of panniculitis (PN), clinical and laboratory parameters.Subjects and methods. The study enrolled 54 patients (48 women and 6 men) aged 15 to 76 years with a documented diagnosis of PN who had been treated at the V.A. …”
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Management of Postoperative Pain Following Primary Total Knee Arthroplasty: A Level I Evidence-Based Bayesian Network Meta-Analysis by Filippo Migliorini, Marcel Betsch, Tommaso Bardazzi, Giorgia Colarossi, Hani Ayad Mohamed Elezabi, Arne Driessen, Frank Hildebrand, Mario Pasurka

“…This Bayesian network meta-analysis compared different treatment options for the management of postoperative pain following primary TKA. <b>Methods:</b> This study was conducted following the 2020 PRISMA statement. …”
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Acceptability, User Satisfaction, and Feasibility of an App-Based Support Service During the COVID-19 Pandemic in a Psychiatric Outpatient Setting: Prospective Longitudinal Observa... by Konstanze Golsong, Luisa Kaufmann, Sabrina Baldofski, Elisabeth Kohls, Christine Rummel-Kluge

“…ObjectiveThe aim of this study was to evaluate the acceptability, usability, and feasibility of an app-based support service specifically developed for outpatients with severe mental disorders in addition to regular face-to-face therapy during the COVID-19 pandemic. MethodsPatients in a psychiatric outpatient department at a German university hospital were invited to use an app-based support service designed transdiagnostically for mental disorders for 4 weeks. …”
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Pregnancy Carpal Tunnel: Nerve/Tendon Ratio (NTR)—A New Paradigm by Fatih Şahin, Recep Yilmaz Bayraktarli, Veli Mihmanlı

“…The objective of this investigation is to explore the clinical importance of a new anthropometric independent parameter called the nerve/tendon ratio (NTR) when compared to EDx and to determine whether it has the utility to be used in clinical practice. Methods: In this prospective case-control study conducted between April 2023 and September 2023, 160 pregnant women displaying clinical symptoms of CTS who presented to the outpatient clinic underwent evaluation employing the Boston Carpal Tunnel Questionnaire, Visual Analog Scale, and provocative tests (Phalen and Tinnel). …”
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