Evaluating the role of astragalus polysaccharide in modulating immune infiltration and enhancing prognostic biomarkers in pediatric acute myeloid leukemia by Min-Hui He, Xian-Hui Zhang, Ji-Hong Zhang, Jie Pan, Chao Yang

“…This study aimed to investigate the role of Astragalus polysaccharide (APS) in immune infiltration and prognosis of pediatric AML.MethodsDifferentially expressed genes (DEGs) were identified from the GEO database (dataset GSE2191), and APS-related genes (APSRGs) were obtained from the Swiss Target Prediction platform. …”
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The role of optical coherence tomography angiography biomarkers in assessing the outcome of long-term anti-VEGF therapy of diabetic macular edema by A. Zh. Fursova, A. S. Derbeneva, M. S. Tarasov, M. V. Vasil’eva, J. A. Gamza, N. V. Chubar

“…The purpose of the study was to assess the changes of biomarkers of diabetic macular edema activity by optical coherence tomography angiography (OCTA) data and the relationship of these biomarkers with the response to anti-VEGF therapy during a two-year follow-up. Material and methods. The study included 59 patients (101) eyes, averagely aged 60.27 ± 9.50 years. …”
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CO30 | Joint prosthetic surgery in patients with hemophilia A: clinical-functional outcomes and quality of life

“…The aim of this study was to evaluate the efficacy of perioperative FVIII treatment in ensuring adequate hemostasis and to assess the clinical-functional outcomes and impact on quality of life following joint replacement in patients with hemophilia A. Methods: This prospective observational study included 22 patients with severe hemophilia A (mean age: 49 years) who underwent a total of 30 prosthetic joint surgeries at our center. …”
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Importance of antenatal identification of small for gestational age fetuses on perinatal and childhood outcomes: A register‐based cohort study by Emma Hertting, Lotta Herling, Pelle G. Lindqvist, Eva Wiberg‐Itzel

“…The aim of this study was to investigate the association between antenatal identification of SGA fetuses and severe adverse perinatal and childhood outcome. Material and methods A register‐based cohort study of all newborns delivered in Stockholm in 2014 and 2017. …”
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Comparison of transrectal and transperineal prostate biopsy: a prospective comparative study by Vladimir A. Vorobev, Gadir R. Akperov, Olga V. Baklanova, Dmitry S. Mickevich, Egor V. Kovalev, Ivan P. Popov, Zahir S. Azizov

“…To compare the diagnostic performance, complication rates, pain levels, and short-term outcomes of TR- and TP-guided prostate biopsies. Materials and methods. A prospective randomized study included 68 men aged ≥40 years with suspected prostate cancer (PSA4 ng/mL, positive DRE, and/or PIRADS≥3). …”
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Healthcare resource utilization and caregiver burden associated with rotavirus gastroenteritis hospitalizations in Taiwan by Yhu-Chering Huang, Chih-Hsien Chuang, Chia-Jung Hsieh, Chiu-Mei Hsieh, Ying Hui Wu, Questa Lin, Joanne Lin, Fei Qin, Janine Verstraete, Michael Herdman, Cristina Carias

“…However, few studies assessed the spillover effect on caregivers’ health-related quality of life (HRQoL) and out-of-pocket costs associated with rotavirus gastroenteritis (RGE) in Taiwan. Methods This is a prospective, observational, survey-based study conducted in Northern Taiwan between March 2021-September 2023. …”
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Enhancing basal cell carcinoma classification in preoperative biopsies via transfer learning with weakly supervised graph transformers by Johan Björkman, Sigrid Lagerroth, Jan Siarov, Filmon Yacob, Noora Neittaanmäki

“…By addressing challenges of scalability and variability, this approach seeks to enhance generalizability and diagnostic accuracy. Methods The Basal Cell Classification (BCCC) dataset included 514 WSIs of punch biopsies (261 with BCC and 253 tumor-free slides), divided into training (70%), validation (15%), and test sets (15%). …”
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Association Between Chronic Pain, Coping Strategies, and Sleep Quality in Rural Chinese Older Adults: A Cross-Sectional Study by Tao X, Cheng C, Bai J

“…A self-reported questionnaire was used to collect data on socio-demographic items, chronic pain (visual analogue scale, VAS), coping strategies (Coping Strategies Questionnaire-Revised, CSQ-R), and sleep quality (Athens Insomnia Scale, AIS). …”
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Differential dynamic functional network connectivity in different motor subtypes of Parkinson's disease by Yu Pan, Hang Qu, Yi Zhao, Zhaoxia Qin, Jiangbing Liu, Wei Wang

“…Therefore, this study aimed to explore brain networks’ dynamic functional connectivity characteristics in patients with TD and ARD PD and their correlation with clinical symptoms. Methods: This study included 37 patients with TD PD, 33 with ARD PD, and 30 healthy controls (HCs). …”
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Feasibility of an at-home telerehabilitation programme for upper limb impairment post-stroke by Louise van Wyk, Maatje Kloppers, Lee-Ann J. Jacobs-Nzuzi Khuabi

“…Setting: Bishop Lavis, South Africa, a low-income area. Methods: A single-site parallel randomised feasibility study was conducted. …”
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Transcriptomic and metabolomic analyses reveal phenolic metabolism regulated by melatonin in pear peel by Shuai Yan, Liangliang Zhao, Deying Zhao, Gongxun Xu, Yufei Wang, Zhiqin Zhou, Cungang Cheng

