Correlation Between Serum Creatinine-to-Cystatin C Ratio and Prognosis of Patients with Hip Fracture by Lu W, Rao M, Jia F, Chen W, Li B, Bian J, Wang J

“…Wenbin Lu,* Miaomiao Rao,* Fan Jia,* Wubin Chen, Bin Li, Jinjun Bian, Jiafeng Wang Faculty of Anesthesiology, Changhai Hospital, Naval Military Medical University, Shanghai, 200433, People’s Republic of China*These authors contributed equally to this workCorrespondence: Jinjun Bian; Faculty of Anesthesiology, Changhai Hospital, Naval Military Medical University, 168, Changhai Road, Shanghai, 200433, People’s Republic of China, Tel/Fax +86-021-31161841, Email jinjunbicu@163.com Jiafeng Wang, Faculty of Anesthesiology, Changhai Hospital, Naval Military Medical University, 168, Changhai Road, Shanghai, 200433, People’s Republic of China, Tel/Fax +86-021-31161886, Email jfwang@smmu.edu.cnObjective: This study aimed to investigate the association between the serum creatinine-to-cystatin C ratio (CCR) and the prognosis of patients with hip fracture.Methods: This retrospective cohort study included patients who underwent hip fracture surgery at a tertiary hospital in China between January 2018 and December 2023. …”
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Decreased risk of chronic fatigue syndrome following influenza vaccine: a 20-year population-based retrospective study by Hsun Chang, Wei-Cheng Yao, Teng-Shun Yu, Heng-Jun Lin, Fuu-Jen Tsai, Shinn-Ying Ho, Chien-Feng Kuo, Shin-Yi Tsai

“…An equal number of participants without influenza were also identified. …”
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Impact of Laboratory-Derived Frailty Index on Clinical Outcomes in Critical Care Patients with COPD: A Retrospective Analysis Using the MIMIC-IV Database by Zhou Z, He Y, Wang Q, Li J, Yu Y

“…This research aims to investigate the relationship between the physiological and laboratory - based frailty index (FI - Lab) and mortality among critical care patients with COPD.Methods: The FI-Lab was constructed using 33 items. …”
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Enhanced in vivo Stability and Antitumor Efficacy of PEGylated Liposomes of Paclitaxel Palmitate Prodrug by Wu X, Wang X, Zhang H, Chen H, He H, Lu Y, Tai Z, Chen J, Wu W

“…This study aimed to propose a straightforward and efficient approach to enhance PTX loading and stability, thereby offering insights for targeted therapy against tumors.Patients and Methods: We synthesized a paclitaxel palmitate (PTX-PA) prodrug by conjugating palmitic acid (PA) to PTX and encapsulating it into liposomal vehicles using a nano delivery system. …”
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The Predictive Value of Absolute Lymphocyte Count and T Cell Subpopulations for Sepsis Prognosis by Jia X, Li X, Miao L, Bao R, Xiong H, You R, Lu Y, Gui X, Qu C

“…This study aims to explore immunologic parameters associated with sepsis prognosis, potentially identifying patients who may benefit from immunotherapy, improving intensive care survival.Methods: A total of 65 patients with sepsis from the Department of Emergency Medicine were divided based on survival at 28 days (47 in the survival group, 18 in the non-survival group). …”
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Mucoadhesive Mini-Containers with Unidirectional Drug Release Capacity for Macromolecular Therapeutics by Han CS, Choi YR, Jung WY, Kang JH, Kim DW, Park CW

“…To address these barriers, we have designed a novel mini-container system with unidirectional drug release and enhanced mucoadhesion capacities.Methods: Mini-containers composed of ethyl cellulose shells of varying degrees of viscosity were fabricated using a simple molding process and integrated with catechol-conjugated chitosan (CC) to improve their mucosal adhesion capacity and structural stability.Results: The catechol substitution levels were optimized (CC-A, CC-B, and CC-C), with the CC-C formulation exhibiting the highest degree of substitution (20.93%) and superior adhesion capacity, maintaining 80% attachment on porcine small intestinal mucosa after 72 h. …”
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Effects of Various Transfer Strategies of Frozen-Thawed Cleavage-Stage and Blastocyst Embryos on Pregnancy and Neonatal Outcomes in Different Age Groups by Jiang J, Wu X, Sun H, Han L, Zhang X, Liu C, Wang Y, Li Q

