Effectiveness and Safety of Neoadjuvant Immunochemotherapy with and without Surgery in Patients with Resectable Esophageal Squamous Cell Carcinoma: A Retrospective Cohort Study by Liao X, Chen X, Hong W, Chen F, Li G, Li L

“…Xuqiang Liao,1,* Xianshan Chen,1,* Wenyuan Hong,1,2,* Fengxia Chen,1 Gao Li,1 Liang Li1 1Department of Thoracic Surgery, Hainan General Hospital, Hainan Affiliated Hospital of Hainan Medical University, Haikou, Hainan, People’s Republic of China; 2Hainan Medical University, Haikou, Hainan, People’s Republic of China*These authors contributed equally to this workCorrespondence: Gao Li, Email drligaokeyan@163.com Liang Li, Email nigoli@126.comBackground: This study aimed to retrospectively compare the effectiveness and safety of neoadjuvant immunochemotherapy with and without surgery for locally advanced esophageal squamous cell carcinoma (ESCC).Methods: This study included patients with ESCC who received neoadjuvant immunochemotherapy from May 2021 to July 2023. …”
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Health-promoting behavior and its determinants towards non-communicable diseases among adult residents of the Gedeo zone, South Ethiopia: the application of the health belief model by Habtamu Endashaw Hareru, Tizalegn Tesfaye Mamo, Mesfin Abebe, Berhanu Gidisa Debela

“…Thus, the purpose of this study was to determine health-promoting behaviors and its associated factors among adult's residents of Gedeo zone.MethodsA cross-sectional study was conducted among 705 adult residents of Gedeo zone, south Ethiopia, selected using a multi-stage sampling technique. …”
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Enhanced hemodynamic stability and patient satisfaction with ciprofol-remifentanil versus propofol-remifentanil for sedation in shorter-duration fiberoptic bronchoscopy: a prospect... by Jia Nie, Yongguo Zhang, Yan Wang, Liang Fang, Huanhuan Ma, Yu Zhang, Hai-ying Wang

“…ObjectiveThis study aimed to compare the efficacy and safety of ciprofol-remifentanil versus propofol-remifentanil in patients undergoing fiberoptic bronchoscopy (FOB).MethodsIn this prospective, randomized, double-blind, non-inferiority trial, 209 patients undergoing FOB were enrolled and equally divided into two groups (n = 106 each). …”
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Cardiovascular risk factors in a treatment-naïve, human immunodeficiency virus-infected rural population in Dikgale, South Africa by Felistas Mashinya, Marianne Alberts, Robert Colebunders, Jean-Pierre van Geertruyden

“…Biochemical parameters were tested using standard biochemical methods. HIV testing and CD4 counts were performed using the Alere Determine™ HIV 1/2 Ag/Ab kit and The Alere Pima™ Analyser. …”
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Patient Interaction Phenotypes With an Automated SMS Text Message–Based Program and Use of Acute Health Care Resources After Hospital Discharge: Observational Study by Klea Profka, Agnes Wang, Emily Schriver, Ashley Batugo, Anna U Morgan, Danielle Mowery, Eric Bressman

“…ObjectiveOur primary aim was to identify and characterize distinct patient interaction phenotypes with a postdischarge automated SMS text messaging program. MethodsThis was a secondary analysis of data from a randomized controlled trial that tested a 30-day postdischarge automated SMS text messaging intervention. …”
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Impact of Subchorionic Hematoma on Pregnancy Outcomes in Obstetric Antiphospholipid Syndrome by Cang R, Ding X, Tian Z, Fu Z, He M, Liang Y

“…Rong Cang,1,* Xuelei Ding,1,* Zan Tian,2 Zijie Fu,3 Meijuan He,1 Ying Liang4 1Department of Gynecological Endocrinology, The Fourth Hospital of Shijiazhuang (Obstetrics and Gynecology Hospital Affiliated to Hebei Medical University), Shijiazhuang, Hebei, People’s Republic of China; 2Department of Dermatology, Hebei Provincial Hospital of Traditional Chinese Medicine, Shijiazhuang, Hebei, People’s Republic of China; 3Department of Gynecology, The First Hospital of Hebei Medical University, Shijiazhuang, Hebei, People’s Republic of China; 4Department of Reproductive Medicine, The Fourth Hospital of Shijiazhuang (Obstetrics and Gynecology Hospital Affiliated to Hebei Medical University), Shijiazhuang, Hebei, 050011, People’s Republic of China*These authors contributed equally to this workCorrespondence: Ying Liang, Email liangyly@126.comObjective: This study aimed to investigate the effects of subchorionic hematoma (SCH) in patients with obstetric antiphospholipid syndrome (OAPS) on pregnancy outcomes, as well as the clinical value of anticoagulant therapy.Methods: This retrospective study included 109 OAPS patients treated at the Fourth Hospital of Shijiazhuang from December 2019 to December 2021. …”
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The effect of tactile versus auditory stimulation on reducing pain associated with invasive procedures among preterm neonates at NICUs by Entsar Shehata Mohammed, Seham Mohammed Elmwafie, Fatma Sayed Abdelaziz Mohamed, Safaa Salah Ismail

