Integrated Bioinformatics and Experimental Validation Reveal Macrophage Polarization-Related Biomarkers for Osteoarthritis Diagnosis by He Q, Liu L, Hu X, Lin L, Song Z, Xia Y, Lin Q, Wei J, Li S

“…In this study, we identified crucial genes associated with macrophage polarization in OA and constructed a diagnostic model to provide novel insights for diagnostic and therapeutic strategies.Methods: The GSE55235 and GSE55457 datasets were merged through the GEO database to identify genes related to macrophage polarization by conducting weighted gene co-expression network analysis (WGCNA) and differential expression analysis. …”
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Multimodal Magnetic Resonance Findings in Parkinson’s Disease With “Antecedent Essential Tremor”: A Case Series of a Large Kindred by Kong Y, Yao L, Xiao X, Chen A, Wang K, Yan H, Sun R, Liu R, Kong Q

“…This study aimed at determining the morphological, microstructural and iron-related changes in these patients’ brains using multimodal magnetic resonance imaging (MRI).Methods: We reviewed a kindred with ET and PD with “antecedent ET” recruited at our hospital in May 2023. …”
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Heme Oxygenase-1 Modulates Macrophage Polarization Through Endothelial Exosomal miR-184-3p and Reduces Sepsis-Induce Lung Injury by Chen W, Zhang Y, Chen J, Dong S, Wu X, Wu Y, Du Z, Yang Y, Gong L, Yu J

“…But research on the mechanism of HO-1 in macrophage polarization via PMVEC exosomes in sepsis-induced lung injury is lacking.Methods: To investigate the role of HO-1 in the interaction between endothelial cells and macrophages, HO-1 knockout mouse model were established. …”
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Unveiling Theranostics: Nanocomplex-Assisted Photodynamic Eradication of Aggressive Cancer Cells and Modulation of Tumor-Associated Macrophages by Butkute A, Kazlauske E, Mlynska A, Peciukaityte E, Karabanovas V, Rotomskis R, Steponkiene S

“…Moreover, diagnostics and treatment are activated simultaneously, without the possibility of switching between two processes.Methods: We used photosensitizer chlorin e6 (Ce6) and luminescent quantum dots (QDs) to create a theranostic nanocomplex. …”
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Butyrylcholinesterase and 24 h-urinary copper excretion as compliance assessment in long-term treated Wilson’s disease by Harald Hefter, Max Novak, Dietmar Rosenthal, Sven G. Meuth, Tom Luedde, Philipp Albrecht, Philipp Albrecht, Christian J. Hartmann, Sara Samadzadeh, Sara Samadzadeh, Sara Samadzadeh, Sara Samadzadeh

“…Evidence is presented that butyrylcholinesterase (CHE) can be used as a sensitive biomarker to detect compliance problems in long-term treated WD-patients.MethodsFor the present retrospective, monocentric study demographical and treatment related data of 108 WD-patients (who had been treated at the Clinic of Neurology of the university hospital in Düsseldorf (Germany) between 2/2005 and 1/2021) were extracted from the charts. …”
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Qing-Luo-Yin Eases T Cells-Mediated Angiogenesis in Adjuvant-Induced Arthritis Rats by Activating PPARγ by Song MK, Wang MQ, Ruan YQ, Cui C, Chen WG, Olatunji OJ, Li Y, Zuo J

“…The study investigated if and how this property contributes to its anti-angiogenesis effects.Methods: Adjuvant-induced arthritis (AIA) rats were orally treated by QLY or rosiglitazone (a PPARγ agonist), and their monocytes and lymphocytes were co-cultured reciprocally in vitro with different sera. …”
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Prevalence of Urinary Incontinence, Risk Factors and Its Impact: Multivariate Analysis from Indonesian Nationwide Survey by Rochani Sumardi, Chaidir A Mochtar, Junizaf Junizaf, Budi I Santoso, Siti Setiati, Siti A Nuhonni, Partini P Trihono, Harrina E Rahardjo, Firtantyo A Syahputra

“… Aim: to describe the profile of urinary infection (UI) and to analyze its risk factors and impacts. Methods: subjects were enrolled consecutively from pediatric, urology, obstetrics & gynecology, and geriatric outpatient clinics at six teaching hospitals in various regions of Indonesia. …”
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Hippocampal Functional Radiomic Features for Identification of the Cognitively Impaired Patients from Low-Back-Related Pain: A Prospective Machine Learning Study by Yang Z, Liang X, Ji Y, Zeng W, Wang Y, Zhang Y, Zhou F

