Adjuvant Trastuzumab in HER2-Positive Early Breast Cancer by Age and Hormone Receptor Status: A Cost-Utility Analysis. by William Leung, Giorgi Kvizhinadze, Nisha Nair, Tony Blakely

“…Given trastuzumab's high cost, we aimed to estimate its cost-effectiveness by heterogeneity in age and estrogen receptor (ER) and progesterone receptor (PR) status, which has previously been unexplored, to assist prioritisation.<h4>Methods and findings</h4>A cost-utility analysis was performed using a Markov macro-simulation model, with a lifetime horizon, comparing a 12-mo regimen of trastuzumab with chemotherapy alone using the latest (2014) effectiveness measures from landmark randomised trials. …”
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Hypericin Nanoparticles-Associated Photodynamic Therapy Modulates the Biological Behavior of Hepatocellular Carcinoma by SERPINE1 by Yan X, Fan J, Qin W, Liao M, Li S, Suo L, Xie Y, Jiang X, Zou D, Liao W

“…However, the role and mechanism of PDT in hepatocellular carcinoma (HCC) remain unclear.Methods: In this study, we investigated the efficacy of hypericin nanoparticles (HC-NPs)-associated PDT (HC-NPs-PDT) on HCC to explore its anti-HCC mechanism both in vitro and in vivo. …”
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Analyzing special needs reports for children: sociodemographic trends, diagnoses, and support areas over five years (2019–2024) by Semih Canpolat, Mehmet Emin Parlak, Esra Kurt Canpolat, Erdogan Oz

“…ObjectiveThis study aims to evaluate the special needs reports for children (SNRC) in terms of sociodemographic characteristics, diagnoses, and areas of special needs in the five years from 2019, when special health boards for children were established with the new diagnostic and evaluation criteria.MethodsThis descriptive study was conducted by retrospectively reviewing the board evaluation reports of children aged 0–18 years who applied to Batman Training and Research Hospital SNRC Health Board between March 2019 and March 2024. …”
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Establishment and Clinical Application of Rh Blood Group Bank in the East China Region by Jin Y, Fu X, Xie S, Liu Z, Xu Z, Wang M, Wang Y, Lu R, Wang L

“…Yiming Jin,1,&ast; Xiaoyan Fu,2,&ast; Shuhong Xie,3 Zhen Liu,1 Zihao Xu,1 Mingyuan Wang,1 Yihan Wang,1 Rong Lu,1 Lingling Wang1 1Department of Blood Screening Test, Suzhou Blood Center, Suzhou, People’s Republic of China; 2Department of Blood Screening Test, Tai Cang Blood Branch Station, Tai Cang, People’s Republic of China; 3Division of Transfusion Medicine, Suzhou Blood Center, Suzhou, People’s Republic of China&ast;These authors contributed equally to this workCorrespondence: Lingling Wang; Rong Lu, Department of Blood Screening Test, Suzhou Blood Center, Suzhou, People’s Republic of China, Email linglingwang0716@163.com; cv-25a@163.comPurpose: To investigate the expression and distribution of Rh phenotypes (C, c, D, E, e) among voluntary blood donors in a specific region of East China, to establish a regional Rh phenotype database, and to enhance the precision and efficacy of clinical blood transfusions.Patients and Methods: A total of 28979 blood samples were collected from voluntary donors at a central blood station in East China between May 2023 and December 2023. …”
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Media Framing and Portrayals of Ransomware Impacts on Informatics, Employees, and Patients: Systematic Media Literature Review by Atiya Avery, Elizabeth White Baker, Brittany Wright, Ishmael Avery, Dream Gomez

“…ObjectiveThis study used collaborative qualitative analysis to understand how news media frames and portrays the impacts of ransomware attacks on health informatic systems, employees, and patients. MethodsWe developed and implemented a systematic search protocol across academic news databases, which included (1) the Associated Press Newswires, (2) Newspaper Source, and (3) Access World News (Newsbank), using the search string “(hospital OR healthcare OR clinic OR medical) AND (ransomware OR denial of service OR cybersecurity).” …”
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Mechanism of Electroacupuncture on Neuropathic Pain via Regulation of CD137L in Hippocampal Glia by ZHENG Changyue, LAN Yanyan, HUANG Qiuling, JIANG Menghong, WANG Zhifu

“…ObjectiveTo investigate the mechanism of CD137L in CA1 region of hippocampus in improving mechanical pain and memory impairment in neuropathic pain rats during electroacupuncture therapy.MethodsA total of 24 SD rats were randomly divided into sham operation group, model group and electroacupuncture group, with 8 rats in each group. …”
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Getting time and building trust: unveiling the systemic, relational, and personal factors influencing clinical pharmacy service implementation in South Africa, a qualitative study by Lucille Crafford, Rashmi A Kusurkar, Elmien Bronkhorst, Andries Gous, Anouk Wouters