“…However, the mechanisms by which pre-harvest application of melatonin regulates the metabolism of phenolic compounds in pear pericarp remain poorly understood. Methods In this study, the effect of pre-harvest spraying of melatonin on the synthesis of phenolics in pear peel and the regulatory mechanism were investigated using a multi-disciplinary approach, integrating physiological and biochemical, transcriptomic, and metabolic analyses, and the “Yuluxiang” pear as the test material. …”
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Breast cancer burden (1990–2040) in individuals aged 55 and above: a GBD 2021 analysis of global trends, sex-specific risk factors, and intervention impact by Shimao Jian, Wanmei Lin, Yuewen Tang, Guangyu Yao

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A Study on the Effects of Gluteal Muscle Activation on the Electromyography of Lower Limb Muscles in Young Male Patients With Patellofemoral Pain Syndrome by Wu Yue, Ren Shuang, Huang Hongshi, Ao Yingfang, Gou Bo

“…This study aims to investigate the impact of gluteal muscle activation exercises on the muscle involvement and movement patterns of young male patients with PFPS. Methods Our study was a randomized controlled clinical trial study from June 2020 to December 2021, included 18 young male patients with PFPS, randomly divided into two groups: the gluteus activation group (GAG) and control group (CON), with nine cases in each group. …”
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Evaluation of the impact of a course of therapy with an injectable form of chondroitin sulfate on the duration of remission and quality of life in patients with osteoarthritis by P. S. Kovalenko, I. S. Dydykina, O. G. Alekseeva, E. L. Shakhramanova, A. S. Potapova, S. I. Glukhova, E. G. Zotkin

“…Parenteral forms of chondroitin sulfate (CS) used for the background therapy of OA are characterized by proven efficacy and safety and, compared to oral forms, have greater bioavailability, faster onset of symptom-modifying effect and maintenance of more stable remission, which can significantly improve patients' quality of life.Objective: to evaluate the clinical efficacy and safety of two-month therapy with injectable CS and the duration of positive dynamics after the end of treatment in patients with knee OA (KOA).Material and methods. The open prospective observational study involved 35 patients (mainly women) aged 50–75 years with stage II–III KOA. …”
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Effectiveness of Intravitreal Dexamethasone Implant Treatment for Diabetic Macular Edema in Vitrectomized Eyes by Hüseyin Baran Özdemir, Murat Hasanreisoğlu, Murat Yüksel, Mestan Ertop, Gökhan Gürelik, Şengül Özdek

“…Objectives:To report the effectiveness and long-term outcomes of intravitreal dexamethasone implantation for diabetic macular edema (DME) in vitrectomized eyesMaterials and Methods:Medical records of patients were retrospectively reviewed. …”
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The Impact of Obesity on Pain Perception During and After Subcutaneous Injections: A Cross-Sectional Analysis by Candelaria de la Merced Díaz-González, Josefa María Ramal-López, Milagros de la Rosa-Hormiga

“…Previous studies have found higher levels of pain in people with obesity receiving SC insulin, and this study thus aimed to measure pain levels <i>during</i> and <i>after</i> an SC injection of low-molecular-weight heparin (LMWH) and identify how age, gender, and obesity may modulate the level of pain <i>during</i> and <i>after</i> the procedure. (2) Methods: This was a cross-sectional study, and the variables included age, gender, body mass index (BMI), BMI quartile, abdominal skin folds (ASFs), ASF quartile, and pain level <i>during</i> and <i>after</i> injection. …”
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A Nomogram Based on S100A7 and Clinicopathological Characteristics to Predict the Efficacy of Neoadjuvant Chemotherapy in Breast Cancer: A Retrospective Study by Zhang T, Yu X, Yang X, Li Y, Li X, Ma L

“…In this study, we investigated whether S100A7 can be used to predict the efficacy of neoadjuvant chemotherapy (NAC) and assessed its relationship with clinicopathological characteristics in BC.Methods: We retrospectively analyzed the clinicopathological data of patients with BC who underwent NAC at the Fourth Hospital of Hebei Medical University between January 2021 and December 2021. …”
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Your brain on art, nature, and meditation: a pilot neuroimaging study by Beatrix Krause-Sorio, Sergio Becerra, Prabha Siddarth, Stacey Simmons, Taylor Kuhn, Helen Lavretsky

“…The instructions were to meditate on the connection to a Universal Soul linked to a sense of expansion and universal connectedness (“one with everything”), which was prompted by a video of the galactic nebula that also controlled for the visual stimuli of the two other conditions.MethodsNine healthy adults (mean age = 29; range = 19–42; 5 women) underwent a block design fMRI scan using a Siemens 3T Prisma scanner. …”
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Omega-3 Polyunsaturated Fatty Acids Effect on Neuropathy of the Peripheral Nervous System in Dietary Obese Rats: Is the Source of These Fatty Acids Important for Outcome? by Davidson E, Obrosov O, Coppey L, Yorek M

“…However, other sources exist that could be a better environmental, safety, and/or economic choice.Methods: Male Sprague Dawley rats 12 weeks of age were fed a 45% kcal diet to induce obesity and model pre-diabetes. …”
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OTX2 expression contributes progression of gastric cancer in young adults by Jingming Zhai, Ting Lyu, Yimin Guo, Yanhui An, Yali Xiang, Linying Xie, Chao Zeng

“…However, there are few reports regarding the genetic alteration in gastric cancer of young adults. Bioinformatics methods were used to screen the key genes and signaling pathways of gastric cancer in young adults, and molecular biology techniques were used to verify the key proteins involved in the occurrence and development of gastric cancer in young adults. …”
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