Evaluation of the tubular penetration of two different types of nanoparticle root canal sealers over apically separated files: a scanning electron microscopic study (in vitro study... by Alaa H. Nagdi, Nayera A. Mokhless, Mahmoud R. Aboelseoud

“…Aim of the study This study aimed to evaluate tubular penetration of two nanoparticles modified root canal sealers compared to conventional sealers using ultrasonic activation over an apically separated file analyzed by scanning electron microscopy (SEM). Materials and methods Forty extracted single canaled mandibular premolar teeth were decoronated and prepared using M-Pro (IMD, Shanghai, China) nickel titanium rotary files which were intentionally separated at apical third. …”
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Exploring Melasma Patients’ Needs Through Social Media: A Qualitative Study by Liu X, Liu X, Han Y, Cheng Y, Luo H, Liu Y, Li D, Guo W, Jiang H, Guo L, Jiang X

“…Xinjin Liu,1,2,* Xu Liu,1,2,* Yanbing Han,1,2 Yifei Cheng,1,2 Hongjie Luo,1,2 Yichen Liu,1,2 Dingling Li,1,2 Weihong Guo,1,2 Haoyu Jiang,1,2 Linghong Guo,1,2 Xian Jiang1,2 1Department of Dermatology, West China Hospital, Sichuan University, Chengdu, 610041, People’s Republic of China; 2Laboratory of Dermatology, Clinical Institute of Inflammation and Immunology, Frontiers Science Center for Disease-Related Molecular Network, West China Hospital, Sichuan University, Chengdu, 610041, People’s Republic of China*These authors contributed equally to this workCorrespondence: Xian Jiang, Department of Dermatology, West China Hospital, Sichuan University, No. 37 Guoxue Xiang, Chengdu, 610041, People’s Republic of China, Tel +86 189 8060 1693, Email jiangxian@scu.edu.cn Linghong Guo, Department of Dermatology, West China Hospital, Sichuan University, No. 37 Guoxue Xiang, Chengdu, 610041, People’s Republic of China, +86 18380131660, Email Linhom.guo@foxmail.comPurpose: To identify the primary concerns and unmet needs of patients with melasma on social media using qualitative analysis and AI-based keyword extraction.Patients and Methods: We conducted a qualitative study of melasma patient discussions using publicly available posts on Facebook and Baidu. …”
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Parents’ perspective on children’s access to healthcare services and associated factors: a cross-sectional study by Nona Salimi, Javad Javan-Noughabi, Vahid Ghavami, Reza Matinfar, Fatemeh Kokabisaghi

“…This research aimed to explore parents’ perspective on children’s access to healthcare services and its associated factors. Methods In this cross-sectional study, 317 parents of children aged ≤ 18, chosen by two-stage cluster sampling participated. …”
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NOSOLOGICAL DIAGNOSIS OF JUVENILE ARTHRITIS AT DIFFERENT FOLLOW-UP STAGES by Svetlana Olegovna Salugina

“…Objective: to define the nosological category of juvenile arthritis (JA) in patients of different ages with different disease stages and follow-up periods. Subjects and methods. Group 1 included 135 children, mainly girls (60.7%), aged 1 to 16 years (range 7.9±5.0 years) with early-onset JA, the duration of which was 2 weeks to 6 months (range 2.9±1.6 months) who were further followed up for 2 years. …”
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MHR Was Associated with Hyperuricemia Risk in Patients with Type 2 Diabetes Mellitus: The Mediating Effect of Body Mass Index by Huang B, Li X, Zhang XX, Li SW, Wang M, Chen Q, Cao YD, Cui JQ

“…Therefore, our study specifically investigates the relationship between MHR and HUA in a T2DM population.Methods: This cross-sectional study enrolled 1,261 T2DM patients. …”
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Varicella-zoster virus vasculopathy: a rare complication of Ramsay Hunt Syndrome: a literature review by Di Wu, Mian Song

“…The aim of this review was to analyze clinical and neuroimaging findings, laboratory findings, treatment and outcome of these patients.MethodsWe report a literature review that includes all case reports identified via PubMed on RHSII complicated by VZV Vasculopathy. …”
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“It’s the Time they Take to Give Feedback; it has Become a Problem” Exploring Barriers and Facilitators for Research Supervision in Postgraduate Medical Education... by Abeid M, Mbekenga C, Jusabani AM, Kassamali SA, Mgonja ML, Sibuma M, Sirili N, Noorani M

