Alflutop Russian longitudinal multicenter observational study: use in patients with chronic back pain (message 3) by A. M. Lila, A. E. Karateev, L. I. Alexeeva, E. A. Taskina, An. B. Danilov, S. A. Zhivolupov, I. N. Samartsev, E. R. Barantsevich, A. P. Rachin

“…The use of slow-acting disease-modifying symptomatic drugs, such as bioactive concentrate from small marine fish (BCSMF, Alflutop), is considered a potential element of complex therapy for chronic non-specific back pain (CNBP).Objective: to evaluate the efficacy of the BCSMF in patients with CNBP in real-life clinical practice.Material and methods. An open observational study included 10,047 patients with CNBP (age – 58.3±14.9 years, 58.4% women) with moderate or severe pain – 60 [50; 70] mm on the visual analogue scale (VAS). …”
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Observation of the clinical effectiveness of transanal opening of the intersphincteric space in the treatment of high intersphincteric anal fistula and suprasphincteric anal fistul... by Huang Luqiao, Li Shanshan, Yang Yong, Meng Qingliang, Liang Chunhui, Pan Dong, Sun Shangying, Xie Guangwei, Zhang Zhengguo

“…[Objectives] To investigate the clinical effectiveness of transanal opening of the intersphincteric space (TROPIS) in the treatment of high intersphincteric anal fistula and suprasphincteric anal fistula. [Methods] A total of 124 patients with high intersphincteric anal fistula and suprasphincteric anal fistula who underwent surgical treatment at the Department of Anorectal Surgery, Xuzhou Central Hospital from September 2021 to June 2023 were selected as the study subjects. …”
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PHARMACOEPIDEMIOLOGY OF ORIGINAL DROTAVERINE USE IN DYSMENORRHEA: RESULTS OF AN INTERNATIONAL MULTICENTER STUDY by A. L. Unanyan, V. A. Alimov, S. E. Arakelov, M. S. Afanasyev, D. V. Baburin, D. V. Blinov, T. D. Guriyev, U. V. Zimovina, A. E. Kadyrova, Yu. M. Kossovich, L. S. Polonskaya

“…Objective: To evaluate the effectiveness of drotaverine in the daily practice management of spasmodic abdominal pain due to gastrointestinal, biliary, urological tract conditions and dysmenorrhea. Material and Methods: a multicenter, prospective, cross-sectional and longitudinal product registry (3 visits), non-interventional on the therapeutic strategy was conducted in Mexico, Kazakhstan, and Russia. …”
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Based on Network Pharmacology Tools to Investigate the Molecular Mechanism of Cordyceps sinensis on the Treatment of Diabetic Nephropathy by Yan Li, Lei Wang, Bojun Xu, Liangbin Zhao, Li Li, Keyang Xu, Anqi Tang, Shasha Zhou, Lu Song, Xiao Zhang, Huakui Zhan

“…This study is aimed at revealing the therapeutic mechanisms of Cordyceps in DN by undertaking a network pharmacology analysis. Materials and Methods. In this study, active ingredients and associated target proteins of Cordyceps sinensis were obtained via Traditional Chinese Medicine Systems Pharmacology Database (TCMSP) and Swiss Target Prediction platform, then reconfirmed by using PubChem databases. …”
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Correlations between symptoms, nasal endoscopy and computed tomography findings in patients with chronic rhinosinusitis without nasal polyps by Savović Slobodan, Dragnić Nataša, Kljajić Vladimir, Jovančević Ljiljana, Buljčik-Čupić Maja, Lemajić-Komazec Slobodanka

“…The aim of this paper was to determine if there is a correlation between the symptoms, nasal endoscopy and CT in patients with CRSsNP. Methods. The study included 110 patients with CRSsNP. …”
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NUCLEAR MEDICINE IMAGING IN THE DETECTION OF LOCALLY ADVANCED LARYNGEAL AND HYPOPHARYNGEAL CANCER by A. A. Medvedeva, V. I. Chernov, R. V. Zeltchan, I. G. Sinilkin, I. G. Frolova, S. V. Chizevskaya, E. L. Choynzonov, O. V. Cheremisina, A. V. Goldberg

“…Diagnostic capabilities of nuclear medicine imaging in the detection and assessment of the spread of laryngeal/hypopharyngeal cancer were studied. Material and methods. The study included 40 patients with histologically verifed laryngeal/ hypopharyngeal cancer, 10 patients with tumor recurrence after completion of therapy and 20 patients with benign laryngeal lesions. …”
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Effect of Laser Photobiomodulation on Postoperative Pain After Single-Visit Endodontic Treatment in Children: A Randomized Control Trial by Yashaswini S. Angolkar, Sadanand Kulkarni, Chandrashekar M. Yavagal, Puja C. Yavagal, Umesh Bhosle, Viplavi Chavan Patil, Sultan Abdulrahman Almalki, Inderjit Murugendrappa Gowdar, Khalid Gufran

