Effectiveness of Self-Help Plus in its digital version in reducing anxiety and post-traumatic symptomatology among nursing home workers during the COVID-19 pandemic: secondary anal... by Marianna Purgato, Federico Tedeschi, Corrado Barbui, José Luis Ayuso-Mateos, Roberto Mediavilla, Marianna Riello, Debora Zaccoletti, David MacTaggart, Elena Rusconi

“…Background Healthcare workers (HCWs) face substantial daily work-related pressures, leading to frequent reports of depression, anxiety and post-traumatic stress disorder (PTSD) symptoms.Objective To compare the effects of Self-Help Plus in its digital version Doing What Matters in Times of Stress (DWM) to an equally structured activity in reducing anxiety and/or PTSD symptoms among HCWs.Methods We compared the proportion of participants with moderate-to-severe anxiety (General Anxiety Disorder Scale; GAD-7 ≥10) and/or PTSD symptoms (Impact of Event Scale-Revised (IES-R)) ≥26) between DWM and the alternative activity. …”
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Intersectionality and mental health in university students: a jeopardy index approach by Juliana Dias de Lima, Jessica Plácido, Beatriz Andrade, Letícia Dalcero Abend, Aline Josiane Waclawovsky, Daniel Alves Pires, Danilo Rodrigues Pereira da Silva, Fabianna Resende de Jesus-Moraleida, Helena Ferreira Moura, Nicole Leite Galvão Coelho, Renato Sobral Monteiro-Junior, Thiago Sousa Matias, Felipe Barreto Schuch, Andrea Camaz Deslandes

“…ABSTRACT OBJECTIVE: To explore the associations between current mental health symptoms and social disparities in university students. METHODS: We recruited participants from nine public universities in Brazil, from August to November 2022, using online advertisements and in-person lectures. …”
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Rationale and design of a large trial of perioperative ketamine for prevention of chronic post-surgical pain by Philip J. Peyton, Sabine Braat, Anurika De Silva, David Story, Lisbeth Evered, Paul S. Myles, Matthew Chan, Stephan Schug, Malcolm Hogg, Alex Holmes, Sofia Sidiropoulos, Kate Leslie

“…Eligible participants are randomised equally to perioperative intravenous ketamine or placebo for up to 72 h. …”
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Association Between Lipoprotein(a) and Risk Factors of Atherosclerosis in Russian Population (Data of Observational ESSE-RF study) by S. A. Shalnova, M. V. Ezhov, V. A. Metelskaya, S. E. Evstifeeva, V. I. Tarasov, G. A. Muromtseva, Yu. A. Balanova, A. E. Imaeva, A. V. Kapustina, A. A. Shabunova, O. A. Belova, I. A. Trubacheva, A. Y. Efanov, Z. T. Astakhova, N. V. Kulakova, S. A. Boytsov, O. M. Drapkina

“…To investigate the distribution of Lp(a) in the population of the regions participating in the Study “Epidemiology of Cardiovascular Diseases in the Regions of the Russian Federation” (ESSE-RF) and to evaluate its associations with cardiovascular risk factors.Material and methods. Representative samples of the male and female population of 7 regions of the Russian Federation, aged from 25 to 64 years, enrolled in the multi-center cross-sectional epidemiological study were analyzed. …”
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Multidose Dalbavancin Population Pharmacokinetic Analysis for Prolonged Target Attainment in Patients Requiring Long-Term Treatment by Giammarco Baiardi, Michela Cameran Caviglia, Silvia Boni, Antonello Di Paolo, Valeria Marini, Giuliana Cangemi, Alessia Cafaro, Emanuele Pontali, Francesca Mattioli

