Establishing a Prediction Model for Weight Loss Outcomes After LSG in Chinese Obese Patients with BMI ≥ 32.5 Kg/m2 Using Body Composition Data by Wang L, Sun Y, Sang Q, Wang Z, Yu C, Li Z, Shang M, Zhang N, Du D

“…However, suboptimal results are observed in certain patients.Objective: Drawing from body composition data at our center, clinically accessible predictive factors for weight loss outcomes were identified, leading to the development and validation of a preoperative predictive model for weight loss following LSG.Methods and Materials: A retrospective analysis was conducted on the general clinical baseline and body composition data of obese patients (body mass index [BMI] ≥ 32.5 kg/m2) who underwent LSG between December 2016 and December 2022. …”
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Increment of Skeletal Muscle Mass Predicts Survival Benefit for Hepatocellular Carcinoma Treated with Transarterial Chemoembolization Combining Molecular Targeted Agents and Immune... by Chen W, Yan HT, Zhang JX, Shen X, Liu J, Liu S, Shi HB, Ding Y, Zu QQ

“…Wen Chen,1,* Hai-Tao Yan,1,* Jin-Xing Zhang,1 Xiao Shen,1 Jin Liu,2 Sheng Liu,1 Hai-Bin Shi,1 Ye Ding,3 Qing-Quan Zu1 1Department of Interventional Radiology, The First Affiliated Hospital with Nanjing Medical University, Nanjing, 210029, People’s Republic of China; 2Department of Clinical Medicine Research Institution, The First Affiliated Hospital with Nanjing Medical University, Nanjing, 210029, People’s Republic of China; 3Department of Maternal, Child and Adolescent Health, School of Public Health, Nanjing Medical University, Nanjing, 211166, People’s Republic of China*These authors contributed equally to this workCorrespondence: Ye Ding, Department of Maternal, Child and Adolescent Health, School of Public Health, Nanjing Medical University, Nanjing, 211166, People’s Republic of China, Tel +86-025-8686-8459, Email dingye@njmu.edu.cn Qing-Quan Zu, Department of Interventional Radiology, The First Affiliated Hospital with Nanjing Medical University, No. 300, Guangzhou Road, Nanjing, 210029, People’s Republic of China, Tel +86-13913807470, Email zuqingquan@njmu.edu.cnPurpose: To assess the relationship between clinical prognosis and changes of skeletal muscle mass for unresectable hepatocellular carcinoma (uHCC) patients who received transarterial chemoembolization (TACE) with molecular-targeted agents and immune checkpoint inhibitors (TACE-MTAs-ICIs).Methods: From June 2019 to June 2023, a total of 92 uHCC patients who received TACE-MTAs-ICIs therapy were included. …”
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Feasibility and Safety of Anlotinib Plus Docetaxel versus Docetaxel Monotherapy in Patients with Previously Immunotherapy-Treated NSCLC: A Retrospective Exploratory Study by Li DW, Li YD, Jin H

“…Da-Wei Li,1,* Ying-Dong Li,2,* Hong Jin3 1Department of Prescription Teaching and Research, Heilongjiang University of Chinese Medicine, Harbin, Heilongjiang, 150006, People’s Republic of China; 2Department of Intensive Care Rehabilitation, The Fourth Affiliated Hospital of Heilongjiang University of Chinese Medicine, Harbin, Heilongjiang, 150070, People’s Republic of China; 3Department of Acupuncture, The First Affiliated Hospital of Heilongjiang University of Chinese Medicine, Harbin, Heilongjiang, 150040, People’s Republic of China*These authors contributed equally to this workCorrespondence: Hong Jin, Department of Acupuncture, The First Affiliated Hospital of Heilongjiang University of Chinese Medicine, No. 26, He Ping Street, Xiang Fang District, Harbin, Heilongjiang, 150040, People’s Republic of China, Tel +86 13836129681, Email 9937200@qq.comObjective: This study aims to evaluate the efficacy and safety of anlotinib plus docetaxel in patients with advanced non-small cell lung cancer (NSCLC) who have previously treated with immunotherapy.Methods: This retrospective analysis was conducted on 86 previously immunotherapy-treated patients with advanced NSCLC from December 2018 to October 2024 in clinical practice. …”
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Time-Course Renal and Pulmonary Injury Analysis and Bioinformatics Screening of Core Pathogenic Genes and Immune Cell Infiltration Patterns in a Sepsis by Apizi A, Li J, Kamilijiang P, Yang CB, Wang ZK, Chai RF, Yu ZX

