Research progress on treatment of pleural effusion related to immune checkpoint inhibitors by AN Tianqi, TIAN Jianhui, ZHOU Yiyang, LUO Bin, QUE Zujun, LIU Yao, YU Pan, ZHAO Ruihua, YANG Yun

“…This review aimed to explore the pathogenesis, histological features, clinical manifestations, diagnostic methods and treatment strategies of ICIs treatment-related pleural effusion, and delve into the characteristics of ICIs treatment-related pleural effusion, in order to enhance understanding of this complication and provide a reference for clinical practice.…”
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Prevalence and Associated Factors of Treatment Regimen Fatigue Among People Living with HIV/AIDS in China: A Cross-Sectional Survey by Liu B, Yang Y, Zhou H, Liu H, Xu Z

“…Long-term adherence to treatment regimens is crucial to maintaining the health and life span of such individuals.Objective: This study aimed to examine treatment regimen fatigue among people living with HIV/AIDS and the relevant factors.Methods: This cross-sectional study was conducted between January and December 2019 at two designated AIDS medical institutions in Harbin, China. …”
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Diagnostic Capability of Pattern Electroretinogram and Three Circumpapillary Retinal Nerve Fiber Layer Thickness Circle Diameter Scans in Glaucoma Suspects by Tirsi A, Tsai J, Abizadeh A, Kacaj D, Procyk O, Gliagias V, Leung N, Yang H, Park SC, Tello C

“…Andrew Tirsi,1,2 Joby Tsai,3 Aaron Abizadeh,2 Danielle Kacaj,4 Oksana Procyk,1 Vasiliki Gliagias,2 Nicholas Leung,2 Hanwen Yang,2 Sung Chul Park,1,2 Celso Tello1,2 1Department of Ophthalmology, Manhattan Eye, Ear, and Throat Hospital/Northwell Health, New York, NY, USA; 2Donald and Barbara Zucker School of Medicine at Hofstra/Northwell Health, Hempstead, NY, USA; 3Broward Health, Department of Ophthalmology, Fort Lauderdale, FL, USA; 4Cornell University, Ithaca, NY, USACorrespondence: Andrew Tirsi, Manhattan Eye Ear & Throat Hospital/Northwell Health, Department of Ophthalmology, 210 East 64th Street, New York, NY, 10065, USA, Tel +1 201 982 4168 ; +1 646 785 8217, Email atirsi@northwell.eduPurpose: To assess the diagnostic capability of pattern electroretinography (PERG) and varying circumpapillary optical coherence tomography (OCT) scan diameters in glaucoma suspects (GS).Methods: This is a prospective, cross-sectional study. …”
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Risk Factors for Postoperative Neurologic Dysfunction in Patients with Spinal Tuberculosis: A Retrospective Study by Shao P, Wang Y, Dong M, Fan H, Gao Y, Gao Y, Hao Z, Lv J, Bai J, Wu Z, Feng Y

“…Pengfei Shao,* Yushan Wang,* Mingjie Dong, Hao Fan, Yingjie Gao, Yu Gao, Zhaoyang Hao, Jia Lv, Junjun Bai, Zhuangzhuang Wu, Yi Feng Department of Orthopedics, The Second Affiliated Hospital of Shanxi Medical University, Taiyuan, Shanxi, People’s Republic of China*These authors contributed equally to this workCorrespondence: Yi Feng, Department of Orthopedics, The Second Affiliated Hospital of Shanxi Medical University, Taiyuan, Shanxi, People’s Republic of China, Email fengyi160@126.comPurpose: Unexplained neurological dysfunction often occurs in patients after spinal tuberculosis(STB) surgery; therefore, this study aimed to analyze the causes of this dysfunction from the perspectives of the patient’s preoperative inflammatory state, carrier bacterial state, and increased degree of autoimmunity.Patients and Methods: We collected 247 patients with STB and 270 patients with degenerative diseases of the spine admitted from May 2015 to December 2024 at the Second Hospital of Shanxi Medical University. …”
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Cerai Gugat Pasangan Pernikahan Dini Atas Penelantaran Prespektif Gender by Rita Latassaqia

“…This research used qualitative methods with in-depth interviews with 10 interviewees, including plaintiffs and court officials, as well as analysis of relevant legal documents. …”
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IL-35 Ameliorates Myocardial Strain in Mice with T2DM-Induced Cardiac Injury: Assessment by Layer-Specific Strain by Wang Z, Han L, Dong M, Liu Y, Hu X, Huang L, Zhang C, Guo L, Liu S, Liao L