“…<b>Methods:</b> Pharmacokinetic analysis was based on a nonlinear mixed effects modelling approach performed in NONMEM v7.5/Pirana, while R was used for data management and graphical summaries. …”
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The effect of oral probiotics on CD4 count in patients with HIV infection undergoing treatment with ART who have had an immunological failure by Masoud Mortezazadeh, Saeed Kalantari, Nooshin Abolghasemi, Mitra Ranjbar, Saeedeh Ebrahimi, Abbas Mofidi, Babak Pezeshkpour, Ensieh Sadat Mansouri, Seyed Zia Tabatabaei, Mehdi Kashani

“…Probiotics play an important role in stimulating natural killer T cells, strengthening the functional gut barrier, and reducing systemic inflammation. Methods This study was a randomized double‐blind clinical trial involving 30 patients treated with antiretroviral therapy who had experienced immunological failure despite HIV viral suppression. …”
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HOMESIDE: home-based family caregiver-delivered music and reading interventions for people living with dementia: protocol of a randomised controlled trial by Sabine Braat, Felicity Anne Baker, Imogen Clark, Young-Eun Claire Lee, Thomas Wosch, Helen Odell-Miller, Nicola Lautenschlager, Jodie Bloska, Anna Bukowska, Ming H Hsu, Tone Kvamme, Agnieszka Smrokowska-Reichmann, Karette A Stensaeth

“…Our project aims to address the need for improved informal care by training cohabiting family CGs to implement music interventions that target BPSD, and the quality of life (QoL) and well-being of people with dementia (PwD) and CGs.Methods and analysis A large international three-arm parallel-group randomised controlled trial will recruit a sample of 495 dyads from Australia, Germany, UK, Poland and Norway. …”
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Universal Bacterium-Vectored COVID-19 Vaccine Expressing Early SARS-CoV-2 Conserved Proteins Cross-Protects Against Late Variants in Hamsters by Qingmei Jia, Helle Bielefeldt-Ohmann, Saša Masleša-Galić, Richard A. Bowen, Marcus A. Horwitz

“…In this study, we evaluate the efficacy of rLVS Δ<i>capB</i>/MN and an enhanced version, rLVS Δ<i>capB</i>::RdRp/MN, which additionally expresses the conserved RNA-dependent RNA polymerase (RdRp) protein from the same strain, in a hamster model. <b>Methods:</b> Both vaccine candidates were administered orally or intranasally to golden Syrian hamsters (equal numbers of males and females) and evaluated against intranasal challenge with SARS-CoV-2 Delta (B.1.617.2-AY.1) and Omicron (BA.5) variants. …”
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Invasive minimal Microvascular Resistance Is a New Index to Assess Microcirculatory Function Independent of Obstructive Coronary Artery Disease by Guus A. de Waard, Sukhjinder S. Nijjer, Martijn A. van Lavieren, Nina W. van der Hoeven, Ricardo Petraco, Tim P. van de Hoef, Mauro Echavarría‐Pinto, Sayan Sen, Peter M. van de Ven, Paul Knaapen, Javier Escaned, Jan J. Piek, Justin E. Davies, Niels van Royen

“…In this study we propose minimal microvascular resistance (mMR) as a new measure of microcirculatory dysfunction and aim to determine whether mMR is influenced by CAD. Methods and Results We obtained 482 simultaneous measurements of intracoronary Doppler flow velocity and pressure. …”
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6-Gingerol, an active compound of ginger, attenuates NASH-HCC progression by reprogramming tumor-associated macrophage via the NOX2/Src/MAPK signaling pathway by Qiurui Li, Meng Wang, Xuekuan Huang, Shang Wang, Chunli Li, Pan Li, Wei Xiang, Ling Yao, Chengdan Deng, Mingming Zhang, Jianwei Wang

“…The therapeutic effects and underlying mechanisms of NASH-HCC, however, remain poorly understood. Methods Network pharmacology, bioinformatics, single-cell RNA sequencing analysis, and molecular docking were used to identify the main active compounds, targets, and possible mechanisms of ginger in treating NASH-HCC. …”
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Q-Ball high-resolution fiber tractography: Optimizing corticospinal tract delineation near gliomas and its role in the prediction of postoperative motor deficits– A proof of concep... by Pavlina Lenga, Moritz Scherer, Robin Peretzke, Peter Neher, Jessica Jesser, Andreas W. Unterberg, Sandro Krieg, Daniela Becker