“…Jianxi Jiang,&ast; Xiaohan Wu,&ast; Hongliang Sun, Lei Han, Xianghui Zhang, Chunjiao Liu, Yanlin Wang, Qingchun Li Department of Reproductive Medicine, Binzhou Medical University Hospital, Binzhou, Shandong, 256603, People’s Republic of China&ast;These authors contributed equally to this workCorrespondence: Qingchun Li, Department of Reproductive Medicine, Binzhou Medical University Hospital, Binzhou, Shandong, 256603, People’s Republic of China, Tel +05433258715, Email liqc1@126.com Yanlin Wang, Department of Reproductive Medicine, Binzhou Medical University Hospital, Binzhou, Shandong, 256603, People’s Republic of China, Tel +05433258713, Email docylwang2003@126.comObjective: The aim of this study is to assess the impact of different embryo transfer strategies, focusing on cleavage-stage embryos and blastocysts, on pregnancy and neonatal outcomes in frozen-thawed embryo transfer (FET) cycles among women < 35 years old and ≥ 35 years old.Methods: A retrospective cohort analysis of 3,065 FET cycles performed between April 2015 and October 2022 categorized patients into seven groups by embryo morphology, quality, and quantity: single/double high-quality cleavage (A/B), single/double high-quality blastocyst (C/D), single/double poor-quality blastocyst (E/F), and mixed-quality blastocyst (G). …”
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Varenicline Solution Nasal Spray for the Treatment of Dry Eye Disease in Sjogren&rsquo;s Disease: A Pilot Study by Gupta AS, Linaburg TJ, Iacobucci E, Augello PA, Qin VL, Ying GS, Bunya VY, Massaro M

“…Angela S Gupta,1,&ast; Taylor J Linaburg,1,&ast; Emma Iacobucci,1 Patrick A Augello,2 Vivian L Qin,3 Gui-Shuang Ying,1,2 Vatinee Y Bunya,1 Mina Massaro1 1Department of Ophthalmology, Scheie Eye Institute, University of Pennsylvania, Philadelphia, PA, USA; 2Department of Ophthalmology, Center for Preventive Ophthalmology and Biostatistics, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA; 3Department of Ophthalmology, University of California Los Angeles, Los Angeles, CA, USA&ast;These authors contributed equally to this workCorrespondence: Taylor J Linaburg, Scheie Eye Institute, Department of Ophthalmology, University of Pennsylvania, 51 N. 39th St, Philadelphia, PA, 19104, USA, Tel +1 412 576 – 7668, Email Taylor.Linaburg@pennmedicine.upenn.eduPurpose: We evaluated the efficacy of varenicline solution nasal spray (VNS) in treating dry eye disease (DED) associated with moderate to severe Sjogren’s disease and analyzed tear film cytokine levels of patients with DED and Sjogren’s disease before and after VNS use.Methods: This was a pilot study involving a single-center, single-arm investigator-initiated trial. …”
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Development of a Ferritin-Based Nano-Allergen and Its Immunological Effects in vitro and in vivo by Zhou D, Ren Y, Zhou Y, Liao Y, Cheng Q, Chen J, Yuan C, Zeng D, Cui Y

“…Dongmei Zhou,1,&amp;ast; Yaning Ren,1,&amp;ast; Ying Zhou,2 Yuanfen Liao,1 Qi Cheng,1 Jinni Chen,3 Cunyin Yuan,1 Dan Zeng,4 Yubao Cui1 1Clinical Research Center, The Affiliated Wuxi People’s Hospital of Nanjing Medical University, Wuxi, 214023, People’s Republic of China; 2Department of Pediatrics Laboratory, The Affiliated Children´s Hospital of Jiangnan University, Wuxi, 214023, People’s Republic of China; 3Department of Respiratory, Hainan Women and Children’s Medical Center, Affiliated Pediatrics Clinical College of Hainan Medical University, Haikou, 570100, People’s Republic of China; 4Department of Allergy, Chongqing General Hospital, Chongqing University, Chongqing, 401147, People’s Republic of China&amp;ast;These authors contributed equally to this workCorrespondence: Yubao Cui; Dan Zeng, Email ybcui1975@hotmail.com; zengdan@cqu.edu.cnIntroduction: We aimed to develop recombinant allergens on the nanoscale by using self-assembly property of ferritin and to investigate their immune response and protective effect.Methods: The cDNA encoding Ftn-Blo t 2 was synthesized and cloned into pET-21a (+) vector, then expressed in E. coli BL21 (DE3). …”
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Neonatal Hearing Loss Risk Factors and miRNA Biomarkers Identified Through AABR Screening by Huang M, Jing Y, Peng X, Xie J, Zhao Q, Yin JL, Xiao WD, Zhao SJ, Tian HJ

