Influence of platelet-rich plasma on RANKL and IL-1 immunohistochemical expression in periodontitis-related bone cell proliferation and differentiation by Hana H. Mustafa, Snur M.A. Hassan, Sozan Ali Mohammed, Mardin O. Mohammed, Hadia Karim Zorab, Hardi Fattah Marif

“…A rat model of experimentally generated periodontitis was used to assess the impact of PRP preparation on the expression of the osteoclastogenic and pro-inflammatory markers respectively; RANKL and IL-1β. Material and Methods: To induce periodontitis by silk ligature, thirty-six adult male Sprague Dawleys rats were used and they were allocated into three equal groups (n = 12): group I consisted of intact periodontal tissue, group II; rat-induced periodontitis without treatment by PRP, and group III of periodontitis + 10 µL PRP injection. …”
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Inhibitory Effects of Paclitaxel-Loaded Iron Oxide Nanoparticles on Non-Small Cell Lung Cancer by Enhancing Autophagy-Dependent Ferroptosis and Apoptosis Pathways by Deng R, Liang G, Chen W, Nie Q, Wen J

“…However, inhibitory effect and possible mechanism of IONP@ PTX on non-small-cell lung cancer (NSCLC) remain unclear.Objective: This work aimed to assess inhibitory effects and potential mechanisms of IONP@PTX on lung cancer A549 cells and further explore the nanomedicine delivery systems for applications in cancer therapies.Methods: Morphology features and qualities of IONP@PTX were directly assessed. …”
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Effectiveness and safety of direct oral anticoagulants versus vitamin K antagonists in atrial fibrillation patients with liver disease: a systematic review and meta-analysis by Qiang Zhou, Xiang Liu, Shuyu Liu, Zhichun Gu, Yanzi Wu, Yuansu Yang, Yingying Tao, Meng Wei

“…IntroductionPatients with atrial fibrillation (AF) and liver disease, particularly cirrhosis, are frequently excluded from anticoagulation trials, leaving the optimal therapeutic strategy uncertain.MethodsThis study aimed to compare the effectiveness and safety of direct oral anticoagulants (DOACs) and vitamin K antagonists (VKAs) in patients with AF and liver disease. …”
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Association of SCN1A Gene Polymorphisms with Sodium Valproate Resistance in Pediatric Epilepsy: A Retrospective Case-Control Study by Wang H, Geng T, Deng N

“…Elucidating the genetic mechanisms underlying sodium valproate resistance could revolutionize personalized treatment strategies, particularly in pediatric epilepsy.Objective: To explore the relationship between polymorphisms in the sodium channel α 1 subunit gene (SCN1A) and resistance to sodium valproate therapy in pediatric epilepsy patients.Methods: A retrospective analysis included 89 pediatric patients with sodium valproate-resistant epilepsy (resistant group) and 89 patients responsive to sodium valproate (responder group), and 89 healthy controls. …”
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Association Between Four Non-Insulin-Based Insulin Resistance Indices and the Risk of Post-Stroke Depression by Wang P, Wang M, Xie Z, Zhi Z, Wang Y, Liu F, Liu Y, Zhao L

“…Therefore, we explored the relationship between four non-insulin-based IR indices and post-stroke depression (PSD).Patients and Methods: A total of 638 consecutive AIS patients were enrolled in this prospective cohort study. …”
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How does integrated knowledge translation work? A realist review by Anita Kothari, Shannon L. Sibbald, Chris McCutcheon, Whitney Berta, Robin Urquhart, Tanya Horsley, Leigha Comer, Ian D. Graham

“…We conducted a realist review to examine the key mechanisms thought to explain how IKT approaches work in relation to the generation of research in the healthcare sector. Methods The research question was the following: what are the necessary conditions (context) and key mechanisms that explain the success of IKT in the healthcare sector? …”
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Head position control strategies in progressive Supranuclear Palsy versus Idiopathic Parkinson’s Disease during dynamic-on-static platform tilt by Stefan Kammermeier, Kathrin Maierbeck, Kathrin Maierbeck, Lucia Dietrich, Lucia Dietrich, Annika Eissner, Stefan Lorenzl, Stefan Lorenzl, Arun Singh, Arun Singh, Kai Bötzel, Christoph Maurer