“…Research question: This study compares the results of conventional DTI-FT and q-ball (QBI)-high resolution FT with patient's postoperative morbidity, relating postoperative MD with the nearest distance from the lesion to the CST (nD-LCST). Materials and methods: In this ongoing prospective trial, we utilized probabilistic High-Resolution Fiber Tracking (HRFT) through q-ball imaging (QBI-FT) and conventional Diffusion Tensor Imaging Fiber Tracking (DTI-FT), based on equal and standard diffusion-weighted MRI. …”
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Features of Celiac Disease in children and adolescents with Down syndrome: a single-center experience of annual screening by Martina Lattuada, Paola Rebora, Paola Rebora, Chiara Fossati, Alessandra Lazzerotti, Lucia Paolini, Alessandro Cattoni, Alessandro Cattoni, Roberto Panceri, Maria Grazia Valsecchi, Maria Grazia Valsecchi, Andrea Biondi, Andrea Biondi, Giovanna Zuin

“…A secondary aim was to analyze the time needed for the normalization of anti-transglutaminase IgA (TGA-IgA) and anti-endomysium IgA (EMA-IgA) levels in DS compared to non-syndromic (NS) children.Materials and methodsThis retrospective monocentric cohort study included patients with DS under 18 years of age, diagnosed with CD between 2005 and 2022. …”
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Retrospective cohort of prenatal home ultrasound utilization and maternal-neonatal outcomes by Anat Pardo, Erkan Kalafat, Shira Hazon, Monica Pailis, Emilie Klochendler-Frishman, Or Lee Rak, Ofri Samueloff, Rachel Gomez-Tolub, Anat Shmueli, Noam Pardo, Tomer Sela, Leor Wolff, Asnat Walfisch, Arnon Wiznitzer, Eran Hadar

“…This service provides a handheld, app-connected ultrasound device for remote basic fetal monitoring, with its use determined at the discretion of the patient as a supplement - rather than a replacement - to standard prenatal care. Methods Retrospective analysis comparing maternal and neonatal outcomes among users versus non-users of the home ultrasound service, between January 2020 and December 2022. …”
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Investigating the prevalence of three medically important pathogens in Ixodes pacificus from southern Oregon by Andrew T. Partin, Emilio E. DeBess, Phillip Q. Spinks, Michael J. Yabsley, Michael J. Yabsley, Michael J. Yabsley, Kayla B. Garrett, Kayla B. Garrett, Kayla B. Garrett, James R. Clover, Geoffrey R. Taylor

“…Ixodes pacificus is common in southern Oregon yet there are few published studies on the distribution of tick-borne pathogens in this region. MethodsUsing real-time quantitative PCR, we assessed the prevalence of B. burgdorferi s.l., B. miyamotoi, and A. phagocytophilum among 2,463 unfed I. pacificus adults and nymphs combined into 260 pools (131 nymph, 129 adult) with nearly equal numbers of each life stage from 12 locations in Jackson County, Oregon. …”
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Adverse Drug Reactions to SGLT2i Reported by Type 2 Diabetes New Users: An Active Surveillance Study by Camelia Bucșa, Ioana Frenț, Ramona Stefan, Adriana Fodor, Georgeta Inceu, Andreea Farcaș, Adriana Rusu, Monica Negovan, Cristina Mogoșan

