Feasibility and potential diagnostic value of [18F]PI-2620 PET in patients with down syndrome and Alzheimer’s disease: a case series by Olivia Wagemann, Olivia Wagemann, Matthias Brendel, Nicolai Franzmeier, Nicolai Franzmeier, Nicolai Franzmeier, Georg Nübling, Georg Nübling, Johannes Gnörich, Mirlind Zaganjori, Catharina Prix, Anna Stockbauer, Anna Stockbauer, Elisabeth Wlasich, Sandra V. Loosli, Sandra V. Loosli, Katja Sandkühler, Lukas Frontzkowski, Günter Höglinger, Günter Höglinger, Günter Höglinger, Johannes Levin, Johannes Levin, Johannes Levin

“…We aim at illustrating feasibility and potential diagnostic value of tau PET imaging with [18F]PI-2620 for the diagnosis of DS-AD.Materials and methodsFive adults with DS (40% female, aged 43–62) and cognitive decline underwent clinical assessments, neuropsychological testing, lumbar puncture and multimodal neuroimaging. …”
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Accuracy of IOL power calculation in pediatric aphakia secondary implantation by Ying-Shi Zou, Jia-Xin Jin, Yun-Qian Li, Ling Jin, Jing-Min Xu, Wei-Ning Zhu, Hui Chen, Qiu-Xia Yin, Yi-Zhi Liu, Zhen-Zhen Liu

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Real-World Validity of Tissue-Agnostic Circulating Tumor DNA Response Monitoring in Lung Cancers Treated With Chemotherapy, Immunotherapy, or Targeted Agents by Anne C. Chiang, MD, PhD, Russell W. Madison, MS, Zoe June Assaf, PhD, Alexander Fine, PhD, Yi Cao, PhD, Ole Gjoerup, PhD, Yanmei Huang, PhD, Dexter X. Jin, PhD, Jason Hughes, PhD, Vladan Antic, MD, PhD, Amanda Young, PhD, David Fabrizio, MS, David Shames, PhD, Sophia Maund, PhD, Alexia Exarchos, MPH, Shailendra Lakhanpal, MD, Richard Zuniga, MD, Lincoln W. Pasquina, PhD, Katja Schulze, PhD

“…We evaluated the validity of tissue-agnostic ctDNA quantification across four treatment modalities in NSCLC and SCLC. Methods: Data from consenting patients were collected from electronic health records as part of the Prospective Clinico-Genomic study (NCT04180176). ctDNA tumor fraction (TF) was retrospectively calculated for plasma collected six to 15 weeks after therapy initiation. …”
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Association of Sociodemographic Factors With Overtriage, Undertriage, and Value of Care After Major Surgery by Tyler J. Loftus, MD, Matthew M. Ruppert, MS, Benjamin Shickel, PhD, Tezcan Ozrazgat-Baslanti, PhD, Jeremy A. Balch, MD, Kenneth L. Abbott, MD, Die Hu, MS, Adnan Javed, MD, Firas Madbak, MD, Faheem Guirgis, MD, David Skarupa, MD, Philip A. Efron, MD, Patrick J. Tighe, MD, William R. Hogan, MD, Parisa Rashidi, PhD, Gilbert R. Upchurch, Jr, MD, Azra Bihorac, MD

“…In a fair system, overtriage of low-acuity patients to intensive care units (ICUs) and undertriage of high-acuity patients to general wards would affect all sociodemographic subgroups equally. Methods:. This multicenter, longitudinal cohort study of hospital admissions immediately after major surgery compared hospital mortality and value of care (risk-adjusted mortality/total costs) across 4 cohorts: overtriage (N = 660), risk-matched overtriage controls admitted to general wards (N = 3077), undertriage (N = 2335), and risk-matched undertriage controls admitted to ICUs (N = 4774). …”
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Retinal Oxygen Kinetics and Hemodynamics in Choroidal Melanoma After Iodine‐125 Plaque Radiotherapy Using a Novel Structural‐Functional Imaging Analysis System by Haihan Zhang, Jingyuan Zhu, Yueming Liu, Shiyi Yin, Jinyuan Wang, Yao Yao, Haowen Li, Ximeng Feng, Chuanqing Zhou, Qiushi Ren, Wenbin Wei

“…ABSTRACT Background To investigate the changes in retinal oxygen kinetics and hemodynamics in patients with choroidal melanoma (CM) within 2 years before and after iodine‐125 plaque radiotherapy (PRT) using a novel noninvasive structure‐functional imaging analysis system. Methods A novel noninvasive cost‐effective imaging analysis system that integrates multimodal structural and functional retinal imaging techniques has been used, which allows rapid acquisition of vascular structural, hemodynamic, and oxygenation metrics using multispectral imaging (MSI) and laser speckle contrast imaging (LSCI) techniques. …”
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Interventions to improve the quality of cataract services: protocol for a global scoping review by Nathan Congdon, João M Furtado, Matthew J Burton, Jacqueline Ramke, Stephen Gichuhi, Helen Burn, Iris Gordon, William H Dean, John Buchan, Ada Aghaji, Miho Yoshizaki, Ana P Marques

