Integrated Fast Reactor Analysis and Calculation of Neutronics-thermal Coupling by LI Haotian, WU Mingyu, WU Zongyun, ZHOU Zhiwei, HUO Xingkai, XIAO Yubai

“…Through multi-physical coupling and refined computations, conducting high-precision numerical simulations of the reactor, and reducing various simplifications and approximations in traditional calculation methods, the actual operation of the reactor can be better reflected, providing verification for the reactor design scheme. …”
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Assessment of aortic elasticity parameters in obese and overweight children by Noor Mohammad Noori, Maryam Nakhaei-Moghadam, Alireza Teimouri

“…The aim of the study was to evaluate the aortic stiffness in obese and overweight children compared to healthy ones. Methods. The study evaluated 98 sex matched children aged 4 to 16 years that were equally distributed in asymptomatic obese or overweight and healthy children groups. …”
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Effectiveness of Microwave Therapy Combined with Berberine /GelMA via COX-2/IL-1β Pathway to Treat Skeletal Muscle Injury: An in vivo Study in Rats by Du T, Zhou L, Liu J, Wang X, Xie H, Yang X, Yang Y

“…Berberine (BBR) has several pharmacological effects, including anti-inflammatory, anti-tumor, and anti-arrhythmic properties.Methods: In order to treat skeletal muscle injuries, a safe and non-toxic nanogel (BBR/GelMA) was developed for efficient berberine delivery. …”
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LBP-CD155 Liposome Nanovaccine Efficiently Resist Colorectal Cancer and Enhance ICB Therapy by Yan Y, Duan T, Xue X, Yang X, Liu M, Ma B, Duan X, Su C

“…Therefore, to improve the current prophylaxis and treatment scheme, offering a favorable strategy efficient against CRC is urgently needed.Methods: Here, we developed a nanovaccine (LBP-CD155L NVs) loaded with CD155 gene in liposome, which was modified by Lycium barbarum polysaccharides (LBP) through electrostatic interaction. …”
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Investigating Remedial Strategies for Missed or Delayed Dose of Sertraline in Chinese Adolescent Patients with Depressive Disorders via Population Pharmacokinetics Modeling and Sim... by Xia H, Deng G, Liang F, Zhang Z, Huang W, Guo Z, Song Q, Wen Y, Shang D, Tan Y

“…Hence, we designed the remedial strategies of different missed dosage scenarios based on population pharmacokinetics (PPK) model simulation, aiming to provide medication guidance to Chinese adolescent depressive patients.Methods: A total of 221 sertraline concentration monitoring data were collected from 103 sertraline-treated adolescent patients with depression. …”
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Relation of oncogenic microRNA-10b and microRNA-21 to glioblastoma size and localization by Nikitović Marina, Stepanović Aleksandar, Arsenijević Tatjana, Petrović Nina

“…Our study aimed to investigate whether there is a link between miR-10b and miR-21 expression levels and tumor size and tumor localization. Methods. The research involved 43 patients diagnosed with glioblastoma. …”
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COST-MINIMIZATION ANALYSIS OF USING SHORT AND LONG-ACTING ERYTHROPOESIS-STIMULATING AGENTS FOR CORRECTION OF NEPHROGENIC ANEMIA AGAINST THE BACKGROUND OF SUBSTITUTION THERAPY by I. S. Krysanov, E. Yu. Ermakova, L. B. Vaskova, M. V. Tiapkina

“…Clinical trials conducted in various countries indicate that the use of epoetin alfa in patients with nephrogenic anemia in chronic kidney disease can increase the effectiveness of treatment, reduce the incidence of cardiovascular and infectious complications, and reduce mortality in patients with chronic kidney disease.The aim of the article was to conduct a comparative clinical and economic assessment of the treatment costs of nephrogenic anemia in adult dialysis patients with recombinant human erythropoietins: epoetin alfa, darbepoetin and long-acting methoxy polyethylene glycol – epoetin beta.Materials and methods. The study took into account direct medical costs of nephrogenic anemia pharmacotherapy on the basis of 1 year maintenance therapy according to the following scheme: epoetin alfa – 3 times per week, darbepoetin alfa – once per week, methoxy polyethylene glycol – epoetin beta – once per 2 or 4 weeks. …”
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Predictors and regional prevalence of food insecurity in Ethiopia during COVID-19: a multilevel analysis by Henok Wariso Waqo, Gezahegn Mekonnen Woldemedihn, Zeytu Gashaw Asfaw

“…This study aimed to analyse country-wise and region-specific food insecurity prevalence; assess its variation among regions; and identify predictors that influenced households’ food insecurity in Ethiopia during COVID-19. Methods This study used longitudinal data from the World Bank's Ethiopia-High Frequency Phone Survey, which looked at 3,300 households' experiences of food insecurity over five rounds, yielding 13,517 observations throughout time. …”
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The Crucial Role of the PPAR Signaling Pathway in the Diagnosis and Treatment of Chronic Obstructive Pulmonary Disease: An Analysis of Gene Expression and Macrophage Polarization by Zhang L, Guo R, Wu H, Abudusalamu A, Ding W, Li D, Wei X, Niu L