“…The study hypothesized that preterm neonates who receive tactile stimulation will exhibit lower pain scores than those who receive auditory stimulation. Methods A comparative (three-group) quasi-experimental design included 90 preterm neonates divided equally into three groups (tactile stimulation group = 30, auditory stimulation group = 30, and control group = 30) at NICU affiliated with Beni-Suef University Hospital. …”
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Focal Staphylococcus Aureus Septic Arthritis Elicits Age and TLR2-Dependent Periarticular Bone Loss by Schultz M, Hu Z, Deshmukh M, Henning P, Lerner UH, Mohammad M, Jin T

“…While intra-articular injections of S. aureus LPPs induces local bone resorption in mice, the influence of aging and TLR2 expression on bone mineral density (BMD) after S. aureus bacteremia remains unclear.Methods: We analyzed distal femoral BMD in young and old TLR2 knock-out and wild-type mice following intravenous S. aureus infection. …”
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Interleukin-6 as a Pan-Cancer Prognostic Inflammatory Biomarker: A Population-Based Study and Comprehensive Bioinformatics Analysis by Xie H, Wei L, Ruan G, Zhang H, Shi H

“…This study aimed to provide a comprehensive assessment of the prognostic value of IL-6 and its immunotherapeutic features using a population-based pan-cancer analysis and comprehensive bioinformatic analysis.Patients and Methods: In the cohort study, 540 patients were included to explore the prognostic value of serum IL-6 levels in cancer. …”
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TyG-WC Index as a Superior Predictor of Hyperuricemia Risk in the Hypertensive Population: A Prospective Cohort Study by Zhang Q, Liu J, Zhang R, Wang C, Song Y, Wang X, Zeng F

“…Qin Zhang,1,* Jian Liu,2,* Ruize Zhang,3 Changfen Wang,4 Yanyan Song,5 Xi Wang,2 Fanling Zeng6 1Department of Cardiology, Xi Chang People’s Hospital, Xi Chang, Sichuan Province, 615000, People’s Republic of China; 2Department of Cardiology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, 400016, People’s Republic of China; 3Dougherty Valley High School, San Ramon, CA, 94582, USA; 4Department of Cardiology, People’s Hospital of Qianxinan Prefecture, Guizhou Province, People’s Republic of China; 5Department of Endocrinology, Chongqing Jianshe Hospital, Chongqing, People’s Republic of China; 6Health Management Ctr, The First Affiliated Hospital of Chongqing Medical University, Chongqing, 400016, People’s Republic of China*These authors contributed equally to this workCorrespondence: Xi Wang; Fanling Zeng, The First Affiliated Hospital of Chongqing Medical University, No. 1 Youyi Road, Yuzhong District, Chongqing, 400016, People’s Republic of China, Email 201884@cqmu.edu.cn; zengfanling@hospital.cqmu.edu.cnObjective: To evaluate the predictive value of the triglyceride-glucose waist circumference index (TyG-WC) for hyperuricemia (HUA) risk in the hypertensive population.Methods: This prospective cohort study involved 831 hypertensive patients with normal uric acid levels, who underwent continuous health examinations for five years. …”
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Surgical outcomes of women undergoing radical resection of deep endometriosis of the sacral plexus: A prospective cohort study by Gernot Hudelist, Ezgi Darici Kurt, Gábor Szabó, Dominika Miklos, Theresa Hudelist, Attila Bokor

“…This study aims to report on the surgical outcomes in terms of pain and neurological symptom reduction in women undergoing surgical resection of SPE. Material and Methods Thirty premenopausal patients with histologically confirmed SPE who underwent surgical resection of the disease between 2018 and 2024 were included in this multicenter prospective analysis. …”
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The impact of retail-sector delivery of artemether-lumefantrine on malaria treatment of children under five in Kenya: a cluster randomized controlled trial. by Beth P Kangwana, Sarah V Kedenge, Abdisalan M Noor, Victor A Alegana, Andrew J Nyandigisi, Jayesh Pandit, Greg W Fegan, James E Todd, Simon Brooker, Robert W Snow, Catherine A Goodman

“…This study in western Kenya aimed to evaluate the impact of providing subsidized artemether-lumefantrine (AL) through retail providers on the coverage of prompt, effective antimalarial treatment for febrile children aged 3-59 months.<h4>Methods and findings</h4>We used a cluster-randomized, controlled design with nine control and nine intervention sublocations, equally distributed across three districts in western Kenya. …”
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Enhanced Antitumor Immunity Through T Cell Activation with Optimized Tandem Double-OX40L mRNAs by Deng Z, Tian Y, Wang J, Xu Y, Liu Z, Xiao Z, Wang Z, Hu M, Liu R, Yang P

