Detection of EGFR Mutations (Ex19Del, T790M, S768I, C797S, Ex20ins, G719X, L858R, L861Q) in Non-small Cell Lung Carcinoma and its Association with Various Clinicopathological Param... by Aditya A Mundra, Abha Mathur, Ram Mohan Jaiswal, Maneesh Vijayvargiya, Neha Sethi, Manoj Sharma, Shweta Bansal, Shikha Goyal

“…Aim: The aim of this study was to detect EGFR mutations in NSCLC and associate the mutation status with clinicopathological parameters. Materials and Methods: The present cross-sectional study was conducted in the Department of Oncopathology and Transplant Immunology Molecular lab at Mahatma Gandhi Hospital, Jaipur, Rajasthan, India, from June 2023 to May 2024. …”
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Pyrethroid-resistant malaria vector Anopheles gambiae restored susceptibility after pre-exposure to piperonyl-butoxide: results from country-wide insecticide resistance monitoring... by Bilali Kabula, Yeromin P. Mlacha, Naomi Serbantez, Samwel L. Nhiga, Sigsbert Mkude, Samson Kiware, James S. Michael, Victor Mero, Sarah-Blythe Ballard, Adeline Chan, Said Abbasi, Charles D. Mwalimu, Nicodem J. Govella

“…Monitoring of insecticide resistance is, therefore, critical for the selection and assessment of the programmatic impact of insecticide-based interventions. Methods The study was conducted country-wide across 22 sentinel districts of Tanzania between May and July 2023 using standard World Health Organization susceptibility test with 1×, 5×, and 10× of deltamethrin, permethrin, and alpha-cypermethrin and discriminating concentrations of 0.25% pirimiphos-methyl. …”
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Effect of staining and whitening systems on color stability of computer aided design/computer aided manufacturing lithium disilicate glass ceramic by Nadia S. Al-Angari, Shahad Quwayhis, Nouf Almayouf, Shahad Meaigel, Abdulelah Aldahash, Sarah S. Al-Angari

“…Purpose: To investigate the effect of coffee stain and whitening systems on the color stability of CAD/CAM glazed lithium disilicate glass-ceramics (LDGCs). Methods:  68 glazed LDGC discs (12 × 10 × 2 mm) were fabricated using blocks of CAD/CAM systems (IPS e.max CAD ceramic). …”
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Bridging the Gap: A Qualitative Study Exploring the Impact of the Involvement of Researchers With Lived Experience on a Multisite Randomised Control Trial in the National Probation... by Elizabeth Simes, Stephen Butler, Elizabeth Allison, Barbara Barrett, Anthony Bateman, Angus Cameron, Mike Crawford, Alison Frater, Zoe Hoare, Mary McMurran, Paul Moran, Stephen Pilling, James Wason, Jessica Yakeley, Peter Fonagy

“…This qualitative study aimed to explore the value of involving researchers with lived experience of the criminal justice system as data collectors in the Mentalization for Offending Adult Males (MOAM), a multisite RCT conducted in the National Probation Service in England and Wales. Methods Semi‐structured interviews were conducted with 30 trial participants and 17 key stakeholders, either in person or via telephone. …”
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Gender-based differences in career paths, parenthood and perspectives on professional barriers among Asian ophthalmologists by Claire L Peterson, Brian S.Y. Yeo, Shelley Yin-Hsi Chang, Rachel S Chong, Marcus Ang, Anna CS Tan, Tina Wong, Andrew S.H. Tsai

“…Background: Gender equality in Asia remains under-researched, especially within medical fields. …”
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Monitoring of liver and kidney profiles in anesthesiologists working in a regional reference teaching hospital in Northern Italy: analysis of health surveillance data using a linea... by Alborz Rahmani, Guglielmo Dini, Alfredo Montecucco, Luca Priano, Marco Leonetti, Alessia Manca, Bruno Kusznir Vitturi, Paolo Durando

“…Moreover, we assessed the appropriateness of applying linear mixed models to occupational health data. Material and Methods A retrospective cohort study was conducted using health surveillance data from a cohort of anesthesiologists and a cohort of unexposed physicians working at the Polyclinic Hospital San Martino of Genoa, Italy, during 2016–2022. …”
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An Integrated Nomogram Combining Deep Learning and Radiomics for Predicting Malignancy of Pulmonary Nodules Using CT‐Derived Nodules and Adipose Tissue: A Multicenter Study by Shidi Miao, Qifan Xuan, Hanbing Xie, Yuyang Jiang, Mengzhuo Sun, Wenjuan Huang, Jing Li, Hongzhuo Qi, Ao Li, Qiujun Wang, Zengyao Liu, Ruitao Wang

