Age-related changes in brain signal variability in autism spectrum disorder by Priyanka Sigar, Nicholas Kathrein, Elijah Gragas, Lauren Kupis, Lucina Q. Uddin, Jason S. Nomi

“…Results When controlling for linear age effects, we observed significant group differences between individuals with ASD and TD individuals in the default-mode network (DMN) and visual network, with decreased BSV in ASD. Similarly, controlling for quadratic age effects revealed significant group differences in the DMN and visual network. …”
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Real-time intestinal perfusion assessment for anastomotic site selection using laser speckle contrast imaging: Verification in a porcine model by Danique J.I. Heuvelings, Mahdi Al-Taher, Joost Calon, Manish Chand, Laurents P.S. Stassen, Tim Lubbers, Kevin P. Wevers, Luigi Boni, Nicole D. Bouvy, Wido Heeman

“…Therefore, we explored the efficacy and feasibility of a new laser speckle contrast imaging system to assess real-time intestinal perfusion. Methods: Three gradually perfused porcine small bowel loops were created, and five senior surgeons were asked to assess the perfusion differences based on laser speckle contrast images using PerfusiX-Imaging®. …”
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Rapid Therapeutic Drug Monitoring of Voriconazole Based on High-Performance Liquid Chromatography: A Single-Center Pilot Study in Outpatients by Satoru Morikawa, Yusuke Yagi, Moemi Okazaki, Narika Yanagisawa, Tomoaki Ishida, Kohei Jobu, Takumi Maruyama, Takahiro Kato, Miyuki Matsushita, Yu Arakawa, Yuka Yamagishi, Yukihiro Hamada

“…This study aimed to evaluate the clinical utility of rapid therapeutic drug monitoring (TDM) for VRCZ using high-performance liquid chromatography with ultraviolet detection (HPLC-UV) compared to conventional outsourced liquid chromatography–tandem mass spectrometry (LC-MS/MS) testing in outpatient care. <b>Methods</b>: VRCZ blood concentrations were measured using HPLC-UV and LC-MS/MS. …”
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Efficacy and Safety of a Dexamethasone Implant in Patients with Diabetic Macular Edema at Tertiary Centers in Korea by Byung Gil Moon, Joo Yong Lee, Hyeong Gon Yu, Ji Hun Song, Young-Hoon Park, Hyun Woong Kim, Yong-Sok Ji, Woohyok Chang, Joo Eun Lee, Jaeryung Oh, Inyoung Chung

“…To evaluate the real-world efficacy and safety of the dexamethasone implant (DEX implant) in patients with diabetic macular edema (DME). Methods. Retrospective, multicenter, and noncomparative study of DME patients who were treated with at least one DEX implant. …”
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Association between psychosocial factors at work and health outcomes after retirement: a protocol for a systematic review and meta-analysis by Hisashi Eguchi, Akizumi Tsutsumi, Akiomi Inoue, Yuka Kobayashi, Norito Kawakami, Kotaro Imamura, Asuka Sakuraya, Natsu Sasaki, Yumi Asai, Hideaki Arima, Emiko Ando, Reiko Inoue, Mai Iwanaga, Yasumasa Otsuka, Kanami Tsuno, Ayako Hino, Kazuhiro Watanabe, Akihito Shimazu

“…The objective of this systematic review and meta-analysis is to examine the association between psychosocial factors at work and health outcomes after retirement, based on a synthesis of well-designed prospective studies.Methods and analysis The participants, exposures, comparisons and outcomes of the studies in this systematic review and meta-analysis are defined as follows: (P) people who have retired from their job, (E) presence of adverse psychosocial factors at work before retirement, (C) absence of adverse psychosocial factors at work before retirement and (O) any physical and mental health outcomes after retirement. …”
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External application of Traditional Chinese medicine in the treatment of acute gouty arthritis (中药外敷治疗急性痛风性关节炎临床效果及护理) by LI Juan (李娟), ZHENG Xiaoya (郑小雅), ZHANG Haiying (张海英), DU Danying (杜丹颖), HAN Shuhua (韩淑花), LI Yan (李雁)

“…Objective To observe the clinical effect of external application of Traditional Chinese Medicine(TCM) in the treatment of acute gouty arthritis. Methods Totally 61 patients with acute gouty arthritis who met the inclusion criteria were included as research subjects. …”
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CHI study: protocol for an observational cohort study on ageing and mental health in community-dwelling older adults by Lei Feng, Lieng Hsi Ling, Qiushi Feng, Rachael Zhi Yi Lee, Junhong Yu, Iris Rawtaer, Patrick Finbarr Allen, Zhiming Bao, Jeong Kyu Lee, Chin Tat Lim, Leng Leng Thang, Thet Naing, D Y Wang, Kai Zhen Yap, EH Kua, Rathi Mahendran

