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29461
Using ChatGPT to Improve the Presentation of Plain Language Summaries of Cochrane Systematic Reviews About Oncology Interventions: Cross-Sectional Study
Published 2025-03-01“…ObjectiveThis study assessed whether a large language model (eg, ChatGPT) can improve the readability and linguistic characteristics of Cochrane PLSs about oncology interventions, without changing evidence synthesis conclusions. MethodsThe dataset included 275 scientific abstracts and corresponding PLSs of Cochrane systematic reviews about oncology interventions. …”
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29462
The Causal Association Analysis between Depression and Cerebrospinal Fluid: From the Perspective of Mendelian Randomization
Published 2025-05-01“…Although cerebrospinal fluid (CSF) biomarkers have been identified as potential indicators and therapeutic targets for depression, their causal relationship with MDD remains unclear.Methods: We analyzed publicly available CSF metabolomics and genotype data, quantifying 338 distinct metabolites. …”
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29463
Predictive Value of Kidney Failure Risk Equation and Neutrophil Gelatinase-Associated Lipocalin for Chronic Kidney Disease Progression in Chinese Population – A Retrospective...
Published 2024-12-01“…Liu Shi,1,* Youxin Liao,2,* Yue Chen3 1Department of Critical Care Medicine, Jiangjin Central Hospital, Chongqing, 402260, People’s Republic of China; 2Department of Medical Administration, Jiangjin Central Hospital, Chongqing, 402260, People’s Republic of China; 3Department of Oncology, Jiangjin Central Hospital, Chongqing, 402260, People’s Republic of China*These authors contributed equally to this workCorrespondence: Yue Chen, Department of Oncology, Jiangjin Central Hospital, No. 725, Jiangzhou Road, Dingshan Street, Jiangjin District, Chongqing, 402260, People’s Republic of China, Tel +86-15823491696, Email wenlinlin0606@163.comObjective: To analyze the independent associations of the Kidney Failure Risk Equation (KFRE) and neutrophil gelatinase-associated lipocalin (NGAL) with end-stage renal disease (ESRD) among patients with chronic kidney disease (CKD) stages 3– 5 in China and evaluate their predictive values for ESRD.Patients and Methods: A total of 716 patients with CKD stages 3– 5 at the time of the initial renal medicine referral were retrospectively enrolled, and the study outcome was the observed incidence of ESRD at 2 years after the initial referral. …”
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29464
Identification and Characterization of Genes Associated with Intestinal Ischemia-Reperfusion Injury and Oxidative Stress: A Bioinformatics and Experimental Approach Integrating Hig...
Published 2025-01-01“…Identifying and characterizing genes associated with the oxidative stress response can offer valuable insights into potential therapeutic targets for managing IIRI.Patients and Methods: The IIRI dataset was sourced from the NCBI Gene Expression Omnibus Database (GEO), while oxidative stress genes were obtained from the Genecards database. …”
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29465
Comparative Study of Vault Measurement by Pentacam, Casia2, and RTVue in Myopic Eyes After Implantable Collamer Lens Implantation
Published 2025-03-01“…USA).Methods: This comparative study recruited 95 eyes of 50 patients (mean age: 28.40± 4.51, male/female 15/35) who underwent implantable collamer lens (ICL) implantation for myopia correction. …”
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29466
THE ECONOMIC TRANSFORMATION: THE ROLE OF SUSTAINABLE BANKING IN QUALITY GROWTH
Published 2025-04-01“…This research explore how sustainable banking methods and economic growth are connected by studying the effects of financial inclusion and green bonds on the Human Development Index (HDI). …”
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29467
Follow-up of Surgical and Nonsurgical Patients With Pulmonary Aspergillosis: A Real-World Study
Published 2025-02-01“…The purpose of this study was to investigate the diagnosis and treatment, follow-up results and prognostic factors of PA patients in the real world, so as to deepen our understanding of PA and improve the prognosis of PA patients.Materials and Methods: Eligible patients with pathologically diagnosed PA (n = 125) were retrospectively enrolled and followed up. …”
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29468
Near-Peer Training: Impact of a Single Session on Students’ OSCE Performance
Published 2025-08-01“…This study aims to assess the impact of a single clinical skill NPT session on students’ overall objective performance at a summative OSCE.Patients and Methods: This prospective study evaluated the impact of a two-hour NPT session focused on three system-related clinical situations on overall clinical performance. …”
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29469
LIPUS Responsive Dopamine-Modified PVDF Piezoelectric Nanofiber Membrane for Full-Thickness Skin Wound Healing
Published 2025-05-01“…This study introduces a portable approach for promoting scarless healing and skin appendage regeneration by utilizing low-intensity pulsed ultrasound (LIPUS) activated piezoelectric electrospun membranes to modulate the local electrical environment.Methods: Dopamine-modified polyvinylidene fluoride (DA/PVDF) nanomembranes were fabricated via electrospinning, followed by piezoelectric characterization under varying LIPUS stimulation. …”
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29470
Inhibition of Colorectal Cancer by Perillaldehyde Through Targeting SRD5A1 to Induce Autophagy via the PI3K/AKT Pathway
Published 2025-07-01“…This study aims to assess the therapeutic potential of PAH against CRC and to clarify its mechanisms of action, providing a rationale for PAH as a promising candidate for anti-CRC therapy.Methods: In vitro, we used CCK-8, colony formation, EdU assays, flow cytometry, and Western blotting to assess the effects of PAH on CRC cell proliferation and apoptosis. …”
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29471