“…This study aimed to construct a deep learning radiomics clinical nomogram (DLRCN) for predicting malignancy of pulmonary nodules. Methods One thousand and ninety‐eight patients with 6–30 mm pulmonary nodules who received histopathologic diagnosis at 3 centers were included and divided into a primary cohort (PC), an internal test cohort (I‐T), and two external test cohorts (E‐T1, E‐T2). …”
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Mortality risk associated with clinical signs of possible serious bacterial infection (PSBI) in young infants in Africa and Asia: protocol for a secondary pooled analysis by Adejumoke Idowu Ayede, Samir K Saha, Saifuddin Ahmed, Mohammad Shahidul Islam, Gary L Darmstadt, Fabian Esamai, Antoinette Tshefu Kitoto, Ebunoluwa A Adejuyigbe, Yasir Bin Nisar, Shamim Ahmad Qazi, Vaishnavi Bhamidi, Khusbu Adhikari, Ivana Marić, Robinson D Wammanda

“…There is a need to further examine the association of signs of PSBI individually and in combination with risk of mortality and to analyse global data to inform global recommendations.Methods and analysis We will create a dataset that integrates data from population-based studies globally with similar designs that have examined the presence of signs of PSBI identified by frontline health workers throughout the young infant period (days 0 to <60) and that have also recorded infant vital status. …”
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A Phase 1/1B Trial of Pembrolizumab and Trametinib in Advanced NSCLC Enriched for KRAS Mutations by Jonathan W. Riess, MD, MS, Matthew S. Lara, BS, Guillaume Luxardi, PhD, Miguel Lopez de Rodas, MD, Michiko Shimoda, PhD, Karen Kelly, MD, Primo N. Lara, MD, Laurel Beckett, PhD, Arta Monjazeb, MD, PhD, Kurt A. Schalper, MD, PhD, Emanual Maverakis, MD, David R. Gandara, MD

“…This phase 1 study evaluated sequencing schemes of MEKi and ICI with trametinib and pembrolizumab in NSCLC. Methods: In this 3+3 dose escalation study, patients with advanced NSCLC were treated with lead-in trametinib (arm A) or lead-in pembrolizumab (arm B) for cycle 1, followed by a 1.5 to 2 mg oral daily dose of trametinib (d 1–10) with pembrolizumab 200 mg intravenously every 21 days. …”
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Investigation of white matter functional networks in young smokers by Junxuan Wang, Ting Xue, Daining Song, Fang Dong, Yongxin Cheng, Juan Wang, Yuxin Ma, Mingze Zou, Shuailin Ding, Zhanlong Tao, Wuyuan Xin, Dahua Yu, Kai Yuan

“…Aims: This study investigated the changes in the organizational and intrinsical activities of the white matter functional networks (WMFNs) in young smokers using resting-state functional magnetic resonance imaging. Methods: A data-driven approach was used to characterize the WMFNs of 30 young smokers and 30 non-smokers. …”
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Evaluation of the risk factors for rhegmatogenous retinal detachment associated with choroidal detachment from the viewpoint of treatment patterns: a retrospective study by Kai Gao, Zi-Ye Chen, Zhuang-Ling Lin, Ya-Ping Liu, Bao-Yi Liu, Yuan Ma, Zi-Tong Chen, Rebiya●Tuxun, Lan Jiang, Zhuo-Jun Xu, Chin-Ling Tsai, Kun-Bei Lai, Tao Li

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The Effect of Protein and Protein Source on Appetite in Older Adults: Preliminary Findings from the FortiPhy Study by Ezgi Ozen, Katherine Roberts-Thomson, Rachel Smith, Claire Sulmont-Rosse, Lisa Methven, Miriam Clegg

“…Therefore, the objective of this study was to assess the effect of the meals fortified with protein from different sources on satiety and appetite. Methods: In this single-blind randomised crossover study, the effect of protein fortification on satiety and appetite was investigated in 10 healthy older adults (n = 7 women and n = 3 men) with a mean age of 76 (SD 3) years and a BMI of 23.7 (SD 2.6). …”
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Network localization of regional homogeneity alterations in Parkinson’s disease by Yuanying Song, Hucheng Yang, Hucheng Yang, Siyu Gu, Yingling Zhu, ZhenYu Dai, Pinglei Pan, Xianxian Zhang

“…Functional Connectivity Network Mapping (FCNM) offers an approach to test this hypothesis.MethodsWe conducted a systematic literature search (PubMed, Embase, Web of Science, CNKI, and Wanfang) for studies reporting whole-brain ReHo differences (PD vs. healthy controls). …”
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Scarf osteotomy combined with akin osteotomy for the treatment of patients with moderate hallux valgus: a retrospective study combining plantar pressure testing and gait analysis by Peng Lu, Songchuan Su, Xin Li, Liqi Ng, Xiaotian Xiong, Qiuping Zhang, Yusong Liu, Yu Zhou

