Insomnia and Female Reproductive Diseases: A Cross-Sectional and Mendelian Randomization Study by Fang L, Wang Y, Wang R, Fang Y, Xie Y, Yang S, Liu S, Zhang Y

“…Nevertheless, few research has been devoted to investigating the relationship between insomnia and female reproductive health.Methods: In our study, we conducted a Mendelian randomization (MR) study to estimate the causal relationship between insomnia and female reproductive diseases. …”
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A Novel Nomogram Model for Predicting the Risk of Hepatocellular Carcinoma in Patients with Chronic Hepatitis B Infection by Wu Y, Wang M, Zhang Z, Chen G, Zhang B

“…This study aimed to construct a novel nomogram model for predicting the risk of HCC in patients with HBV infection.Patients and Methods: This retrospective study analyzed clinical data from healthcare databases in Xiamen, encompassing 5161 adults with HBV infection without HCC and 2819 adults with HBV-related HCC between January 2016 and December 2020. …”
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Risk Prediction Models for Perioperative Hypothermia: A Systematic Review by Liu J, Liu F, Xu W, Du L, Li Y, Liang A, Li B, Zhang M

“…The aim is to provide clinical staff with a reference for selecting or developing an appropriate prediction model.Methods: A systematic search was carried out in PubMed, Embase, Web of Science, the Cochrane Library, and CINAHL to find relevant studies on perioperative hypothermia risk prediction models from the inception of databases to May 23, 2024. …”
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Right ventricular dysfunction as a predictor of complicated course in left heart surgery by E. Z. Golukhova, I. V. Slivneva, I. I. Skopin, I. Yu. Farulova, Yu. D. Pirushkina, D. V. Murysova, D. I. Marapov, I. V. Volkovskaya

“…To analyze the right ventricular (RV) functionality in a cohort of heterogeneous cardiac surgical patients with left-sided valvular heart disease and determine the contribution of RV dysfunction in the complicated postoperative period according to echocardiography.Material and methods. A single-center prospective study of patients with left heart defects operated on in 2022 was conducted. …”
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The Necessity of Using MRI as an Imaging Modality in Acute Code Stroke in Indonesia by Hidayat R, Fisher M, Rima SPP, Wiyarta E, Fathi GC, Mustika AP, Irfannadhira AC, Pangeran D, Mesiano T, Kurniawan M, Rasyid A, Harris S

“…Cipto Mangunkusumo Hospital, Jakarta, Indonesia; 3Universitas Indonesia Hospital, Depok, Indonesia; 4Department of Neurology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA*These authors contributed equally to this workCorrespondence: Rakhmad Hidayat, Email rhidayat.md@gmail.comPurpose: To evaluate the performance and outcomes of the 6-minute magnetic resonance imaging (MRI) protocol in diagnosing stroke within Indonesian healthcare setting compared to computed tomography (CT).Patients and methods: This retrospective single-center study was conducted at the Universitas Indonesia Hospital in Depok, Indonesia from September 2021 to September 2023. …”
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Therapeutic Mechanism of Zhuyang Tongbian Decoction in Treating Functional Constipation: Insights from a Pilot Study Utilizing 16S rRNA Sequencing, Metagenomics, and Metabolomics by Zhang X, Yin H, Yang X, Kang J, Sui N

“…Xuan Zhang,1,* Hang Yin,2,* Xu Yang,3,* Jie Kang,1 Nan Sui1,4 1Graduate School, Liaoning University of Traditional Chinese Medicine, Shenyang, Liaoning Province, People’s Republic of China; 2Scientific Education Section, The Third Affiliated Hospital of Liaoning University of Traditional Chinese Medicine, Shenyang, Liaoning Province, People’s Republic of China; 3Department of Rehabilitation Medicine, General Hospital of Northern Theater Command, Shenyang, Liaoning Province, People’s Republic of China; 4Department of Anorectal Diseases, The Third Affiliated Hospital of Liaoning University of Traditional Chinese Medicine, Shenyang, Liaoning Province, People’s Republic of China*These authors contributed equally to this workCorrespondence: Nan Sui, The Third Affiliated Hospital of Liaoning University of Traditional Chinese Medicine, No. 35, Eleventh Wei Road, Shenyang, Liaoning, 110003, People’s Republic of China, Email suinan2226@163.comPurpose: To explore the mechanism of Zhuyang Tongbian Decoction (ZTD) in treating functional constipation (FC) by observing its effects on intestinal flora composition, the metabolic function of gut microbiota, fecal short-chain fatty acid (SCFA) levels, and serum concentrations of TLR4, NF-κB, TNF-α, and IL-6 in patients with FC.Patients and Methods: 40 patients with FC were randomly divided into the control group and the treatment group, 20 cases in each group. …”
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Assessing Work–Life Balance in Malta and Italy: A Cross-Cultural Investigation Using Exploratory Structural Equation Modelling (ESEM) by Bottaro R, De Giovanni K, Faraci P

