Non-invasive neuromodulation for alleviating dyspnoea: protocol for a feasibility sham-controlled randomised trial by Guillaume Léonard, Christian Iorio-Morin, Simon Couillard, Joël St-Pierre, Samuel Mailhot-Larouche, Geneviève Garand, Félix-Antoine Vézina

“…We speculate that non-invasive transcutaneous vagus nerve stimulation (tVNS) and trigeminal transcutaneous electric nerve stimulation (TENS) could improve dyspnoea management by targeting relevant neural circuits.Methods and analysis We will conduct a feasibility cross-over trial in people with severe COPD and significant exertional dyspnoea referred for pulmonary rehabilitation. …”
Get full text

Effects of Wheat Varieties on Bacterial Community and Volatile Flavor Compounds in Nongxiangxing Daqu by Xiaoge HOU, Junpeng FAN, Fuli GUO, Zheng LI, Xin HU, Ming HUI, Ruifang LI, Xiyu SUN, Chunmei PAN

“…The correlation between wheat quality indices and the dominant bacterial genera was visualized by constructing a Spearman rank correlation-based network diagram. …”
Get full text

Use of MedSafer electronic decision support for deprescribing in patients on hemodialysis: a qualitative study by Émilie Bortolussi-Courval, Jimmy J. Lee, Emilie Trinh, Lisa M. McCarthy, M. Battistella, Ryan Hanula, Todd C. Lee, Kathleen Rice, Emily G. McDonald

“…Deprescribing is a promising intervention to reduce PIMs.Methods We previously conducted a prospective controlled trial whereby we provided deprescribing decision support to nephrologists in one of two tertiary care outpatient hemodialysis units in Montreal, Canada. …”
Get full text

CLINICAL EFFECTIVENESS OF NEUROTRANSMITTERS PATIENTS WITH PRIMARY GLAUCOMA VEGF INHIBITOR IN PATIENTS WITH CHOROIDAL NEOVASCULARIZATION CAUSED BY DEGENERATIVE MYOPIA by L. P. Danilova, V. V. Egorov, G. P. Smolyakova, L. P. Emanova, D. A. Povalyaeva

“…Morphological and functional evaluation of results of intravitreal injections of ranibizumab in treatment of choroidal neovascularization (CNV) caused by degenerative myopia (DM). patients and methods. The study included 32 patients (32 eyes) aged from 29 to 55 years with the CNV, developed due to the DM. …”
Get full text

Environmental monitoring and spatiotemporal trend analysis of avian influenza virus in Xinjiang, 2021-2023 by Zhe Yin, Fuerhati Wushouer, Jia Huang, Yan Dong, Qi Wang, Xiapikatijiang Aihaiti, Xiayidanmu Abudusaimaiti, Yuanyuan Ma, Zihan Chen, Ruiying Qiu, Quanxi Li, Zhenguo Gao

“…This study aims to analyze the spatiotemporal distribution of avian influenza virus in the external environment of Xinjiang from 2021 to 2023, to enhance understanding of its transmission patterns and provide a scientific basis for public health response measures. Methods A total of 3913 avian-related environmental samples were collected from nine monitoring areas in Xinjiang. …”
Get full text

Leveraging FastViT based knowledge distillation with EfficientNet-B0 for diabetic retinopathy severity classification by Jyotirmayee Rautaray, Ali B.M. Ali, Meenakshi Kandpal, Pranati Mishra, Rzgar Farooq Rashid, Farzona Alimova, Mohamed Kallel, Nadia Batool

Get full text

Grip Strength and Age-Related Ocular Diseases: Insights from Observational, Mendelian Randomization, and Mediation Analyses by Chao Chen, Dongling Guo, Jiaqi Meng, MD, Jiao Qi, MD, Keke Zhang, MD, Wenwen He, MD, Yih Chung Tham, PhD, Xiangjia Zhu, PhD

Get full text

Evaluation of the efficacy of angiotensin receptor–neprilysin inhibitor in patients with aortic stenosis undergoing transcatheter aortic valve implantation: protocol for a randomis... by Hideki Hanaoka, Yoshio Kobayashi, Hideki Kitahara, Takeshi Sugawara, Goro Matsumiya, Yosuke Inaba, Shogo Okita, Hiroaki Yaginuma, Hiroki Goto, Hiroaki Yamamoto, Tomoyoshi Kanda, Kaoru Matsuura

Get full text

A Comparison of the Association of Fasting Plasma Glucose and HbA1c Levels with Diabetic Retinopathy in Japanese Men by Yumi Matsushita, Norio Takeda, Yosuke Nakamura, Natsuyo Yoshida-Hata, Shuichiro Yamamoto, Mitsuhiko Noda, Tetsuji Yokoyama, Tetsuya Mizoue, Toru Nakagawa

Get full text

Optimal infiltration depth threshold for low-temperature plasma ablation in fungal keratitis by Zhengwei Yang, Miaomiao Liu, Guihua Yang, Lijin Wen, Juan Yang, Hanqiao Li, Zhiwen Xie, Xie Fang, Shunrong Luo, Xianwen Xiao, Yuan Lin, Huping Wu

Get full text

Comparative efficacy of acupuncture for chronic low back pain: A network meta-analysis by Feng Gao, Dongming Jia, Shengxia Xue

“…This network meta-analysis (NMA) evaluates the comparative effectiveness of acupuncture interventions for CNSLBP. Methods: A systematic review and NMA were conducted following PRISMA-NMA guidelines (PROSPERO: CRD42024507870). …”
Get full text