“…We aimed to explore the barriers and facilitators for research supervision in postgraduate medical education in Tanzania.Methods: We adopted an exploratory qualitative case study and conducted key informant interviews with three purposively selected faculty in leadership and four focus group discussions with 14 postgraduate trainees and 10 faculty members. …”
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Huanglian Ejiao Decoction Alleviates Ulcerative Colitis in Mice Through Regulating the Gut Microbiota and Inhibiting the Ratio of Th1 and Th2 Cells by Tang J, Hu Y, Fang J, Zhu W, Xu W, Yu D, Zheng Z, Zhou Q, Fu H, Zhang W

“…Therefore, this study aimed to investigate whether HED could exert anti-inflammatory effects on 2,4,6-Trinitrobenzenesulfonic acid (TNBS)-induced colitis (UC) model through the regulation of CD4+T subsets and gut microbiota.Methods: Fifty-eight major compounds in HED were identified by UPLC-Q-TOF/MS. …”
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Combination of Diane-35 and Cangfu Daotan Wan Effectively Ameliorates Inflammatory Response, Stress State, and Hormone Levels in Patients with Polycystic Ovary Syndrome (PCOS), Lea... by Chen L, Fang CP, Chen Y, Gu WH, Wang SL, Niu N, Zhang QH

“…Li Chen,1,* Cai-Ping Fang,1,* Yan Chen,1 Wei-Hua Gu,1 Sai-Li Wang,1 Ning Niu,1 Qin-Hua Zhang2 1Department of Gynecology, Taizhou Hospital of Traditional Chinese Medicine, Taizhou, People’s Republic of China; 2Department of Gynecology, Shanghai Shuguang Hospital, Shanghai, People’s Republic of China*These authors contributed equally to this workCorrespondence: Qin-Hua Zhang, Email bzie564@163.comObjective: To assess the impact of combining Diane-35 with Cangfu Daotan Wan on inflammatory response, stress response, and hormone levels in patients with polycystic ovary syndrome (PCOS), and to offer insights for clinical management.Methods: A retrospective analysis was conducted from January 2022 to March 2024, encompassing PCOS patients treated at our hospital who fulfilled the inclusion criteria. …”
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Evaluation of Medical Device Aging and Replacement Decisions within Hospital Environments: A User-Centered Approach by Park S, Seo G, Park Y, Kim EJ, Lee H, Lee M, Jakovljevic M

“…We seek to prioritize criteria for medical device replacement and develop feasible strategies applicable to real-world healthcare settings.Methods: This analysis was conducted by reviewing previous studies to identify the key factors in medical device replacements. …”
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The Accuracy of Dynamic Parameters for Prediction of Fluid Responsiveness in Elderly Patients with Septic Shock by Paphawin S, Theerawit P, Junhasavasdikul D, Sutherasan Y

“…Sittikorn Paphawin,1,* Pongdhep Theerawit,2,* Detajin Junhasavasdikul,3 Yuda Sutherasan3 1Department of Medicine, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, Thailand; 2Division of Critical Care Medicine, Department of Medicine, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, Thailand; 3Division of Pulmonary and Pulmonary Critical Care Medicine, Department of Medicine, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, Thailand*These authors contributed equally to this workCorrespondence: Yuda Sutherasan, Division of Pulmonary and Pulmonary Critical Care Medicine, Department of Medicine, Faculty of Medicine Ramathibodi Hospital, 270 Rama VI Road, Ratchathewi, Bangkok, 10400, Thailand, Tel +6622011619, Fax +6622011629 Ext 2, Email Sutherasan_yuda@yahoo.comPurpose: Assessed the accuracy of stroke volume variation (SVV), pulse pressure variation (PPV), and dynamic arterial elastance (Eadyn) in predicting fluid responsiveness (FR) and mean arterial pressure (MAP) response in elderly patients with septic shock.Patients and Methods: Mechanically ventilated patients aged over 65 with septic shock were enrolled. …”
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The Advances in Utilizing Right Ventricular Function as a Predictor of Peripartum Cardiomyopathy Recovery: A Single Centre Prospective Cohort Study by Akbar MR, Sakasasmita S, Achmad C, Dewi TI, Hasan M, Prameswari HS