“…This study aimed to evaluate the effect of IL-35 treatment on diabetic mice with diabetes-induced cardiac injury using layer-specific strain analysis.Patients and Methods: Twenty-six mice were allocated into three groups: the control group (CON, n=10), the diabetic group (DM, n=10), and the diabetic group treated with IL-35 (DMIL, n=6). …”
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Effect of Salt Substitution on Cardiac Structure and ECG Parameters in Middle-aged and Elderly Hypertensive Patients by Li Che, Ying Zhang, Xia Chen, Haiqing Du, Wei Song, Yinong Jiang

“…A total of 352 patients were enrolled and equally randomized to either the normal salt (NS) group or SS group. …”
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Long-Term Outcomes of Laparoscopic Anatomical versus Non-Anatomical Liver Resection for Hepatocellular Carcinoma by Leng S, Cao L, Wang X, Chen J, Wang X, Cao Y, Li X, Zheng S, Tian F, Li J

“…Songyao Leng,1,2,* Li Cao,1,* Xingru Wang,1,3 Jian Chen,1 Xiaojun Wang,1 Yong Cao,1 Xuesong Li,1 Shuguo Zheng,1 Feng Tian,1 Jianwei Li1 1Department of Hepatobiliary Surgery, Southwest Hospital, Army Medical University, Chongqing, People’s Republic of China; 2Department of General Surgery, The First People’s Hospital of Neijiang, Neijiang, Sichuan, People’s Republic of China; 3Department of Hepatobiliary Surgery, Qujing Second People’s Hospital of Yunnan Province, Qujing, Yunnan, People’s Republic of China*These authors contributed equally to this workCorrespondence: Jianwei Li; Feng Tian, Department of Hepatobiliary Surgery, Southwest Hospital, Army Medical University, No. 30 Gaotanyan Street, Shapingba District, Chongqing, 400038, People’s Republic of China, Email ljianwei1015@yeah.net; tianfeng@tmmu.edu.cnObjective: The objective of this study was to investigate the long-term outcomes between laparoscopic anatomical liver resection (LAR) and laparoscopic non-anatomical liver resection (LNAR) in patients with hepatocellular carcinoma (HCC).Methods: In this single-center retrospective cohort study, 1773 patients, from January 2009 to December 2017, were assessed for inclusion. …”
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Post-TACE ALBI-Score Trajectory in Intermediate and Advanced Hepatocellular Carcinoma: Prognostic Implications and Influencing Factors Analysis by Li J, Feng T, Cui C, Wang H, Su T, Jin L, Zhao X, Xiao W

“…This study aims to characterize the longitudinal trajectories of ALBI-scores after TACE, evaluate their impact on clinical outcomes, and identify factors influencing these trajectories.Materials and Methods: This retrospective study included patients with BCLC stage B/C HCC who underwent TACE, with baseline and at least two post-TACE ALBI-score measurements. …”
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Proteomic Analysis of Retinas in a Rat Model of High-Fat Diet-Induced Type 2 Diabetes: Implications of Interventional Targets for Nonproliferative Diabetic Retinopathy by Pang X, Bai S, Feng Z, Zhang Y, Hu B, Zhang Y

“…Xueyi Pang,* Siqiong Bai,* Zhinan Feng, Yumin Zhang, Bojie Hu, Yan Zhang Tianjin Key Laboratory of Retinal Functions and Diseases, Tianjin Branch of National Clinical Research Center for Ocular Disease, Eye Institute and School of Optometry, Tianjin Medical University Eye Hospital, Tianjin, 300384, People’s Republic of China*These authors contributed equally to this workCorrespondence: Bojie Hu; Yan Zhang, Tianjin Key Laboratory of Retinal Functions and Diseases, Tianjin Branch of National Clinical Research Center for Ocular Disease, Eye Institute and School of Optometry, Tianjin Medical University Eye Hospital, Tianjin, 300384, People’s Republic of China, Tel +86 22 86428700 ; +86 22 86428863, Fax +86 22 86428777, Email bhu07@tmu.edu.cn; yanzhang04@tmu.edu.cnPurpose: This study aimed to establish a high-fat diet (HFD)-induced rat model of type 2 diabetes mellitus (T2DM) and employed tandem mass tag (TMT) proteomics to search for novel interventional targets for nonproliferative diabetic retinopathy (NPDR).Patients and Methods: Six-week-old male Sprague–Dawley rats were randomly divided into a T2DM group fed a HFD and a normal group (NOR group) fed normal chow. …”
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Assessing the influence of Katana™ Cleaner on the clinical performance of bulk-fill restorations in endodontically treated teeth: study protocol for a randomized clinical study by Jacqueline Vitória do Nascimento Azevedo, Ceci Nunes Carvalho, Hadda Lyzandra Austriaco Leite, Suellen Nogueira Linares Lima, Wallace Vieira Mendes, Sebastião Marinho Pinheiro Neto, Andrés Felipe Millian Cardenas, Fabiana Suellen Figueredo Siqueira, Rossana Aboud Matos de Almeida, Etevaldo Matos Maia Filho