“…ObjectivesWe investigated differences in head stabilization among Progressive Supranuclear Palsy (PSP), advanced Idiopathic Parkinson’s Disease (IPD) and healthy controls during passive anteroposterior platform tilting to determine factors for disease-specific falling.MethodsSeventeen PSP, eleven IPD and eighteen control subjects were exposed to pseudorandom multi-frequency antero-posterior platform tilts, while recording 3D motion of body segments with a Zebris ultrasound positioning system. …”
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Edema progression in proximity to traumatic microbleeds: Evolution of cytotoxic and vasogenic edema on serial MRI by Jacquie Lee, Emily Baniewicz, Nicole L. Peterkin, Danielle Greenman, Allison D. Griffin, Neekita Jikaria, L. Christine Turtzo, Marie Luby, Lawrence L. Latour

“…Quantitative analysis confirmed the visual progression of some TMB lesions from ADC + to FLAIR+. …”
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Germans de Mario. Xiquets de primària jugant amb les seues consoles DS Hermanos de Mario. Niños de primaria jugando con sus consolas DS Mario’s brothers. Primary school children pl... by Ricard Huerta, Remigi Morant

“…Des de les àrees d'educació en arts visuals i d'educació musical, com a disciplines coincidents i complementàries en relació a la pràctica observada, aportem una reflexió conjunta de les experiències receptives de tipus visual i auditiu que barregen les tecnologies. …”
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Standard Triple Therapy versus Sequential Therapy in Helicobacter pylori Eradication: A Double-Blind, Randomized, and Controlled Trial by Jaime Natan Eisig, Tomás Navarro-Rodriguez, Ana Cristina Sá Teixeira, Fernando Marcuz Silva, Rejane Mattar, Decio Chinzon, Christiane Haro, Márcio Augusto Diniz, Joaquim Prado Moraes-Filho, Ronnie Fass, Ricardo Correa Barbuti

“…In Brazil, standard triple therapy is as equally effective as sequential therapy in eradicating Helicobacter pylori patients. …”
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Is the combination of linagliptin and allopurinol better prophylaxis against post-contrast acute kidney injury? A multicenter prospective randomized controlled study by Ahmed Fayed, Ahmed A. Hammad, Dina O. Abdulazim, Hany Hammad, Mohamed Amin, Samir Elhadidy, Mona M. Salem, Ibrahim M. Abd ElAzim, Lajos Zsom, Eva Csongradi, Karim M. Soliman, Usama A. Sharaf El Din

“…We speculated that linagliptin as a single agent or in combination with allopurinol may reduce the incidence of post-contrast AKI in stage 3–5 chronic kidney disease (CKD) patients with underlying DKD.Methods Out of 951 DKD patients eligible for this study, 800 accepted to sign informed consent. …”
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Receptor tyrosine kinase inhibition leads to regression of acral melanoma by targeting the tumor microenvironment by Eric A. Smith, Rachel L. Belote, Nelly M. Cruz, Tarek E. Moustafa, Carly A. Becker, Amanda Jiang, Shukran Alizada, Anastasia Prokofyeva, Tsz Yin Chan, Tori A. Seasor, Michael Balatico, Emilio Cortes-Sanchez, David H. Lum, John R. Hyngstrom, Hanlin Zeng, Dekker C. Deacon, Allie H. Grossmann, Richard M. White, Thomas A. Zangle, Robert L. Judson-Torres

“…Methods An independent analysis of published sequencing data was performed to evaluate the frequency of receptor tyrosine kinase (RTK) ligands and adapter protein gene variants and expression. …”
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An Italian Survey on the Management of Pediatric Convulsive Status Epilepticus: More Than Just a Pharmacological Choice by Caterina Zanus, Giulia Cannizzaro, Giacomo Danieli, Angela Amigoni, Silvia Buratti, Francesca Izzo, Massimo Mastrangelo, Maria Cristina Mondardini, Paola Costa, Anna Rosati, Carla Marini, Lucia Fusco, Italian Paediatric Status Epilepticus Group