“…Thus, the present cross-cultural study aimed to provide new evidence about the dimensionality, validity, reliability, and cultural invariance of the Work-Life Balance Scale and its practical impact on employee well-being.Participants and Methods: A sample of 362 employees (50% Maltese; 50% Italian), with a mean age of 43.36 (SD = 11.51) completed the WLBS in an online survey from March to April 2023. …”
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Exploring the Therapeutic Mechanism of Jianpi Zhidong Decoction on Tourette Syndrome Based on Proteomics and Network Pharmacology by Zhang N, Zhang H, Guo J, Ma Y, Bai X, Ma N, Ji X, Meng Y, Li H, Sangwanit T, Shi Y, Zhao J, Li X, Lin J, Cui X

“…Ning Zhang,1,* Hongxian Zhang,1,* Jianning Guo,2 Yaluan Ma,3 Xue Bai,1 Ning Ma,1 Xiaoxiao Ji,1 Yanli Meng,1 Huifang Li,1 Tananan Sangwanit,1 Yixin Shi,1 Jing Zhao,1 Xiang Li,1 Jingyuan Lin,1 Xia Cui1 1Pediatric Department, Beijing University of Chinese Medicine Third Affiliated Hospital, Beijing, People’s Republic of China; 2Pediatric Department, China-Japan Friendship Hospital, Beijing, People’s Republic of China; 3Laboratory of Molecular Biology, Institute of Basic Theory of Traditional Chinese Medicine, China Academy of Chinese Medical Sciences, Beijing, People’s Republic of China*These authors contributed equally to this workCorrespondence: Xia Cui, Department of Pediatrics, Beijing University of Chinese Medicine Third Affiliated Hospital, No. 51 Xiaoguan Street, Andingmen Wai, Chaoyang District, Beijing, 100029, People’s Republic of China, Email cuixia68@163.comPurpose: To explore the pharmacological effects of Jianpi Zhidong Decoction (JPZDD) on Tourette Syndrome (TS) using proteomics and network pharmacology.Materials and Methods: Chemical components of JPZDD were identified via UPLC-MS/MS. …”
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Treatment of Proximal Humeral Fractures in Older Patients During COVID-19 Pandemic in Germany by Sußiek J, Koeppe J, Fischhuber K, Iking J, Marschall U, Raschke MJ, Katthagen JC, Stolberg-Stolberg J

“…Was a SARS-CoV-2 infection associated with a worse outcome?Methods: Retrospective claims data of the BARMER health insurance were analysed. …”
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Effects of immersive virtual therapy on psychological and physical wellbeing in women with breast cancer at different stages of disease and treatment conditions: an experimental co... by Oliver Czech, Rafal Matkowski, Rafal Matkowski, Jakub Skórniak, Iwona Malicka

“…Virtual Reality (VR) has shown promise as a supportive, non-pharmacological intervention by reducing anxiety, depression, pain and aiding physical rehabilitation in cancer care.ObjectiveThis study evaluated the impact of immersive VR therapy in improving the psychological and physical wellbeing of women with BC at different stages of treatment and compared outcomes across treatment groups.MethodsFifty-six women were recruited at the Lower Silesian Oncology, Pulmonology and Hematology Center in Wroclaw, Poland, and divided into four equal groups (n = 14) based on their treatment stage: recently diagnosed before treatment (diagnosis group), in the perioperative period (surgery group), undergoing radiotherapy (radiotherapy group), and post-treatment (healed group). …”
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Sodium Propionate Alleviates Atopic Dermatitis by Inhibiting Ferroptosis via Activation of LTBP2/FABP4 Signaling Pathway by Xie A, Li W, Ye D, Yin Y, Wang R, Wang M, Yu R

“…This study aims to explore whether SP alleviates AD by modulating ferroptosis-related pathways through bioinformatic and in vitro analyses.Methods: We analyzed the GEO AD cohort (GSE107361). …”
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FGF-2 enriched nanofiber scaffold for advancing achilles tendon healing: a comparative experimental investigation by Necmettin Turgut, Funda Cengiz Çallıoğlu, Aytül Bayraktar, Mehtap Savran, Halil Aşcı, Kanat Gülle, Meriç Ünal