“…We aimed to prospectively follow-up on type 2 diabetes (T2D) patients who were new users of sodium-glucose co-transporter 2 inhibitors (SGLT2i) and to characterize the patient-reported ADRs within routine practice in Romania. <b>Methods</b>: T2D patients from ambulatory settings were interviewed over the phone based on standardized forms, at four time-points across 12 months. …”
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Acupuncture improves the symptoms, serum ghrelin, and autonomic nervous system of patients with postprandial distress syndrome: a randomized controlled trial by Zi-tong Fu, Cun-zhi Liu, Mi-Rim Kim, Yi-duo Liu, Yu Wang, Yi-Ming Fu, Jing-Wen Yang, Na-Na Yang

“…Objective This study aims to investigate the effects of acupuncture on symptoms, serum hormones, and ANS in PDS patients. Methods This randomized controlled clinical trial was conducted at Beijing Hospital of Traditional Chinese Medicine affiliated with Capital Medical University. …”
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Retinal ganglion cell repopulation for vision restoration in optic neuropathy: a roadmap from the RReSTORe Consortium by Jonathan R. Soucy, Erika A. Aguzzi, Julie Cho, Michael James Gilhooley, Casey Keuthan, Ziming Luo, Aboozar Monavarfeshani, Meher A. Saleem, Xue-Wei Wang, Juilette Wohlschlegel, The RReSTORe Consortium, Petr Baranov, Adriana Di Polo, Brad Fortune, Kimberly K. Gokoffski, Jeffrey L. Goldberg, William Guido, Alex L. Kolodkin, Carol A. Mason, Yvonne Ou, Thomas A. Reh, Ahmara G. Ross, Brian C. Samuels, Derek Welsbie, Donald J. Zack, Thomas V. Johnson

“…The RGC Repopulation, Stem Cell Transplantation, and Optic Nerve Regeneration (RReSTORe) Consortium was established to address the challenges associated with the therapeutic repair of the visual pathway in optic neuropathy. In 2022, the RReSTORe Consortium initiated ongoing international collaborative discussions to advance the RGC repopulation field and has identified five critical areas of focus: (1) RGC development and differentiation, (2) Transplantation methods and models, (3) RGC survival, maturation, and host interactions, (4) Inner retinal wiring, and (5) Eye-to-brain connectivity. …”
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Identification of hypoxia-related diagnostic biomarkers and immune signatures in diminished ovarian reserve by Minxue Song, Lili Ni, Zebing Ma, Xin Zhong, Yibing Liu, Jilin Kuang, Ping Li

“…This study investigated the genetic links between hypoxia and DOR.MethodsThe GSE87201 dataset for DOR was sourced from Gene Expression Omnibus database, normalized for common differentially expressed genes (Co-DEGs), and identified Hypoxia-related differentially expressed genes (HRDEGs) via GeneCards; Receiver Operating Characteristic (ROC) curves evaluated HRDEGs’ diagnostic value, and protein-protein interaction networks were visualized with STRING and Cytoscape. …”
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Feasibility of home initiation of an airway clearance device (SIMEOX) by telecare in people with non-cystic fibrosis bronchiectasis: a pilot study by Jean-Christian Borel, Nathalie Arnol, Sylvie Leroy, Marlène Murris-Espin, Rebecca Hamidfar, Marie Mahot, Raphael Abouly, Hughes Gauchez, Sophie Jacques, Eloise Joffray, Laurent Morin

“…We hypothesised that telecare would be an effective means to train people with NCFB in the handling of device and to monitor and promote device adherence.Objectives (1) To evaluate frequency of use of the SIMEOX for 10 weeks after telecare training. (2) To assess user satisfaction and clinical efficacy of the SIMEOX+telecare.Methods Multicentre, prospective, pilot study in adults with NCFB. …”
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Ocular manifestations in pediatric tumor suppressor gene mutations: a case series and literature review of RB1, NF1, NF2, VHL, and TSC by Aoxiang Wang, Chanyuan Wang, Wen Li, Jing Qiao, Yulin Luo, Yu Tian

“…We have summarized the ocular presentations of these common tumor suppressor gene mutations in pediatric patients. Methods We reviewed 11 representative case reports, documenting in detail the ocular manifestations and progression of each case. …”
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