“…The Community Health and Intergenerational study aims to holistically examine ageing in place by investigating the resilience and vulnerability factors of the ageing process in the biological, psychological and social domains within the environment.Methods and analysis Using a cohort multiple randomised controlled trial design, comprehensive health profiles of community-dwelling older adults will be collected. …”
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Distinctive clinical features of early and late-onset Ménière’s disease by Jianwei Lin, Heng Xiao, Heng Xiao, Heng Xiao, Chenxin Lin, Gengliang Huang, Xiaojing Guo, Huimin Cai, Huimin Cai, Huimin Cai, Shengnan Ye, Shengnan Ye, Shengnan Ye

“…PurposeTo compare the clinical characteristics of patients with early and late-onset Ménière’s disease (MD) and to investigate the impact of psychological factors between the two groups.MethodsThe patients were divided into two groups based on their age of onset: early-onset (&lt;45 years old) and late-onset (&gt;55 years old). …”
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Determining the optimum high-flow nasal cannula flow rate to achieve the desired fraction of inspired oxygen: A bench study by Chao-Lan Huang, Chun-Ching Lu, Cheng Chiang, Heng-Sheng Chao, Ting-Yun Chiang, Wei-Nung Teng, Wen-Kuei Chang, Chien-Kun Ting

“…We aimed to determine the actual FiO2 under different respiratory conditions and develop a regression model using a spontaneous breathing lung model. Methods: A spontaneous breathing simulation model was built using an airway manikin and a model lung. …”
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Efficacy and safety of electroacupuncture and electroacupuncture combined with warm needling for subjective tinnitus: A multicenter, three-arm randomized controlled trial by Lai Fun Ho, Yuanqi Guo, Liyi Chen, Herbert Fung, Wai Yan Mak, Siu Chuen Cheung, Ping Him Tsang, Min Chen, Kam Leung Chan, Hongwei Zhang, Wai Tsz Chang, Bacon Fung-Leung Ng, Zhi Xiu Lin

“…Objective: To evaluate the clinical efficacy and safety of electroacupuncture (EA) and electroacupuncture combined with warm needling (EAWN) on reducing tinnitus loudness and tinnitus-related distress among older adults. Methods: This multicenter, assessor-blinded, parallel-group, randomized clinical trial was conducted from December 2022 to April 2024 at three out-patient clinics in Hong Kong. …”
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Large-scale analysis highlights obesity as a risk factor for chronic, non-communicable inflammatory diseases by Sadegh Mousavi, Katja Bieber, Henner Zirpel, Artem Vorobyev, Henning Olbrich, Cristian Papara, Cristian Papara, David A. De Luca, David A. De Luca, Diamant Thaci, Enno Schmidt, Gabriele Riemekasten, Peter Lamprecht, Matthias Laudes, Khalaf Kridin, Khalaf Kridin, Khalaf Kridin, Ralf J. Ludwig, Ralf J. Ludwig

“…Yet, several knowledge gaps remain: For several CIDs, inconsistent results have been reported, relating to their obesity-imposed risk, data on most rare CIDs remain unavailable, sex differences and racial disparities remain mostly unaddressed.MethodsA large-scale cohort study compared the risk of developing 46 CIDs in individuals with overweight/obesity (n=3,101,824) to an equal number of non-overweight/obese individuals. …”
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Associations of long-term joint exposure to multiple ambient air pollutants with the incidence of age-related eye diseases by Yingan Li, Yuzhou Zhang, Ka Wai Kam, Poemen Chan, Dong Liu, Ebenezer Zaabaar, Xiu Juan Zhang, Mary Ho, Mandy PH Ng, Patrick Ip, Alvin Young, Chi Pui Pang, Clement C. Tham, Mei Po Kwan, Li Jia Chen, Jason C. Yam

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Comparative analysis of mini-open trans-thoracic transpleural and posterior approaches in thoracic disc herniation surgery: A 10-year retrospective review by Ali Baram, Giorgio Cracchiolo, Marco Riva, Gabriele Capo, Leonardo Anselmi, Carlo Brembilla, Stefania Radice, Maria Pia Tropeano, Carla Anania, Emanuela Morenghi, Maurizio Fornari, Federico Pessina