“…Background: This study aimed to assess the effectiveness of laser photobiomodulation (PBM) in reducing postoperative pain following single-visit endodontic treatment in children aged 5–9 years. Methods: Forty children aged 5–9 years with acute irreversible pulpitis in deciduous molars requiring single-visit pulpectomy were included in the study. …”
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Oral donor site evaluation in the early and late postoperative periods for augmentation and replacement urethroplasty by M. M. Iritsyan, A. A. Klimenko, A. A. Mantsov, I.-N. K. Suyundikov, A. P. But, R. A. Rakhmatov, M. V. Prismakova, E. M. Alekberov, S. V. Kotov

“…To evaluate early and late postoperative changes in the donor area after oral graft extraction for urethroplastyMaterials & methods. A retrospective analysis of the results of surgical treatment using oral mucosa from 2017 to 2022 was carried out. …”
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Language function improvement and cortical activity alteration using scalp acupuncture coupled with speech-language training in post-stroke aphasia: A randomised controlled study by Bingbing Lin, Jinglei Ni, Xiao Xiong, Lanlan Zhang, Jian Song, Mengxue Wang, Linsong Chai, Yunshi Huang, Jia Huang

“…Our objectives were to evaluate the impact of scalp acupuncture on the cerebral cortex of post-stroke aphasia patients. Methods: This assessor-blinded, parallel-arm design, single-center, randomized clinical trial recruited 64 patients with post-stroke aphasia. …”
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Generating synthetic brain PET images of synaptic density based on MR T1 images using deep learning by Xinyuan Zheng, Patrick Worhunsky, Qiong Liu, Xueqi Guo, Xiongchao Chen, Heng Sun, Jiazhen Zhang, Takuya Toyonaga, Adam P. Mecca, Ryan S. O’Dell, Christopher H. van Dyck, Gustavo A. Angarita, Kelly Cosgrove, Deepak D’Souza, David Matuskey, Irina Esterlis, Richard E. Carson, Rajiv Radhakrishnan, Chi Liu

“…We therefore aim to generate synthetic [11C]UCB-J PET images based on MRI in this study. Methods We implemented a convolution-based 3D encoder-decoder to predict [11C]UCB-J SV2A PET images. …”
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Health-related quality of life with bemarituzumab plus mFOLFOX6 in patients with FGFR2b-overexpressing, advanced gastric or gastroesophageal junction cancer by Z.A. Wainberg, P.C. Enzinger, S. Qin, K. Yamaguchi, J. Wang, X. Zhou, A. Gnanasakthy, K. Taylor, A. Yusuf, I. Majer, A. Jamotte, Y.-K. Kang

“…Using data from the final analysis, we analyzed patient-reported outcomes (PROs) to evaluate the impact of adding bemarituzumab to mFOLFOX6 on health-related quality of life (HRQoL). Materials and methods: Patients were randomized 1 : 1 to bemarituzumab plus mFOLFOX6 (n = 77) or placebo plus mFOLFOX (n = 78). …”
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Functional Recovery After Hip Arthroplasty with a Minimal Invasive or Classical Approach Eight Years After Intervention by Mirela Vuckovic, Lana Ruzic, Karlo Tudor, Tomislav Prpic, Zdravko Jotanovic, Silvije Segulja, Andrica Lekic, Ksenija Bazdaric

“…<b>Background:</b> The aim of this study was to investigate differences in functional recovery eight years after total hip arthroplasty in patients who underwent hip joint surgery using two different approaches: the classic lateral approach and the anterolateral minimally invasive surgical approach. <b>Methods:</b> Eight years after the hip replacement, 68 subjects, 32 in the classic and 36 in the minimally invasive group, underwent follow-up measurements involving the Harris Hip Score (HHS), range of motion, strength of the abductor muscles, 50-m walk time, body mass index (BMI), physical activity questionnaire, and visual analogue scale (VAS) pain during general activities. …”
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Bipolar disorders and creativity: the roles of ambition, effort-based decision-making, and exploration by Samson Tse, Sheri L. Johnson, Chong Ho Yu, Winnie Yuen, Iris Lo, Luke Clark, Luke Clark, Erin E. Michalak, Erin E. Michalak, Manon Ironside, Kiana Modavi

