Prognostic Value of Gd-BOPTA Enhanced MRI in Solitary Resected Hepatocellular Carcinoma Without Microvascular Invasion by Zhang J, Luo H, Li Y, Feng Y, Pan X, Ouyang B, Nian G, Jia N, Li Y

“…Juan Zhang,1,2,* Hongmei Luo,2,* Yinqiao Li,2,* Yayuan Feng,2 Xingpeng Pan,2 Beilei Ouyang,2 Guihong Nian,2 Ningyang Jia,2 Yonggang Li1,3 1Department of Radiology, The First Affiliated Hospital of Soochow University, Suzhou City, Jiangsu Province, 215006, People’s Republic of China; 2Department of Radiology, Eastern Hepatobiliary Surgery Hospital, Third Affiliated Hospital of Naval Medical University, Shanghai, 200438, People’s Republic of China; 3Institute of Medical Imaging, Soochow University, Suzhou City, Jiangsu Province, 215000, People’s Republic of China*These authors contributed equally to this workCorrespondence: Ningyang Jia; Yonggang Li, Email ningyangjia@163.com; liyonggang@suda.edu.cnObjective: This study aims to evaluate the prognostic predictive efficacy of Gadobenate dimeglumine (Gd-BOPTA)-enhanced magnetic resonance imaging (MRI) in patients with solitary hepatocellular carcinoma (HCC) without microvascular invasion (MVI) and to investigate the potential clinical and imaging parameters for stratifying the risk of recurrence following hepatectomy.Methods: This retrospective study included 134 patients with histopathologically confirmed solitary HCC without microvascular invasion (MVI) from two hospital districts, which divided into the training cohort and validation cohort. …”
Get full text

Effects of escitalopram with a Chinese traditional compound Jiuweizhenxin-keli on mismatch negativity and P50 in patients with major depressive disorders by Kuang W, Tian L, Yue L, Li J

“…Weihong Kuang,1,* Liantian Tian,2,* Lili Yue,1 Jin Li1 1Department of Psychiatry and Mental Health Center, West China Hospital, Sichuan University, Chengdu, People’s Republic of China; 2Occupational Respiratory Disease Research Center, No 4 West China Hospital/West China School of Public Health, Sichuan University, Chengdu, People’s Republic of China *These authors contributed equally to this work Objective: The objective of this study was to investigate the therapeutic effects of escitalopram in conjunction with Jiuweizhenxin-keli on neuroelectrophysiology in patients with major depressive disorders (MDD).Patients and methods: Patients with depressive episode of MDD according to the criteria of Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition, were randomly assigned to Esc group (30 patients) receiving escitalopram treatment and JK group (30 patients) treated with a combination of escitalopram and Jiuweizhenxin-keli. …”
Get full text

Relationship Between Obstructive Sleep Apnea and Enuresis in Children: Current Perspectives and Beyond by Wang Z, Zhang P, Shi R, Yang S, Liu K, Zhou Z, Li Q

“…This review summarizes the relationship between NE and OSA and how to treat them, aiming to provide a reference for the clinical treatment of OSA and NE in children.Methods: All pertinent original publications to this point from PubMed database have been collected, including investigations on the connection between OSA and NE as well as studies on the mechanism and therapeutic strategy of NE in children with OSA.Results: There is a bidirectional relationship between OSA and NE in children. …”
Get full text

Evaluation of the Efficacy of a Nomogram to Predict Multidrug-Resistant Pulmonary Infections Based on Data from Neurosurgery Ward Patients by Zhou R, Chen X, Jia H, Duan W

“…Ran Zhou,1,* Xiaolong Chen,2,* Hengmin Jia,3 Wen Duan4 1Department of Pharmacy, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, Anhui, 230001, People’s Republic of China; 2Department of Pharmacy, The Second People’s Hospital of Chizhou, Chizhou, Anhui, 247100, People’s Republic of China; 3Department of Infection Office, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, Anhui, 230001, People’s Republic of China; 4Department of Orthopedics, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, Anhui, 230001, People’s Republic of China*These authors contributed equally to this workCorrespondence: Wen Duan, Department of Orthopedics, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, 230001, People’s Republic of China, Email duanwen1717@gmail.comObjective: This study aimed to construct and evaluate a nomogram based on data from neurosurgery ward patients to predict the probability of multidrug-resistant (MDR) pneumonia occurrence.Methods: We retrospectively collected clinical data, early laboratory test results, and physician prescriptions for 35 variables from patients. …”
Get full text