“…Abstract Background and Purpose To explore specialists’ opinions on the current management of pediatric convulsive status epilepticus (CSE) in Italy and the main factors influencing the applicability of guidelines. Methods We conducted a national survey of child neurologists, pediatric emergency physicians, and intensivists. …”
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Acromegaly as a Multisystem Disease – Analysis of Metabolic Complications. Review of Current Literature by Daria Anna Krzyżanowska, Paula Bętkowska, Magdalena Strzelczyk, Joanna Wziątek, Iwona Koziołek, Gabriela Pabis, Patrycja Fatyga, Wiktoria Fatyga, Piotr Kowalik, Kinga Dowierciał

“…The aim of this review is to deepen the understanding of acromegaly as a systemic disease, with particular emphasis on its metabolic complications.  Material and methods The paper analyzes scientific publications on acromegaly and its metabolic complications published between 2008 and 2024. …”
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Fundus changes in healthy adults after high altitude exposure by Jiaxin Li, Yunzhu Kong, Peiyu Wang, Chen Chen, Juping Liu, Xiaorong Li, Yan Shao

“…The aim is to provide a reference for the prevention and treatment of high altitude ophthalmopathy. Methods: 30 eyes of 15 healthy participants exposed to high altitude were recruited in this study. …”
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Single-row arthroscopic rotator cuff repair improves functional outcomes at a minimum follow-up of 3 years by Hastomo A. Wibowo, MD, Iman W. Aminata, MD, Andri M.T. Lubis, MD, PhD, Indah S. Widyahening, MD, PhD, Achmad F. Kamal, MD, PhD, Aryadi Kurniawan, MD, PhD, Ismail H. Dilogo, MD, PhD, Wahyu Widodo, MD, Thomas Erwin C.J. Huwae, MD, PhD, Renaldi P.N. Rasyid, MD, PhD, Oryza Satria, MD, Dina Aprilya, MD, Ali R. Alkaff, MD

“…Background: To evaluate patients who underwent arthroscopic rotator cuff repair (ARCR) using a single-row technique and compare functional outcomes before and after surgery at a minimum follow-up of 3 years. Methods: This retrospective cohort study reviewed the functional outcomes of 38 patients who underwent ARCR with a single-row technique between 2015 and 2020 with a minimum follow-up of 3 years. …”
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Media Role of Graphic in Harmonizing The Meanings Association Pattern with Forms of Expression and Literacy Genre by Amir Reza Estakhrian Haghighi, Setareh Ahsant

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Patient participation in free cataract surgery: a cross-sectional study of the low-income elderly in urban China by Bo Qu, Hui Chen, Xuhua Tan, Xiaohang Wu, Haotian Lin, Zhenzhen Liu, Lixia Luo, Bo Zhang, Erping Long, Duoru Lin, Weirong Chen, Yizhi Liu, Haofeng Jiang, Jingjing Chen, Zhuoling Lin, Xiaoyan Li, Jinzhu Tang, Yingfen Lin

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Metformin inhibits pathological retinal neovascularization but promotes retinal fibrosis in experimental neovascular age-related macular degeneration by Xin Wang, Xin Wang, Xu Liang, Shiya Huang, Mingyan Wei, Yuan Xu, Xiaodong Chen, Yanliang Miao, Rongrong Zong, Xiang Lin, Shiying Li, Zuguo Liu, Zuguo Liu, Qian Chen, Qian Chen

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Influence of Emergent Vegetation Layout on Flow Pattern in a Rectangular Shallow Basin by Junnan LYU, Yuxuan JIANG, Zhidong YAO, Chen YE, Xufeng YAN

“…Prior research has extensively debated shallow basins’ functions and influencing factors from these perspectives, employing methods such as field investigations, aerial remote sensing, physical experiments, large-scale modeling, and surveys. …”
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