“…One of the contemporary predictors studied in cardiomyopathy is right ventricular (RV) function during initial presentation.Purpose: This study aimed to determine the role of RV systolic function based on the various RV function parameters by two-dimensional transthoracic echocardiography (2DE) to predict PPCM recovery within 6 months of follow-up and identify the most accurate parameter among them.Patients and Methods: This was a prospective cohort study that include all patients registered in the “Long Term Registry on Patients with Peripartum Cardiomyopathy” at Dr. …”
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CLSI-derived hematology and biochemistry reference intervals for healthy adults in eastern and southern Africa. by Etienne Karita, Nzeera Ketter, Matt A Price, Kayitesi Kayitenkore, Pontiano Kaleebu, Annet Nanvubya, Omu Anzala, Walter Jaoko, Gaudensia Mutua, Eugene Ruzagira, Joseph Mulenga, Eduard J Sanders, Mary Mwangome, Susan Allen, Agnes Bwanika, Ubaldo Bahemuka, Ken Awuondo, Gloria Omosa, Bashir Farah, Pauli Amornkul, Josephine Birungi, Sarah Yates, Lisa Stoll-Johnson, Jill Gilmour, Gwynn Stevens, Erin Shutes, Olivier Manigart, Peter Hughes, Len Dally, Janet Scott, Wendy Stevens, Pat Fast, Anatoli Kamali

“…The objective of this study was to establish clinical laboratory reference intervals for 25 hematology, immunology and biochemistry values among healthy African adults typical of those who might join a clinical trial.<h4>Methods and findings</h4>Equal proportions of men and women were invited to participate in a cross sectional study at seven clinical centers (Kigali, Rwanda; Masaka and Entebbe, Uganda; two in Nairobi and one in Kilifi, Kenya; and Lusaka, Zambia). …”
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Examining the Prevalence and Associated Factors of Sexually Transmitted Infections in People Living With HIV/AIDS at a Community Health Center in Bandung City, Indonesia by Nuraeni S, Alfian SD, Puspitasari IM

“…Sani Nuraeni,1,&ast; Sofa Dewi Alfian,2,3 Irma Melyani Puspitasari2,3,&ast; 1Master of Pharmacy Program, Faculty of Pharmacy, Universitas Padjadjaran, Sumedang, Indonesia; 2Department of Pharmacology and Clinical Pharmacy, Faculty of Pharmacy, Universitas Padjadjaran, Sumedang, Indonesia; 3Center of Excellence for Pharmaceutical Care Innovation (PHARCI), Universitas Padjajdjaran, Sumedang, Indonesia&ast;These authors contributed equally to this workCorrespondence: Irma Melyani Puspitasari, Department of Pharmacology and Clinical Pharmacy, Faculty of Pharmacy, Universitas Padjadjaran, Sumedang, Indonesia, Tel +62 22 84288888 Ext 3510, Email irma.melyani@unpad.ac.idPurpose: This study aims to investigate the prevalence of sexually transmitted infections (STIs) and associated factors among people living with human immunodeficiency virus (HIV)/acquired immune deficiency syndrome (AIDS) (PLWHA) registered in a community health center (CHC) with HIV/AIDS support and treatment services in Indonesia.Methods: A cross-sectional study that included all PLWHA data from medical records registered in a CHC with HIV/AIDS support and treatment services was conducted in Bandung City, Indonesia, between March 2019 and March 2024. …”
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eHealth Literacy and Health-Related Internet Use Among Swedish Primary Health Care Visitors: Cross-Sectional Questionnaire Study by Anna Sjöström, Senada Hajdarevic, Åsa Hörnsten, Ulf Isaksson

“…ObjectiveThis study investigated eHealth literacy and its association with health-related internet use and sociodemographic characteristics among primary health care visitors. MethodsThis cross-sectional study used a quantitative, descriptive approach. …”
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The effect of fall-proof training on functional capacities, working memory and Muscle strength of the elderly with stroke by Farahnaz Ayatizadeh Tafti, Saeed Abedinzadeh Masuleh, Mohammad Reza Sadeghian Shahi, Hamidreza Maleki nezhad

“…The aim of the present study was to investigate the effect of fall-proof training on functional capacities, working memory and Muscle strength of the elderly with stroke.Materials and Methods: 24 elderly patients suffering from a stroke were divided into two experimentally equal groups and control. …”
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The safety and effectiveness of sintilimab versus camrelizumab, both plus targeted drugs, in advanced hepatocellular carcinoma by Chenglong Zhao, Qiongni Zhu, Xiaoyan Qian, Zhonghua Fu, Wei Zhang, Yaqin Wang

“…Then the effectiveness was compared between sintilimab-lenvatinib and camrelizumab-apatinib.MethodsPatients diagnosed as advanced HCC were included from January 2017 to December 2023. …”
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Ultrasound-Guided Percutaneous Microwave Coagulation Studies on VX2 Rabbit Models for Breast Cancer Treatment and Ultrasound Imaging Assessment by Gao Q, Huang H, Shi JJ, Wang L, Li WM