“…This scoping review aims to summarise the nature and extent of the published literature on interventions to improve the quality of services for primary age-related cataract globally.Methods and analysis We will search MEDLINE, Embase and Global Health for peer-reviewed manuscripts published since 1990, with no language, geographic or study design restrictions. …”
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Mangrove wetlands distribution status identification, changing trend analyzation and carbon storage assessment of China by Chang Li, Fu Wang, Peng Yang, Fei-cui Wang, Yun-zhuang Hu, Yan-lin Zhao, Li-zhu Tian, Rui-bin Zhao

“…This research investigates the ecological importance, changes, and status of mangrove wetlands along China’s coastline. Visual interpretation, geological surveys, and ISO clustering unsupervised classification methods are employed to interpret mangrove distribution from remote sensing images from 2021, utilizing ArcGIS software platform. …”
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Complication rates after shoulder arthroplasty in patients aged 45 years and younger by Blake Hajek, BS, Jeff Klott, MD, Erick Marigi, MD, Brian Wahlig, MD, John Sperling, MD, Jeff Murphy, MS, Tyler J. Brolin, MD, Thomas W. Throckmorton, MD

“…We hypothesized that the complication rates would be comparable with those of older patients in existing literature. Methods: This multicenter, retrospective study included patients aged 45 years and younger undergoing primary TSA, HA, or rTSA with a minimum 2-year follow-up. …”
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Impact of prior arthroscopic rotator cuff repair on postoperative outcomes of reverse shoulder arthroplasty: a comparative analysis of muscle strength recovery and clinical results by Yoshihiro Hirakawa, MD, PhD, Tomoya Manaka, MD, PhD, Katsumasa Nakazawa, MD, PhD, Yoichi Ito, MD, PhD, So Taniguchi, MD, Ayako Ogura, PT, Hidetomi Terai, MD, PhD

“…By focusing on postoperative range of motion, clinical scores, and muscle strength over a minimum 2-year follow-up period, we sought to reveal critical insights into how previous ARCR influences recovery trajectories. Methods: We analyzed all patients diagnosed with cuff tear arthropathy or massive rotator cuff tears who underwent rTSA between April 2014 and March 2021, with at least two years of follow-up. …”
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Patient satisfaction with radio-frequency identification (RFID) tag localization compared with wire localization for nonpalpable breast lesions: the RFID trial by Raphaël Pete, Céleste Pinard, Fanny Sirodot, Ioana Molnar, Margot Dressaire, Angeline Ginzac, Catherine Abrial, Xavier Durando, Marielle Tekath

“…The purpose of this clinical trial was to assess the superiority of RFID tags (HOLOGIC) in terms of patient satisfaction, over wire localization of non-palpable breast lesions. Methods This was a single-centre, prospective, controlled and non-interventional trial. …”
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Using explainable machine learning and eye-tracking for diagnosing autism spectrum and developmental language disorders in social attention tasks by Adoración Antolí, Adoración Antolí, Francisco Javier Rodriguez-Lozano, José Juan Cañas, Julia Vacas, Julia Vacas, Fátima Cuadrado, Fátima Cuadrado, Araceli Sánchez-Raya, Araceli Sánchez-Raya, Carolina Pérez-Dueñas, Carolina Pérez-Dueñas, Juan Carlos Gámez-Granados

“…Two key challenges must be addressed: the difficulty in reliably distinguishing between disorders with overlapping features, and the efficient management of eye-tracking data to yield clinically meaningful outcomes.PurposeThe aim of this study is to apply explainable machine learning (XML) algorithms to eye-tracking data from social attention tasks involving children with ASD, developmental language disorder (DLD), and typical development (TD), in order to assess classification accuracy and identify the variables that best differentiate between groups.MethodsNinety-three children participated in a visual preference task that paired social and non-social stimuli, specifically designed to capture features characteristic of ASD. …”
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Exoskeleton Training for Spinal Cord Injury Neuropathic Pain (ExSCIP): Protocol for a Phase 2 Feasibility Randomised Trial [version 1; peer review: 1 approved, 2 approved with rese... by Orlaith Doherty, Conor White, Nanna Brix Finnerup, Eimear Smith, Mark Pollock, Nathan Kirwan, Olive Lennon, Catherine Blake

“…Our primary aim is to assess the impact of exoskeleton-based walking on NP intensity and interference after SCI and examine feasibility outcomes for progression to a definitive trial. Methods This is a phase 2 single-blinded, randomised feasibility study. …”
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Association Between Sociodemographic Disparities and Door to Computerized Tomography Time in Patients with Acute Ischemic Stroke Across COVID-19 Periods in the Emergency Department... by Yu-Lin Hsieh, Ching-Fang Tiffany Tzeng, Maha Khan, Andrew Shedd, Thomas Damrow, Dahlia Hassani, Matthew Danley, Jaydeep Shah, Jennifer Walker, Eric H. Chou