“…Methods The study will be a blinded randomized clinical trial conducted according to the Consolidated Standards of Reporting Trials (CONSORT) statement. …”
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Evaluating the efficacy of rumination-focused cognitive-behavioral therapy in alleviating depression, negative affect, and rumination among patients with recurrent major depressive... by Mohsen Hasani, Saeedeh Zenoozian, Reza Ahmadi, Sahel Khakpoor, Soleiman Saberi, Reza Pirzeh, Omid Saed

“…In light of these developments, the present study was conducted to evaluate the efficacy of RFCBT in reducing rumination severity, depressive symptoms, and negative affect among individuals with recurrent MDD. Methods This randomized clinical trial enrolled 44 university students diagnosed with MDD. …”
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Dual-Mode Treatment of Hepatocellular Carcinoma Using RGD Cyclopeptide-Modified Liposomes Loaded with Ce6/DOX by Xu W, Zheng J, Zhang J, Shi H, Peng W, Liu Y, Feng G, Wang Y, Liang YJ, Chen J

“…Therefore, an effective drug delivery system must enhance drug accumulation at the target site, enable selective drug release there, and facilitate escape from lysosomes.Methods: cRGD-Lipo@Ce6/DOX was prepared by modifying c(RGDyK) onto the surface of drug-loaded liposomes containing Chlorin e6 (Ce6) and doxorubicin (DOX) through an amide reaction. …”
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Expression and Clinical Significance of Irisin in Serum and Placenta Tissues of Pregnant Women with Severe Preeclampsia by Ren Y, Bi H, Zhang J, Yin Q, Zhang X, Gong X, Li Y, Shi J

“…Irisin levels in the serum and placental tissues of healthy pregnant women and those with early- and late-onset SPE were measured and compared.Methods: A total of 70 pregnant women treated at our hospital from January to November 2023 were selected for this study. …”
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Digital Mental Health Interventions for Young People Aged 16-25 Years: Scoping Review by Courtney Potts, Carmen Kealy, Jamie M McNulty, Alba Madrid-Cagigal, Thomas Wilson, Maurice D Mulvenna, Siobhan O'Neill, Gary Donohoe, Margaret M Barry

“…ObjectiveThis scoping review aims to explore the range of digital mental health interventions available for young people aged 16-25 years, with a particular focus on digital tool types, modalities, delivery formats, target populations, and study retention rates. MethodsThe scoping review was conducted in 6 databases (PubMed, Web of Science, Scopus, MEDLINE, Cochrane Library, and PsychInfo). …”
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Cordycepin Ameliorates Renal Interstitial Fibrosis by Inhibiting Drp1-Mediated Mitochondrial Fission by Sun Y, Jin S, Chen J, Zhang J, Lu Y, Gu Q, Yan Z, Chen W, Chen A, Fang Y, Geng W, Xu X, Song N