“…Clinical assessment measures encompassed the Visual Analogue Scale (VAS) and the Japanese Society for Surgery of the Foot (JSSF) HV scale. …”
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Evaluating Sperm Recovery Time and Efficacy of Monotherapy vs. Combination Therapies in Men with Congenital Hypogonadotropic Hypogonadism: A Systematic Review and Meta-Analysis by Edoardo Pozzi, Vishal Ila, Francis Petrella, Christian Corsini, Armin Ghomeshi, Rohan Dureja, Daniel Boaretto, Tharun Somasundar, Andrea Salonia, Ranjith Ramasamy

“…We aimed to investigate the time and rates to recover spermatogenesis among azoospermic CHH men receiving monotherapy vs. combination therapy. Materials and Methods: We conducted a systematic review and meta-analysis following the PRISMA guidelines. …”

Mobile Therapeutic Attention for Treatment-Resistant Schizophrenia (m-RESIST) Solution for Improving Clinical and Functional Outcomes in Treatment-Resistant Schizophrenia: Prospect... by Jussi Seppälä, Eva Grasa, Anna Alonso-Solis, Alexandra Roldan-Bejarano, Marianne Haapea, Matti Isohanni, Jouko Miettunen, Johanna Caro Mendivelso, Cari Almazán, Katya Rubinstein, Asaf Caspi, Zolt Unoka, Kinga Farkas, Elisenda Reixach, Jesus Berdun, Judith Usall, Susana Ochoa, Iluminada Corripio, Erika Jääskeläinen

“…ObjectiveWe aim to evaluate the effects of m-RESIST on the clinical and functional outcomes and on the perceived quality of life in people with TRS. MethodsA feasibility study without a control group was performed to test the m-RESIST solution on patients with TRS. …”
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PROGNOSTIC FACTORS FOR THE RESPONSE TO TOCILIZUMAB THERAPY IN PATIENTS WITH JUVENILE IDIOPATHIC ARTHRITIS WITHOUT SYSTEMIC MANIFESTATIONS: A COHORT STUDY by Ekaterina I. Alexeeva, Tatyana M. Dvoryakovskaya, Kseniya B. Isaeva, Tatyana V. Sleptsova, Rina V. Denisova, Margarita A. Soloshenko, Olga L. Lomakina, Anna N. Fetisova, Mariya G. Rudnickaya, Dariya D. Vankova, Alina A. Alshevskaya, Andrei V. Moskalev, Anna V. Mamutova

“…Our aim was to reveal early predictors for the response to tocilizumab therapy in patients with JIA without systemic symptoms.Methods. A retrospective cohort study enrolled patients with JIA without systemic symptoms who received tocilizumab therapy between July 2009 and August 2017. …”
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Dynamic Anterior Shoulder Stabilization Using a Long Head of the Biceps Transfer and Bankart Repair Improves Clinical Outcomes in Patients With Subcritical Bone Loss: A Systematic... by Neil Jain, M.D., Jonathan McKeeman, M.D., M.B.A., Margaret Higgins, M.D., Alexander Johnson, M.D., Tyler Smith, D.O., Brian Waterman, M.D.

“…Purpose: To assess the clinical outcomes of dynamic anterior stabilization using a long head of the biceps transfer (DAS-LHB) with Bankart repair for management of anterior shoulder instability with subcritical glenoid bone loss. Methods: Using the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines, a review of the PubMed, Scopus, EMBASE, and Medline databases was performed in March 2025. …”
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The Use of Specialized Neuropsychological Training for the Rehabilitation of Patients with Neglect Syndrome by Maria S. Kovyazina, Nataliya A. Varako, Georgiy K. Stepanov, Daria D. Yurina, Victoria A. Propustina, Svetlana A. Vasilyeva, Vadim D. Daminov, Yury P. Zinchenko

“…Currently, insufficient attention is being paid to methods of rehabilitation of patients with negleсt syndrome. …”
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Donor Perceptions and Preferences of Telemedicine and In-Person Visits for Living Kidney Donor Evaluation by Ellie Kim, Hannah C. Sung, Katya Kaplow, Victoria Bendersky, Carolyn Sidoti, Abimereki D. Muzaale, Jasmine Akhtar, Macey Levan, Suad Esayed, Amir Khan, Christina Mejia, Fawaz Al Ammary

“…We aimed to deeply understand donor experiences and preferences using hybrid telemedicine video/in-person visits to ease access to donor evaluation or counseling. Methods: We conducted in-depth, semistructured interviews with donors or donor candidates who completed their evaluation through telemedicine/in-person, or in-person only visits at a tertiary transplant center between November 27, 2019 and March 1, 2021. …”
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