“…However, sociodemographic backgrounds may impact the DTCT in acute stroke patients. Methods: This was a retrospective, multicenter, cohort study between January 2018 and August 2022 throughout North Texas. …”
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Effect of Moxibustion on HIF-1α and VEGF Levels in Patients with Rheumatoid Arthritis by Yuanyuan Gong, Zeyun Yu, Yingni Wang, Yan Xiong, Yumei Zhou, Chen-xi Liao, Yuan Li, Yun Luo, Yu Bai, Bailu Chen, Yuzhi Tang, Ping Wu

“…To evaluate the effect of moxibustion on serum levels of hypoxia-inducible factor-1α (HIF-1α) and vascular endothelial growth factor (VEGF) in patients with RA and to explore the possible mechanism of moxibustion. Methods. This study involved 46 RA patients who had fulfilled the inclusion criteria and were randomly assigned to a treatment group and a control group in an equal ratio. …”
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Drug utilisation trends in a physical rehabilitation hospital by Ljubojević Gordana, Mastikosa Milan, Dostanić-Došenović Tanja, Novaković-Bursać Snježana, Tomić Nataša, Talić Goran, Škrbić Ranko, Stojiljković Miloš P.

“…The objective of this study was to analyse the drug utilisation patterns in a rehabilitation hospital over the period 2011–2016. Methods. The Anatomic Therapeutic Chemical classification/Defined Daily Dose (ATC/DDD) methodology was used to monitor the drug utilisation expressed as a number of DDD per 100 patient-days (HPD). …”
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A nerve root decompression position identified by 3D CT scan: the modified reversed contralateral axial rotation position for patients with lumbar disc prolapse by Ahmed Raffet, Mark Laslett, Raymond Lee, Noha Khaled, Ghada Abdel Moneim Mohamed, Hossam Y. Sayed, Ahmed H. Omar, Maged M. Hawana, Mahmoud M. Ali, Salam M. Elhafez, Mohamed M. ElMeligie, Hossam Eddein Fawaz

“…Purpose To investigate real-time effects of specific 3 dimensional positioning of the trunk on the cross sectional area (CSA) of the LIVF in patients with lumbar disc prolapse and radiculopathy using 3D-CT scan imaging. Methods Ninety males aged between 20 and 40 years with unilateral lumbar disc prolapse and radiculopathy were separated into three equal groups based on the level of disc prolapse. …”
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Intraoperative Fluoroscopy Decreases Magnitude and Incidence of Leg-Length Discrepancy Following Total Hip Arthroplasty by Christopher L. Blum, MD, Andrew J. Luzzi, MD, Jeremy S. Frederick, MD, H. John Cooper, MD, Roshan P. Shah, MD, JD, Jakub Tatka, MD, Jeffrey A. Geller, MD, Carl L. Herndon, MD

“…This study examines the impact of intraoperative fluoroscopy on the magnitude and incidence of LLD after THA. Methods: Patients undergoing primary THA were identified and stratified into cohorts based on one out of 4 surgical approaches and intraoperative fluoroscopy use. …”
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Investigating the Expression Level of Mir-361 in Patients with Breast Cancer by S Igder, M Sharifat, S Iranparast, A Tallaeizade, M Ghasemi Deh Cheshmeh, M Rashno, A Ghadiri, A Amari, A Saeedi Boroujeni, A Khodadadi

“…The aim of this study was to investigate the expression of miR-361 in breast tumor tissue of patients with breast cancer. Methods: In this cross-sectional study conducted from January 2012 to February 2021 in Ahvaz Jundishapur University of Medical Sciences, 30 breast cancer samples were grouped based on clinicopathological characteristics including tumor size, cancer stage, lymphovascular invasion, molecular subtypes, etc. …”
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Role of Patient’s Age and Comorbidities in Therapy of Chronic Lymphocytic Leukemia by VV Strugov, EA Stadnik, YuV Virts, TO Silina, AYu Zaritskii

“…The aim of the study is to evaluate the prognostic significance of patient’s age and the CIRS-G index in elderly patients treated with fludarabine-containing regimens in first line treatment outside clinical trials. Methods. A retrospective analysis of 90 elderly CLL patients, treated with standard FC and FCR regimens in the clinic of internal medicine of the First St. …”
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Sedimentologika: a community-driven diamond open access journal in sedimentology by Camille Thomas, Aurelia M-L. J. Privat, Romain Vaucher, Yvonne Spychala, Valentin Zuchuat, Marta Marchegiano, Miquel Poyatos-Moré, Ian Kane, Domenico Chiarella

“…It will publish high-quality research that will advance the field of sedimentary science, and will encourage multidisciplinarity, new teaching practices, tools and methods, and progress in accessibility to science. …”
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