“…Qi Gao,1,&ast; Hu Huang,2,&ast; Jin-Jun Shi,1 Ling Wang,1 Wei-Min Li3 1Department of Ultrasonography, Zhongda Hospital, Medical School, Southeast University, Nanjing, Jiangsu, People’s Republic of China; 2Department of Thyroid and Breast Surgery, Affiliated Hospital of Jiangnan University, Wuxi, Jiangsu, People’s Republic of China; 3Department of Ultrasonography, Affiliated Hospital of Jiangnan University, Wuxi, Jiangsu, People’s Republic of China&ast;These authors contributed equally to this workCorrespondence: Wei-Min Li, Department of Ultrasonography, Affiliated Hospital of Jiangnan University, Wuxi, Jiangsu, 214000, People’s Republic of China, Tel +8613912362309, Email 1005342597@qq.com Ling Wang, Department of Ultrasonography, Zhongda Hospital, Medical School, Southeast University, Nanjing, Jiangsu, 210009, People’s Republic of China, Tel +8613852292915, Email wl031995@163.comBackground: The study aimed to explore the tissue morphology and hemodynamics of rabbit VX2 breast carcinoma by high-frequency ultrasound (US) and the effectiveness and safety of US-guided percutaneous microwave coagulation (PMC) therapy on rabbit VX2 breast tumors.Methods: Twenty VX2 tumor-bearing rabbits were assessed using color Doppler ultrasound for tumor growth characteristics including echo, size, blood supply and hemodynamic parameters once a week for six weeks. …”
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Distribution and Related Influencing Factors of AMH Level in Family-Planning Women of Childbearing Age: A Cross-Sectional Study from Beijing, China by Song J, Gao S, Zhao L, Tong X

“…Jinwei Song,1,&ast; Songkun Gao,2,&ast; Lixia Zhao,1 Xiaolong Tong1 1Women ‘s Health Department, Xicheng District Maternal and Child Health Care Hospital, Beijing, 100054, People’s Republic of China; 2Gynecologic Oncology Department,Beijing Obstetrics and Gynecology Hospital, Capital Medical University, Beijing Maternal and Child Health Care Hospital, Beijing, 100026, People’s Republic of China&ast;These authors contributed equally to this workCorrespondence: Jinwei Song; Xiaolong Tong, Women ‘s Health Department, Xicheng District Maternal and Child Health Care Hospital, Building 19, Pingyuanli Community, Baizhifang Street, Xicheng District, Beijing, 100054, People’s Republic of China, Email songjinwei2023@163.com; 18519309607@163.comPurpose: This study aimed to analyze the distribution and factors influencing anti-Müllerian hormone (AMH) levels among family-planning women of childbearing age in Beijing, China.Patients and Methods: We collected the data of 3,236 family-planning women of childbearing age who underwent pre-pregnancy examinations at Xicheng District Maternal and Child Health Hospital in Beijing between October 2021 and July 2024. …”
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Serum Apolipoprotein B and B/A1 Ratio as Early Negative Biomarkers for OCT- and OCTA-Detected Retinal Changes in Diabetic Macular Edema by Soedarman S, Julia M, Gondhowiardjo TD, Kurnia KH, Prasetya ADB, Triyoga IF, Sasongko MB

“…Sardjito General Hospital, Yogyakarta, Indonesia; 3Department of Paediatrics and Child Health, Faculty of Medicine, Public Health, and Nursing, Universitas Gadjah Mada, Yogyakarta, Indonesia; 4Faculty of Medicine, University of Indonesia, Jakarta, Indonesia&amp;ast;These authors contributed equally to this workCorrespondence: Soefiandi Soedarman, JEC @Menteng Eye Hospitals, Jalan Teuku Cik Ditiro No. 46, Menteng, Jakarta, Indonesia, Tel +62 2922 1000; +62 8041221000, Email sandi_soedarman@yahoo.comPurpose: This study aimed to explore the relationships between serum apolipoprotein A1 (ApoA1) and B (ApoB) levels and the ApoB/A1 ratio with structural and vascular changes in the retinas of patients with diabetic macular edema (DME), as assessed through optical coherence tomography (OCT) and OCT angiography (OCTA).Methods: 62 eyes from 38 treatment-naive diabetic retinopathy patients were assessed. …”
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