“…Ling Zhang,* Rong Guo,* Haixia Wu, Abula Abudusalamu, Wei Ding, Dewei Li, Xuemei Wei, Lin Niu Department of Respiratory and Critical Care Medicine, People’s Hospital of Xinjiang Uygur Autonomous Region, Urumqi, 830001, People’s Republic of China*These authors contributed equally to this workCorrespondence: Xuemei Wei, Department of Respiratory and Critical Care Medicine, People’s Hospital of Xinjiang Uygur Autonomous Region, No. 91 Tianchi Road, Tianshan District, Urumqi, 830001, People’s Republic of China, Tel +86-13579846469, Email wu1208522@163.com Lin Niu, Department of Respiratory and Critical Care Medicine, People’s Hospital of Xinjiang Uygur Autonomous Region, No. 91 Tianchi Road, Tianshan District, Urumqi, 830001, People’s Republic of China, Tel +86-1319989525, Email 363141843@qq.comPurpose: To explore the role of the peroxisome proliferator-activated receptor (PPAR) signaling pathway in chronic obstructive pulmonary disease (COPD) and identify potential biomarkers and therapeutic targets, given that COPD is a major global health burden and the specific molecular mechanisms of the PPAR pathway in COPD are not fully understood.Patients and Methods: Gene expression data from the GEO database were analyzed to identify key genes and immune cells related to COPD. …”
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Esketamine as an Epidural Adjuvant for Postoperative Analgesia in Gynecological Malignancy Surgery: A Randomized Trial by Luo H, Yang Y, He Z, Pan C, Wu X, Cao S, Zhang J

“…Huanyu Luo,1,2,* Yuecheng Yang,1,2,* Zhiyong He,1,2 Congxia Pan,1,2 Xing Wu,1,2 Shumei Cao,1,2 Jun Zhang1,2 1Department of Anesthesiology, Fudan University Shanghai Cancer Center, Shanghai, People’s Republic of China; 2Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, People’s Republic of China*These authors contributed equally to this workCorrespondence: Jun Zhang, Department of Anesthesiology, Shanghai Cancer Center, Fudan University, No. 270 Dong-An Road, Shanghai, 200032, People’s Republic of China, Tel +86-021-64175590, Fax +86-021-64174774, Email snapzhang@aliyun.comObjective: This study aims to evaluate the efficacy of esketamine as an epidural adjuvant in mitigating postoperative pain, particularly following the discontinuation of epidural analgesia in patients undergoing open surgery for gynecological malignancies.Design: A randomized controlled trial.Methods: Eighty-eight patients were randomized to receive either esketamine (0.4 mg/kg) combined with sufentanil and ropivacaine (eskatamine group) or sufentanil and ropivacaine alone (control group) via patient-controlled epidural analgesia. …”
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Chemical, optical, and morphological properties of TPU and PET-G samples after aging in artificial saliva: an in vitro study by Edoardo Staderini, Giuseppe Chiusolo, Massimiliano Papi, Mario Palone, Luca Lombardo, Massimo Cordaro

“…The analysis focused on the morphological, chemical, and optical properties of the samples, including thickness, weight, and surface roughness. Methods The study examined 48 thermoplastic samples, equally divided between PET-G and TPU. …”
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Genetic Evidence for Causal Effects of Immune Cell Subtypes on Postherpetic Neuralgia by Chen T, Tang S, Chen R, Ding W, Chen Y, Jian Z, Wu M, Jia M, Zhang X

“…However, the specific dynamic immune profile, the underlying molecular mechanisms, and especially the causal relationship between immune cells and PHN have yet to be comprehensively elucidated.Methods: We implemented a comprehensive analytical framework incorporating two-sample Mendelian randomization (MR), multivariable Mendelian randomization(MVMR), and colocalization analyses to elucidate the causal relationships between immune cell phenotypes and PHN. …”
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Local Effect of Insulin on Healing of Extraction Socket of Diabetic Rabbits (Experimental Study) by Waqass S. Thanoon, Omar W. Majid, Ali Khalil Marie

“…Evaluating oral mucosa healing and bone regeneration of the healing process during three intervals 3-, 10- and 30-days post-extraction. Materials and Methods: Twelve male albino diabetic rabbit were used in this study, these were randomly sub-divided into three sub-groups (N=4) for the histological and immunohistochemistry evaluation at 3, 10, 30 days post-extraction and compared to the controls. …”
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Potential of Using New Indole- and Benzimidazo[1,2-C]quinazolines in Anticancer Therapy Based on Mesenchymal Stem Cells by Radzikowska-Bűchner E, Radej S, Niezabitowska E, Sitarz R, Szewc M