“…Yingxue Sun,1,* Shi Jin,1,* Jun Chen,2,* Jian Zhang,1 Yufei Lu,1 Qiuyu Gu,1 Zhixin Yan,1 Weize Chen,1 Annan Chen,1 Yi Fang,1 Wenye Geng,3 Xialian Xu,1 Nana Song1 1Department of Nephrology, Zhongshan Hospital, Fudan University; Shanghai Medical Center of Kidney; Shanghai Institute of Kidney and Dialysis; Shanghai Key Laboratory of Kidney and Blood Purification; Hemodialysis Quality Control Center of Shanghai, Shanghai, 200032, People’s Republic of China; 2Department of Pathology, Changzheng Hospital, Naval Military Medical University, Shanghai, 200003, People’s Republic of China; 3Scientific Research Department of Shanghai Medical College, Fudan Zhangjiang Institute, Fudan University, Shanghai, 201203, People’s Republic of China*These authors contributed equally to this workCorrespondence: Xialian Xu; Nana Song, Division of Nephrology, Zhongshan Hospital, Fudan University, Shanghai, People’s Republic of China, Tel +86-021-64041990-2138, Fax +86-021-64038038, Email xu.xialian@zs-hospital.sh.cn; song.nana@zs-hospital.sh.cnObjective: This study aimed to investigate the mechanisms and specific targets of cordycepin in the treatment of renal fibrosis using a unilateral ischemia-reperfusion (UIR) model.Methods: A UIR mouse model was established, followed by intraperitoneal injections of cordycepin and Mdivi-1. …”
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Development of a Nomogram for Prognostic Prediction of Large Hepatocellular Carcinoma With HBV After TACE Combined Conversion Therapy by Xu W, Ding X, Xu Y, Zhang Y, Xu H, Guo L, Li L

“…Wei Xu,1,* Xia Ding,2,* Yan Xu,3 Yongchuang Zhang,1 Huaxiao Xu,1 Lin Guo,1 Lei Li1 1Department of Interventional Radiology, Qingdao Central Hospital, University of Health and Rehabilitation Sciences (Qingdao Central Hospital), Qingdao, Shandong, 266042, People’s Republic of China; 2Department of Oncology, Qingdao Hospital, University of Health and Rehabilitation Sciences (Qingdao Municipal Hospital), Qingdao, Shandong, 266071, People’s Republic of China; 3Department of Oncology, Qingdao Central Hospital, University of Health and Rehabilitation Sciences (Qingdao Central Hospital), Qingdao, Shandong, 266042, People’s Republic of China*These authors contributed equally to this workCorrespondence: Lei Li, Department of Interventional Radiology, Qingdao Central Hospital, University of Health and Rehabilitation Sciences(Qingdao Central Hospital), Qingdao, Shandong, 266042, People’s Republic of China, Email 369542019@qq.comBackground: Surgical resection (SR) following transarterial chemoembolization (TACE) is a promising option for large hepatocellular carcinoma (LHCC) with HBV, and identification of these patients at high-risk of prognosis may help individualized treatment.Purpose: To develop and validate pre- and postoperative prognostic nomograms integrating clinico-therapeutic-pathological features for predicting overall survival (OS) after TACE combined therapy.Materials and Methods: Between May 2010 and October 2021, 255 consecutive patients with LHCC receiving conversion therapy of TACE combined with Lenvatinib plus PD-1 inhibitors were included from three tertiary-care hospitals. …”
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A Comprehensive Study of Part-Solid Lung Adenocarcinoma with Lymph Node Metastasis: Clinical, Pathological, and Radiological Perspectives by Zhao Z, Gan H, Fu BJ, Li W, Lv F, Chu Z

“…This study aims to comprehensively investigate the clinical, pathological, and CT characteristics of part-solid LUADs with LNM.Patients and Methods: This study collected 70 pathologically confirmed part-solid LUADs at two centers, including 35 cases with LNM and 35 matched cases without LNM based on size, CT pattern, and pathological subtype. …”
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A Tentative Clinical Study: Colistin Combined with Ceftazidime/Avibactam in the Treatment of Carbapenem-Resistant Gram-Negative Bacilli Infection by Zhang R, Zheng Z, Lu Y, Shi K, Lin Z, Tang S, Shao Z, Yang X, Liu J

“…This study aimed to assess the efficacy of colistin (COL) combined with ceftazidime/avibactam (CAZ/AVI) in the treatment of CR-GNB infections.Patients and Methods: A retrospective, single-center observational study was conducted on patients diagnosed with CR-GNB infections who were treated with COL combined with CAZ/AVI (C/C), COL combined with Tigecycline (C/T), and COL combined with meropenem (C/M). …”
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Effect of Telemonitoring on Moderate and Severe Exacerbations in Patients with COPD: Pooled Analysis of Two Randomized Controlled Trials in Denmark by Hyldgaard C, Ringbæk T, Andersen FD, Hansen EF, Jensen MS, Fenger-Grøn M, Trolle C, Ulrik CS

“…The aim of the present study was to combine data from two randomized controlled trials conducted in Denmark in similar healthcare settings to explore number of hospitalizations for COPD, days of admission, and exacerbations treated outside hospitals.Methods: Recruitment took place during hospitalization for AECOPD and from outpatient COPD clinics. …”
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