“…Research question: What are the clinical, surgical, and radiological outcomes of anterior and posterior surgical approaches for TDHs over a 10-year period? Material and methods: A retrospective analysis of 54 patients who underwent surgery for TDHs (2013–2022) was performed. …”
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Anatomic characteristics of the lacrimal sac and adjacent bony structures–a computed tomographic-dacryocystography research by Xin-Han Cui, Yan-Wen Fang, Li-Min Zhang, Ji-Ni Qiu, Chao-Ran Zhang, Yan Wang

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Bile Acid Metabolism Changes in Patients with a CRB1-Associated Inherited Retinal Degeneration by Lude Moekotte, MD, PhD, Joke H. de Boer, MD, PhD, Sanne Hiddingh, MSc, Bram Gerritsen, PhD, Jutta Lintelmann, PhD, Alexander Cecil, PhD, L. Ingeborgh van den Born, MD, PhD, Xuan-Thanh-An Nguyen, MD, PhD, Camiel J.F. Boon, MD, PhD, Maria M. van Genderen, MD, PhD, Jonas J.W. Kuiper, PhD

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Impact of religious fasting on ocular dryness: objective and subjective assessment by Amal F. Alomari, Sara Issa, Asma Musleh, Mohammad Abusamak, Mohammad Abusamak, Omar Bdair, Omar Bdair, Saif Aldeen AlRyalat, Saif Aldeen AlRyalat, Alanoud Al-Wakfi, Mohammed Jaber, Ahmad Alloubani, Haitham Sahawneh, Haitham Sahawneh, Muhannd El-Faouri, Ayman Abdul Aziz, Muawyah Al Bdour

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A matched pilot cohort study of intravenous omadacycline in the treatment of severe pneumonia associated with carbapenem-resistant Acinetobacter baumannii by Dayu Chen, Yechao Chen, Yechao Chen, Na Hu, Qiaoling Gu, Qiaoling Gu, Jingjing Kan, Jingjing Kan, Jinchun Liu, Haixia Zhang

“…We conducted this study to explore the efficacy of omadacycline in CRAB-caused severe pneumonia.MethodsThis retrospective cohort study was performed by collecting data on severe CRAB-caused pneumonia cases treated with omadacycline or tigecycline at Nanjing Drum Tower Hospital from January 2022 to June 2024. …”
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Cognitive Impairment in CMV Seropositive and CMV Seronegative Deceased Donor Kidney Transplant Recipients by Maheen Z. Abidi, MD, Xiaomeng Chen, MSPH, Yi Liu, ScM, Nadia M. Chu, PhD, Aarti Mathur, MD, PhD, Adriana Weinberg, MD, Bruce Kaplan, MD, Silas Norman, MD, Jingyao Hong, MHS, Dorry L. Segev, MD, PhD, Kristine M. Erlandson, MD, Mara A. McAdams-DeMarco, PhD

“…We tested whether CMV was associated with post-KT cognitive impairment. Methods. In a 2-center prospective cohort study of 574 KTRs (mean age: 54.7 y), we obtained CMV donor/recipient (D/R) serostatus and measured pre- and post-KT cognitive function using the Modified Mini-Mental State Examination. …”
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Screening and mechanistic study of natural compounds that enhance T cell anti-tumor effects post-heat treatment by Zhaoyi Wang, Zhongqi Diao, Yiyan Zhang, Jiangying Liu, Yeshan Li, Zijin Sun, Huimin Zhen, Haojia Wang, Siyun Yang, Tieshan Wang, Lei Ni

“…Optimizing the cytotoxic effects of immune cells under in vitro culture conditions represents a current hot research topic in this domain.MethodsIn the current experiment, we conducted in vitro heat treatment on Jurkat-derived T cells at 39°C. …”
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Immunomodulatory Effects of <i>Cucurbita pepo</i> L. Extract in Chronic Stress-Induced Dysregulation of Lymphoid Organs in Rats by Safa H. Qahl, Hailah M. Almohaimeed, Sami A. Algaidi, Ashwaq H. Batawi, Zuhair M. Mohammedsaleh, Tarek Hamdy Abd-Elhamid, Nawal H. Almohammadi, Nasra N. Ayuob, Amany Refaat Mahmoud

“…(<i>CP</i>) on chronic unpredictable mild stress (CUMS)-induced changes in lymphoid organs through evaluating its effect on the histological structure of spleen, thymus gland, and lymph nodes compared to the antidepressant fluoxetine (FLU). <b>Materials and Methods</b>: Fifty male albino rats equally distributed into five groups that included control, control + <i>CP</i>, CUMS-exposed, FLU-treated, and <i>CP</i>-treated groups were used in this study. …”
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