“…This study investigates the use of mRNA-based cancer agents as promising tools to combat and reverse refractory TIME conditions.Methods: We optimized and engineered an mRNA cancer agent encoding double tandemly repeated sequences of the T cell costimulator Oxford 40 ligand (diOX40L). …”
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Shen-Qi-Jie-Yu-Fang exerts effects on a rat model of postpartum depression by regulating inflammatory cytokines and CD4+CD25+ regulatory T cells by Li J, Zhao R, Li X, Sun W, Qu M, Tang Q, Yang X, Zhang S

“…Aim: To further investigate the effect of SJF on the immune system, including the inflammatory response system and CD4+CD25+ regulatory T (Treg) cells. Materials and methods: Sprague Dawley rats were used to create an animal model of PPD by inducing hormone-simulated pregnancy followed by hormone withdrawal. …”
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Type II diabetes mellitus risk assessment using FINDRISC questionnaire in systemic lupus erythematosus patients by L. V. Kondratieva, T. V. Popkova

“…To evaluate the prevalence of traditional risk factors in systemic lupus erythematosus (SLE) patients, assess the 10-years risk of developing type 2 diabetes mellitus (DM) in SLE patients and identify those necessitating preventive interventions following altered glucose metabolism using the Finnish Type 2 Diabetes Risk Score (FINDRISK) questionnaire.Materials and methods. The study included 119 SLE patients (107 women, 12 men, with median age 39 [33; 47] years and mean disease duration 6 [1,12] years.The control group included 100 age and sex matched individuals without immune-mediated inflammatory rheumatic diseases and without previous DM history. …”
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Outcomes after Cortical Bone Trajectory Screw versus Traditional Pedicle Screw in Single-Level Lumbar Spine Surgery: A Systematic Review and Meta-Analysis of Randomized Controlled... by Muhammad Talal Ibrahim, Cole Veliky, Elizabeth Yu

“…The systematic review aims to compare randomized controlled trials comparing CBTS with PS in single-level lumbar spine fusion surgery. Methods: A systematic search was conducted on PubMed (MEDLINE), Scopus, Embase, Web of Science, and Cochrane. …”
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CECT-Based Radiomic Nomogram of Different Machine Learning Models for Differentiating Malignant and Benign Solid-Containing Renal Masses by Qian L, Fu B, He H, Liu S, Lu R

“…Lu Qian,1,&ast; BinHai Fu,2,&ast; Hong He,2 Shan Liu,1 RenCai Lu2 1Department of Pathology, the First People’s Hospital of Yunnan Province, The Affiliated Hospital of Kunming University of Science and Technology, Kunming, Yunnan, 650032, People’s Republic of China; 2Department of Nuclear Medicine, The First People’s Hospital of Yunnan Province, the Affiliated Hospital of Kunming University of Science and Technology, Kunming, Yunnan, 650032, People’s Republic of China&ast;These authors contributed equally to this workCorrespondence: RenCai Lu, Department of Nuclear Medicine, The First People’s Hospital of Yunnan Province, the Affiliated Hospital of Kunming University of Science and Technology, No. 157 Jinbi Road, Kunming, Yunnan, 650032, People’s Republic of China, Tel +86 087163614503, Email lrc_09@126.comObjective: This study aimed to explore the value of a radiomic nomogram based on contrast-enhanced computed tomography (CECT) for differentiating benign and malignant solid-containing renal masses.Materials and Methods: A total of 122 patients with pathologically confirmed benign (n=47) or malignant (n=75) solid-containing renal masses were enrolled in this study. …”
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Hamstring vs Peroneus Longus Tendon Autograft in Anterior Cruciate Ligament Reconstruction: A Comparative Study by Khadri M Khalid, Adarsh Vajrangi, Eswara Reddy, Nagesh Sherikar, Rakshith Chakravarthy Harish Yellappa, Ranganatha B Kurupati

“…In this article, we will explore whether the peroneus longus (PL) graft can be a comparable alternative to the HT graft. Materials and methods: We conducted a prospective randomized study involving 80 patients who underwent ACLR. …”
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From illiteracy to the University: The Institutional development of Albanian education in Kosovo 1945-1990 by Avni Rexha

“…On the other hand, the raising of the educational level influenced the articulation of Kosovo Albanians claims for political equality and national rights.…”
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Altered intra- and interregional synchronization in relapsing&amp;ndash;remitting multiple sclerosis: a resting-state fMRI study by Wu L, Zhang Y, Zhou F, Gao L, He L, Zeng X, Gong H

“…However, few studies have explored the local brain activity of RRMS patients in the resting state. Patients and methods: In this study, regional homogeneity (ReHo) and resting-state functional connectivity (FC) were used to investigate intra- and interregional synchronized activity in 22 patients with RRMS and 22 matched healthy controls (HCs). …”
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