“…Min Huang,1,&amp;ast; Yunlong Jing,1,&amp;ast; Xiangyue Peng,1 Jiang Xie,1 Qin Zhao,1 Jiang-Long Yin,1 Wen-Du Xiao,1 Si-Jun Zhao,1 Hong-Ju Tian2 1Department of Otorhinolaryngology, Head and Neck Surgery, The Affiliated Children’s Hospital, Xiangya School of Medicine, Central South University (Hunan Children’s Hospital), Changsha, Hunan, 410007, People’s Republic of China; 2Obstetrics and Gynecology Center of Hunan Occupational Disease Prevention and Control Institute, Changsha, 410007, People’s Republic of China&amp;ast;These authors contributed equally to this workCorrespondence: Si-Jun Zhao, Department of Otorhinolaryngology, Head and Neck Surgery, The Affiliated Children’s Hospital, Xiangya School of Medicine, Central South University (Hunan Children’s Hospital), Yuhua District, Changsha, 410007, People’s Republic of China, Tel +86 073185356311, Fax +86073185356666, Email zhao_sijun@126.com Hong-Ju Tian, Obstetrics and Gynecology Center of Hunan Occupational Disease Prevention and Control Institute, Yuhua District, Changsha City, Hunan Province, 410007, People’s Republic of China, Tel +86 85303109, Fax +86 85534673, Email tianhongju713@outlook.comObjective: To determine the prevalence of hearing impairment in neonates and identify associated risk factors through auditory brainstem response (ABR) screening.Study Design: A prospective observational longitudinal study was conducted involving 158 infants, with Automated Auditory Brainstem Response (AABR) evaluations performed by 6 months of age.Setting: The study was undertaken in a hospital-based neonatal care unit.Methods: Infants with significant hearing loss in one or both ears were referred for further assessment and rehabilitation. …”
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Comprehensive Analysis of Pathogen Diversity and Diagnostic Biomarkers in Patients with Suspected Pulmonary Tuberculosis Through Metagenomic Next-Generation Sequencing by Li Y, Li C, Fang Y, Zhang L, Ying X, Ren R, Zang Y, Ying D, Zhu S, Liu J, Cao X

“…., Ltd, Hangzhou, People’s Republic of China&amp;ast;These authors contributed equally to this workCorrespondence: Yuecui Li, Department of Infectious Disease, The First People’s Hospital of Yongkang, affiliated to Hangzhou Medical College, 599 Jinshan West Road, Jinhua, 321300, People’s Republic of China, Email yklycwh@126.com Xuefang Cao, MatriDx Biotechnology Co., Ltd, Hangzhou, 311112, People’s Republic of China, Email xfczju@163.comBackground: This study aimed to investigate the co-infecting pathogens and lung microbiomes in patients with clinically confirmed pulmonary tuberculosis (TB) and explore potential diagnostic biomarkers to differentiate between varied infection patterns.Methods: We conducted a retrospective cohort study by analyzing 198 bronchoalveolar lavage fluid (BALF) samples collected from patients with suspected pulmonary TB. …”
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Modeling the epidemiological impact of the UNAIDS 2025 targets to end AIDS as a public health threat by 2030. by John Stover, Robert Glaubius, Yu Teng, Sherrie Kelly, Tim Brown, Timothy B Hallett, Paul Revill, Till Bärnighausen, Andrew N Phillips, Christopher Fontaine, Luisa Frescura, Jose Antonio Izazola-Licea, Iris Semini, Peter Godfrey-Faussett, Paul R De Lay, Adèle Schwartz Benzaken, Peter D Ghys

“…This study reports on efforts to use mathematical models to estimate the impact of achieving those targets.<h4>Methods and findings</h4>We simulated the impact of achieving the targets at country level using the Goals model, a mathematical simulation model of HIV epidemic dynamics that includes the impact of prevention and treatment interventions. …”
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Relationship Between Sleep Time and Depressive Symptoms in Middle-Aged and Elderly Chinese: Mediating Role of Body Pain by Yang Z, Li B, Ma D, Lv Y, Qiu X, Zhang W, Wang J, Zhang Y, Xu C, Deng Y, Li J, Zhen X, Zhang J