“…Understanding these dynamics, particularly in resource-constrained settings, is crucial for optimizing integration and healthcare delivery. Methods Adopting a constructivist approach, this qualitative study was conducted using focus group discussions. …”
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CITED2 Mediates Metabolic Reprogramming in Renal Tubular Epithelial Cells via the AKT Signaling Pathway to Induce Sepsis-Associated Acute Kidney Injury by Deng R, Yang H, Zhong W, Zhou J, Huang G, Zeng K

“…The aim of this study was to investigate the role of CITED2 in the metabolic reprogramming of TECs and its effects on inflammation and kidney injury in S-AKI.Material and Methods: The C57BL/6 mouse model of S-AKI was established using cecal ligation and puncture (CLP). …”
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Distance between implants has a potential impact of crestal bone resorption by Matteo Danza, Ilaria Zollino, Anna Avantaggiato, Alessandra Lucchese, Francesco Carinci

“…Implant length was shorter than 13 mm, equal to 13 mm and 16 mm in 23 (39%), 23 (39%) and 13 (22%) SFIs. …”
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The Prevalence of Potential Drug-Drug-Gene Interactions: A Descriptive Study Using Swiss Claims Data by Wittwer NL, Meier CR, Huber CA, Moser JD, Meyer zu Schwabedissen HE, Allemann SS, Schneider C

“…Nina L Wittwer,1,2 Christoph R Meier,1– 3 Carola A Huber,4 Julie D Moser,1 Henriette E Meyer zu Schwabedissen,5 Samuel S Allemann,6,&amp;ast; Cornelia Schneider1,2,&amp;ast; 1Basel Pharmacoepidemiology Unit, Division of Clinical Pharmacy and Epidemiology, Department of Pharmaceutical Sciences, University of Basel, Basel, Switzerland; 2Hospital Pharmacy, University Hospital Basel, Basel, Switzerland; 3Boston Collaborative Drug Surveillance Program, Lexington, MA, USA; 4Department of Health Sciences, Helsana Group, Zürich, Switzerland; 5Biopharmacy, Department of Pharmaceutical Sciences, University of Basel, Basel, Switzerland; 6Pharmaceutical Care, Department of Pharmaceutical Sciences, University of Basel, Basel, Switzerland&amp;ast;These authors contributed equally to this workCorrespondence: Samuel S Allemann, Pharmaceutical Care Research Group, University of Basel Department of Pharmaceutical Sciences Klingelbergstrasse 504056 Basel, Switzerland, Email s.allemann@unibas.chPurpose: We aimed to determine the prevalence of interactions between PGx drugs metabolized by CYP2C9, CYP2C19, and CYP2D6 and drugs that act as inhibitors or inducers of those enzymes in the Swiss population.Patients and Methods: We defined concomitant use of PGx drugs and inhibitors/inducers as instances where a claim of a PGx drug and a claim of an inducer or inhibitor concerning the same enzyme were made within a specified temporal window, either ± 5 days or ± 30 days. …”
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Effect of Different Doses of Esketamine on Postoperative Recovery in Patients Undergoing Gynecologic Laparoscopic Surgery, a Randomized, Double-Blind, Single-Center Clinical Study by Li T, Han L, Wu Z, Chen Y, Wang Y

“…Tingting Li,1,&ast; Liuhu Han,2,3,&ast; Zhen Wu,1 Yanfang Chen,1 Yiqiao Wang1 1Department of Anesthesiology, Anhui No.2 Provincial People’s Hospital, Hefei, People’s Republic of China; 2Department of Anesthesiology, The First Affiliated Hospital of Anhui Medical University, Hefei, People’s Republic of China; 3Department of Anesthesiology, Anhui Medical University, Hefei, People’s Republic of China&ast;These authors contributed equally to this workCorrespondence: Yiqiao Wang, Department of Anesthesiology, Anhui No.2 Provincial People’s Hospital, North Second Ring, Yaohai District, Hefei, Anhui, People’s Republic of China, Tel +86 158 5694 0528, Email wyq20188@163.comPurpose: This study aimed to explore the effect of preoperative different doses of esketamine on postoperative recovery in patients undergoing gynecologic laparoscopic surgery.Methods: A total of 99 women scheduled for gynecologic laparoscopic surgery under general anesthesia were enrolled and randomized. …”
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Evaluating the Relationship Between Occupational Exposure to Polycyclic Aromatic Hydrocarbons (PAHs) and Urinary Metabolite Levels in Built-Up Roofing Asphalt Workers in Ilam City by Hossein Ali Rangkooy, Behzad Fouladi Dehaghi, Maedeh Kamalvandi, Hojatollah Kakaei

“…The aim of this study was to investigate the relationship between exposure to PAHs and urinary metabolites among built-up roofing installers. Material and Methods: The current case-control study, conducted in 2021 in Ilam City, involved 35 built-up roofing workers as the case group and 15 non-exposed workers as the control group. …”
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Indicators of cellular metabolism alterationsin patients with traumatic disease due to hypoxia, depending on a management regimen of intensive care by M. S. Matvieienko, Y. V. Volkova, I. V. Belozorov, K. E. Shamoun, O. V. Riabov, V. O. Pronin