Dietary protein and risk of type 2 diabetes: findings from a registry-based cohort study and a meta-analysis of prospective cohort studies by Mingjing Xu, Jianheng Zheng, Tao Ying, Yang Zhu, Jun Du, Fan Li, Bo Chen, Yuwei Liu, Gengsheng He

“…We aimed to investigate the associations of various protein intake exposures with the risk of incident T2D in adults with or without metabolic diseases. Methods We followed 29517 residents enrolled in the Shanghai Suburban Adult Cohort and Biobank (SSACB) without diabetes at baseline through the electronic information system. …”
Get full text

Incidence and Risk Factors of Lumbosacral Complications Following Long‐Segment Spinal Fusion in Adult Degenerative Scoliosis by Tinghua Jiang, Xinuo Zhang, Qingjun Su, Xianglong Meng, Aixing Pan, Hanwen Zhang, Yong Hai

“…This study aimed to identify the risk factors for LSC after long‐segment instrumented fusion with distal fixation to the L5 vertebral body in adult degenerative scoliosis (ADS). Methods We retrospectively evaluated 294 patients with ADS who underwent long‐segment floating fusion between January 2014 and March 2022, with follow‐up for at least 2 years. …”
Get full text

The Influence of Vitamin D Levels and Supplementation on the Treatment of Patients Affected by MRONJ by Filip Michalak, Marzena Dominiak, Jan Kiryk, Paweł Popecki, Dominik Kubicki, Jacek Matys, Kinga Grzech-Leśniak

“…The aim of this study was to evaluate the impact of different blood levels of vitamin D on the course of treatment, as well as the role of vitamin D supplementation during the treatment of primary diseases involving bisphosphonates or denosumab. Methods: The clinical trial involved 64 patients diagnosed with medication-related osteonecrosis of the jaw (MRONJ) treated at the Department of Oral Surgery. …”
Get full text

A multi-algorithm prognostic model combining inflammatory indices and surgical features in distal cholangiocarcinoma by Yi Yin, Yi Yin, Luyuan Bai, Xinyue Mu, Xinyue Mu, Shan Zhang, Panpan Zhai, Panpan Zhai

“…This study aimed to investigate the prognostic significance of dNLR in patients with distal cholangiocarcinoma (dCCA) after curative resection.MethodsClinicopathological data of patients with dCCA in our hospital from Jan.2014 to Jun.2024 was analyzed retrospectively. …”
Get full text

Improving Malaria diagnosis through interpretable customized CNNs architectures by Md. Faysal Ahamed, Md Nahiduzzaman, Golam Mahmud, Fariya Bintay Shafi, Mohamed Arselene Ayari, Amith Khandakar, M. Abdullah-Al-Wadud, S. M. Riazul Islam

“…The proposed SPCNN model surpassed all these TL methods in every evaluation measure. The SPCNN model, with 2.207 million parameters and a size of 26 MB, is more complex than PCNN but simpler than SFPCNN. …”
Get full text

Quality of life, pain, depression, fatigue and sleep in patients with remission or mild fibromyalgia: a comparison with remission or low disease activity rheumatoid arthritis and h... by Yidan Wang, Pengxiao Liu, Zihao Li, Shiya Wu, Meijuan Long, Yang Li, Juan Jiao, Zheng Xie

“…Objective To compare the severity of clinical symptoms and quality of life (QOL) in patients with remission or mild fibromyalgia (RFM) and remission or low disease activity in rheumatoid arthritis (RRA) patients and healthy controls (HCs) to investigate whether fibromyalgia in a stable stage can be disease-free. Methods This cross-sectional study evaluated a total of 266 RFM and 252 RRA patients and 50 HCs using Revised Fibromyalgia Impact Questionnaire (FIQR), Widespread Pain Index (WPI), Pain Visual Analogue Scale (VAS), Numerical Rating Scale, Multidimensional Fatigue Inventory (MFI-20), Pittsburgh Sleep Quality Index (PSQI), and Beck Depression Inventory (BDI), and Short Form-36 Health Status Questionnaire (SF-36). …”
Get full text

Patient-reported outcome measures for systemic lupus erythematosus: an expert Delphi consensus to guide implementation in routine care by Isabel Castrejón, Laura Cano, María José Cuadrado, Joaquín Borrás, Maria Galindo, Tarek C. Salman-Monte, Carlos Amorós, Carmen San Román, Isabel Cabezas, Marta Comellas, Alejandro Muñoz

“…We aimed to explore the current situation, appropriateness, and feasibility of PROMs to monitor patients with SLE in routine care, from healthcare professionals’ and patients’ perspectives. Methods A scientific committee developed a Delphi questionnaire, based on a focus group with patients and a literature review, including 22 statements concerning: 1) Use of PROMs in routine care (n = 2); 2) PROMs in SLE management (n = 13); 3) Multidisciplinary management of patients with SLE (n = 4), and 4) Aspects on patient empowerment (n = 3). …”
Get full text

Neural mechanisms of spatial navigation in ASD and TD children: insights from EEG microstate and functional connectivity analysis by Yao Wang, Yao Wang, Yao Wang, Jianing Wang, Chong Lu, Chong Lu, Chong Lu, Chong Lu, Chong Lu

“…This study examines alterations in EEG microstates and theta-band FC during map-reading tasks in children with ASD (n = 12) compared to typically developing (TD) peers (n = 12), aiming to uncover neural mechanisms underlying spatial processing deficits in ASD.MethodsEEG data were collected from children with ASD (n = 12) and TD controls (n = 12) aged 6-10 years during a map-reading task. …”
Get full text