“…Ziwei Yang,1,2,* Xiao Liang,1,2,* Yuqi Ji,1,2 Wei Zeng,1,2 Yao Wang,1,2 Yong Zhang,3 Fuqing Zhou1,2 1Jiangxi Provincial Key Laboratory for Precision Pathology and Intelligent Diagnosis, Department of Radiology, the First Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, 330006, People’s Republic of China; 2Neuroradiology Laboratory, Jiangxi Province Medical Imaging Research Institute, Nanchang, 330006, People’s Republic of China; 3Department of Pain Clinic, The First Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, Jiangxi Province, 330006, People’s Republic of China*These authors contributed equally to this workCorrespondence: Yong Zhang, Department of Pain Clinic, The First Affiliated Hospital, Jiangxi Medical College, Nanchang University, 17 Yongwaizheng Street, Nanchang, Jiangxi, 330006, People’s Republic of China, Tel +86 791 8869 5036, Email zy830226@163.com Fuqing Zhou, Jiangxi Provincial Key Laboratory for Precision Pathology and Intelligent Diagnosis, Department of Radiology, the First Affiliated Hospital, Jiangxi Medical College, Nanchang University, 17 Yongwaizheng Street, Nanchang, Jiangxi, 330006, People’s Republic of China, Tel +86 791 8869 5132, Email ndyfy02301@ncu.edu.cnPurpose: To investigate whether functional radiomic features in bilateral hippocampi can identify the cognitively impaired patients from low-back-related leg pain (LBLP).Patients and Methods: For this retrospective study, a total of 95 clinically definite LBLP patients (40 cognitively impaired patients and 45 cognitively preserved patients) were included, and all patients underwent functional MRI and clinical assessments. …”
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Bloodstream Infections Leading to Sepsis: Clinical and Microbiological Profiling of Bacteremia among Hospitalized Patients in Surabaya, Indonesia by Nuritsna Marwasyifa, Tri Pudy Asmarawati, Firman Setiawan, Pepy Dwi Endraswari

“…This study examined the characteristics of bacteremia cases in 2022 at Universitas Airlangga Hospital, Surabaya, Indonesia. Methods: A retrospective, descriptive observational study was conducted utilizing hospitalized bacteremia patients' medical records. …”
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Tobacco Smoking Was Positively Associated with Disease Relapse at week 24 and 48 Among Patients with Psoriasis Vulgaris in Shanghai: A Prospective Study by Shen F, Ding Y, Qiang Y, Duan Z, Xu Q, Gao X, Zhang R, Wang R

“…This study aims to examine the relapse condition in psoriasis patients and explore the association between tobacco smoking and psoriasis relapse.Patients and Methods: We conducted an observational study with 551 psoriasis patients recruited from 2022 to 2024 in Shanghai Skin Disease Hospital. …”
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Effects of Continuous Erector Spinae Plane Block on the Postoperative Sleep Quality for Patients Undergoing Thoracoscopic Lung Lobe Resection Surgery: A Prospective, Randomized Con... by Zhang Q, Lu X, Zhang W, Zhong Z, Wang L, Qiao Y, Ling F, Qiu X, Zhang Y

“…Qian Zhang,1,2,* Xian Lu,3,* Wen Zhang,4,* Zhenyu Zhong,5,* Lili Wang,4 Yuhan Qiao,4 Fei Ling,4 Xinyuan Qiu,4 Yueying Zhang1,2 1Department of Anesthesiology, The Affiliated Hospital of Xuzhou Medical University, Xuzhou, People’s Republic of China; 2Jiangsu Province Key Laboratory of Anesthesiology, Xuzhou Medical University, Xuzhou, People’s Republic of China; 3Shanghai Key Laboratory of Psychotic Disorders, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, People’s Republic of China; 4Xuzhou Medical University, Xuzhou, People’s Republic of China; 5Department of Anesthesiology, The First Affiliated Hospital of Ningbo University, Ningbo, People’s Republic of China*These authors contributed equally to this workCorrespondence: Yueying Zhang, Department of Anesthesiology, The Affiliated Hospital of Xuzhou Medical University, Xuzhou, People’s Republic of China, Email zyy0218@126.comPurpose: To investigate the effect of continuous erector spinae plane block (ESPB) on postoperative sleep in patients undergoing thoracoscopic lung lobe resection surgery.Patients and Methods: Eighty-six patients were randomly assigned into two groups: ESPB group (Group E) or control group (Group P). …”
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Impact of COVID-19-associated Dysautonomia Phenotypes on the Effectiveness of Venovenous Extracorporeal Membrane Oxygenation by G. E. Savkov, S. S. Petrikov, N. V. Rybalko, L. T. Khamidova, O. Yu. Markatyuk, D. A. Lebedev, K. V. Kiselev, Yu. N. Vrabiy, N. E. Altshuler, K. A. Popugaev

“…The purpose of the presented work is to study the effect of different COVID-19-DA phenotypes on the performance parameters and effectiveness of VV ECMO, gas exchange and hemodynamics in patients with COVID-19.   MATERIAL AND METHODS. The study included 20 patients, 12 (60%) women, 8 (40%) men, with COVID-19 who underwent VV ECMO. …”
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The effects of treadmill exercise and diet control on cognitive function in HFD-induced ApoE-/- mice based on the SIRT1-NF-κB/PGC-1α-BDNF signaling pathways by Xu Ting, Deng Wenjuan, Li Shufeng, Liu Yi, Shi Zhitong, Zhang Xiaoyue, Wang Ningping