“…This study aims to investigate the efficacy of FGF-2 in promoting tendon healing in a rat model of Achilles tendon rupture, providing insights into its potential as a therapeutic option.Materials and methodsForty-eight rat hind legs with complete Achilles tendon ruptures were divided into four equal groups: the Sham (S) group (tendon repair only), the Polymer (P) group (tendon repair with scaffold wrapping), the Produced FGF-2 (PF) group (scaffold coated with lab-produced FGF-2), and the Commercial FGF-2 (CF) group (scaffold coated with commercially sourced FGF-2). …”
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Effects of specific symbiotic supplements on anthropometric measurements, glycaemic control, and lipid profiles among individuals with type 2 diabetes mellitus in two teaching hosp... by Sarah Hayder Ali Zalzala, Ban Abdul-Ridha Salman Al-Hashimi, Zahraa Hayder Ali Zalzala, Khalid Saeed Fahad

“…This study aimed to investigate the effects of symbiotics on the anthropometric measures, glycaemic control, and lipid profiles of patients with T2DM. Methods A double-blind, placebo-controlled, parallel clinical trial was conducted at two diabetes outpatient clinics. …”
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Apoptotic Vesicles Attenuate Acute Lung Injury via CD73-Mediated Inhibition of Platelet Activation and NETosis by Tan L, Zhang C, Kou X, Zhao L, Wu D, Li J, Yu C, Xu T, Gao L, Mao X, Zhao C

“…In this study, our aim was to investigate the therapeutic effects and underlying mechanisms of apoVs in ALI.Methods: ALI was induced in mice through intratracheal instillation of lipopolysaccharide (LPS). …”
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Cholera in conflict: outbreak analysis and response lessons from Gadaref state, Sudan (2023–2024) by Ahmad Izzoddeen, Hafsa Abualgasim, Mazza Abasher, Hala Elnoor, Mustafa Magbol, Safaa Fadlelmoula, Ali Abolgassim, Alaa Hamed Dafaalla, Khalid Elgamry, Anwar Banaga, Babiker Magboul, Muntasir M. Osman, Elfadil Mahmoud

“…This study describes the cholera outbreak amidst conflict in Gadaref state, discusses the possible factors mediated its spread and proposes future improvements in preparedness and response measures. Methods A retrospective analytical study was conducted using national surveillance records of cholera cases, supported by interviews with key informants involved in preparedness and response, along with a review of state reports, to identify possible factors contributing to the spread and to evaluate the response. …”
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Effect of a Narrative-Based Online Course Aimed at Reducing Stigma Toward Transgender Children and Adolescents: Longitudinal Observational Study by Merlin Greuel, Van Kinh Nguyen, Doron Amsalem, Maya Adam, Till Bärnighausen

“…ObjectiveThis study aims to evaluate the impact of an animated online course, rooted in authentic, personal narratives, on course participants’ stigma toward transgender youth. MethodsThe online course was offered free of charge on Coursera and contained 19 teaching videos (3-7 minutes each), intermittent practice quizzes, and discussion prompts. …”
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Hsa_circ_0078767 Enhances Osteosarcoma Chemoresistance to Doxorubicin Through the Regulation of the miR-188-3p/GPX4 Axis by Tang Y, He Y, Wu L

“…This analysis sought to examine hsa_circ_0078767 as a mediator of doxorubicin (DOX) resistance in OS.Methods: Levels of hsa_circ_0078767, miR-188-3p, and glutathione peroxidase 4 (GPX4) in OS clinical tissue samples and cell lines were evaluated by quantitative polymerase chain reaction (qPCR) and Western blotting. …”
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Evaluation of the Shear Bond Strength of Orthodontic Adhesive Incorporated with Titanium Dioxide Nanoparticle: An In-vitro Study by M Ashfaq Ahmed, S Sumalatha, N Narendran, G Dinesh Nandakumar, A Agasthiya

“…Aim: To evaluate the shear bond strength of Titanium Dioxide (TiO2) nanoparticle-incorporated orthodontic adhesive. Materials and Methods: The present in-vitro study was conducted in the Department of Orthodontics and Dentofacial Orthopaedics, Best Dental Science College, Madurai, Tamil Nadu, India, between July 2022 and December 2023. …”
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A Mortality Risk Prediction Model for Septic Shock in Patients Aged ≥50: Role of Norepinephrine Index and Procalcitonin by Li XL, Mi T, Liu C, Feng M

“…This study aimed to develop and validate a predictive model using norepinephrine index (NEI)—a novel biomarker defined as the norepinephrine dose administered within the first 24 hours of ICU admission divided by BMI and 24 hours—and procalcitonin (PCT) to improve risk stratification and clinical decision-making.Methods: A retrospective cohort of 94 patients aged ≥ 50 years with septic shock was analyzed. …”
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Pregnancy in adolescence and adverse neonatal outcomes in Ecuadorian mestizo newborns by Fabricio González-Andrade, Xavier Saeteros-Cordero

“…Background: To establish the association between pregnancy in early and middle adolescence and adverse neonatal outcomes in Ecuadorian mestizo newborns. Methods: Study design: epidemiological, observational/descriptive, and cross-sectional. …”
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