Quantitative examination of video-recorded NHS Health Checks: comparison of the use of QRISK2 versus JBS3 cardiovascular risk calculators
Published 2020-09-01“…Recruitment was stratified by patients’ age, gender and ethnicity.Methods Video recordings of NHSHC were coded, second-by-second, to quantify who was speaking and what was being discussed. …”
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29472
Trends in Global Burden of Alzheimer’s Disease and Other Dementias Attributable to High Fasting Plasma Glucose, 1990–2021
Published 2024-10-01“…This study aimed to assess the global burden of Alzheimer’s disease and other dementias attributable to high fasting plasma glucose in the last decades. <i>Materials and Methods</i>: A descriptive epidemiological study was conducted. …”
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29473
miR-21-5p Enriched Exosomes from Human Embryonic Stem Cells Promote Osteogenesis via YAP1 Modulation
Published 2024-12-01“…Xinqia Huang,1,* Ziquan Zhao,1,* Weiqiang Zhan,1 Mingzhu Deng,1 Xuyang Wu,1 Zhoutao Chen,1 Jiahao Xie,2 Wei Ye,3 Mingyan Zhao,1,4 Jiaqi Chu3,4 1Orthopaedic Center, Affiliated Hospital of Guangdong Medical University, Zhanjiang, Guangdong, 524001, People’s Republic of China; 2Department of Dermatology, Affiliated Hospital of Guangdong Medical University, Zhanjiang, Guangdong, 524001, People’s Republic of China; 3Department of Obstetrics and Gynecology, Affiliated Hospital of Guangdong Medical University, Zhanjiang, Guangdong, 524001, People’s Republic of China; 4Stem Cell Research and Cellular Therapy Center, Affiliated Hospital of Guangdong Medical University, Zhanjiang, Guangdong, 524001, People’s Republic of China*These authors contributed equally to this workCorrespondence: Jiaqi Chu; Mingyan Zhao, Affiliated Hospital of Guangdong Medical University, No. 57 Renmin Avenue South Road, Zhanjiang, Guangdong, 524001, People’s Republic of China, Email chujiaqi@gdmu.edu.cn; mingyan.zhao@gdmu.edu.cnPurpose: To investigate the osteogenic potential of human embryonic stem cell-derived exosomes (hESC-Exos) and their effects on the differentiation of human umbilical cord mesenchymal stem cells (hUCMSCs).Methods: hESC-Exos were isolated and characterized using transmission electron microscopy (TEM), nanoparticle tracking analysis (NTA), and Western blotting. hUCMSCs were cultured with hESC-Exos to assess osteogenic differentiation through alizarin red staining, quantitative PCR (qPCR), and Western blotting. miRNA profiling of hESC-Exos was performed using miRNA microarray analysis. …”
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29474
The Impact of Exercise Training on the Brain and Cognition in Type 2 Diabetes, and its Physiological Mediators: A Systematic Review
Published 2025-04-01“…Resistance and endurance exercise were found to be equally effective for achieving cognitive improvement. …”
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29475
Ethyl Acetate Extract of Elsholtzia bodinieri Vaniot Attenuates Oxidative Stress in ALI Mice
Published 2025-06-01“…This study was carried to investigate the role and mechanisms of EBE ethyl acetate extract (EBEE) against oxidative stress in ALI.Methods: By multiple bioinformatics analysis, AGER and ITGB2 were found to be the potential target genes of EBEE against oxidative stress in ALI. …”
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29476
NLRP3 Mediates NOXs-Induced Iron Overload and Inflammation but Not Oxidative Damage in Colons of DSS-Treated Mice
Published 2025-04-01“…Here, we investigated the effects of chemical inhibition of NOXs and NLRP3 activity on colonic iron metabolism and inflammatory reactions in a murine model of dextran sodium sulfate (DSS)-induced ulcerative colitis.Methods: The mice were randomly divided into five groups: normal control group, DSS-induced ulcerative colitis model group (DSS), DSS + Dapansutrile group, DSS + Diphenyleneiodonium chloride group, and DSS + Dapansutrile + Diphenyleneiodonium chloride group. …”
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29477
Intrathecal Morphine and Ropivacaine for Quality of Recovery After Laparoscopic Colorectal Surgery: A Randomized Controlled Trial
Published 2024-12-01“…This study aimed to evaluate this combination’s effect on recovery outcomes after laparoscopic colorectal surgery.Patients and Methods: In this randomized, double-blind, placebo-controlled trial, 78 patients undergoing laparoscopic colorectal surgery received either preservative-free intrathecal morphine 250 μg with ropivacaine 15 mg (Intrathecal group) or a sham subcutaneous saline injection (Control group). …”
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29478
Involvement in Parasocial Relationships among Middle-Aged Women
Published 2025-03-01“…Women who feel lonely, as well as those who do not feel lonely, are equally prone to becoming involved in parasocial relationships. …”
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29479
Risk Factors for Pleural Reaction in CT-Guided Percutaneous Lung Nodule Localization: A Single-Center Retrospective Study
Published 2025-07-01“…This study aims to identify the risk factors associated with PR in CT-guided percutaneous lung nodule localization (CT-PLNL) procedures.Methods: This retrospective study included 467 patients who underwent video-assisted thoracic surgery (VATS) at Nanjing Drum Tower Hospital between January 2022 and December 2023, all of whom had received CT-PLNL. …”
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29480
Biometry and Intraocular Lens Power Calculation by Combined Scheimpflug-Placido Disc versus Optical Interferometry Devices
Published 2022-11-01“…Abstract Purpose: To compare the results of the current gold standard, laser interferometry, and keratometry by the IOL-Master, with a newly developed Galilei G6 using raytracing software Okulix for intraocular lens (IOL) power calculations. Methods: For comparison of the IOL-power calculation of both devices, we analyzed the difference between the actual one-month postoperative subjective refraction and the theoretically calculated target refraction before cataract surgery. …”
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