“…The aim of this study was to evaluate the cytotoxic activity of 4-(6-indolo[1,2-c]quinazoline)2-methyl-benzene-1,3-diol (compound A) and 4-(6-benzimidazolo[1,2-c]quinazoline)2-methyl-benzene-1,3-diol (compound B) relative to the adipose-derived mesenchymal stem cells line (ASC52-telo) and the fibroblast line (HDFa).Materials and Methods: The test was performed on commercial cell lines: ASC52-telo and HDFa which were incubated with compounds A and B at four concentrations: 1 μg/mL, 2 μg/mL, 4 μg/mL, 8 μg/mL for 48 and 72 hours. …”
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Potential hepatoprotective role of Amphora coffeaeformis algae against diazinon-induced hepatotoxicity in adult Sprague–Dawley rats by Hager Ali Fathy, Sahar Hassan Orabi, Ahmed Farag Elkirdasy, Eman Mohamed Abd El Fattah, Reda M. S. Korany, Hanem Kamal Khalifa, Mohamed Mohamed Ahmed

“…This study aimed to investigate the potential protective effects of Amphora coffeaeformis (A. coffeaeformis) algae against DZN-induced hepatotoxicity in male Sprague–Dawley rats and to elucidate the underlying mechanisms. Methods Thirty-six rats were randomly allocated into six equal groups (n = 6 per group) and treated for 8 weeks. …”
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Comparative analysis of a survey of outand inpatient physicians on secondary prevention of noncommunicable diseases by M. N. Mamedov, V. A. Kutsenko, B. U. Mardanov, O. M. Drapkina

“…To determining the potential of secondary prevention of noncommunicable diseases (NCDs) at the outpatient and inpatient stages by conducting a cross-sectional medical and social survey of a cohort of physicians from various Russian cities.Material and methods. Physicians from outpatient clinics (16 cities, 545 physicians) and hospitals (13 cities, 151 physicians) took part in the cross-sectional study. …”
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Association between sleep disorders and subsequent heart failure by Jamschid Sedighi, Mark Luedde, Julia Gaensbacher-Kunzendorf, Hans-Joerg Hippe, Pascal Bauer, Birgit Assmus, Samuel Sossalla, Karel Kostev

“…Objective: The purpose of this study was to investigate whether sleep disorders are associated with an increased risk of developing HF. Methods: We conducted a retrospective cohort study using data from 1,293 general practices across Germany sourced from the IQVIA Disease Analyzer database. …”
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Lactiplantibacillus plantarum P101 Ameliorates TiO2 NP-Induced Bone Injury in Young Rats by Remodeling the Gut Microbiota and Inhibiting the Production of Pro-Inflammatory Cytokine... by Xie L, Feng L, Tang X, Xu Y, Xu H, Liu Y

“…Lixin Xie,1,* Lihua Feng,1,* Xiaomin Tang,1 Yunping Xu,1 Hengyi Xu,2 Yang Liu1 1Department of Pediatrics, The Second Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, People’s Republic of China; 2State Key Laboratory of Food Science and Resources, Nanchang University, Nanchang, People’s Republic of China*These authors contributed equally to this workCorrespondence: Hengyi Xu, State Key Laboratory of Food Science and Resources, Nanchang University, 235 Nanjing East Road, Nanchang, 330047, People’s Republic of China, Tel +0086-791-8830-4447-ext-9520, Fax +0086-791-8830-4400, Email kidyxu@163.com; HengyiXu@ncu.edu.cn Yang Liu, Department of Pediatrics, The Second Affiliated Hospital, Jiangxi Medical College, Nanchang University, No. 1 minde Road, Nanchang, 330006, People’s Republic of China, Tel +86-791-8631-1209, Email ocean3166@yeah.netPurpose: To evaluate the therapeutic effect of oral administration of Lactiplantibacillus plantarum P101 (P101) on skeletal injury in young rats exposed to titanium dioxide nanoparticles (TiO2 NPs), and explore the potential mechanism.Methods: Four-week-old male rats were orally administration to TiO2 NPs and supplemented with P101 2 hours later for 4 weeks. …”
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Current Advances and Challenges in CAR-T Therapy for Hematological and Solid Tumors by Zhang G, Bai M, Du H, Yuan Y, Wang Y, Fan W, Zhu H, Wu D, He P, Xue B

“…This review aims to provide a comprehensive overview of the current landscape and future perspectives of CAR-T therapy in both hematological malignancies and solid tumors.Methods: A thorough literature search was conducted to identify relevant preclinical and clinical studies, as well as review articles, focusing on CAR-T therapy in various hematological malignancies and solid tumors. …”
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Coilin Affects the Prognosis of Hepatocellular Carcinoma Through Cell Cycle and Apoptosis by Lu L, Zhou X, Zheng J, Li D

“…We investigated the diagnostic and prognostic value of COIL expression in HCC.Patients and Methods: This study evaluated the expression and prognostic significance of COIL using data from the TCGA and local hospital samples, with 374 and 118 liver cancer patients in the TCGA database and local hospital, respectively. …”
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