Intraoperative Intraluminal Endoscopy in the Surgical Treatment of Patients with Esophageal Diverticula of Various Localization by A. L. Shestakov, M. V. Khrustaleva, M. E. Shahbanov, N. A. Bulganina, T. T. Bitarov, I. A. Boeva, A. T. Tskhovrebov, I. A. Tarasova, O. V. Rykov, I. M. Selivanova, A. A. Bezaltynnykh

“…To improve the results of surgical treatment of patients with esophageal diverticulum of various localization using intraoperative intraluminal endoscopy. Materials and Methods: The Department of Surgery of the Esophagus and Stomach, the Petrovsky National Research Centre of Surgery, has accumulated a large experience in treating diverticulosis patients. …”
Get full text

Implementation of Therapeutic Patient Education (TPE) in Primary Care, as Perceived by Professionals: A Narrative Review by Kirkove D, Durieux N, Allory E, Louis G, Gagnayre R, Pétré B

“…The review included 12 articles, revealing that TPE practices in primary care are often underdeveloped, primarily individual, and focused on oral, informative methods. Obstacles identified by healthcare professionals primarily fall into two TDF domains: environmental context (eg, lack of time, resources, and fragmented healthcare systems) and individual skills deficits. …”
Get full text

The Impact of Sarcopenic Obesity on Weight Loss Outcomes and Recurrent Weight Gain Following Laparoscopic Sleeve Gastrectomy by Wang X, Shu X, Pei W, Yuan C, Su X, Xiong J, Chen W, Zhang G, Jie Z, Liu Y

“…Although the prevalence of SO is on the rise, there is a notable paucity of research examining the impact of SO on weight loss efficacy following laparoscopic sleeve gastrectomy (LSG).Purpose: To investigate the impact of SO on weight loss outcomes and recurrent weight gain following LSG.Methods: We retrospectively gathered clinical data of 104 patients with obesity who underwent LSG in our hospital between January 2020 and September 2023. …”
Get full text

Efficacy and Long-Term Outcomes of Tacrolimus versus Cyclophosphamide and Mycophenolate Mofetil in the Management of Pediatric IgA Vasculitis Nephritis: A Cohort Study in Single-Ce... by Han Y, Yang F, Zhou L, Yang J, Yang Y, Wang Y, Qiu L, Zhang Y, Zhou J

“…Therefore, the objective of this study is to compare the effectiveness and long-term outcome of TAC, CYC, and MMF in combination with glucocorticoid in pediatric IgAVN.Patients and Methods: A retrospective analysis was conducted on children with grade II–V IgAVN by renal biopsy at Tongji Hospital from November 2011 to October 2021. …”
Get full text

Adipose-Derived Stem Cell Products and Combination Therapies for the Treatment of Pathological Scars: A Review of Current Preclinical and Clinical Studies by Alfarafisa NM, Chou Y, Santika R, Riestiano BE, Soedjana H, Syamsunarno MRAA

“…The effectiveness of ADSC products as monotherapies and in combination with other treatments has also been explored.Methods: A comprehensive literature search followed the PICO framework, utilizing electronic databases such as PubMed and Scopus. …”
Get full text

The Association Between Neonatal Respiratory Distress Syndrome and Plasma IgG N-Glycosylation: A Case-Control Study by Wang Y, Shen Q, Yan R, Wang M, Xu M, Chen H, Li D

“…However, its implications and clinical significance in NRDS remain to be clarified.Methods: To determine the effect of IgG N-glycosylation on NRDS, we recruited 88 NRDS participants and 120 control participants from December 2021 to September 2022. …”
Get full text

Trajectories and Interactions of Dyadic Coping and Depression in Patients After Thrombolysis for Acute Ischemic stroke: A Longitudinal Study in China by Liu J, Xu L, Li XQ, Chen D, Ji KX, Qiu LF

“…Jingxiu Liu,* Lei Xu,* Xiao-qin Li,* Dandan Chen, Kang-xiang Ji, Lan-feng Qiu Department of Emergency Medicine, The First Affiliated Hospital of Soochow University, Suzhou, Jiangsu, 215009, People’s Republic of China*These authors contributed equally to this workCorrespondence: Lan-feng Qiu, Department of Emergency Medicine, The First Affiliated Hospital of Soochow University, Suzhou, Jiangsu, 215009, People’s Republic of China, Email 15062100130@163.comObjective: To explore the developmental trajectory of dyadic coping and depression in stroke patients and the predictive relationship between the two and to provide a theoretical basis for improving depression in stroke patients.Design: A longitudinal study.Methods: Two hundred and forty-two stroke patients who underwent thrombolysis in the emergency department of our hospital from January 2023 to March 2024 were selected as the study subjects, and their dyadic coping and depression were tracked and investigated in T1 (after thrombolysis), T2 (3 months after the disease), and T3 (6 months after the disease), and the data were analyzed using a cross-lagged model and latent variable growth model.Results: Two hundred and twelve valid serial questionnaires were recovered at the completion of the three time points. …”
Get full text