“…[Objective] To investigate the effect and mechanism of treadmill exercise and diet control on cognitive dysfunction in apolipoprotein E knockout(ApoE-/-)mice model. [Methods] Forty ApoE -/- male mice fed a high-fat diet for 8 weeks were randomly and equally divided into a high-fat diet exercise (HFD + TR) group, a high-fat diet rest (HFD + SED) group, a diet-controlled exercise (DC + TR) group, and a diet-controlled rest (DC + SED) group, with 10 mice in each group. …”
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Contezolid Harbored Equivalent Efficacy to Linezolid in Tuberculosis Treatment in a Prospective and Randomized Early Bactericidal Activity Study by Jiang G, Liu R, Xue Y, Ge Q, Nie L, Lv Z, Kong Z, Shi J, Chen H, Li H, Wu X, Xie L, Song Y, Huang H, Gao M

“…In this study, we evaluated the early bactericidal activity (EBA) of CZD compared to LZD, with LZD serving as a control.Methods: Naive, smear-positive pulmonary TB patients were enrolled and randomly assigned to receive either a 14-day monotherapy regimen of 600 mg LZD once daily (QD) or 800 mg CZD twice daily (BID). …”
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Feasibility and Outcomes of Vessel-Sparing Surgery for Soft Tissue Sarcoma of the Thigh Adjacent to Femoral Vessels by Yang ZM, Qu H, Wang KY, Wu JD, Liu B, Jin LB, Huang X, Lin N, Tao HM, Ye ZM

“…A comparison was made with cases where the tumor was not adjacent to the femoral vessels, focusing on recurrence rates, survival prognosis, and the viability of vessel-sparing surgical techniques.Methods: A retrospective analysis was conducted on 211 cases. …”
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Saikosaponin-d Attenuates Irinotecan-Induced Intestinal Toxicity via TAK1/NF-κB Pathway and Enhances Antitumor Efficacy by Zheng P, Ma R, Liu X, Song L, Ma B, Zou G

“…This study investigates the therapeutic potential and mechanisms of SSD against irinotecan (IRI)-induced intestinal mucositis.Methods: Using a CT26 colorectal cancer Syngeneic mouse model (BALB/c mice), we evaluated the synergistic antitumor efficacy of SSD combined with IRI. …”
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Assessment of Anxiety and Depression in the Perioperative Period in Women of Reproductive Age During Regional Anesthesia by O. A. Chernykh, R. E. Lakhin, A. V. Shchegolev

“…Prediction, early detection and effective treatment of these disorders are important for the well-being of women and their offspring.Aim of study To evaluate the effect of anesthesia and surgery on the level of anxiety, depression, short-term memory, and concentration in pregnant and nonpregnant women.Material and methods The observational prospective study included 120 patients who were divided into two equal groups — pregnant (n=60) and nonpregnant (n=60) women. …”
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Impacts of Avoiding Emergency Department Visits During the COVID-19 Pandemic Among Patients With Acute Ischemic Heart Events by Sung TC, Wang YC, Hsu HC, Huang YT, Shih HI

“…This study investigated how the pandemic influenced medical avoidance in such cases and assessed potential collateral damage and adverse outcomes in an ED that managed limited COVID-19 instances during this period.Methods: An observational cross-sectional study was conducted on adult ED visits at a tertiary hospital from January 2017 to December 2020, focusing on symptoms associated with acute ischemic heart events and complications. …”
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Impact of Comorbid Asthma on Life Quality of Patients with Chronic Rhinosinusitis and Nasal Polyps by Wu PW, Chang PH, Huang CC, Lee TJ, Fan YH, Huang CC

“…Pei-Wen Wu,1,2,* Po-Hung Chang,1,* Chi-Che Huang,1,2 Ta-Jen Lee,1– 3 Yu-Hsi Fan,1 Chien-Chia Huang1,2 1Division of Rhinology, Department of Otolaryngology, Chang Gung Memorial Hospital and Chang Gung University, Taoyuan, Taiwan; 2School of Medicine, Chang Gung University, Taoyuan, Taiwan; 3Department of Otolaryngology, Xiamen Chang Gung Hospital, Xiamen, People’s Republic of China*These authors contributed equally to this workCorrespondence: Chien-Chia Huang, Division of Rhinology, Department of Otolaryngology, Chang Gung Memorial Hospital, Linkou Branch, No. 5, Fu-Shin Street, Kweishan, Taoyuan, 333, Taiwan, Tel +886-3-3281200 ext. 8466, Fax +886-3-3979361, Email agar@cgmh.org.twObjective: This study aimed to characterize the clinical features of patients with comorbid asthma and chronic rhinosinusitis with nasal polyps and to evaluate the impact of comorbid asthma on the quality of life of these patients.Methods: Adult patients with bilateral chronic rhinosinusitis with nasal polyps scheduled for sinus surgery were prospectively enrolled. …”
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Knowledge, Attitude, and Practice of Palliative Care Among Physicians and Nurses in Intensive Care Units in Shanghai, China by He X, Cai H, Zhang J, Chen W, Zhu B

“…The study aims to assess the KAP of palliative care ICU physicians and nurses and identify influencing factors.Patients and Methods: A cross-sectional survey was conducted among ICU physicians and nurses at three Shanghai hospitals. …”
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