“…This study seeks to elucidate the interconnections between these three elements.Methods: The study used 2020 CHARLS data for analysis. …”
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A randomized comparison of intramuscular high-dose versus oral maintenance vitamin D to prevent severe exacerbations in deficient/insufficient asthmatic children by Khalid Alansari, MD, Bruce L. Davidson, MD, MPH, Michael F. Holick, MD, PhD

“…Objective: We sought to compare high-dose intramuscular (IM) + daily oral maintenance vitamin D dose versus daily oral maintenance vitamin D dose for preventing asthma exacerbations in prospectively randomized vitamin D–deficient/insufficient children aged 5 to 14 years with moderate to severe asthma. Methods: This is an accessory post hoc analysis from a larger vitamin D supplementation trial, analyzing results of the randomized stratum of older children receiving the high dose presenting with emergency department (ED) visits for asthma and baseline blood 25-hydroxyvitamin D concentration less than or equal to 25 ng/mL. …”
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Recent Advances in the Delivery of Bone Morphogenetic Proteins for Targeting Glioma: An Updated Review by Bao H, Chen Y, Zong Y, Jin K, Lan H

“…Hydrogels, scaffolds, and microspheres’ local delivery methods are also discussed as prospective options. …”
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The use of Revenue-sharing Contracts in Two-level Supply Chain Coordination with the Presence of Vendor-managed Inventory and Advertising Investment by Bahareh Osuli, Mohammad Reza Gholamian, Maryam Noroozi

“…Additionally, in the developed model, the demand function incorporates a multiplicative factor of elements influencing the profit function, such as retail price, retailer, and manufacturer advertising investments. MethodsIn this article, we study the coordination in a two-level supply chain including one manufacturer and multiple retailers under a revenue-sharing contract, where the pricing and advertising investment strategy of each member of the supply chain is implemented despite vendor-managed inventory in a centralized supply chain. …”
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Risk factors for hospitalization at the pediatric intensive care unit among infants and children younger than 5 years of age diagnosed with infectious diseases by Judah Freedman, Eugene Leibovitz, Ruslan Sergienko, Amalia Levy

“…The objectives of this study were to identify independent risk factors for PICU hospitalization with an infectious disease in children <5 years of age. Methods: In southern Israel, two populations live side by side: the middle–high income Jewish population and the low-income Bedouin population, both receiving equal and free medical care at the only tertiary medical center in the area. …”
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Suppression of Inflammation by Si Miao San in Experimental Rheumatoid Arthritis Through Modulation of the AKT/ROS/Autophagy Axis by Zhang H, Jiang H, Wei Q, Xu J, Zhao Z, Sun Y, Lu Q

“…The goal of this study was to explore the therapeutic effects of Si Miao San (SMS) on adjuvant-induced arthritis in mice and the regulatory mechanisms of NETs both in vivo and in vitro.Methods: SMS decoctions were identified using LC-MS/MS analysis and TCMSP. …”
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A novel equation synthesis for estimating resting energy expenditure in prostate cancer patients by Nilüfer Acar Tek, Tevfik Koçak, Süleyman Yeşil, Tevfik Sinan Sözen

“…The purpose of this research was to evaluate the accuracy of the established novel equation for predicting REE in malign and benign prostate patients versus the accuracy of the previously used predictive equations based on REE measured by indirect calorimetry. Methods The study was conducted as a cross-sectional case-control study and between December 2020 and May 2021 with 40 individuals over the age of 40 who applied to the Urology Clinic of Gazi University Faculty of Medicine. …”
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Associations Between Renal Dysfunction Subtypes and Vertebral Fracture in Patients with Type 2 Diabetes: A Longitudinal Study by Hu N, Zhang Y, Wei Z, Yu R, Zhang Y, Chen X

“…In this longitudinal study, we evaluated the associations between different subtypes of renal dysfunction and vertebral fracture (VF) in patients with type 2 diabetes.Methods: This study recruited T2DM patients aged 50 years or older whose computed tomography (CT) imaging screening revealed no VFs from January 2019–December 2021. …”
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