“…The current work is the first to examine ambition, exploration versus exploitation ratio, and insensitivity to effort/rewards among individuals with and without BD in an Asian cultural context.MethodsWriters and visual artists from Hong Kong who were diagnosed with BD completed a questionnaire to assess lifetime creative accomplishments, a self-rated measure of ambition, and two laboratory-based tasks: the observe-or-bet task to detect exploration versus exploitation tendencies, and an effort discounting task to measure sensitivity to effort required and reward level.ResultsThe sample included 44 participants diagnosed with BD and 69 control participants, with 87 (77%) being female and an average age of 35.1 years (range: 18 to 65). …”
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Exploring the interaction effects of subclinical hypothyroidism and major depressive disorder on brain networks by Shuai Zhao, Jindan Wu, Xiaomei Liu, Yishan Du, Xiaoqin Wang, Yi Xia, Hao Sun, Haowen Zou, Xumiao Wang, Zhilu Chen, Rui Yan, Hao Tang, Qing Lu, Zhijian Yao

“…This study aimed was to investigate the neurological mechanisms underlying this co-occurrence using a data-driven approach to analyze brain activity patterns. Methods Twenty-nine patients diagnosed with MDD without any comorbid conditions (nSHypo-MDD) were included in the study, along with 29 MDD patients who also had SHypo (SHypo-MDD), 26 patients with SHypo only, and 29 healthy individuals as controls (HCs). …”
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Long-Term Outcomes of Modified Expansive Open-Door Laminoplasty Combined with Short-Level Anterior Cervical Fusion in Multilevel Cervical Spondylotic Myelopathy by Szu-Wei Chen, Kuang-Ting Yeh, Cheng-Huan Peng, Chia-Ming Chang, Hao-Wen Chen, Tzai-Chiu Yu, Ing-Ho Chen, Jen-Hung Wang, Wan-Ting Yang, Wen-Tien Wu

“…This study aimed to assess the long-term efficacy of modified expansive open-door laminoplasty (MEOLP) combined with short-level anterior cervical fusion (ACF) in providing decompression, preserving alignment, and maintaining range of motion (ROM) over a nine-year follow-up. <i>Materials and Methods</i>: A retrospective analysis was conducted on 124 MCSM patients treated with MEOLP combined with ACF between 2011 and 2015. …”
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The cellular and extracellular proteomic signature of human dopaminergic neurons carrying the LRRK2 G2019S mutation by Felix Knab, Giambattista Guaitoli, Mohamed Ali Jarboui, Felix von Zweydorf, Fatma Busra Isik, Franziska Klose, Anto Praveen Rajkumar, Thomas Gasser, Thomas Gasser, Christian Johannes Gloeckner

“…With LRRK2 inhibitors entering clinical trials, there is an unmet need for biomarkers that reflect LRRK2-specific pathology and target engagement.MethodsIn this study, we used induced pluripotent stem cells derived from a patient with Parkinson’s disease carrying the LRRK2 G2019S mutation and an isogenic gene-corrected control to generate human dopaminergic neurons. …”
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The effects of the physical procedures in patients with diabetic neuropathy by Grbović Vesna, Stefanović Srđan, Đukić Svetlana, Nurković Jasmin, Zdravković-Petrović Nataša, Parezanović-Ilić Katarina, Divjak Ana, Jurišić-Škevin Aleksandra

“…The aim of our study was to compare the effects of physical therapy (PT) and alpha-lipoic acid (ALA) supplementation on pain reduction and quality of life improvement in the DSP patients. Methods. The study was performed on 60 adult patients with DM type 2 and DSP. …”
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Statistical learning to identify and characterise neurodevelopmental outcomes at 2 years in babies born preterm: model development and validation using population-level data from E... by Sadia Haider, Athanasios Tsanas, G. David Batty, Rebecca M. Reynolds, Heather C. Whalley, Simon R. Cox, Riccardo E. Marioni, Cheryl Battersby, James P. Boardman

“…This study applies statistical learning to a national database to identify transdomain clusters and their maternal and neonatal predictors. Methods: Latent class analysis (LCA) was used to derive transdomain clusters from parent-reported visual, auditory, neuromotor, and communication impairments in preterm-born children at two years corrected age using the UK National Neonatal Research Database data (N = 27,261). …”
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Blood-brain barrier disruption mediates the association between cerebral small vessel disease and clinical outcome after stroke: a secondary analysis of the Lesion Evolution in Str... by Derrick N. Okine, Derrick N. Okine, Kyle C. Kern, Kyle C. Kern, Kyle C. Kern, Marie Luby, Lawrence L. Latour, Rebecca F. Gottesman

“…WMH were visually graded on baseline FLAIR for presence and severity (minor or moderate-severe). …”
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Layered structural engineering of Bi2O3/PP and WO3/PP composites for γ-ray shielding in high energy range: anisotropic attenuation mechanisms via Monte Carlo simulation and experim... by Xiangjie Duan, Jie Zhao, Shuaida Song, Na Zhou, Jizhuang Fan, Bo Tian, Yunchen Du

“…Herein, FLUKA Monte Carlo simulations capable of visualizing γ-photon transport behaviors are investigated in Bi2O3/PP and WO3/PP multi-layer composites with various layered configurations. …”
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