Outperforming Traditional Staging: A Novel Nomogram for HR-Positive Breast Cancer by Liu C, Ding J, Xu J, Fang C, Zhang G, Shi C, Qiu F

“…Improved prognostic tools are needed to enhance individualized risk stratification.Materials and Methods: Clinical information from the Surveillance, Epidemiology, and End Results (SEER) database and the First Affiliated Hospital of Nanchang University were analyzed to evaluate outcomes across HR-positive BC subtypes. …”
Get full text

Effect of Machine Learning on Risk Stratification for Antiretroviral Treatment Failure in People Living with HIV by Zhang W, Ren L, Yang K, Yan J, Yu Q, Qi S, Ruan H, Zhao D, Ruan L

“…This study aims to develop and validate a nomogram-based scoring system to predict the incidence and determinants of virologic failure in people living with HIV (PLWH), facilitating timely interventions and reducing unnecessary transitions to second-line regimens.Methods: A total of 9879 patients with HIV/AIDS were included. …”
Get full text

The in vitro Activity of Omadacycline Alone and in Combination Against Carbapenem-Resistant Klebsiella pneumoniae by Du Y, Liu Y, Liu T, Pan F, Mu S, Zhu Y, Gao H, Jing X, Wang X, Liu Y, Wang S

“…Yingying Du,1– 3,* Yan Liu,4,* Tong Liu,1 Fen Pan,5 Shikui Mu,2 Yunlou Zhu,2 Hanlu Gao,2 Xin Jing,2 Xing Wang,6 Yuhao Liu,2 Sheng Wang1– 3 1Intensive Care Medical Center, Tongji Hospital, School of Medicine, Tongji University, Shanghai, 200065, People’s Republic of China; 2Department of Critical Care Medicine, Shanghai Tenth People’s Hospital, School of Medicine, Tongji University, Shanghai, 200072, People’s Republic of China; 3Key Laboratory of Pathogen-Host Interaction, Ministry of Education, Shanghai, 200092, People’s Republic of China; 4Department of Clinical Microbiology, Shanghai Tenth People’s Hospital, School of Medicine, Tongji University, Shanghai, 200072, People’s Republic of China; 5Department of Laboratory Medicine, Children’s Hospital of Fudan University, National Children’s Medical Center, Shanghai, 200032, People’s Republic of China; 6Department of Laboratory Medicine, Shanghai Children’s Medical Center, School of Medicine, Shanghai Jiao Tong University, Shanghai, People’s Republic of China*These authors contributed equally to this workCorrespondence: Yuhao Liu; Sheng Wang, Email lyh-7906@163.com; wangsheng@tongji.edu.cnObjective: This study aimed to evaluate the in vitro activity of omadacycline (OMC) and OMC-based combination therapy against carbapenem-resistant Klebsiella pneumoniae (CRKP).Methods: The broth microdilution assay assessed the in vitro susceptibility of CRKP to OMC. …”
Get full text

Simulation-Based Evaluation of Large Language Models for Comorbidity Detection in Sleep Medicine – a Pilot Study on ChatGPT o1 Preview by Seifen C, Bahr-Hamm K, Gouveris H, Pordzik J, Blaikie A, Matthias C, Kuhn S, Buhr CR

“…Here, we investigate whether the novel LLM ChatGPT o1 preview can identify individual health risks or potentially existing comorbidities from the medical data of fictitious sleep medicine patients.Methods: We conducted a simulation-based study using 30 fictitious patients, designed to represent realistic variations in demographic and clinical parameters commonly seen in sleep medicine. …”
Get full text

A Longitudinal Dynamic Change in LMR Can Be a Biomarker for Recurrence in Fusobacterium Nucleatum-Positive Colorectal Cancer Patients by Chen S, Chang WH, Zhang J, Liu XY, Gao T, Qi XW, Cai DY, Mao Y, Lu TX