“…The aim of this study was to evaluate changes in the level of erythrocyte metabolism under conditions of hypoxia in patients with traumatic disease in polytrauma depending on the components of intensive care (IC). Materials and methods. A prospective study was carried out in 88 patients suffering from polytrauma in the period from 2015 to 2017. …”
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Unveiling the Therapeutic Potential of Baicalin in Intervertebral Disc Degeneration: Integrative Bulk and Single-Cell Transcriptome Analysis with Experimental Validation of PANopto... by Wang X, Gao S, Zhou D, Cai W, Lv J, Wei Z, Song C, Shan X, Liu Z

“…PANoptosis, a recently identified form of PCD integrating pyroptosis, apoptosis, and necroptosis, may represent a more comprehensive target for therapeutic intervention in IVDD.Objective: To explore the role of PANoptosis in IVDD and investigate the therapeutic potential and underlying mechanism of baicalin in regulating PANoptosis to alleviate disc degeneration.Methods: We performed integrative analyses of bulk transcriptomic datasets (GSE167199, GSE245147, GSE266883) and a single-cell RNA-seq dataset (GSE244889) to identify PANoptosis-related genes involved in IVDD. …”
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Intermedin1-53 Improves Atherosclerosis by Reducing Local Endothelial Damage via AMPK Signaling Pathway in Obese apoE-Deficient Mice by Zhu HX, Ren JL, Cao WJ, Wang R, Chen LL, Gao Q, Zhou YB

“…In the present study, the role and mechanism of intermedin (IMD), a potent active peptide, in endothelial damage in AS in obese apolipoprotein E-deficient (apoE−/−) mice were investigated.Methods and Results: In vivo, IMD1-53 was infused via Alzet mini-osmotic pump in apoE−/− mice with high-fat diet (HFD) for 4 weeks. …”
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Healthy lifestyle and life expectancy in people with multimorbidity in the UK Biobank: A longitudinal cohort study. by Yogini V Chudasama, Kamlesh Khunti, Clare L Gillies, Nafeesa N Dhalwani, Melanie J Davies, Thomas Yates, Francesco Zaccardi

“…We investigated the associations between healthy lifestyle and life expectancy in people with and without multimorbidity.<h4>Methods and findings</h4>A total of 480,940 middle-aged adults (median age of 58 years [range 38-73], 46% male, 95% white) were analysed in the UK Biobank; this longitudinal study collected data between 2006 and 2010, and participants were followed up until 2016. …”
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Circulation of Fungi of the Genus Candida in Children's and Adult Multi Purpose Hospitals by M. I. Petrukhina, A. M. Martynova2, N. G. Politova, N. V. Starostina, A. N. Cairo

“…The aim of the work is to study the circulation of fungi of the genus Candida in children's and adult multi purpose hospitals.Materials and methods. A total of 61,226 studies of material obtained from patients in the children's hospital were performed. …”
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Increased Co-Expression of PD-L1 and CTLA-4 Predicts Poor Overall Survival in Patients with Acute Myeloid Leukemia Following Allogeneic Hematopoietic Stem Cell Transplantation by Chen C, Qiu K, Chen J, Wang S, Zhang Y, Wang C, Li Y

“…This study aims to investigate the significance of the alteration of IC co-expression for evaluating the prognosis of AML patients following allogeneic hematopoietic stem cell transplantation (allo-HSCT).Patients and Methods: Quantitative real-time PCR (qRT-PCR) data of bone marrow (BM) samples from 62 de novo AML patients, including 37 patients who received allo-HSCT and 25 patients who received chemotherapy only, were used for prognostic analysis.Results: High expression of PD-1, PD-L1, PD-L2, CTLA-4, and LAG-3 was associated with poor overall survival (OS) in AML patients receiving allo-HSCT, while the expression levels of PD-1, PD-L2, CTLA-4, and LAG-3, other than PD-L1, were not significantly correlated with OS in AML patients receiving chemotherapy. …”
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Retrospective cohort study on cumulative live birth rate of in vitro fertilization/intracytoplasmic sperm injection after multiple complete cycles in patients with diminished ovari... by Sisi Xi, Xiuli Yang, Jing Shang, Qing Xue

“…This study aimed to evaluate the cumulative live birth rate of in vitro fertilization / intracytoplasmic sperm injection after multiple complete cycles in patients with diminished ovarian reserve. Methods We performed a retrospective cohort study in female patients with diminished ovarian reserve undergoing in vitro fertilization / intracytoplasmic sperm injection cycle during the period from January 2016 to December 2020. …”
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Allopurinol in the complex therapy of acute decompensation of heart failure by Laura H. Sarieva, Marina D. Muksinova, Svetlana N. Nasonova, Igor V. Zhirov, Sergey N. Tereshchenko

“…To evaluate the efficacy of allopurinol in patients with ADHF, hyperuricemia, and reduced glomerular filtration rate compared with standard of care for 6 months. Materials and methods. We present the results of a 6-month follow-up for 72 patients with ADHF, hyperuricemia, and reduced filtration function of the kidneys, calculated using the CKD-EPI formula, divided equally into two groups: group 1 received standard of care for HF combined with a xanthine oxidase inhibitor – allopurinol, and group 2 received standard of care only. …”
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