“…Anwaier Apizi,* Jian Li,* Paiheriding Kamilijiang, Chun-Bo Yang, Zheng-Kai Wang, Rui-Feng Chai, Zhao-Xia Yu Department of Intensive Care Unit, The First Affiliated Hospital of Xinjiang Medical University, Urumqi, 830054, People’s Republic of China*These authors contributed equally to this workCorrespondence: Zhao-Xia Yu, Department of Intensive Care Unit, The First Affiliated Hospital of Xinjiang Medical University, Urumqi, 830054, People’s Republic of China, Tel +86 13899858397, Email zhaoxia_yu01@126.com Rui-Feng Chai, Department of Intensive Care Unit, The First Affiliated Hospital of Xinjiang Medical University, Urumqi, 830054, People’s Republic of China, Tel +86 13999819217, Email chairuifeng_chai@126.comObjective: This study aimed to evaluate the extent of organ damage associated with sepsis and to identify key genes implicated in its pathogenesis.Methods: Eighteen rats were randomized into experimental and control groups. …”
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Diabetes mellitus as an economic problem in Russian Federation by Ivan Ivanovich Dedov, Vitaliy Vladimirovich Omelyanovskiy, Marina Vladimirovna Shestakova, Maria Vladimirovna Avksentieva, Viktoria Igorevna Ignatieva

“…Objective.To estimate annual expenditures attributed to diabetes mellitus (DM) per patient in Russia based on data from epidemiologic studies and to analyse DM cost drivers.Methods.The expenditures per diabetic patient were calculated as the sum of medical costs (outpatient and emergency room visits, inpatient care and medications provided during outpatient care), payments for sick leaves, disability pensions and gross domestic production (GDP) losses due to temporary disability (indirect costs). …”
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Therapeutic Innovations in Nanomedicine: Exploring the Potential of Magnetotactic Bacteria and Bacterial Magnetosomes by Yadav VK, Pramanik S, Alghamdi S, Atwah B, Qusty NF, Babalghith AO, Solanki VS, Agarwal N, Gupta N, Niazi P, Patel A, Choudhary N, Zairov R

“…Further authors have reviewed the various functionalization methods of the magnetosomes for cancer treatment. …”
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Trends and Hospitalization Outcomes of Tetanus Cases: A Multicenter Retrospective Study in Suzhou, 2013–2023 by Yu J, Zheng B, Liu N, Zhu Y, Hui F, Zhang J, Luan L

“…Jiangtao Yu,1,* Benfeng Zheng,2,* Na Liu,2,3 Yiheng Zhu,4 Fen Hui,5 Jin Zhang,5 Lin Luan1,2 1Department of Epidemiology, School of Public Health, National Vaccine Innovation Platform, Nanjing Medical University, Nanjing, 210000, People’s Republic of China; 2Department of Immunization Program, Suzhou Center for Disease Control and Prevention, Suzhou, 215000, People’s Republic of China; 3Center for Immunization Planning, Chinese Center for Disease Control and Prevention, Beijing, 100050, People’s Republic of China; 4Suzhou Municipal Health Commission, Suzhou, 215000, People’s Republic of China; 5The Fifth People’s Hospital of Suzhou, Suzhou, 215000, People’s Republic of China*These authors contributed equally to this workCorrespondence: Lin Luan, Email szluanlin@163.comObjective: To investigate the epidemiology, and hospitalization of tetanus in Suzhou, Jiangsu Province, China, focusing on the severity of the disease, treatment, outcomes and hospitalization costs, and to explore the risk factors for severe tetanus.Methods: This retrospective, multicenter observational study analyzed tetanus patients admitted to various medical institutions between 2013 and 2023. …”
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Clinicopathological Features and Prognostic Factors of Renal Cell Carcinoma in Young Patients Under 45 Years: A Single-Center Retrospective Study by Gao Y, Yan H, Zhang T, Lu G, Ma L