“…Shan Chen,1,* Wan-Hua Chang,2,* Jie Zhang,1,* Xiao-Yuan Liu,3,* Ting Gao,1 Xiao-Wei Qi,4 Dong-Yan Cai,1 Yong Mao,1 Ting-Xun Lu1 1Department of Oncology, Affiliated Hospital of Jiangnan University, Wuxi, Jiangsu Province, People’s Republic of China; 2Department of Gastroenterology, Huaian Hospital of Huaian City, Huai’an, Jiangsu Province, People’s Republic of China; 3Department of Clinical Pharmacy, Affiliated Hospital of Jiangnan University, Wuxi, Jiangsu Province, People’s Republic of China; 4Department of Pathology, Affiliated Hospital of Jiangnan University, Wuxi, Jiangsu Province, People’s Republic of China*These authors contributed equally to this workCorrespondence: Ting-Xun Lu, Department of Oncology, Affiliated Hospital of Jiangnan University, Wuxi, Jiangsu Province, People’s Republic of China, Email lutingxun@163.comPurpose: This study assessed lymphocyte-to-monocyte ratio (LMR) changes to predict postoperative recurrence in Fusobacterium nucleatum-positive (Fn-positive) CRC patients.Patients and Methods: Clinical information and paraffin tissue specimens were collected from a retrospective cohort of 332 patients. …”
Get full text

Predictors of diplopia following orbital fractures based on anatomical location, a retrospective cohort study by Honglin Chen, Yiqing Bao, Yuxin Chen, Yiqun Li, Peng Wu, Guohua Fan, Ji Zhang

“…Abstract Purpose This study aimed to identify predictors of diplopia following orbital fractures. Methods We retrospectively analyzed clinical and imaging data from 155 patients who experienced orbital fractures at our center between 2021 and 2023. …”
Get full text

Correlation Between Tear Film Stability and Myopia in Children by Huang PW, Kuo YK, Chen NN, Li JH, Wu CH, Chen HM, Su KW, Sun CC

“…Pei-Wei Huang,1,2,* Yu-Kai Kuo,2,* Nan-Ni Chen,3 Ju-Hsien Li,2 Cheng‐Hsiu Wu,2 Ho-Min Chen,2 Kuan-Wen Su,4,5 Chi-Chin Sun2,6 1Department of Ophthalmology, Lo-Hsu Medical Foundation, Lotung Poh-Ai Hospital, Yilan, Taiwan; 2Department of Ophthalmology, Keelung Chang Gung Memorial Hospital, Keelung City, Taiwan; 3Department of Ophthalmology, Chiayi Chang Gung Memorial Hospital, Chiayi, Taiwan; 4Department of Paediatrics, Keelung Chang Gung Memorial Hospital, Keelung City, Taiwan; 5Department of Paediatrics, College of Medicine, Chang Gung University, Taoyuan, Taiwan; 6Department of Medicine, College of Medicine, Chang Gung University, Taoyuan, Taiwan*These authors contributed equally to this workCorrespondence: Chi-Chin Sun, Department of Ophthalmology, Chang Gung Memorial Hospital, 222 Mai Chin Road, An Leh District, Keelung, Taiwan, Email chichinsun@gmail.comPurpose: To investigate the correlation between dry eye and myopia in Taiwanese school children.Methods: This retrospective cohort study enrolled children aged 5– 14-years-old between January 2021 and April 2022. …”
Get full text

Association of MTMR3 rs12537 at miR-181a Binding Site with Ischemic Stroke in Southern Chinese Han Population by Chen L, Wei S, Zhang Y, Li Y, Li Z, Huang P, Xiao C, Zhang Y

“…This research examined the potential association between the SNP rs12537 in the miRNA-181a binding location within the 3′ untranslated region (3′-UTR) of MTMR3 and the incidence and prognosis of IS.Methods: An improved multitemperature ligase detection reaction assay was used to perform genotyping analysis in two independent case-control datasets consisting of 1128 subjects with IS and 1140 healthy controls with matched ages.Results: The distribution frequencies of the T allele (p = 5.2× 10− 4) of SNP rs12537 in MTMR3 were elevated significantly in IS patients as compared to healthy controls. …”
Get full text

Cholinesterase Inhibitor Reveals Synergistic Potential for Neural Stem Cell-Based Therapy in the 5xFAD Mouse Model of Alzheimer’s Disease by Wu CC, Lee YK, Tsai JK, Su YT, Ho YC, Chu TH, Chen KT, Chang CL, Chen JS

“…This study aimed to determine if combining ChEI treatment with stem cell therapy could improve therapeutic outcomes.Methods: Neural stem cells (NSCs) were injected into the hippocampus of the 5xFAD AD mice using a stereotactic technique. …”
Get full text