“…Yu Gao,1,* Haisheng Yan,2,* Tao Zhang,2 Guanjun Lu,1 Lianghong Ma1,3 1Urology Department of General Hospital of Ningxia Medical University, Yinchuan, 750004, People’s Republic of China; 2The First Clinical Medical College, Ningxia Medical University, Yinchuan, 750004, People’s Republic of China; 3Key Laboratory of Fertility Preservation and Maintenance of Ministry of Education, School of Basic Medical Sciences, Ningxia Medical University, Yinchuan, 750004, People’s Republic of China*These authors contributed equally to this workCorrespondence: Lianghong Ma, Email mmm1770@163.comObjective: To explore the clinicopathological characteristics, diagnostic approaches, and therapeutic strategies for renal cell carcinoma (RCC) in young patients under 45 years of age, aiming to provide insights for early detection and improved prognosis.Methods: We retrospectively analyzed the clinical data of 150 RCC patients aged 18 to 45 years treated at the General Hospital of Ningxia Medical University from 2011 to 2023. …”
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Seroprevalence of SARS-CoV-2 antibodies in people with an acute loss in their sense of smell and/or taste in a community-based population in London, UK: An observational cohort stu... by Janine Makaronidis, Jessica Mok, Nyaladzi Balogun, Cormac G Magee, Rumana Z Omar, Alisia Carnemolla, Rachel L Batterham

“…It also evaluated whether smell or taste loss are indicative of COVID-19 infection.<h4>Methods and findings</h4>Text messages, sent via primary care centers in London, United Kingdom, invited people with loss of smell and/or taste in the preceding month, to participate. …”
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Restricted kinematic total knee arthroplasty provided better functional outcomes and higher satisfaction rates for Asians of genu varum with apex distal joint line over unrestricte... by Jia Yi Loh, Ming Han Lincoln Liow, Glen Purnomo, Merrill Lee, Jerry Yongqiang Chen, Hee-Nee Pang, Keng Jin Darren Tay, Seng-Jin Yeo

“…Unrestricted calipered KA-TKA targeted equal bone cuts while restricted KA-TKA utilized intraoperative navigation to restrict tibia varus to 4°. …”
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Risk Factors Affecting Quality of Life in Chronic Limb Threatening Ischemia Patients by Wu R, Yu Y, Guo J, Gao X, Tong Z, Guo J, Cui S, Zhang C, Guo L

“…Understanding these relationships could provide insights into optimizing patient management and improving their overall QoL.Patients and Methods: This study was conducted at our center from January 2021 to January 2024. …”
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The Role of PLIN3 in Prognosis and Tumor-Associated Macrophage Infiltration: A Pan-Cancer Analysis by Yang S, Liu H, Zheng Y, Chu H, Lu Z, Yuan J, Xu S

“…This study leverages data retrieved from multiple databases to address these questions.Methods: PLIN3 mRNA and protein expressions were analyzed across a diverse range of normal and cancerous tissues, utilizing data retrieved from multiple databases. …”
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Buyang Huanwu Decoction Alleviates Ischemic Stroke Injury by Inhibiting Ferroptosis via the Nrf2/GPX4 Pathway by Huang H, Liu S, Wu J, Zhu J, Xu J, Yu S, Bei L, Zhang B, Luo Y

“…Despite its long history in stroke treatment, the mechanism of Buyang Huanwu Decoction (BHD) in ferroptosis remains unclear.Methods: Network pharmacology predicted BHD’s active components and pathways, while Ultra Performance Liquid Chromatography-Tandem Mass Spectrometry (UPLC-MS/MS) confirmed its main ingredients. …”
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Exploring the Anti-Inflammatory and Anti-NET Properties of Zidian Zhenxiao Granule in IgA Vasculitis: A Network Pharmacology and Proteomic Study by Zhang X, Yang M, Duan X, Feng X, Fang Y

“…This study aimed to investigate the main component of ZDZX and its underlying mechanism in IgAV treatment.Methods: Combining UHPLC-QE-MS/MS, network pharmacology, 4D-FastDIA proteomics, and a gliadin-induced IgAV murine model, we systematically deciphered ZDZX’s renoprotective and anti-inflammatory mechanisms.Results: 19 key components were identified in ZDZX, targeting 46 IgAV-associated proteins, predominantly enriched in TNF and IL-17 signaling pathways. …”
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The Upregulation of IL-1&beta; Induced by Cisplatin Triggers PI3K/AKT/MMP9 Pathway in Pericytes Mediating the Leakage of the Blood Labyrinth Barrier by Yu M, Jiang WJ, Yu M, Zhou Z, Wang M, Li L

“…However, the relationship between CDDP-induced inflammation and BLB dysfunction remains elusive.Materials and Methods: In vivo and in vitro BLB models were used to explore the inflammatory mechanisms underlying CDDP ototoxicity. …”
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Efficacy of Magnetic Seizure Therapy in Patients with Schizophrenia and Combined fMRI-EEG to Explore the Regulatory Mechanisms of Brain Networks by Wei S, Chen B, Guo Z, Zhang H, Li J, Hu X, Yang C, Li J, Li X, Liu Z, Xu Y, Liu S

“…However, as far as magnetic shock therapy itself is concerned, there are few studies specifically focusing on its efficacy in depth, and the mechanism of MST in treating schizophrenia is still unclear.Methods: This study centered on the key question of “the efficacy of magnetic stunning therapy for patients with schizophrenia and the combined fMRI-EEG to explore the regulatory mechanisms of brain networks”. …”
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Association of Conventional and Unconventional Lipid Profiles with Visceral Fat Area in Overweight/Obese Individuals with Type 2 Diabetes Mellitus by Ma X, Jiang X, Gao G, Ban B, Sheng J, Shi S, Zhao H, Ji B

“…Emphasizing the overall relationship between lipid metabolism and visceral fat accumulation.Methods: This cross-sectional study included 1288 overweight/obese T2DM patients, with VFA measured using bioelectrical impedance analysis and visceral fat obesity (VFO) was defined as VFA ≥ 100 cm². …”
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Identification of Specific Abnormal Brain Functional Activity and Connectivity in Cancer Pain Patients: A Preliminary Resting-State fMRI Study by Hua Y, Geng Y, Liu S, Xia S, Liu Y, Cheng S, Chen C, Pang C, Zhao Z, Peng B, Dai Y, Ji J, Wu D

“…The Fifth Affiliated Hospital of Wenzhou Medical University, Lishui, Zhejiang Province, People’s Republic of China&ast;These authors contributed equally to this workCorrespondence: Jiansong Ji; Dan Wu, Email jjstcty@wmu.edu.cn; 215066083@qq.comObjective: This study investigates the differences in brain functional activity and connectivity patterns between Cancer Pain (CP) patients and Healthy Controls (HCs) using resting-state functional magnetic resonance imaging (rs-fMRI) to identify potential neuroimaging biomarkers.Methods: This study collected rs-fMRI data from 25 CP patients and 25 hCs, processed the functional MRI images, and calculated metrics such as amplitude of low-frequency fluctuation (ALFF), Regional Homogeneity (ReHo), and FC. …”
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Genomic Epidemiology of Clostridioides difficile ST81 in Multiple Hospitals in China by Xia X, Lv T, Zheng L, Zhao Y, Shen P, Zhu D, Chen Y

“…However, given the potential for C. difficile ST81 transmission, research into the epidemiological characteristics of this type of ST remain limited.Methods: We conducted a genomic epidemiology study addressing the genetic characteristics of C. difficile ST81 in five tertiary hospitals covering different regions in China between January 2010 and January 2021. …”
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Upregulation of ARHGAP18 by miR-613 Inhibits Cigarette Smoke Extract-Induced Apoptosis and Epithelial-Mesenchymal Transition in Bronchial Epithelial Cells by Fu H, Liu K, Zheng Y, Zhao J, Xie T, Ding Y

“…This study is intended to explore the function and molecular mechanism of ARHGAP18 and miR-613 in COPD pathogenesis.Methods: We initially identified the marker gene closely related to epithelial dysfunction in COPD by integrating bioinformatic analyses. …”
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